Histidine kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Histidine kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIR6_LEIBR

TriTrypDb:

LbrM.30.3310 , LBRM2903_300040000

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HIR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	95	97	PF00082	0.461
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.461
CLV_PCSK_PC7_1	91	97	PF00082	0.443
CLV_PCSK_SKI1_1	111	115	PF00082	0.441
CLV_PCSK_SKI1_1	2	6	PF00082	0.499
DEG_Nend_UBRbox_1	1	4	PF02207	0.671
DOC_CDC14_PxL_1	54	62	PF14671	0.544
DOC_MAPK_gen_1	25	35	PF00069	0.548
DOC_MAPK_MEF2A_6	111	120	PF00069	0.673
DOC_MAPK_MEF2A_6	72	81	PF00069	0.361
DOC_PP2B_LxvP_1	55	58	PF13499	0.552
DOC_SPAK_OSR1_1	96	100	PF12202	0.617
DOC_USP7_MATH_1	156	160	PF00917	0.736
DOC_USP7_MATH_1	38	42	PF00917	0.369
LIG_14-3-3_CanoR_1	72	77	PF00244	0.402
LIG_APCC_ABBA_1	64	69	PF00400	0.430
LIG_BRCT_BRCA1_1	28	32	PF00533	0.570
LIG_BRCT_BRCA1_1	40	44	PF00533	0.369
LIG_eIF4E_1	30	36	PF01652	0.543
LIG_FHA_1	124	130	PF00498	0.585
LIG_LIR_Gen_1	27	38	PF02991	0.545
LIG_LIR_Gen_1	41	50	PF02991	0.344
LIG_LIR_Nem_3	142	147	PF02991	0.703
LIG_LIR_Nem_3	27	33	PF02991	0.540
LIG_LIR_Nem_3	41	45	PF02991	0.298
LIG_MYND_1	58	62	PF01753	0.444
LIG_NRBOX	50	56	PF00104	0.468
LIG_NRBOX	83	89	PF00104	0.434
LIG_SH2_CRK	21	25	PF00017	0.579
LIG_SH2_CRK	30	34	PF00017	0.512
LIG_SH2_STAP1	145	149	PF00017	0.685
LIG_SH2_STAT5	149	152	PF00017	0.725
LIG_SH3_3	150	156	PF00018	0.678
LIG_SH3_3	53	59	PF00018	0.401
LIG_SH3_3	95	101	PF00018	0.634
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.444
LIG_SUMO_SIM_par_1	77	83	PF11976	0.501
LIG_TYR_ITIM	19	24	PF00017	0.583
LIG_UBA3_1	87	95	PF00899	0.530
LIG_WRC_WIRS_1	39	44	PF05994	0.444
MOD_CK1_1	46	52	PF00069	0.485
MOD_GSK3_1	34	41	PF00069	0.561
MOD_NEK2_1	19	24	PF00069	0.571
MOD_PIKK_1	43	49	PF00454	0.444
MOD_PKA_2	90	96	PF00069	0.632
MOD_Plk_1	102	108	PF00069	0.600
MOD_Plk_1	26	32	PF00069	0.548
MOD_Plk_4	19	25	PF00069	0.617
MOD_Plk_4	38	44	PF00069	0.345
MOD_Plk_4	80	86	PF00069	0.444
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.499
TRG_ENDOCYTIC_2	144	147	PF00928	0.739
TRG_ENDOCYTIC_2	21	24	PF00928	0.566
TRG_ENDOCYTIC_2	30	33	PF00928	0.519
TRG_ER_diArg_1	138	141	PF00400	0.687
TRG_NLS_MonoExtN_4	91	98	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K3	Leptomonas seymouri	81%	100%
A0A1X0P2W0	Trypanosomatidae	52%	100%
A0A3R7N1L0	Trypanosoma rangeli	55%	100%
A0A3S7X3X3	Leishmania donovani	93%	100%
A4I611	Leishmania infantum	93%	100%
C9ZRD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	81%
E9B1A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q6W2	Leishmania major	94%	100%