RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HIQ2_LEIBR

TriTrypDb:

LbrM.30.3170 , LBRM2903_300038600

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIQ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0005488	binding	1	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.309
CLV_PCSK_KEX2_1	103	105	PF00082	0.532
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.571
CLV_PCSK_SKI1_1	107	111	PF00082	0.543
CLV_PCSK_SKI1_1	4	8	PF00082	0.474
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DOC_CKS1_1	136	141	PF01111	0.411
DOC_CYCLIN_RxL_1	103	115	PF00134	0.459
DOC_MAPK_gen_1	103	111	PF00069	0.506
DOC_MAPK_gen_1	3	9	PF00069	0.409
DOC_MAPK_MEF2A_6	70	77	PF00069	0.423
DOC_MAPK_MEF2A_6	80	87	PF00069	0.437
DOC_PP1_RVXF_1	2	9	PF00149	0.504
DOC_USP7_MATH_1	127	131	PF00917	0.632
DOC_USP7_MATH_1	83	87	PF00917	0.404
DOC_WW_Pin1_4	135	140	PF00397	0.516
DOC_WW_Pin1_4	79	84	PF00397	0.441
LIG_14-3-3_CanoR_1	107	112	PF00244	0.333
LIG_14-3-3_CanoR_1	23	31	PF00244	0.517
LIG_APCC_ABBA_1	34	39	PF00400	0.530
LIG_Clathr_ClatBox_1	108	112	PF01394	0.333
LIG_FHA_2	108	114	PF00498	0.343
LIG_FHA_2	49	55	PF00498	0.555
LIG_LIR_Apic_2	135	139	PF02991	0.414
LIG_LIR_Nem_3	22	28	PF02991	0.480
LIG_LIR_Nem_3	46	52	PF02991	0.479
LIG_PTB_Apo_2	14	21	PF02174	0.491
LIG_PTB_Phospho_1	14	20	PF10480	0.491
LIG_SH2_CRK	136	140	PF00017	0.406
LIG_SH2_CRK	28	32	PF00017	0.530
LIG_SH2_NCK_1	44	48	PF00017	0.471
LIG_SH2_SRC	44	47	PF00017	0.508
LIG_SH2_STAT5	20	23	PF00017	0.477
LIG_SH3_3	120	126	PF00018	0.536
LIG_SUMO_SIM_par_1	107	113	PF11976	0.467
LIG_SUMO_SIM_par_1	73	79	PF11976	0.444
LIG_TRAF2_1	99	102	PF00917	0.543
LIG_TYR_ITIM	47	52	PF00017	0.477
LIG_UBA3_1	74	80	PF00899	0.469
MOD_CK1_1	10	16	PF00069	0.546
MOD_CK1_1	79	85	PF00069	0.457
MOD_CK2_1	107	113	PF00069	0.340
MOD_GlcNHglycan	25	28	PF01048	0.291
MOD_GSK3_1	23	30	PF00069	0.459
MOD_GSK3_1	7	14	PF00069	0.546
MOD_GSK3_1	79	86	PF00069	0.396
MOD_N-GLC_1	10	15	PF02516	0.330
MOD_NEK2_1	7	12	PF00069	0.499
MOD_NEK2_2	27	32	PF00069	0.467
MOD_NEK2_2	83	88	PF00069	0.504
MOD_OFUCOSY	64	69	PF10250	0.527
MOD_Plk_1	10	16	PF00069	0.530
MOD_Plk_1	45	51	PF00069	0.508
MOD_Plk_4	83	89	PF00069	0.479
MOD_ProDKin_1	135	141	PF00069	0.519
MOD_ProDKin_1	79	85	PF00069	0.440
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.317
TRG_ENDOCYTIC_2	28	31	PF00928	0.477
TRG_ENDOCYTIC_2	44	47	PF00928	0.471
TRG_ENDOCYTIC_2	49	52	PF00928	0.459
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z2	Leptomonas seymouri	85%	100%
A0A0N1I2T7	Leptomonas seymouri	29%	100%
A0A0S4J311	Bodo saltans	30%	100%
A0A0S4JKJ5	Bodo saltans	47%	76%
A0A0S4JP51	Bodo saltans	32%	71%
A0A1X0P0Y7	Trypanosomatidae	26%	100%
A0A1X0P102	Trypanosomatidae	29%	100%
A0A1X0P2H6	Trypanosomatidae	52%	100%
A0A3Q8II67	Leishmania donovani	92%	100%
A0A3Q8IMA7	Leishmania donovani	30%	100%
A4HLK8	Leishmania braziliensis	30%	100%
A4I5Z5	Leishmania infantum	92%	100%
A4I919	Leishmania infantum	30%	100%
C9ZRC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	92%
E9B192	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B3Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q440	Leishmania major	28%	100%
Q4Q6X2	Leishmania major	91%	100%
V5BSJ4	Trypanosoma cruzi	53%	93%