Meiosis-specific nuclear structural protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania braziliensis

UniProt:

A4HIQ1_LEIBR

TriTrypDb:

LbrM.30.3160 , LBRM2903_300038500

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HIQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.443
CLV_NRD_NRD_1	106	108	PF00675	0.309
CLV_NRD_NRD_1	155	157	PF00675	0.276
CLV_NRD_NRD_1	201	203	PF00675	0.253
CLV_NRD_NRD_1	225	227	PF00675	0.314
CLV_NRD_NRD_1	282	284	PF00675	0.334
CLV_NRD_NRD_1	336	338	PF00675	0.276
CLV_NRD_NRD_1	347	349	PF00675	0.275
CLV_NRD_NRD_1	354	356	PF00675	0.184
CLV_NRD_NRD_1	366	368	PF00675	0.145
CLV_NRD_NRD_1	54	56	PF00675	0.285
CLV_NRD_NRD_1	77	79	PF00675	0.318
CLV_PCSK_FUR_1	104	108	PF00082	0.323
CLV_PCSK_KEX2_1	106	108	PF00082	0.297
CLV_PCSK_KEX2_1	155	157	PF00082	0.275
CLV_PCSK_KEX2_1	200	202	PF00082	0.255
CLV_PCSK_KEX2_1	225	227	PF00082	0.271
CLV_PCSK_KEX2_1	234	236	PF00082	0.232
CLV_PCSK_KEX2_1	282	284	PF00082	0.327
CLV_PCSK_KEX2_1	322	324	PF00082	0.276
CLV_PCSK_KEX2_1	336	338	PF00082	0.214
CLV_PCSK_KEX2_1	356	358	PF00082	0.122
CLV_PCSK_KEX2_1	366	368	PF00082	0.282
CLV_PCSK_KEX2_1	77	79	PF00082	0.309
CLV_PCSK_KEX2_1	97	99	PF00082	0.255
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.263
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.288
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.235
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.250
CLV_PCSK_PC7_1	332	338	PF00082	0.317
CLV_PCSK_SKI1_1	183	187	PF00082	0.318
CLV_PCSK_SKI1_1	2	6	PF00082	0.657
CLV_PCSK_SKI1_1	28	32	PF00082	0.465
CLV_PCSK_SKI1_1	283	287	PF00082	0.358
CLV_PCSK_SKI1_1	336	340	PF00082	0.306
CLV_PCSK_SKI1_1	88	92	PF00082	0.288
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DOC_MAPK_gen_1	128	137	PF00069	0.511
DOC_MAPK_gen_1	233	241	PF00069	0.470
DOC_MAPK_gen_1	249	257	PF00069	0.542
DOC_MAPK_gen_1	387	397	PF00069	0.323
DOC_PP1_RVXF_1	392	398	PF00149	0.537
DOC_USP7_UBL2_3	340	344	PF12436	0.534
LIG_Actin_WH2_2	42	57	PF00022	0.534
LIG_LIR_Gen_1	167	176	PF02991	0.506
LIG_LIR_Nem_3	167	172	PF02991	0.468
LIG_LIR_Nem_3	293	299	PF02991	0.459
LIG_LIR_Nem_3	38	42	PF02991	0.486
LIG_LIR_Nem_3	382	386	PF02991	0.534
LIG_LYPXL_yS_3	39	42	PF13949	0.558
LIG_NRBOX	236	242	PF00104	0.468
LIG_SH2_CRK	383	387	PF00017	0.525
LIG_SH2_CRK	51	55	PF00017	0.377
LIG_SH2_SRC	383	386	PF00017	0.534
LIG_SH2_STAT5	194	197	PF00017	0.468
LIG_SH2_STAT5	364	367	PF00017	0.468
LIG_SH2_STAT5	53	56	PF00017	0.534
LIG_TRAF2_1	123	126	PF00917	0.517
LIG_TRAF2_1	185	188	PF00917	0.507
LIG_TYR_ITIM	49	54	PF00017	0.200
MOD_CK2_1	54	60	PF00069	0.466
MOD_Cter_Amidation	223	226	PF01082	0.419
MOD_GlcNHglycan	2	5	PF01048	0.485
MOD_GlcNHglycan	404	407	PF01048	0.337
MOD_NEK2_1	149	154	PF00069	0.372
MOD_NEK2_1	54	59	PF00069	0.466
MOD_PKA_2	248	254	PF00069	0.414
MOD_PKA_2	54	60	PF00069	0.429
MOD_Plk_2-3	41	47	PF00069	0.239
MOD_SUMO_for_1	185	188	PF00179	0.395
MOD_SUMO_for_1	90	93	PF00179	0.387
MOD_SUMO_rev_2	203	209	PF00179	0.308
MOD_SUMO_rev_2	21	30	PF00179	0.466
MOD_SUMO_rev_2	302	310	PF00179	0.409
MOD_SUMO_rev_2	341	350	PF00179	0.431
MOD_SUMO_rev_2	391	395	PF00179	0.552
TRG_DiLeu_BaEn_1	236	241	PF01217	0.308
TRG_DiLeu_BaEn_1	274	279	PF01217	0.327
TRG_DiLeu_BaEn_1	334	339	PF01217	0.200
TRG_DiLeu_BaEn_3	392	398	PF01217	0.542
TRG_DiLeu_BaEn_4	334	340	PF01217	0.419
TRG_DiLeu_LyEn_5	334	339	PF01217	0.200
TRG_ENDOCYTIC_2	383	386	PF00928	0.407
TRG_ENDOCYTIC_2	39	42	PF00928	0.452
TRG_ENDOCYTIC_2	51	54	PF00928	0.254
TRG_ER_diArg_1	105	107	PF00400	0.408
TRG_ER_diArg_1	200	202	PF00400	0.229
TRG_ER_diArg_1	225	227	PF00400	0.419
TRG_ER_diArg_1	282	284	PF00400	0.391
TRG_ER_diArg_1	336	338	PF00400	0.371
TRG_ER_diArg_1	365	367	PF00400	0.311
TRG_ER_diArg_1	77	79	PF00400	0.397
TRG_NLS_MonoExtC_3	54	60	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.233
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF3	Leptomonas seymouri	77%	93%
A0A0S4JLP4	Bodo saltans	39%	94%
A0A1X0P1N3	Trypanosomatidae	52%	94%
A0A3Q8IF15	Leishmania donovani	87%	100%
A0A422P0U0	Trypanosoma rangeli	53%	94%
A4I5Z6	Leishmania infantum	87%	100%
C9ZRC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	94%
E9B191	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q2KIQ2	Bos taurus	29%	83%
Q4Q6X3	Leishmania major	87%	100%
Q61884	Mus musculus	28%	84%