Putative serine/threonine phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HIR7_LEIBR

TriTrypDb:

LbrM.30.3320 , LBRM2903_300040100

Length:

422

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 14
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HIR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0016787	hydrolase activity	2	26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.260
CLV_NRD_NRD_1	56	58	PF00675	0.538
CLV_NRD_NRD_1	82	84	PF00675	0.273
CLV_PCSK_FUR_1	202	206	PF00082	0.252
CLV_PCSK_KEX2_1	204	206	PF00082	0.247
CLV_PCSK_KEX2_1	50	52	PF00082	0.546
CLV_PCSK_KEX2_1	82	84	PF00082	0.243
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.546
CLV_PCSK_SKI1_1	187	191	PF00082	0.238
CLV_PCSK_SKI1_1	205	209	PF00082	0.170
CLV_PCSK_SKI1_1	243	247	PF00082	0.461
CLV_PCSK_SKI1_1	275	279	PF00082	0.447
DEG_APCC_DBOX_1	317	325	PF00400	0.203
DEG_Nend_UBRbox_1	1	4	PF02207	0.382
DOC_CYCLIN_RxL_1	240	249	PF00134	0.193
DOC_MAPK_gen_1	315	324	PF00069	0.210
DOC_MAPK_gen_1	47	55	PF00069	0.532
DOC_MAPK_gen_1	57	64	PF00069	0.480
DOC_MAPK_MEF2A_6	318	326	PF00069	0.378
DOC_MAPK_MEF2A_6	57	64	PF00069	0.445
DOC_MAPK_RevD_3	189	205	PF00069	0.374
DOC_MAPK_RevD_3	68	83	PF00069	0.293
DOC_USP7_MATH_1	401	405	PF00917	0.639
DOC_USP7_UBL2_3	287	291	PF12436	0.259
DOC_WW_Pin1_4	248	253	PF00397	0.257
DOC_WW_Pin1_4	402	407	PF00397	0.582
DOC_WW_Pin1_4	56	61	PF00397	0.383
DOC_WW_Pin1_4	8	13	PF00397	0.366
LIG_14-3-3_CanoR_1	19	28	PF00244	0.352
LIG_14-3-3_CanoR_1	2	12	PF00244	0.374
LIG_14-3-3_CanoR_1	51	56	PF00244	0.464
LIG_BRCT_BRCA1_1	16	20	PF00533	0.385
LIG_Clathr_ClatBox_1	321	325	PF01394	0.276
LIG_FHA_1	102	108	PF00498	0.430
LIG_FHA_1	403	409	PF00498	0.695
LIG_FHA_1	50	56	PF00498	0.478
LIG_FHA_1	72	78	PF00498	0.291
LIG_FHA_2	259	265	PF00498	0.310
LIG_Integrin_RGD_1	167	169	PF01839	0.298
LIG_LIR_Nem_3	169	173	PF02991	0.465
LIG_LIR_Nem_3	25	31	PF02991	0.472
LIG_LIR_Nem_3	290	296	PF02991	0.273
LIG_MYND_1	406	410	PF01753	0.524
LIG_SH2_NCK_1	40	44	PF00017	0.350
LIG_SH2_STAP1	40	44	PF00017	0.350
LIG_SH2_STAP1	94	98	PF00017	0.526
LIG_SH2_STAT5	200	203	PF00017	0.476
LIG_SH2_STAT5	378	381	PF00017	0.325
LIG_SH2_STAT5	399	402	PF00017	0.673
LIG_SH3_3	265	271	PF00018	0.233
LIG_SH3_3	302	308	PF00018	0.338
LIG_SH3_3	6	12	PF00018	0.480
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.444
LIG_SUMO_SIM_anti_2	97	102	PF11976	0.483
LIG_SUMO_SIM_par_1	270	276	PF11976	0.243
LIG_SUMO_SIM_par_1	320	325	PF11976	0.262
LIG_SUMO_SIM_par_1	59	65	PF11976	0.333
LIG_SUMO_SIM_par_1	69	74	PF11976	0.359
LIG_SUMO_SIM_par_1	75	80	PF11976	0.506
LIG_SUMO_SIM_par_1	83	89	PF11976	0.479
LIG_TYR_ITIM	417	422	PF00017	0.399
LIG_UBA3_1	227	233	PF00899	0.318
MOD_CDC14_SPxK_1	11	14	PF00782	0.445
MOD_CDK_SPxK_1	8	14	PF00069	0.449
MOD_CDK_SPxxK_3	248	255	PF00069	0.409
MOD_CK1_1	192	198	PF00069	0.288
MOD_CK1_1	221	227	PF00069	0.272
MOD_CK1_1	239	245	PF00069	0.244
MOD_CK1_1	357	363	PF00069	0.682
MOD_CK1_1	39	45	PF00069	0.659
MOD_CK2_1	258	264	PF00069	0.298
MOD_Cter_Amidation	48	51	PF01082	0.421
MOD_GlcNHglycan	180	183	PF01048	0.396
MOD_GlcNHglycan	41	44	PF01048	0.551
MOD_GlcNHglycan	64	67	PF01048	0.262
MOD_GSK3_1	14	21	PF00069	0.445
MOD_GSK3_1	174	181	PF00069	0.303
MOD_GSK3_1	353	360	PF00069	0.598
MOD_GSK3_1	71	78	PF00069	0.350
MOD_N-GLC_1	192	197	PF02516	0.291
MOD_N-GLC_1	246	251	PF02516	0.342
MOD_NEK2_1	101	106	PF00069	0.315
MOD_NEK2_1	178	183	PF00069	0.329
MOD_NEK2_1	227	232	PF00069	0.352
MOD_NEK2_1	246	251	PF00069	0.349
MOD_NEK2_1	273	278	PF00069	0.296
MOD_NEK2_1	326	331	PF00069	0.334
MOD_NEK2_1	353	358	PF00069	0.446
MOD_NEK2_1	62	67	PF00069	0.342
MOD_NEK2_1	73	78	PF00069	0.330
MOD_PKA_2	101	107	PF00069	0.398
MOD_PKA_2	18	24	PF00069	0.438
MOD_Plk_1	174	180	PF00069	0.220
MOD_Plk_1	94	100	PF00069	0.309
MOD_Plk_4	24	30	PF00069	0.516
MOD_Plk_4	359	365	PF00069	0.722
MOD_Plk_4	96	102	PF00069	0.322
MOD_ProDKin_1	248	254	PF00069	0.296
MOD_ProDKin_1	402	408	PF00069	0.473
MOD_ProDKin_1	56	62	PF00069	0.470
MOD_ProDKin_1	8	14	PF00069	0.449
MOD_SUMO_rev_2	286	294	PF00179	0.331
TRG_DiLeu_BaEn_1	116	121	PF01217	0.409
TRG_DiLeu_BaEn_1	80	85	PF01217	0.301
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.247
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.354
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.527
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.331
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.464
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.485
TRG_ENDOCYTIC_2	170	173	PF00928	0.379
TRG_ENDOCYTIC_2	210	213	PF00928	0.427
TRG_ENDOCYTIC_2	399	402	PF00928	0.411
TRG_ENDOCYTIC_2	419	422	PF00928	0.513
TRG_ER_diArg_1	201	204	PF00400	0.266
TRG_ER_diArg_1	318	321	PF00400	0.239
TRG_ER_diArg_1	82	84	PF00400	0.277
TRG_NES_CRM1_1	132	146	PF08389	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V2	Leptomonas seymouri	74%	100%
A0A0N1P9R1	Leptomonas seymouri	27%	100%
A0A0S4JBT9	Bodo saltans	33%	100%
A0A0S4KJG1	Bodo saltans	58%	100%
A0A1X0NU01	Trypanosomatidae	25%	100%
A0A3Q8IBB4	Leishmania donovani	28%	100%
A0A3Q8IIK0	Leishmania donovani	29%	100%
A0A3R7NTC0	Trypanosoma rangeli	63%	100%
A0A3S7X3U9	Leishmania donovani	81%	100%
A4HCJ2	Leishmania braziliensis	28%	100%
A4HH45	Leishmania braziliensis	29%	100%
A4I008	Leishmania infantum	28%	100%
A4I498	Leishmania infantum	29%	100%
A4I612	Leishmania infantum	82%	100%
C9ZQ86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZRD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	95%
E9ADP5	Leishmania major	29%	100%
E9AM35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6W1	Leishmania major	81%	100%
Q4QBJ8	Leishmania major	28%	100%
V5ARZ9	Trypanosoma cruzi	25%	100%
V5BX32	Trypanosoma cruzi	57%	100%