TATE DNA transposons

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATE DNA transposons

Species:

Leishmania braziliensis

UniProt:

A4HIQ7_LEIBR

TriTrypDb:

LbrM.30.3220

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015074	DNA integration	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.513
CLV_C14_Caspase3-7	553	557	PF00656	0.402
CLV_NRD_NRD_1	116	118	PF00675	0.711
CLV_NRD_NRD_1	239	241	PF00675	0.576
CLV_NRD_NRD_1	282	284	PF00675	0.582
CLV_NRD_NRD_1	287	289	PF00675	0.564
CLV_NRD_NRD_1	42	44	PF00675	0.542
CLV_NRD_NRD_1	448	450	PF00675	0.413
CLV_NRD_NRD_1	476	478	PF00675	0.391
CLV_NRD_NRD_1	798	800	PF00675	0.685
CLV_NRD_NRD_1	946	948	PF00675	0.605
CLV_PCSK_KEX2_1	226	228	PF00082	0.528
CLV_PCSK_KEX2_1	238	240	PF00082	0.518
CLV_PCSK_KEX2_1	287	289	PF00082	0.620
CLV_PCSK_KEX2_1	351	353	PF00082	0.651
CLV_PCSK_KEX2_1	367	369	PF00082	0.362
CLV_PCSK_KEX2_1	372	374	PF00082	0.518
CLV_PCSK_KEX2_1	447	449	PF00082	0.419
CLV_PCSK_KEX2_1	476	478	PF00082	0.391
CLV_PCSK_KEX2_1	797	799	PF00082	0.686
CLV_PCSK_KEX2_1	87	89	PF00082	0.529
CLV_PCSK_KEX2_1	945	947	PF00082	0.580
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.523
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.506
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.651
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.362
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.518
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.529
CLV_PCSK_PC7_1	283	289	PF00082	0.605
CLV_PCSK_PC7_1	368	374	PF00082	0.616
CLV_PCSK_SKI1_1	206	210	PF00082	0.541
CLV_PCSK_SKI1_1	339	343	PF00082	0.625
CLV_PCSK_SKI1_1	372	376	PF00082	0.479
CLV_PCSK_SKI1_1	394	398	PF00082	0.517
CLV_PCSK_SKI1_1	449	453	PF00082	0.452
CLV_PCSK_SKI1_1	484	488	PF00082	0.376
CLV_PCSK_SKI1_1	507	511	PF00082	0.380
CLV_PCSK_SKI1_1	638	642	PF00082	0.472
CLV_PCSK_SKI1_1	671	675	PF00082	0.579
CLV_PCSK_SKI1_1	84	88	PF00082	0.529
CLV_PCSK_SKI1_1	847	851	PF00082	0.544
DEG_APCC_DBOX_1	591	599	PF00400	0.614
DEG_APCC_DBOX_1	9	17	PF00400	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.493
DOC_ANK_TNKS_1	150	157	PF00023	0.502
DOC_CKS1_1	108	113	PF01111	0.497
DOC_CKS1_1	545	550	PF01111	0.577
DOC_MAPK_gen_1	43	50	PF00069	0.520
DOC_MAPK_gen_1	481	491	PF00069	0.379
DOC_MAPK_gen_1	677	687	PF00069	0.595
DOC_MAPK_MEF2A_6	484	491	PF00069	0.375
DOC_MAPK_MEF2A_6	632	641	PF00069	0.405
DOC_PP1_RVXF_1	682	688	PF00149	0.605
DOC_PP2B_LxvP_1	362	365	PF13499	0.639
DOC_PP4_FxxP_1	108	111	PF00568	0.494
DOC_PP4_FxxP_1	144	147	PF00568	0.507
DOC_PP4_FxxP_1	381	384	PF00568	0.579
DOC_PP4_FxxP_1	439	442	PF00568	0.622
DOC_PP4_FxxP_1	806	809	PF00568	0.748
DOC_PP4_FxxP_1	929	932	PF00568	0.558
DOC_USP7_MATH_1	109	113	PF00917	0.500
DOC_USP7_MATH_1	298	302	PF00917	0.704
DOC_USP7_MATH_1	6	10	PF00917	0.492
DOC_USP7_MATH_1	80	84	PF00917	0.503
DOC_USP7_MATH_1	917	921	PF00917	0.599
DOC_USP7_UBL2_3	632	636	PF12436	0.404
DOC_WW_Pin1_4	107	112	PF00397	0.494
DOC_WW_Pin1_4	116	121	PF00397	0.514
DOC_WW_Pin1_4	351	356	PF00397	0.630
DOC_WW_Pin1_4	544	549	PF00397	0.573
DOC_WW_Pin1_4	586	591	PF00397	0.423
DOC_WW_Pin1_4	75	80	PF00397	0.518
DOC_WW_Pin1_4	8	13	PF00397	0.494
LIG_14-3-3_CanoR_1	137	142	PF00244	0.536
LIG_14-3-3_CanoR_1	230	237	PF00244	0.569
LIG_14-3-3_CanoR_1	287	296	PF00244	0.592
LIG_14-3-3_CanoR_1	368	375	PF00244	0.534
LIG_14-3-3_CanoR_1	448	454	PF00244	0.410
LIG_14-3-3_CanoR_1	520	525	PF00244	0.392
LIG_14-3-3_CanoR_1	529	533	PF00244	0.390
LIG_14-3-3_CanoR_1	628	632	PF00244	0.557
LIG_14-3-3_CanoR_1	649	655	PF00244	0.410
LIG_14-3-3_CanoR_1	684	688	PF00244	0.616
LIG_14-3-3_CanoR_1	726	735	PF00244	0.622
LIG_14-3-3_CanoR_1	819	826	PF00244	0.469
LIG_14-3-3_CanoR_1	935	939	PF00244	0.336
LIG_Actin_WH2_2	375	393	PF00022	0.510
LIG_Actin_WH2_2	624	640	PF00022	0.396
LIG_Actin_WH2_2	919	937	PF00022	0.398
LIG_BIR_III_2	152	156	PF00653	0.540
LIG_BIR_III_2	198	202	PF00653	0.500
LIG_BIR_III_2	496	500	PF00653	0.552
LIG_BIR_III_2	694	698	PF00653	0.613
LIG_BIR_III_4	916	920	PF00653	0.622
LIG_BRCT_BRCA1_1	104	108	PF00533	0.508
LIG_BRCT_BRCA1_1	655	659	PF00533	0.555
LIG_BRCT_BRCA1_1	909	913	PF00533	0.441
LIG_deltaCOP1_diTrp_1	761	769	PF00928	0.593
LIG_eIF4E_1	874	880	PF01652	0.384
LIG_FHA_1	176	182	PF00498	0.636
LIG_FHA_1	230	236	PF00498	0.578
LIG_FHA_1	401	407	PF00498	0.444
LIG_FHA_1	450	456	PF00498	0.577
LIG_FHA_1	537	543	PF00498	0.399
LIG_FHA_1	550	556	PF00498	0.430
LIG_FHA_1	609	615	PF00498	0.548
LIG_FHA_1	768	774	PF00498	0.661
LIG_FHA_1	881	887	PF00498	0.368
LIG_FHA_1	916	922	PF00498	0.468
LIG_FHA_2	193	199	PF00498	0.682
LIG_FHA_2	352	358	PF00498	0.603
LIG_FHA_2	400	406	PF00498	0.612
LIG_FHA_2	438	444	PF00498	0.470
LIG_FHA_2	539	545	PF00498	0.370
LIG_FHA_2	551	557	PF00498	0.395
LIG_FHA_2	727	733	PF00498	0.498
LIG_Integrin_isoDGR_2	621	623	PF01839	0.627
LIG_LIR_Apic_2	105	111	PF02991	0.489
LIG_LIR_Apic_2	178	182	PF02991	0.559
LIG_LIR_Apic_2	270	274	PF02991	0.514
LIG_LIR_Apic_2	927	932	PF02991	0.573
LIG_LIR_Gen_1	330	340	PF02991	0.629
LIG_LIR_Gen_1	492	502	PF02991	0.400
LIG_LIR_Gen_1	539	548	PF02991	0.422
LIG_LIR_Gen_1	732	743	PF02991	0.413
LIG_LIR_Nem_3	330	335	PF02991	0.622
LIG_LIR_Nem_3	385	390	PF02991	0.606
LIG_LIR_Nem_3	490	494	PF02991	0.428
LIG_LIR_Nem_3	515	521	PF02991	0.586
LIG_LIR_Nem_3	539	543	PF02991	0.404
LIG_LIR_Nem_3	656	662	PF02991	0.490
LIG_LIR_Nem_3	686	690	PF02991	0.550
LIG_LIR_Nem_3	732	738	PF02991	0.437
LIG_LIR_Nem_3	746	751	PF02991	0.393
LIG_LIR_Nem_3	893	899	PF02991	0.495
LIG_LIR_Nem_3	937	941	PF02991	0.320
LIG_PCNA_yPIPBox_3	827	837	PF02747	0.572
LIG_Pex14_1	273	277	PF04695	0.552
LIG_Pex14_2	929	933	PF04695	0.557
LIG_SH2_CRK	387	391	PF00017	0.474
LIG_SH2_CRK	495	499	PF00017	0.381
LIG_SH2_CRK	679	683	PF00017	0.409
LIG_SH2_CRK	735	739	PF00017	0.412
LIG_SH2_CRK	77	81	PF00017	0.487
LIG_SH2_NCK_1	495	499	PF00017	0.381
LIG_SH2_NCK_1	735	739	PF00017	0.587
LIG_SH2_NCK_1	77	81	PF00017	0.487
LIG_SH2_SRC	698	701	PF00017	0.440
LIG_SH2_SRC	898	901	PF00017	0.529
LIG_SH2_STAP1	470	474	PF00017	0.535
LIG_SH2_STAP1	482	486	PF00017	0.308
LIG_SH2_STAP1	735	739	PF00017	0.587
LIG_SH2_STAP1	820	824	PF00017	0.648
LIG_SH2_STAP1	882	886	PF00017	0.364
LIG_SH2_STAP1	909	913	PF00017	0.580
LIG_SH2_STAT3	485	488	PF00017	0.368
LIG_SH2_STAT5	161	164	PF00017	0.514
LIG_SH2_STAT5	618	621	PF00017	0.576
LIG_SH2_STAT5	698	701	PF00017	0.440
LIG_SH2_STAT5	882	885	PF00017	0.367
LIG_SH2_STAT5	898	901	PF00017	0.390
LIG_SH3_3	248	254	PF00018	0.545
LIG_SH3_3	424	430	PF00018	0.598
LIG_SH3_3	712	718	PF00018	0.426
LIG_SUMO_SIM_anti_2	653	659	PF11976	0.383
LIG_SUMO_SIM_par_1	541	547	PF11976	0.383
LIG_SUMO_SIM_par_1	569	576	PF11976	0.561
LIG_TRAF2_1	318	321	PF00917	0.628
LIG_TRAF2_1	599	602	PF00917	0.512
LIG_TRAF2_1	706	709	PF00917	0.595
MOD_CDC14_SPxK_1	589	592	PF00782	0.439
MOD_CDK_SPxK_1	107	113	PF00069	0.496
MOD_CDK_SPxK_1	116	122	PF00069	0.516
MOD_CDK_SPxK_1	586	592	PF00069	0.422
MOD_CDK_SPxxK_3	120	127	PF00069	0.528
MOD_CDK_SPxxK_3	75	82	PF00069	0.519
MOD_CK1_1	307	313	PF00069	0.718
MOD_CK1_1	608	614	PF00069	0.592
MOD_CK1_1	630	636	PF00069	0.401
MOD_CK1_1	650	656	PF00069	0.397
MOD_CK2_1	399	405	PF00069	0.615
MOD_CK2_1	437	443	PF00069	0.466
MOD_CK2_1	596	602	PF00069	0.483
MOD_CK2_1	703	709	PF00069	0.532
MOD_CK2_1	726	732	PF00069	0.489
MOD_Cter_Amidation	445	448	PF01082	0.432
MOD_Cter_Amidation	474	477	PF01082	0.574
MOD_GlcNHglycan	137	140	PF01048	0.563
MOD_GlcNHglycan	246	249	PF01048	0.619
MOD_GlcNHglycan	289	292	PF01048	0.607
MOD_GlcNHglycan	31	34	PF01048	0.512
MOD_GlcNHglycan	321	325	PF01048	0.541
MOD_GlcNHglycan	329	332	PF01048	0.535
MOD_GlcNHglycan	607	610	PF01048	0.591
MOD_GlcNHglycan	801	804	PF01048	0.770
MOD_GlcNHglycan	820	823	PF01048	0.346
MOD_GSK3_1	107	114	PF00069	0.496
MOD_GSK3_1	116	123	PF00069	0.517
MOD_GSK3_1	304	311	PF00069	0.728
MOD_GSK3_1	363	370	PF00069	0.635
MOD_GSK3_1	699	706	PF00069	0.604
MOD_GSK3_1	727	734	PF00069	0.630
MOD_GSK3_1	757	764	PF00069	0.494
MOD_LATS_1	116	122	PF00433	0.528
MOD_NEK2_1	209	214	PF00069	0.539
MOD_NEK2_1	390	395	PF00069	0.446
MOD_NEK2_1	641	646	PF00069	0.620
MOD_NEK2_1	662	667	PF00069	0.401
MOD_NEK2_1	934	939	PF00069	0.380
MOD_NEK2_2	201	206	PF00069	0.499
MOD_NEK2_2	298	303	PF00069	0.704
MOD_NEK2_2	683	688	PF00069	0.615
MOD_PIKK_1	304	310	PF00454	0.729
MOD_PIKK_1	662	668	PF00454	0.574
MOD_PK_1	137	143	PF00069	0.535
MOD_PKA_1	287	293	PF00069	0.602
MOD_PKA_1	367	373	PF00069	0.625
MOD_PKA_2	229	235	PF00069	0.585
MOD_PKA_2	287	293	PF00069	0.602
MOD_PKA_2	367	373	PF00069	0.625
MOD_PKA_2	390	396	PF00069	0.478
MOD_PKA_2	528	534	PF00069	0.381
MOD_PKA_2	6	12	PF00069	0.491
MOD_PKA_2	627	633	PF00069	0.429
MOD_PKA_2	683	689	PF00069	0.617
MOD_PKA_2	767	773	PF00069	0.601
MOD_PKA_2	818	824	PF00069	0.497
MOD_PKA_2	934	940	PF00069	0.328
MOD_PKB_1	447	455	PF00069	0.444
MOD_PKB_1	797	805	PF00069	0.777
MOD_Plk_1	201	207	PF00069	0.554
MOD_Plk_1	320	326	PF00069	0.432
MOD_Plk_1	616	622	PF00069	0.399
MOD_Plk_1	699	705	PF00069	0.610
MOD_Plk_1	731	737	PF00069	0.553
MOD_Plk_1	741	747	PF00069	0.534
MOD_Plk_1	880	886	PF00069	0.502
MOD_Plk_2-3	596	602	PF00069	0.458
MOD_Plk_2-3	731	737	PF00069	0.623
MOD_Plk_4	267	273	PF00069	0.702
MOD_Plk_4	298	304	PF00069	0.706
MOD_Plk_4	357	363	PF00069	0.631
MOD_Plk_4	382	388	PF00069	0.594
MOD_Plk_4	550	556	PF00069	0.404
MOD_Plk_4	608	614	PF00069	0.475
MOD_Plk_4	650	656	PF00069	0.397
MOD_ProDKin_1	107	113	PF00069	0.496
MOD_ProDKin_1	116	122	PF00069	0.516
MOD_ProDKin_1	351	357	PF00069	0.629
MOD_ProDKin_1	544	550	PF00069	0.573
MOD_ProDKin_1	586	592	PF00069	0.422
MOD_ProDKin_1	75	81	PF00069	0.517
MOD_ProDKin_1	8	14	PF00069	0.495
MOD_SUMO_rev_2	39	46	PF00179	0.512
TRG_DiLeu_BaEn_1	338	343	PF01217	0.627
TRG_DiLeu_BaEn_4	601	607	PF01217	0.515
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.452
TRG_DiLeu_BaLyEn_6	622	627	PF01217	0.585
TRG_ENDOCYTIC_2	387	390	PF00928	0.467
TRG_ENDOCYTIC_2	495	498	PF00928	0.372
TRG_ENDOCYTIC_2	518	521	PF00928	0.565
TRG_ENDOCYTIC_2	679	682	PF00928	0.403
TRG_ENDOCYTIC_2	735	738	PF00928	0.536
TRG_ER_diArg_1	258	261	PF00400	0.568
TRG_ER_diArg_1	447	449	PF00400	0.454
TRG_ER_diArg_1	476	479	PF00400	0.579
TRG_ER_diArg_1	510	513	PF00400	0.404
TRG_ER_diArg_1	519	522	PF00400	0.400
TRG_ER_diArg_1	765	768	PF00400	0.600
TRG_ER_diArg_1	796	799	PF00400	0.758
TRG_ER_diArg_1	82	85	PF00400	0.526
TRG_ER_diArg_1	945	947	PF00400	0.580
TRG_NES_CRM1_1	431	443	PF08389	0.600
TRG_NLS_Bipartite_1	226	242	PF00514	0.498
TRG_NLS_MonoExtC_3	237	242	PF00514	0.507
TRG_NLS_MonoExtN_4	237	242	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZ81	Trypanosomatidae	48%	100%
A0A1X0NZU3	Trypanosomatidae	46%	100%
A0A1X0P2J1	Trypanosomatidae	49%	100%
A4H9A6	Leishmania braziliensis	100%	100%
A4HEK4	Leishmania braziliensis	94%	85%
A4HIW1	Leishmania braziliensis	100%	100%
A4HIW3	Leishmania braziliensis	98%	71%
A4HJX9	Leishmania braziliensis	93%	100%
A4HM37	Leishmania braziliensis	95%	100%