Translocon-associated protein subunit beta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translocon-associated protein beta (TRAPB), putative

Species:

Leishmania braziliensis

UniProt:

A4HIP9_LEIBR

TriTrypDb:

LbrM.30.3140 , LBRM2903_300038200

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HIP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.612
CLV_NRD_NRD_1	128	130	PF00675	0.491
CLV_NRD_NRD_1	207	209	PF00675	0.396
CLV_PCSK_SKI1_1	129	133	PF00082	0.510
CLV_PCSK_SKI1_1	171	175	PF00082	0.643
CLV_PCSK_SKI1_1	5	9	PF00082	0.368
DEG_APCC_DBOX_1	128	136	PF00400	0.291
DOC_CDC14_PxL_1	182	190	PF14671	0.308
DOC_MAPK_MEF2A_6	5	12	PF00069	0.368
DOC_MAPK_NFAT4_5	5	13	PF00069	0.350
DOC_USP7_MATH_1	125	129	PF00917	0.296
DOC_WW_Pin1_4	62	67	PF00397	0.273
DOC_WW_Pin1_4	99	104	PF00397	0.262
LIG_14-3-3_CanoR_1	154	160	PF00244	0.303
LIG_14-3-3_CanoR_1	195	205	PF00244	0.583
LIG_14-3-3_CanoR_1	5	11	PF00244	0.193
LIG_14-3-3_CanoR_1	98	102	PF00244	0.352
LIG_Actin_WH2_2	82	100	PF00022	0.334
LIG_BRCT_BRCA1_1	64	68	PF00533	0.286
LIG_FHA_1	115	121	PF00498	0.257
LIG_FHA_1	175	181	PF00498	0.315
LIG_FHA_1	23	29	PF00498	0.179
LIG_FHA_2	40	46	PF00498	0.339
LIG_FHA_2	49	55	PF00498	0.346
LIG_LIR_Gen_1	163	173	PF02991	0.328
LIG_LIR_Gen_1	176	187	PF02991	0.269
LIG_LIR_Nem_3	150	156	PF02991	0.329
LIG_LIR_Nem_3	163	168	PF02991	0.314
LIG_LIR_Nem_3	176	182	PF02991	0.252
LIG_LRP6_Inhibitor_1	131	137	PF00058	0.437
LIG_MYND_1	186	190	PF01753	0.308
LIG_PCNA_yPIPBox_3	195	205	PF02747	0.610
LIG_Pex14_2	156	160	PF04695	0.219
LIG_SH2_STAP1	109	113	PF00017	0.318
LIG_SH2_STAT5	172	175	PF00017	0.337
LIG_SH2_STAT5	179	182	PF00017	0.289
LIG_SH2_STAT5	191	194	PF00017	0.427
LIG_SH2_STAT5	99	102	PF00017	0.212
MOD_CK1_1	158	164	PF00069	0.362
MOD_CK1_1	22	28	PF00069	0.381
MOD_CK1_1	39	45	PF00069	0.365
MOD_CK1_1	80	86	PF00069	0.372
MOD_CK2_1	109	115	PF00069	0.394
MOD_CK2_1	48	54	PF00069	0.385
MOD_GlcNHglycan	103	106	PF01048	0.378
MOD_GSK3_1	15	22	PF00069	0.398
MOD_GSK3_1	196	203	PF00069	0.294
MOD_GSK3_1	36	43	PF00069	0.329
MOD_GSK3_1	49	56	PF00069	0.327
MOD_GSK3_1	93	100	PF00069	0.298
MOD_NEK2_1	15	20	PF00069	0.391
MOD_NEK2_1	53	58	PF00069	0.338
MOD_NEK2_1	85	90	PF00069	0.280
MOD_NEK2_1	97	102	PF00069	0.267
MOD_NEK2_2	155	160	PF00069	0.251
MOD_NEK2_2	93	98	PF00069	0.410
MOD_PIKK_1	19	25	PF00454	0.205
MOD_PKA_2	136	142	PF00069	0.488
MOD_PKA_2	97	103	PF00069	0.434
MOD_Plk_1	114	120	PF00069	0.356
MOD_Plk_1	149	155	PF00069	0.456
MOD_Plk_1	174	180	PF00069	0.417
MOD_Plk_1	53	59	PF00069	0.196
MOD_Plk_4	200	206	PF00069	0.330
MOD_ProDKin_1	62	68	PF00069	0.325
MOD_ProDKin_1	99	105	PF00069	0.308
TRG_DiLeu_BaEn_1	200	205	PF01217	0.537
TRG_ENDOCYTIC_2	165	168	PF00928	0.385
TRG_ENDOCYTIC_2	179	182	PF00928	0.328
TRG_ER_diArg_1	205	208	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC54	Leptomonas seymouri	77%	100%
A0A0S4JI19	Bodo saltans	48%	100%
A0A1X0P213	Trypanosomatidae	53%	100%
A0A3R7RRG4	Trypanosoma rangeli	50%	100%
A0A3S7X3S9	Leishmania donovani	87%	100%
A4I662	Leishmania infantum	87%	100%
C9ZRC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B189	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q6X5	Leishmania major	84%	100%
V5B7D0	Trypanosoma cruzi	50%	100%