Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIS1_LEIBR

TriTrypDb:

LbrM.30.3370 , LBRM2903_300040700

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.534
CLV_NRD_NRD_1	376	378	PF00675	0.597
CLV_NRD_NRD_1	379	381	PF00675	0.558
CLV_NRD_NRD_1	8	10	PF00675	0.687
CLV_PCSK_FUR_1	374	378	PF00082	0.595
CLV_PCSK_KEX2_1	196	198	PF00082	0.621
CLV_PCSK_KEX2_1	245	247	PF00082	0.550
CLV_PCSK_KEX2_1	376	378	PF00082	0.597
CLV_PCSK_KEX2_1	379	381	PF00082	0.558
CLV_PCSK_KEX2_1	8	10	PF00082	0.592
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.621
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.550
CLV_PCSK_SKI1_1	141	145	PF00082	0.591
CLV_PCSK_SKI1_1	239	243	PF00082	0.518
CLV_PCSK_SKI1_1	296	300	PF00082	0.640
CLV_PCSK_SKI1_1	3	7	PF00082	0.606
CLV_PCSK_SKI1_1	9	13	PF00082	0.612
DEG_Nend_UBRbox_3	1	3	PF02207	0.592
DEG_SPOP_SBC_1	205	209	PF00917	0.540
DOC_CKS1_1	98	103	PF01111	0.499
DOC_PP1_RVXF_1	173	179	PF00149	0.548
DOC_PP1_RVXF_1	243	250	PF00149	0.537
DOC_PP1_RVXF_1	303	310	PF00149	0.478
DOC_PP2B_LxvP_1	299	302	PF13499	0.630
DOC_PP4_FxxP_1	351	354	PF00568	0.544
DOC_USP7_MATH_1	113	117	PF00917	0.597
DOC_USP7_MATH_1	203	207	PF00917	0.685
DOC_USP7_MATH_1	251	255	PF00917	0.641
DOC_USP7_MATH_1	314	318	PF00917	0.571
DOC_USP7_UBL2_3	280	284	PF12436	0.522
DOC_USP7_UBL2_3	296	300	PF12436	0.704
DOC_WW_Pin1_4	261	266	PF00397	0.507
DOC_WW_Pin1_4	332	337	PF00397	0.694
DOC_WW_Pin1_4	70	75	PF00397	0.693
DOC_WW_Pin1_4	97	102	PF00397	0.596
LIG_14-3-3_CanoR_1	197	202	PF00244	0.623
LIG_14-3-3_CanoR_1	318	322	PF00244	0.578
LIG_14-3-3_CterR_2	379	384	PF00244	0.577
LIG_BRCT_BRCA1_1	253	257	PF00533	0.539
LIG_BRCT_BRCA1_1	347	351	PF00533	0.537
LIG_FHA_1	130	136	PF00498	0.664
LIG_FHA_1	171	177	PF00498	0.506
LIG_FHA_1	220	226	PF00498	0.616
LIG_FHA_1	289	295	PF00498	0.503
LIG_FHA_1	335	341	PF00498	0.562
LIG_FHA_1	43	49	PF00498	0.668
LIG_FHA_2	322	328	PF00498	0.590
LIG_FHA_2	354	360	PF00498	0.474
LIG_LIR_Apic_2	348	354	PF02991	0.466
LIG_LIR_Gen_1	53	62	PF02991	0.529
LIG_LIR_Nem_3	53	59	PF02991	0.520
LIG_PDZ_Class_1	379	384	PF00595	0.492
LIG_Pex14_2	39	43	PF04695	0.421
LIG_PTB_Apo_2	366	373	PF02174	0.629
LIG_PTB_Phospho_1	366	372	PF10480	0.628
LIG_SH2_CRK	56	60	PF00017	0.506
LIG_SH2_STAT5	261	264	PF00017	0.523
LIG_SH2_STAT5	357	360	PF00017	0.509
LIG_SH3_3	104	110	PF00018	0.545
LIG_SH3_3	131	137	PF00018	0.795
LIG_SH3_3	161	167	PF00018	0.694
LIG_SH3_3	259	265	PF00018	0.517
LIG_SH3_3	335	341	PF00018	0.527
LIG_SH3_3	71	77	PF00018	0.703
LIG_SH3_3	95	101	PF00018	0.570
LIG_SH3_4	296	303	PF00018	0.502
LIG_SH3_5	368	372	PF00018	0.633
LIG_SUMO_SIM_anti_2	45	53	PF11976	0.453
LIG_SUMO_SIM_par_1	218	228	PF11976	0.515
LIG_SUMO_SIM_par_1	45	53	PF11976	0.443
LIG_TYR_ITIM	54	59	PF00017	0.491
MOD_CDC14_SPxK_1	264	267	PF00782	0.493
MOD_CDK_SPxK_1	261	267	PF00069	0.501
MOD_CK1_1	120	126	PF00069	0.580
MOD_CK1_1	15	21	PF00069	0.473
MOD_CK1_1	150	156	PF00069	0.594
MOD_CK1_1	206	212	PF00069	0.612
MOD_CK1_1	221	227	PF00069	0.501
MOD_CK1_1	282	288	PF00069	0.640
MOD_CK1_1	317	323	PF00069	0.494
MOD_CK2_1	213	219	PF00069	0.683
MOD_CK2_1	327	333	PF00069	0.539
MOD_Cter_Amidation	194	197	PF01082	0.662
MOD_GlcNHglycan	127	130	PF01048	0.788
MOD_GlcNHglycan	16	20	PF01048	0.577
MOD_GlcNHglycan	191	194	PF01048	0.541
MOD_GlcNHglycan	283	287	PF01048	0.631
MOD_GlcNHglycan	64	67	PF01048	0.631
MOD_GSK3_1	113	120	PF00069	0.703
MOD_GSK3_1	121	128	PF00069	0.664
MOD_GSK3_1	141	148	PF00069	0.667
MOD_GSK3_1	205	212	PF00069	0.720
MOD_GSK3_1	213	220	PF00069	0.622
MOD_GSK3_1	221	228	PF00069	0.608
MOD_GSK3_1	278	285	PF00069	0.451
MOD_GSK3_1	288	295	PF00069	0.479
MOD_GSK3_1	317	324	PF00069	0.541
MOD_GSK3_1	327	334	PF00069	0.437
MOD_GSK3_1	62	69	PF00069	0.609
MOD_GSK3_1	78	85	PF00069	0.667
MOD_GSK3_1	92	99	PF00069	0.672
MOD_LATS_1	378	384	PF00433	0.578
MOD_N-GLC_1	62	67	PF02516	0.485
MOD_NEK2_1	130	135	PF00069	0.570
MOD_NEK2_1	4	9	PF00069	0.608
MOD_NEK2_1	62	67	PF00069	0.693
MOD_NEK2_2	345	350	PF00069	0.521
MOD_PIKK_1	142	148	PF00454	0.753
MOD_PIKK_1	29	35	PF00454	0.516
MOD_PIKK_1	42	48	PF00454	0.645
MOD_PIKK_1	66	72	PF00454	0.573
MOD_PKA_2	292	298	PF00069	0.562
MOD_PKA_2	317	323	PF00069	0.577
MOD_PKA_2	345	351	PF00069	0.669
MOD_Plk_1	120	126	PF00069	0.528
MOD_Plk_1	15	21	PF00069	0.424
MOD_Plk_1	218	224	PF00069	0.514
MOD_Plk_2-3	327	333	PF00069	0.539
MOD_Plk_2-3	353	359	PF00069	0.474
MOD_Plk_4	130	136	PF00069	0.607
MOD_ProDKin_1	261	267	PF00069	0.501
MOD_ProDKin_1	332	338	PF00069	0.686
MOD_ProDKin_1	70	76	PF00069	0.688
MOD_ProDKin_1	97	103	PF00069	0.601
MOD_SUMO_for_1	167	170	PF00179	0.711
MOD_SUMO_for_1	34	37	PF00179	0.551
MOD_SUMO_for_1	50	53	PF00179	0.441
TRG_DiLeu_BaEn_1	181	186	PF01217	0.461
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.606
TRG_ENDOCYTIC_2	56	59	PF00928	0.503
TRG_ER_diArg_1	374	377	PF00400	0.589
TRG_ER_diArg_1	379	381	PF00400	0.561
TRG_NLS_MonoCore_2	195	200	PF00514	0.663
TRG_NLS_MonoExtN_4	194	200	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU67	Leptomonas seymouri	44%	85%
A0A3Q8IFV3	Leishmania donovani	67%	98%
A4I617	Leishmania infantum	67%	98%
E9B1A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	98%
Q4Q6V6	Leishmania major	65%	100%
V5BPG9	Trypanosoma cruzi	30%	70%