UV excision repair protein RAD23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UV excision repair RAD23-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIR8_LEIBR

TriTrypDb:

LbrM.30.3340 , LBRM2903_300040300

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005829	cytosol	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HIR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006289	nucleotide-excision repair	6	12
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	11
GO:0031593	polyubiquitin modification-dependent protein binding	4	11
GO:0032182	ubiquitin-like protein binding	3	11
GO:0043130	ubiquitin binding	4	11
GO:0097159	organic cyclic compound binding	2	12
GO:0140030	modification-dependent protein binding	3	11
GO:1901363	heterocyclic compound binding	2	12
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.494
CLV_C14_Caspase3-7	264	268	PF00656	0.481
CLV_NRD_NRD_1	69	71	PF00675	0.293
CLV_PCSK_KEX2_1	71	73	PF00082	0.261
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.261
CLV_PCSK_SKI1_1	194	198	PF00082	0.423
CLV_PCSK_SKI1_1	2	6	PF00082	0.305
CLV_PCSK_SKI1_1	266	270	PF00082	0.325
CLV_PCSK_SKI1_1	27	31	PF00082	0.310
DEG_APCC_DBOX_1	265	273	PF00400	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.409
DEG_SPOP_SBC_1	111	115	PF00917	0.746
DEG_SPOP_SBC_1	247	251	PF00917	0.434
DOC_CDC14_PxL_1	168	176	PF14671	0.447
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.536
DOC_MAPK_MEF2A_6	186	193	PF00069	0.302
DOC_MAPK_MEF2A_6	309	317	PF00069	0.527
DOC_MAPK_NFAT4_5	186	194	PF00069	0.449
DOC_PIKK_1	347	355	PF02985	0.438
DOC_PP1_RVXF_1	38	44	PF00149	0.555
DOC_PP4_FxxP_1	94	97	PF00568	0.488
DOC_USP7_MATH_1	154	158	PF00917	0.647
DOC_USP7_MATH_1	160	164	PF00917	0.474
DOC_USP7_MATH_1	232	236	PF00917	0.645
DOC_USP7_MATH_1	237	241	PF00917	0.622
DOC_USP7_MATH_1	324	328	PF00917	0.711
DOC_USP7_UBL2_3	2	6	PF12436	0.387
DOC_WW_Pin1_4	149	154	PF00397	0.665
DOC_WW_Pin1_4	333	338	PF00397	0.738
LIG_BRCT_BRCA1_1	400	404	PF00533	0.491
LIG_FHA_1	18	24	PF00498	0.486
LIG_FHA_1	241	247	PF00498	0.557
LIG_FHA_1	284	290	PF00498	0.511
LIG_FHA_2	20	26	PF00498	0.457
LIG_FHA_2	360	366	PF00498	0.555
LIG_LIR_Apic_2	93	97	PF02991	0.492
LIG_LIR_Gen_1	312	321	PF02991	0.468
LIG_LIR_Gen_1	61	68	PF02991	0.374
LIG_LIR_Nem_3	205	211	PF02991	0.508
LIG_LIR_Nem_3	312	317	PF02991	0.464
LIG_LIR_Nem_3	61	67	PF02991	0.471
LIG_Rb_pABgroove_1	202	210	PF01858	0.332
LIG_SH2_NCK_1	304	308	PF00017	0.520
LIG_SH2_NCK_1	34	38	PF00017	0.496
LIG_SH2_SRC	34	37	PF00017	0.536
LIG_SH2_STAT5	206	209	PF00017	0.505
LIG_SH2_STAT5	389	392	PF00017	0.485
LIG_SH3_3	102	108	PF00018	0.632
LIG_SH3_3	120	126	PF00018	0.732
LIG_SH3_3	145	151	PF00018	0.650
LIG_SH3_3	222	228	PF00018	0.680
LIG_SH3_3	331	337	PF00018	0.699
LIG_TRAF2_1	422	425	PF00917	0.431
LIG_UBA3_1	4	11	PF00899	0.491
MOD_CK1_1	110	116	PF00069	0.704
MOD_CK1_1	163	169	PF00069	0.492
MOD_CK1_1	235	241	PF00069	0.684
MOD_CK1_1	251	257	PF00069	0.393
MOD_CK1_1	333	339	PF00069	0.722
MOD_CK1_1	79	85	PF00069	0.654
MOD_Cter_Amidation	68	71	PF01082	0.261
MOD_GlcNHglycan	109	112	PF01048	0.633
MOD_GlcNHglycan	119	122	PF01048	0.710
MOD_GlcNHglycan	156	159	PF01048	0.602
MOD_GlcNHglycan	162	165	PF01048	0.524
MOD_GlcNHglycan	237	240	PF01048	0.595
MOD_GlcNHglycan	253	256	PF01048	0.356
MOD_GlcNHglycan	381	386	PF01048	0.545
MOD_GlcNHglycan	81	84	PF01048	0.577
MOD_GlcNHglycan	93	97	PF01048	0.648
MOD_GlcNHglycan	98	101	PF01048	0.688
MOD_GSK3_1	106	113	PF00069	0.556
MOD_GSK3_1	127	134	PF00069	0.625
MOD_GSK3_1	247	254	PF00069	0.629
MOD_GSK3_1	256	263	PF00069	0.553
MOD_GSK3_1	343	350	PF00069	0.637
MOD_GSK3_1	92	99	PF00069	0.654
MOD_NEK2_1	48	53	PF00069	0.511
MOD_NEK2_1	98	103	PF00069	0.663
MOD_PIKK_1	389	395	PF00454	0.559
MOD_PIKK_1	416	422	PF00454	0.624
MOD_PKA_2	232	238	PF00069	0.614
MOD_Plk_1	381	387	PF00069	0.500
MOD_Plk_4	163	169	PF00069	0.398
MOD_Plk_4	19	25	PF00069	0.529
MOD_Plk_4	313	319	PF00069	0.556
MOD_Plk_4	347	353	PF00069	0.696
MOD_Plk_4	398	404	PF00069	0.524
MOD_ProDKin_1	149	155	PF00069	0.666
MOD_ProDKin_1	333	339	PF00069	0.734
MOD_SUMO_rev_2	21	29	PF00179	0.503
MOD_SUMO_rev_2	49	54	PF00179	0.447
TRG_DiLeu_BaEn_2	346	352	PF01217	0.699
TRG_ENDOCYTIC_2	304	307	PF00928	0.502
TRG_NLS_MonoCore_2	69	74	PF00514	0.511
TRG_NLS_MonoExtC_3	70	75	PF00514	0.651
TRG_NLS_MonoExtN_4	70	75	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC65	Leptomonas seymouri	56%	98%
A0A0S4KFK0	Bodo saltans	37%	100%
A0A1X0P199	Trypanosomatidae	33%	100%
A0A3R7KQ25	Trypanosoma rangeli	34%	100%
A0A3S7X3W6	Leishmania donovani	77%	100%
A3KMV2	Bos taurus	26%	100%
A4I614	Leishmania infantum	77%	100%
C9ZRD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B1A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O74803	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P54725	Homo sapiens	27%	100%
P54726	Mus musculus	26%	100%
P54727	Homo sapiens	28%	100%
P54728	Mus musculus	28%	100%
Q29RK4	Bos taurus	27%	100%
Q40742	Oryza sativa subsp. japonica	28%	100%
Q4KMA2	Rattus norvegicus	28%	100%
Q4Q6V9	Leishmania major	76%	100%
Q84L30	Arabidopsis thaliana	26%	100%
Q84L31	Arabidopsis thaliana	29%	100%
Q84L32	Arabidopsis thaliana	26%	100%
Q84L33	Arabidopsis thaliana	28%	100%
V5B773	Trypanosoma cruzi	36%	100%