LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
Ankyrin repeats (3 copies), putative
Species:
Leishmania braziliensis
UniProt:
A4HIR5_LEIBR
TriTrypDb:
LbrM.30.3300 , LBRM2903_300039900
Length:
412

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HIR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 183 187 PF00656 0.388
CLV_C14_Caspase3-7 266 270 PF00656 0.448
CLV_C14_Caspase3-7 326 330 PF00656 0.505
CLV_NRD_NRD_1 319 321 PF00675 0.391
CLV_NRD_NRD_1 32 34 PF00675 0.356
CLV_NRD_NRD_1 353 355 PF00675 0.470
CLV_NRD_NRD_1 397 399 PF00675 0.475
CLV_PCSK_KEX2_1 306 308 PF00082 0.402
CLV_PCSK_KEX2_1 32 34 PF00082 0.334
CLV_PCSK_KEX2_1 353 355 PF00082 0.391
CLV_PCSK_KEX2_1 362 364 PF00082 0.397
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.267
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.286
CLV_PCSK_SKI1_1 13 17 PF00082 0.373
CLV_PCSK_SKI1_1 162 166 PF00082 0.362
CLV_PCSK_SKI1_1 239 243 PF00082 0.174
CLV_PCSK_SKI1_1 303 307 PF00082 0.372
CLV_PCSK_SKI1_1 36 40 PF00082 0.296
CLV_PCSK_SKI1_1 400 404 PF00082 0.525
DEG_Nend_UBRbox_2 1 3 PF02207 0.439
DOC_CKS1_1 119 124 PF01111 0.314
DOC_MAPK_gen_1 32 41 PF00069 0.261
DOC_MAPK_gen_1 343 352 PF00069 0.428
DOC_MAPK_MEF2A_6 140 149 PF00069 0.404
DOC_USP7_MATH_1 128 132 PF00917 0.321
DOC_USP7_MATH_1 263 267 PF00917 0.308
DOC_USP7_UBL2_3 405 409 PF12436 0.550
DOC_WW_Pin1_4 118 123 PF00397 0.333
DOC_WW_Pin1_4 141 146 PF00397 0.398
DOC_WW_Pin1_4 188 193 PF00397 0.243
DOC_WW_Pin1_4 254 259 PF00397 0.302
DOC_WW_Pin1_4 85 90 PF00397 0.243
LIG_14-3-3_CanoR_1 140 147 PF00244 0.364
LIG_14-3-3_CanoR_1 198 208 PF00244 0.187
LIG_14-3-3_CanoR_1 220 228 PF00244 0.166
LIG_14-3-3_CanoR_1 379 383 PF00244 0.421
LIG_BIR_III_2 189 193 PF00653 0.308
LIG_BRCT_BRCA1_1 119 123 PF00533 0.323
LIG_BRCT_BRCA1_1 34 38 PF00533 0.388
LIG_FHA_1 142 148 PF00498 0.292
LIG_FHA_1 189 195 PF00498 0.290
LIG_FHA_1 200 206 PF00498 0.251
LIG_FHA_1 342 348 PF00498 0.461
LIG_FHA_2 379 385 PF00498 0.524
LIG_LIR_Apic_2 253 258 PF02991 0.339
LIG_LIR_Gen_1 270 281 PF02991 0.302
LIG_LIR_Gen_1 35 45 PF02991 0.265
LIG_LIR_Gen_1 381 387 PF02991 0.272
LIG_LIR_Nem_3 2 6 PF02991 0.554
LIG_LIR_Nem_3 35 41 PF02991 0.265
LIG_NRP_CendR_1 409 412 PF00754 0.634
LIG_PCNA_yPIPBox_3 343 356 PF02747 0.269
LIG_PTB_Apo_2 249 256 PF02174 0.380
LIG_PTB_Phospho_1 249 255 PF10480 0.308
LIG_SH2_CRK 255 259 PF00017 0.308
LIG_SH2_STAP1 382 386 PF00017 0.494
LIG_SH2_STAT5 300 303 PF00017 0.421
LIG_SH2_STAT5 70 73 PF00017 0.277
LIG_SH2_STAT5 98 101 PF00017 0.247
LIG_TRAF2_1 272 275 PF00917 0.249
MOD_CDK_SPxxK_3 141 148 PF00069 0.396
MOD_CK2_1 197 203 PF00069 0.166
MOD_CK2_1 325 331 PF00069 0.446
MOD_CK2_1 378 384 PF00069 0.524
MOD_GlcNHglycan 157 160 PF01048 0.245
MOD_GlcNHglycan 269 272 PF01048 0.534
MOD_GlcNHglycan 409 412 PF01048 0.594
MOD_GSK3_1 110 117 PF00069 0.307
MOD_GSK3_1 118 125 PF00069 0.335
MOD_GSK3_1 184 191 PF00069 0.308
MOD_GSK3_1 263 270 PF00069 0.451
MOD_GSK3_1 295 302 PF00069 0.529
MOD_LATS_1 265 271 PF00433 0.217
MOD_N-GLC_1 290 295 PF02516 0.364
MOD_N-GLC_1 348 353 PF02516 0.411
MOD_N-GLC_1 79 84 PF02516 0.282
MOD_N-GLC_2 223 225 PF02516 0.166
MOD_PIKK_1 115 121 PF00454 0.526
MOD_PIKK_1 197 203 PF00454 0.332
MOD_PIKK_1 92 98 PF00454 0.249
MOD_PKA_1 295 301 PF00069 0.429
MOD_PKA_1 32 38 PF00069 0.308
MOD_PKA_2 139 145 PF00069 0.560
MOD_PKA_2 155 161 PF00069 0.193
MOD_PKA_2 169 175 PF00069 0.175
MOD_PKA_2 197 203 PF00069 0.166
MOD_PKA_2 32 38 PF00069 0.388
MOD_PKA_2 378 384 PF00069 0.421
MOD_Plk_1 110 116 PF00069 0.258
MOD_Plk_1 348 354 PF00069 0.490
MOD_ProDKin_1 118 124 PF00069 0.327
MOD_ProDKin_1 141 147 PF00069 0.401
MOD_ProDKin_1 188 194 PF00069 0.243
MOD_ProDKin_1 254 260 PF00069 0.302
MOD_ProDKin_1 85 91 PF00069 0.243
MOD_SUMO_rev_2 142 149 PF00179 0.447
MOD_SUMO_rev_2 357 364 PF00179 0.279
TRG_DiLeu_BaEn_1 275 280 PF01217 0.316
TRG_DiLeu_BaEn_2 202 208 PF01217 0.166
TRG_DiLeu_BaLyEn_6 189 194 PF01217 0.243
TRG_DiLeu_BaLyEn_6 236 241 PF01217 0.204
TRG_DiLeu_BaLyEn_6 246 251 PF01217 0.220
TRG_DiLeu_BaLyEn_6 313 318 PF01217 0.268
TRG_ENDOCYTIC_2 382 385 PF00928 0.275
TRG_ER_diArg_1 31 33 PF00400 0.308
TRG_ER_diArg_1 352 354 PF00400 0.431
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.294
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.242
TRG_Pf-PMV_PEXEL_1 32 37 PF00026 0.368
TRG_Pf-PMV_PEXEL_1 353 357 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 390 395 PF00026 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVX1 Leptomonas seymouri 73% 100%
A0A0S4IZB7 Bodo saltans 24% 74%
A0A0S4J2H9 Bodo saltans 27% 72%
A0A0S4KFJ4 Bodo saltans 51% 100%
A0A1X0P1M7 Trypanosomatidae 50% 100%
A0A3R7KWY8 Trypanosoma rangeli 52% 100%
A0A3S7X3U4 Leishmania donovani 85% 100%
A4I610 Leishmania infantum 85% 100%
C9ZRD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D3J162 Medicago truncatula 28% 76%
E9ALW3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1A1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q3KP44 Homo sapiens 23% 67%
Q4Q6W3 Leishmania major 85% 100%
Q8Q0U0 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 26% 100%
Q9J569 Fowlpox virus (strain NVSL) 26% 68%
Q9J5H9 Fowlpox virus (strain NVSL) 23% 71%
V5BMS1 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS