Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIR0_LEIBR

TriTrypDb:

LbrM.30.3250 , LBRM2903_300039400

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIR0

PDB structure(s): 7ane_ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.476
CLV_C14_Caspase3-7	273	277	PF00656	0.490
CLV_NRD_NRD_1	238	240	PF00675	0.316
CLV_NRD_NRD_1	313	315	PF00675	0.458
CLV_NRD_NRD_1	329	331	PF00675	0.325
CLV_NRD_NRD_1	360	362	PF00675	0.486
CLV_NRD_NRD_1	8	10	PF00675	0.508
CLV_NRD_NRD_1	97	99	PF00675	0.343
CLV_PCSK_KEX2_1	238	240	PF00082	0.316
CLV_PCSK_KEX2_1	315	317	PF00082	0.486
CLV_PCSK_KEX2_1	329	331	PF00082	0.328
CLV_PCSK_KEX2_1	360	362	PF00082	0.486
CLV_PCSK_KEX2_1	8	10	PF00082	0.530
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.546
CLV_PCSK_PC7_1	234	240	PF00082	0.304
CLV_PCSK_SKI1_1	147	151	PF00082	0.388
CLV_PCSK_SKI1_1	238	242	PF00082	0.343
CLV_PCSK_SKI1_1	25	29	PF00082	0.374
CLV_PCSK_SKI1_1	259	263	PF00082	0.411
CLV_PCSK_SKI1_1	30	34	PF00082	0.353
CLV_PCSK_SKI1_1	345	349	PF00082	0.367
CLV_PCSK_SKI1_1	43	47	PF00082	0.356
CLV_PCSK_SKI1_1	79	83	PF00082	0.445
CLV_PCSK_SKI1_1	99	103	PF00082	0.455
DEG_Nend_UBRbox_1	1	4	PF02207	0.504
DOC_CYCLIN_yCln2_LP_2	348	351	PF00134	0.362
DOC_MAPK_gen_1	144	153	PF00069	0.425
DOC_MAPK_gen_1	329	337	PF00069	0.431
DOC_MAPK_gen_1	341	349	PF00069	0.390
DOC_MAPK_HePTP_8	327	339	PF00069	0.461
DOC_MAPK_MEF2A_6	147	155	PF00069	0.428
DOC_MAPK_MEF2A_6	330	339	PF00069	0.466
DOC_MAPK_MEF2A_6	375	383	PF00069	0.454
DOC_PP1_RVXF_1	131	137	PF00149	0.426
DOC_PP2B_LxvP_1	335	338	PF13499	0.424
DOC_PP2B_LxvP_1	347	350	PF13499	0.340
DOC_PP4_FxxP_1	66	69	PF00568	0.475
DOC_SPAK_OSR1_1	239	243	PF12202	0.493
DOC_USP7_MATH_1	328	332	PF00917	0.289
DOC_WW_Pin1_4	112	117	PF00397	0.558
LIG_14-3-3_CanoR_1	17	23	PF00244	0.389
LIG_14-3-3_CanoR_1	329	334	PF00244	0.442
LIG_APCC_ABBAyCdc20_2	98	104	PF00400	0.297
LIG_BRCT_BRCA1_1	298	302	PF00533	0.507
LIG_DLG_GKlike_1	329	337	PF00625	0.450
LIG_EH_1	201	205	PF12763	0.429
LIG_eIF4E_1	215	221	PF01652	0.509
LIG_FHA_1	191	197	PF00498	0.473
LIG_FHA_1	388	394	PF00498	0.527
LIG_FHA_1	5	11	PF00498	0.560
LIG_FHA_2	112	118	PF00498	0.383
LIG_FHA_2	176	182	PF00498	0.431
LIG_FHA_2	268	274	PF00498	0.526
LIG_FHA_2	399	405	PF00498	0.433
LIG_FHA_2	45	51	PF00498	0.466
LIG_Integrin_isoDGR_2	257	259	PF01839	0.614
LIG_LIR_Apic_2	285	291	PF02991	0.550
LIG_LIR_Apic_2	65	69	PF02991	0.486
LIG_LIR_Gen_1	148	156	PF02991	0.395
LIG_LIR_Gen_1	180	191	PF02991	0.501
LIG_LIR_Gen_1	201	212	PF02991	0.328
LIG_LIR_Gen_1	292	301	PF02991	0.373
LIG_LIR_Gen_1	392	402	PF02991	0.444
LIG_LIR_Gen_1	404	410	PF02991	0.450
LIG_LIR_Nem_3	148	153	PF02991	0.383
LIG_LIR_Nem_3	180	186	PF02991	0.397
LIG_LIR_Nem_3	201	207	PF02991	0.349
LIG_LIR_Nem_3	213	218	PF02991	0.438
LIG_LIR_Nem_3	223	227	PF02991	0.353
LIG_LIR_Nem_3	292	296	PF02991	0.368
LIG_LIR_Nem_3	34	39	PF02991	0.391
LIG_LIR_Nem_3	392	398	PF02991	0.432
LIG_LIR_Nem_3	404	410	PF02991	0.450
LIG_LYPXL_yS_3	215	218	PF13949	0.392
LIG_MYND_1	70	74	PF01753	0.522
LIG_PDZ_Class_2	405	410	PF00595	0.447
LIG_Pex14_1	18	22	PF04695	0.371
LIG_Pex14_1	380	384	PF04695	0.391
LIG_Pex14_2	179	183	PF04695	0.381
LIG_SH2_SRC	353	356	PF00017	0.473
LIG_SH2_STAT5	210	213	PF00017	0.451
LIG_SH2_STAT5	295	298	PF00017	0.416
LIG_SH2_STAT5	353	356	PF00017	0.364
LIG_SH2_STAT5	384	387	PF00017	0.507
LIG_SH2_STAT5	395	398	PF00017	0.459
LIG_SH2_STAT5	55	58	PF00017	0.521
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.497
LIG_SUMO_SIM_par_1	389	394	PF11976	0.334
LIG_SUMO_SIM_par_1	44	50	PF11976	0.355
LIG_TYR_ITIM	393	398	PF00017	0.508
LIG_UBA3_1	187	195	PF00899	0.336
LIG_UBA3_1	241	248	PF00899	0.496
LIG_WW_1	350	353	PF00397	0.383
MOD_CK1_1	115	121	PF00069	0.474
MOD_CK1_1	267	273	PF00069	0.477
MOD_CK1_1	370	376	PF00069	0.508
MOD_CK1_1	54	60	PF00069	0.296
MOD_CK2_1	111	117	PF00069	0.458
MOD_CK2_1	175	181	PF00069	0.457
MOD_CK2_1	194	200	PF00069	0.454
MOD_CK2_1	370	376	PF00069	0.474
MOD_CK2_1	398	404	PF00069	0.316
MOD_CK2_1	44	50	PF00069	0.446
MOD_GlcNHglycan	230	233	PF01048	0.514
MOD_GlcNHglycan	264	267	PF01048	0.517
MOD_GSK3_1	111	118	PF00069	0.482
MOD_GSK3_1	190	197	PF00069	0.423
MOD_NEK2_1	262	267	PF00069	0.493
MOD_NEK2_1	302	307	PF00069	0.508
MOD_NEK2_1	362	367	PF00069	0.519
MOD_NEK2_1	369	374	PF00069	0.517
MOD_NEK2_1	398	403	PF00069	0.424
MOD_NEK2_1	4	9	PF00069	0.579
MOD_NEK2_2	379	384	PF00069	0.518
MOD_PIKK_1	367	373	PF00454	0.463
MOD_PKA_1	329	335	PF00069	0.434
MOD_PKA_2	233	239	PF00069	0.367
MOD_PKA_2	296	302	PF00069	0.517
MOD_PKA_2	328	334	PF00069	0.426
MOD_Plk_1	283	289	PF00069	0.509
MOD_Plk_1	37	43	PF00069	0.588
MOD_Plk_1	398	404	PF00069	0.474
MOD_Plk_2-3	387	393	PF00069	0.324
MOD_Plk_2-3	44	50	PF00069	0.526
MOD_Plk_4	267	273	PF00069	0.472
MOD_Plk_4	283	289	PF00069	0.364
MOD_Plk_4	329	335	PF00069	0.434
MOD_Plk_4	362	368	PF00069	0.510
MOD_Plk_4	37	43	PF00069	0.574
MOD_Plk_4	44	50	PF00069	0.521
MOD_Plk_4	51	57	PF00069	0.279
MOD_ProDKin_1	112	118	PF00069	0.554
MOD_SUMO_rev_2	96	101	PF00179	0.523
TRG_DiLeu_BaEn_2	199	205	PF01217	0.424
TRG_DiLeu_BaEn_4	129	135	PF01217	0.427
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.505
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.437
TRG_ENDOCYTIC_2	215	218	PF00928	0.377
TRG_ENDOCYTIC_2	36	39	PF00928	0.553
TRG_ENDOCYTIC_2	395	398	PF00928	0.468
TRG_ER_diArg_1	237	239	PF00400	0.314
TRG_ER_diArg_1	313	316	PF00400	0.416
TRG_ER_diArg_1	342	345	PF00400	0.384
TRG_ER_diArg_1	359	361	PF00400	0.485
TRG_ER_diArg_1	8	11	PF00400	0.539
TRG_NES_CRM1_1	165	176	PF08389	0.384
TRG_NES_CRM1_1	38	50	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A9	Leptomonas seymouri	75%	99%
A0A0S4JLK9	Bodo saltans	46%	98%
A0A1X0P1F3	Trypanosomatidae	54%	100%
A0A3Q8IS88	Leishmania donovani	87%	100%
A0A422P0Y0	Trypanosoma rangeli	53%	100%
A4I605	Leishmania infantum	87%	100%
C9ZRC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B196	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6W8	Leishmania major	86%	100%
V5BMY6	Trypanosoma cruzi	55%	100%