SH3-domain GRB2-like endophilin B2b

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIS0_LEIBR

TriTrypDb:

LbrM.30.3360 , LBRM2903_300040600

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.838
CLV_NRD_NRD_1	133	135	PF00675	0.506
CLV_NRD_NRD_1	9	11	PF00675	0.600
CLV_PCSK_KEX2_1	133	135	PF00082	0.506
CLV_PCSK_KEX2_1	9	11	PF00082	0.600
CLV_PCSK_SKI1_1	106	110	PF00082	0.529
CLV_PCSK_SKI1_1	156	160	PF00082	0.578
CLV_PCSK_SKI1_1	199	203	PF00082	0.482
CLV_Separin_Metazoa	114	118	PF03568	0.487
DEG_APCC_DBOX_1	198	206	PF00400	0.489
DEG_COP1_1	71	79	PF00400	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.672
DEG_SPOP_SBC_1	305	309	PF00917	0.792
DOC_CDC14_PxL_1	231	239	PF14671	0.534
DOC_CDC14_PxL_1	73	81	PF14671	0.545
DOC_CKS1_1	265	270	PF01111	0.597
DOC_CKS1_1	319	324	PF01111	0.650
DOC_CKS1_1	338	343	PF01111	0.570
DOC_PP2B_LxvP_1	302	305	PF13499	0.542
DOC_USP7_MATH_1	184	188	PF00917	0.493
DOC_USP7_MATH_1	291	295	PF00917	0.700
DOC_USP7_MATH_1	305	309	PF00917	0.812
DOC_USP7_MATH_1	336	340	PF00917	0.792
DOC_USP7_MATH_1	80	84	PF00917	0.532
DOC_WW_Pin1_4	22	27	PF00397	0.615
DOC_WW_Pin1_4	264	269	PF00397	0.583
DOC_WW_Pin1_4	318	323	PF00397	0.699
DOC_WW_Pin1_4	337	342	PF00397	0.671
LIG_14-3-3_CanoR_1	151	158	PF00244	0.417
LIG_14-3-3_CanoR_1	177	185	PF00244	0.479
LIG_14-3-3_CanoR_1	199	208	PF00244	0.483
LIG_14-3-3_CanoR_1	30	38	PF00244	0.632
LIG_14-3-3_CanoR_1	9	18	PF00244	0.605
LIG_Actin_WH2_2	113	129	PF00022	0.334
LIG_Actin_WH2_2	51	69	PF00022	0.347
LIG_BRCT_BRCA1_1	186	190	PF00533	0.586
LIG_BRCT_BRCA1_1	215	219	PF00533	0.492
LIG_CtBP_PxDLS_1	26	30	PF00389	0.678
LIG_deltaCOP1_diTrp_1	169	176	PF00928	0.500
LIG_EVH1_1	242	246	PF00568	0.718
LIG_FHA_1	10	16	PF00498	0.598
LIG_FHA_1	202	208	PF00498	0.452
LIG_FHA_1	319	325	PF00498	0.583
LIG_FHA_1	338	344	PF00498	0.496
LIG_FHA_2	23	29	PF00498	0.478
LIG_FHA_2	327	333	PF00498	0.673
LIG_FHA_2	41	47	PF00498	0.499
LIG_FHA_2	63	69	PF00498	0.504
LIG_FHA_2	98	104	PF00498	0.509
LIG_LIR_Apic_2	348	354	PF02991	0.792
LIG_LIR_Apic_2	366	372	PF02991	0.700
LIG_LIR_Gen_1	110	120	PF02991	0.487
LIG_LIR_Gen_1	139	147	PF02991	0.494
LIG_LIR_Gen_1	157	162	PF02991	0.555
LIG_LIR_Gen_1	210	219	PF02991	0.490
LIG_LIR_Nem_3	110	116	PF02991	0.493
LIG_LIR_Nem_3	139	143	PF02991	0.489
LIG_LIR_Nem_3	157	161	PF02991	0.557
LIG_LIR_Nem_3	210	214	PF02991	0.490
LIG_LIR_Nem_3	220	226	PF02991	0.535
LIG_LIR_Nem_3	71	76	PF02991	0.541
LIG_MYND_1	235	239	PF01753	0.597
LIG_MYND_1	250	254	PF01753	0.683
LIG_Pex14_2	219	223	PF04695	0.513
LIG_PTAP_UEV_1	231	236	PF05743	0.433
LIG_REV1ctd_RIR_1	140	150	PF16727	0.500
LIG_SH2_CRK	351	355	PF00017	0.707
LIG_SH2_CRK	369	373	PF00017	0.713
LIG_SH2_CRK	73	77	PF00017	0.544
LIG_SH2_SRC	269	272	PF00017	0.800
LIG_SH2_SRC	351	354	PF00017	0.714
LIG_SH2_SRC	369	372	PF00017	0.712
LIG_SH2_STAT3	271	274	PF00017	0.756
LIG_SH2_STAT5	337	340	PF00017	0.575
LIG_SH3_1	74	80	PF00018	0.548
LIG_SH3_3	223	229	PF00018	0.548
LIG_SH3_3	232	238	PF00018	0.588
LIG_SH3_3	240	246	PF00018	0.612
LIG_SH3_3	262	268	PF00018	0.577
LIG_SH3_3	280	286	PF00018	0.642
LIG_SH3_3	298	304	PF00018	0.721
LIG_SH3_3	312	318	PF00018	0.675
LIG_SH3_3	319	325	PF00018	0.684
LIG_SH3_3	335	341	PF00018	0.731
LIG_SH3_3	74	80	PF00018	0.548
LIG_TRAF2_1	100	103	PF00917	0.514
LIG_TRAF2_1	25	28	PF00917	0.578
LIG_TRFH_1	300	304	PF08558	0.543
LIG_WRC_WIRS_1	116	121	PF05994	0.578
LIG_WRC_WIRS_1	208	213	PF05994	0.491
MOD_CK1_1	200	206	PF00069	0.483
MOD_CK1_1	263	269	PF00069	0.706
MOD_CK1_1	308	314	PF00069	0.756
MOD_CK2_1	11	17	PF00069	0.576
MOD_CK2_1	207	213	PF00069	0.486
MOD_CK2_1	22	28	PF00069	0.439
MOD_CK2_1	326	332	PF00069	0.674
MOD_CK2_1	40	46	PF00069	0.503
MOD_CK2_1	62	68	PF00069	0.473
MOD_CK2_1	97	103	PF00069	0.504
MOD_GlcNHglycan	191	194	PF01048	0.591
MOD_GlcNHglycan	232	235	PF01048	0.434
MOD_GlcNHglycan	261	265	PF01048	0.612
MOD_GlcNHglycan	271	274	PF01048	0.706
MOD_GlcNHglycan	365	368	PF01048	0.616
MOD_GSK3_1	197	204	PF00069	0.480
MOD_GSK3_1	213	220	PF00069	0.499
MOD_GSK3_1	259	266	PF00069	0.658
MOD_GSK3_1	304	311	PF00069	0.745
MOD_GSK3_1	355	362	PF00069	0.728
MOD_N-GLC_1	281	286	PF02516	0.670
MOD_N-GLC_1	345	350	PF02516	0.805
MOD_N-GLC_1	363	368	PF02516	0.716
MOD_NEK2_1	115	120	PF00069	0.473
MOD_NEK2_1	142	147	PF00069	0.539
MOD_NEK2_1	150	155	PF00069	0.489
MOD_NEK2_1	189	194	PF00069	0.584
MOD_NEK2_1	219	224	PF00069	0.523
MOD_NEK2_1	40	45	PF00069	0.346
MOD_NEK2_1	62	67	PF00069	0.497
MOD_NEK2_1	97	102	PF00069	0.495
MOD_NEK2_2	291	296	PF00069	0.551
MOD_NEK2_2	326	331	PF00069	0.577
MOD_PIKK_1	150	156	PF00454	0.401
MOD_PIKK_1	184	190	PF00454	0.364
MOD_PIKK_1	217	223	PF00454	0.509
MOD_PIKK_1	9	15	PF00454	0.596
MOD_PIKK_1	98	104	PF00454	0.509
MOD_PKA_1	9	15	PF00069	0.596
MOD_PKA_2	150	156	PF00069	0.401
MOD_PKA_2	176	182	PF00069	0.482
MOD_PKA_2	252	258	PF00069	0.546
MOD_PKA_2	29	35	PF00069	0.643
MOD_PKA_2	8	14	PF00069	0.594
MOD_Plk_1	156	162	PF00069	0.564
MOD_Plk_1	197	203	PF00069	0.483
MOD_Plk_1	281	287	PF00069	0.668
MOD_Plk_4	207	213	PF00069	0.486
MOD_Plk_4	326	332	PF00069	0.577
MOD_ProDKin_1	22	28	PF00069	0.604
MOD_ProDKin_1	264	270	PF00069	0.584
MOD_ProDKin_1	318	324	PF00069	0.698
MOD_ProDKin_1	337	343	PF00069	0.672
MOD_SUMO_rev_2	68	76	PF00179	0.532
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.590
TRG_ENDOCYTIC_2	140	143	PF00928	0.489
TRG_ENDOCYTIC_2	73	76	PF00928	0.536
TRG_NES_CRM1_1	85	99	PF08389	0.493
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P436	Leptomonas seymouri	60%	100%
A0A3Q8IG34	Leishmania donovani	78%	100%
A4I616	Leishmania infantum	77%	100%
E9B1A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q6V7	Leishmania major	75%	95%