Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIQ9_LEIBR

TriTrypDb:

LbrM.30.3240 , LBRM2903_300039300

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIQ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	3
GO:0003824	catalytic activity	1	3
GO:0016853	isomerase activity	2	3
GO:0016859	cis-trans isomerase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.610
CLV_C14_Caspase3-7	254	258	PF00656	0.615
CLV_C14_Caspase3-7	516	520	PF00656	0.318
CLV_NRD_NRD_1	229	231	PF00675	0.558
CLV_NRD_NRD_1	313	315	PF00675	0.552
CLV_NRD_NRD_1	480	482	PF00675	0.432
CLV_NRD_NRD_1	496	498	PF00675	0.420
CLV_PCSK_FUR_1	210	214	PF00082	0.509
CLV_PCSK_KEX2_1	212	214	PF00082	0.427
CLV_PCSK_KEX2_1	229	231	PF00082	0.557
CLV_PCSK_KEX2_1	313	315	PF00082	0.575
CLV_PCSK_KEX2_1	324	326	PF00082	0.621
CLV_PCSK_KEX2_1	361	363	PF00082	0.555
CLV_PCSK_KEX2_1	480	482	PF00082	0.441
CLV_PCSK_KEX2_1	496	498	PF00082	0.393
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.464
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.700
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.628
CLV_PCSK_SKI1_1	131	135	PF00082	0.443
CLV_PCSK_SKI1_1	333	337	PF00082	0.602
CLV_PCSK_SKI1_1	355	359	PF00082	0.512
CLV_PCSK_SKI1_1	378	382	PF00082	0.572
CLV_PCSK_SKI1_1	394	398	PF00082	0.459
CLV_PCSK_SKI1_1	481	485	PF00082	0.447
CLV_PCSK_SKI1_1	539	543	PF00082	0.520
CLV_PCSK_SKI1_1	624	628	PF00082	0.589
CLV_PCSK_SKI1_1	764	768	PF00082	0.723
CLV_Separin_Metazoa	226	230	PF03568	0.316
DEG_APCC_DBOX_1	312	320	PF00400	0.582
DEG_APCC_KENBOX_2	127	131	PF00400	0.517
DEG_SPOP_SBC_1	746	750	PF00917	0.480
DOC_AGCK_PIF_1	699	704	PF00069	0.390
DOC_CKS1_1	870	875	PF01111	0.514
DOC_CYCLIN_RxL_1	478	486	PF00134	0.496
DOC_CYCLIN_yClb3_PxF_3	739	745	PF00134	0.703
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.633
DOC_CYCLIN_yCln2_LP_2	741	747	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	766	772	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	815	821	PF00134	0.475
DOC_MAPK_gen_1	126	135	PF00069	0.548
DOC_MAPK_gen_1	445	453	PF00069	0.475
DOC_MAPK_gen_1	496	504	PF00069	0.476
DOC_MAPK_HePTP_8	209	221	PF00069	0.512
DOC_MAPK_MEF2A_6	188	197	PF00069	0.437
DOC_MAPK_MEF2A_6	212	221	PF00069	0.460
DOC_MAPK_MEF2A_6	447	455	PF00069	0.572
DOC_MAPK_RevD_3	217	231	PF00069	0.443
DOC_PP1_RVXF_1	669	676	PF00149	0.351
DOC_PP1_RVXF_1	848	854	PF00149	0.740
DOC_PP2B_LxvP_1	741	744	PF13499	0.716
DOC_PP2B_LxvP_1	815	818	PF13499	0.652
DOC_PP2B_LxvP_1	819	822	PF13499	0.743
DOC_PP4_FxxP_1	174	177	PF00568	0.522
DOC_USP7_MATH_1	115	119	PF00917	0.445
DOC_USP7_MATH_1	261	265	PF00917	0.753
DOC_USP7_MATH_1	692	696	PF00917	0.577
DOC_USP7_MATH_1	809	813	PF00917	0.720
DOC_WW_Pin1_4	754	759	PF00397	0.473
DOC_WW_Pin1_4	765	770	PF00397	0.496
DOC_WW_Pin1_4	786	791	PF00397	0.689
DOC_WW_Pin1_4	794	799	PF00397	0.648
DOC_WW_Pin1_4	821	826	PF00397	0.667
DOC_WW_Pin1_4	869	874	PF00397	0.591
LIG_14-3-3_CanoR_1	333	342	PF00244	0.555
LIG_14-3-3_CanoR_1	452	458	PF00244	0.470
LIG_14-3-3_CanoR_1	513	521	PF00244	0.522
LIG_14-3-3_CanoR_1	624	633	PF00244	0.531
LIG_14-3-3_CanoR_1	728	732	PF00244	0.618
LIG_Actin_WH2_2	295	312	PF00022	0.614
LIG_AP2alpha_2	700	702	PF02296	0.600
LIG_APCC_ABBAyCdc20_2	728	734	PF00400	0.414
LIG_BIR_II_1	1	5	PF00653	0.436
LIG_BRCT_BRCA1_1	87	91	PF00533	0.320
LIG_EH1_1	341	349	PF00400	0.528
LIG_eIF4E_1	342	348	PF01652	0.544
LIG_FHA_1	114	120	PF00498	0.477
LIG_FHA_1	260	266	PF00498	0.538
LIG_FHA_1	304	310	PF00498	0.566
LIG_FHA_1	330	336	PF00498	0.561
LIG_FHA_1	383	389	PF00498	0.484
LIG_FHA_1	41	47	PF00498	0.445
LIG_FHA_1	5	11	PF00498	0.440
LIG_FHA_1	507	513	PF00498	0.494
LIG_FHA_1	55	61	PF00498	0.221
LIG_FHA_1	625	631	PF00498	0.619
LIG_FHA_1	636	642	PF00498	0.467
LIG_FHA_1	761	767	PF00498	0.690
LIG_FHA_1	787	793	PF00498	0.724
LIG_FHA_1	794	800	PF00498	0.743
LIG_FHA_1	837	843	PF00498	0.766
LIG_FHA_2	21	27	PF00498	0.516
LIG_FHA_2	252	258	PF00498	0.697
LIG_FHA_2	302	308	PF00498	0.594
LIG_FHA_2	310	316	PF00498	0.618
LIG_FHA_2	467	473	PF00498	0.460
LIG_FHA_2	514	520	PF00498	0.527
LIG_FHA_2	647	653	PF00498	0.557
LIG_FHA_2	76	82	PF00498	0.477
LIG_LIR_Apic_2	730	735	PF02991	0.681
LIG_LIR_Gen_1	290	298	PF02991	0.612
LIG_LIR_Gen_1	5	14	PF02991	0.469
LIG_LIR_Gen_1	520	527	PF02991	0.545
LIG_LIR_Gen_1	703	710	PF02991	0.667
LIG_LIR_Gen_1	73	82	PF02991	0.362
LIG_LIR_Nem_3	23	27	PF02991	0.336
LIG_LIR_Nem_3	290	295	PF02991	0.601
LIG_LIR_Nem_3	5	9	PF02991	0.479
LIG_LIR_Nem_3	520	526	PF02991	0.547
LIG_LIR_Nem_3	698	702	PF02991	0.649
LIG_LIR_Nem_3	703	707	PF02991	0.639
LIG_LIR_Nem_3	73	79	PF02991	0.363
LIG_LIR_Nem_3	84	89	PF02991	0.343
LIG_MYND_1	739	743	PF01753	0.693
LIG_MYND_1	754	758	PF01753	0.470
LIG_NRBOX	159	165	PF00104	0.481
LIG_PCNA_yPIPBox_3	683	691	PF02747	0.614
LIG_Pex14_1	87	91	PF04695	0.307
LIG_Pex14_2	142	146	PF04695	0.427
LIG_SH2_CRK	27	31	PF00017	0.421
LIG_SH2_CRK	523	527	PF00017	0.466
LIG_SH2_CRK	666	670	PF00017	0.597
LIG_SH2_NCK_1	732	736	PF00017	0.691
LIG_SH2_PTP2	224	227	PF00017	0.462
LIG_SH2_SRC	224	227	PF00017	0.462
LIG_SH2_STAP1	474	478	PF00017	0.518
LIG_SH2_STAP1	523	527	PF00017	0.500
LIG_SH2_STAT5	224	227	PF00017	0.414
LIG_SH2_STAT5	54	57	PF00017	0.405
LIG_SH2_STAT5	76	79	PF00017	0.385
LIG_SH2_STAT5	860	863	PF00017	0.730
LIG_SH3_1	737	743	PF00018	0.671
LIG_SH3_3	737	743	PF00018	0.613
LIG_SH3_3	795	801	PF00018	0.645
LIG_SH3_3	819	825	PF00018	0.690
LIG_SH3_3	848	854	PF00018	0.720
LIG_SUMO_SIM_par_1	485	494	PF11976	0.346
LIG_TRAF2_1	469	472	PF00917	0.404
LIG_TRAF2_1	490	493	PF00917	0.433
LIG_TRAF2_1	653	656	PF00917	0.634
LIG_TYR_ITIM	521	526	PF00017	0.372
LIG_WRC_WIRS_1	14	19	PF05994	0.495
LIG_WRC_WIRS_1	76	81	PF05994	0.324
MOD_CK1_1	118	124	PF00069	0.500
MOD_CK1_1	150	156	PF00069	0.659
MOD_CK1_1	20	26	PF00069	0.404
MOD_CK1_1	285	291	PF00069	0.662
MOD_CK1_1	334	340	PF00069	0.424
MOD_CK1_1	748	754	PF00069	0.570
MOD_CK1_1	757	763	PF00069	0.754
MOD_CK1_1	784	790	PF00069	0.668
MOD_CK2_1	108	114	PF00069	0.472
MOD_CK2_1	13	19	PF00069	0.463
MOD_CK2_1	159	165	PF00069	0.527
MOD_CK2_1	20	26	PF00069	0.517
MOD_CK2_1	301	307	PF00069	0.579
MOD_CK2_1	309	315	PF00069	0.608
MOD_CK2_1	397	403	PF00069	0.458
MOD_CK2_1	466	472	PF00069	0.461
MOD_CK2_1	487	493	PF00069	0.320
MOD_CK2_1	625	631	PF00069	0.588
MOD_CK2_1	646	652	PF00069	0.549
MOD_CK2_1	692	698	PF00069	0.587
MOD_GlcNHglycan	1	4	PF01048	0.586
MOD_GlcNHglycan	110	113	PF01048	0.295
MOD_GlcNHglycan	19	22	PF01048	0.291
MOD_GlcNHglycan	272	275	PF01048	0.704
MOD_GlcNHglycan	279	282	PF01048	0.524
MOD_GlcNHglycan	284	287	PF01048	0.605
MOD_GlcNHglycan	329	332	PF01048	0.621
MOD_GlcNHglycan	336	339	PF01048	0.512
MOD_GlcNHglycan	398	402	PF01048	0.528
MOD_GlcNHglycan	604	607	PF01048	0.496
MOD_GlcNHglycan	694	697	PF01048	0.604
MOD_GlcNHglycan	810	814	PF01048	0.741
MOD_GSK3_1	13	20	PF00069	0.499
MOD_GSK3_1	147	154	PF00069	0.543
MOD_GSK3_1	172	179	PF00069	0.557
MOD_GSK3_1	327	334	PF00069	0.644
MOD_GSK3_1	483	490	PF00069	0.392
MOD_GSK3_1	513	520	PF00069	0.322
MOD_GSK3_1	56	63	PF00069	0.337
MOD_GSK3_1	625	632	PF00069	0.527
MOD_GSK3_1	776	783	PF00069	0.675
MOD_GSK3_1	81	88	PF00069	0.457
MOD_N-GLC_1	150	155	PF02516	0.601
MOD_N-GLC_1	453	458	PF02516	0.429
MOD_N-GLC_1	472	477	PF02516	0.270
MOD_N-GLC_1	624	629	PF02516	0.490
MOD_N-GLC_2	220	222	PF02516	0.486
MOD_NEK2_1	108	113	PF00069	0.462
MOD_NEK2_1	17	22	PF00069	0.515
MOD_NEK2_1	309	314	PF00069	0.589
MOD_NEK2_1	34	39	PF00069	0.430
MOD_NEK2_1	382	387	PF00069	0.481
MOD_NEK2_1	397	402	PF00069	0.555
MOD_NEK2_1	411	416	PF00069	0.333
MOD_NEK2_1	453	458	PF00069	0.461
MOD_NEK2_1	483	488	PF00069	0.473
MOD_NEK2_1	504	509	PF00069	0.549
MOD_NEK2_1	633	638	PF00069	0.559
MOD_NEK2_1	781	786	PF00069	0.670
MOD_NEK2_1	792	797	PF00069	0.689
MOD_NEK2_2	75	80	PF00069	0.389
MOD_PIKK_1	246	252	PF00454	0.679
MOD_PIKK_1	411	417	PF00454	0.538
MOD_PIKK_1	506	512	PF00454	0.509
MOD_PIKK_1	625	631	PF00454	0.502
MOD_PIKK_1	646	652	PF00454	0.544
MOD_PIKK_1	679	685	PF00454	0.588
MOD_PIKK_1	828	834	PF00454	0.769
MOD_PKA_2	309	315	PF00069	0.600
MOD_PKA_2	327	333	PF00069	0.486
MOD_PKA_2	667	673	PF00069	0.418
MOD_PKA_2	727	733	PF00069	0.626
MOD_Plk_1	246	252	PF00069	0.562
MOD_Plk_1	340	346	PF00069	0.481
MOD_Plk_1	4	10	PF00069	0.526
MOD_Plk_1	40	46	PF00069	0.449
MOD_Plk_1	453	459	PF00069	0.471
MOD_Plk_1	81	87	PF00069	0.508
MOD_Plk_2-3	165	171	PF00069	0.568
MOD_Plk_2-3	472	478	PF00069	0.530
MOD_Plk_4	115	121	PF00069	0.443
MOD_Plk_4	159	165	PF00069	0.529
MOD_Plk_4	414	420	PF00069	0.317
MOD_Plk_4	56	62	PF00069	0.452
MOD_Plk_4	727	733	PF00069	0.631
MOD_ProDKin_1	754	760	PF00069	0.475
MOD_ProDKin_1	765	771	PF00069	0.495
MOD_ProDKin_1	786	792	PF00069	0.689
MOD_ProDKin_1	794	800	PF00069	0.650
MOD_ProDKin_1	821	827	PF00069	0.670
MOD_ProDKin_1	869	875	PF00069	0.592
MOD_SUMO_for_1	446	449	PF00179	0.461
MOD_SUMO_for_1	514	517	PF00179	0.564
MOD_SUMO_rev_2	123	133	PF00179	0.538
MOD_SUMO_rev_2	391	396	PF00179	0.462
MOD_SUMO_rev_2	459	467	PF00179	0.442
TRG_DiLeu_BaEn_1	247	252	PF01217	0.617
TRG_DiLeu_BaEn_1	290	295	PF01217	0.583
TRG_DiLeu_BaEn_4	448	454	PF01217	0.574
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.447
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.587
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.486
TRG_ENDOCYTIC_2	224	227	PF00928	0.404
TRG_ENDOCYTIC_2	27	30	PF00928	0.423
TRG_ENDOCYTIC_2	272	275	PF00928	0.477
TRG_ENDOCYTIC_2	523	526	PF00928	0.454
TRG_ENDOCYTIC_2	666	669	PF00928	0.601
TRG_ENDOCYTIC_2	76	79	PF00928	0.325
TRG_ENDOCYTIC_2	86	89	PF00928	0.311
TRG_ER_diArg_1	228	230	PF00400	0.510
TRG_ER_diArg_1	450	453	PF00400	0.515
TRG_ER_diArg_1	495	497	PF00400	0.438
TRG_ER_diArg_1	848	851	PF00400	0.716
TRG_NES_CRM1_1	493	506	PF08389	0.487
TRG_NLS_MonoExtN_4	210	216	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	859	863	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD41	Leptomonas seymouri	63%	100%
A0A0S4JFL0	Bodo saltans	25%	71%
A0A1X0P1A9	Trypanosomatidae	37%	87%
A0A1X0P287	Trypanosomatidae	25%	77%
A0A3S7X3W0	Leishmania donovani	80%	100%
A0A422NMN4	Trypanosoma rangeli	25%	80%
A0A422P0Y3	Trypanosoma rangeli	37%	88%
A4I604	Leishmania infantum	80%	100%
C9ZQI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	70%
C9ZRC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B195	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6W9	Leishmania major	79%	100%
V5BCD0	Trypanosoma cruzi	24%	79%
V5BMS4	Trypanosoma cruzi	36%	93%