Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIR1_LEIBR

TriTrypDb:

LbrM.30.3260 , LBRM2903_300039500

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HIR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.382
CLV_NRD_NRD_1	3	5	PF00675	0.408
CLV_NRD_NRD_1	62	64	PF00675	0.414
CLV_NRD_NRD_1	72	74	PF00675	0.259
CLV_PCSK_KEX2_1	3	5	PF00082	0.421
CLV_PCSK_KEX2_1	62	64	PF00082	0.437
CLV_PCSK_KEX2_1	72	74	PF00082	0.234
CLV_PCSK_SKI1_1	72	76	PF00082	0.218
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DOC_MAPK_FxFP_2	25	28	PF00069	0.638
DOC_MAPK_FxFP_2	83	86	PF00069	0.289
DOC_MAPK_gen_1	72	78	PF00069	0.469
DOC_PP1_RVXF_1	71	78	PF00149	0.436
DOC_PP4_FxxP_1	25	28	PF00568	0.638
DOC_PP4_FxxP_1	83	86	PF00568	0.289
DOC_PP4_FxxP_1	87	90	PF00568	0.289
DOC_USP7_MATH_1	32	36	PF00917	0.594
DOC_WW_Pin1_4	110	115	PF00397	0.430
LIG_APCC_ABBA_1	15	20	PF00400	0.685
LIG_deltaCOP1_diTrp_1	65	71	PF00928	0.599
LIG_FHA_2	64	70	PF00498	0.557
LIG_KLC1_Yacidic_2	116	121	PF13176	0.321
LIG_LIR_Gen_1	65	76	PF02991	0.550
LIG_LIR_Nem_3	34	40	PF02991	0.639
LIG_LIR_Nem_3	65	71	PF02991	0.553
LIG_PDZ_Class_3	136	141	PF00595	0.442
LIG_Pex14_2	44	48	PF04695	0.578
LIG_Pex14_2	79	83	PF04695	0.272
LIG_SH2_SRC	106	109	PF00017	0.475
LIG_SH2_STAP1	64	68	PF00017	0.559
LIG_SH2_STAT3	10	13	PF00017	0.599
LIG_SH2_STAT3	50	53	PF00017	0.683
LIG_SH2_STAT5	106	109	PF00017	0.416
LIG_SH2_STAT5	119	122	PF00017	0.453
LIG_SH2_STAT5	82	85	PF00017	0.314
MOD_CK2_1	63	69	PF00069	0.560
MOD_CMANNOS	45	48	PF00535	0.377
MOD_N-GLC_1	32	37	PF02516	0.392
MOD_NEK2_1	2	7	PF00069	0.699
MOD_NEK2_2	32	37	PF00069	0.592
MOD_PKA_2	2	8	PF00069	0.665
MOD_Plk_1	32	38	PF00069	0.626
MOD_Plk_1	64	70	PF00069	0.557
MOD_Plk_4	32	38	PF00069	0.600
MOD_ProDKin_1	110	116	PF00069	0.428
MOD_SUMO_rev_2	14	24	PF00179	0.688
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.540
TRG_ENDOCYTIC_2	12	15	PF00928	0.595
TRG_ENDOCYTIC_2	82	85	PF00928	0.314
TRG_ER_diArg_1	2	4	PF00400	0.623
TRG_ER_diArg_1	62	64	PF00400	0.632
TRG_ER_diArg_1	71	73	PF00400	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P439	Leptomonas seymouri	91%	100%
A0A0S4JI01	Bodo saltans	65%	100%
A0A1X0P1B3	Trypanosomatidae	78%	100%
A0A3S7X3Z1	Leishmania donovani	96%	100%
A4I606	Leishmania infantum	95%	100%
C9ZRC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9B197	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6W7	Leishmania major	94%	100%
V5BMX6	Trypanosoma cruzi	79%	100%