Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIP8_LEIBR

TriTrypDb:

LbrM.30.3130 , LBRM2903_300038100

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.623
CLV_NRD_NRD_1	153	155	PF00675	0.491
CLV_NRD_NRD_1	209	211	PF00675	0.544
CLV_PCSK_KEX2_1	153	155	PF00082	0.515
CLV_PCSK_KEX2_1	208	210	PF00082	0.543
CLV_PCSK_KEX2_1	51	53	PF00082	0.538
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.538
CLV_PCSK_PC7_1	149	155	PF00082	0.516
CLV_PCSK_SKI1_1	118	122	PF00082	0.607
CLV_PCSK_SKI1_1	167	171	PF00082	0.543
DEG_SPOP_SBC_1	32	36	PF00917	0.539
DOC_PP4_FxxP_1	140	143	PF00568	0.623
DOC_USP7_MATH_1	15	19	PF00917	0.730
DOC_USP7_MATH_1	176	180	PF00917	0.455
DOC_USP7_MATH_1	32	36	PF00917	0.485
DOC_USP7_MATH_1	92	96	PF00917	0.703
DOC_WW_Pin1_4	170	175	PF00397	0.599
LIG_14-3-3_CanoR_1	132	140	PF00244	0.507
LIG_14-3-3_CanoR_1	195	200	PF00244	0.403
LIG_14-3-3_CanoR_1	91	101	PF00244	0.693
LIG_BRCT_BRCA1_1	44	48	PF00533	0.759
LIG_Clathr_ClatBox_1	56	60	PF01394	0.659
LIG_FHA_1	32	38	PF00498	0.532
LIG_FHA_2	67	73	PF00498	0.632
LIG_GBD_Chelix_1	180	188	PF00786	0.587
LIG_LIR_Gen_1	175	184	PF02991	0.480
LIG_LIR_Nem_3	175	180	PF02991	0.485
LIG_LYPXL_SIV_4	176	184	PF13949	0.501
LIG_PCNA_yPIPBox_3	105	113	PF02747	0.556
LIG_Pex14_1	197	201	PF04695	0.504
LIG_SH2_CRK	177	181	PF00017	0.494
LIG_SH2_SRC	3	6	PF00017	0.505
LIG_SH2_STAP1	177	181	PF00017	0.509
LIG_SH2_STAP1	44	48	PF00017	0.516
LIG_SH2_STAT5	139	142	PF00017	0.508
LIG_SH2_STAT5	201	204	PF00017	0.508
LIG_SH2_STAT5	41	44	PF00017	0.529
LIG_SH3_3	9	15	PF00018	0.587
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.554
LIG_TRFH_1	170	174	PF08558	0.612
LIG_UBA3_1	155	161	PF00899	0.496
MOD_CK1_1	100	106	PF00069	0.642
MOD_CK1_1	16	22	PF00069	0.682
MOD_CK1_1	28	34	PF00069	0.693
MOD_CK2_1	61	67	PF00069	0.644
MOD_GlcNHglycan	102	105	PF01048	0.637
MOD_GlcNHglycan	135	138	PF01048	0.571
MOD_GlcNHglycan	222	225	PF01048	0.524
MOD_GSK3_1	114	121	PF00069	0.678
MOD_GSK3_1	27	34	PF00069	0.644
MOD_GSK3_1	40	47	PF00069	0.675
MOD_N-GLC_1	92	97	PF02516	0.699
MOD_NEK2_1	114	119	PF00069	0.504
MOD_NEK2_1	220	225	PF00069	0.524
MOD_NEK2_1	27	32	PF00069	0.694
MOD_PIKK_1	25	31	PF00454	0.583
MOD_PKA_1	118	124	PF00069	0.436
MOD_PKA_2	114	120	PF00069	0.574
MOD_PKA_2	97	103	PF00069	0.563
MOD_Plk_1	66	72	PF00069	0.475
MOD_Plk_2-3	4	10	PF00069	0.511
MOD_Plk_2-3	61	67	PF00069	0.622
MOD_Plk_4	176	182	PF00069	0.460
MOD_Plk_4	183	189	PF00069	0.416
MOD_Plk_4	97	103	PF00069	0.539
MOD_ProDKin_1	170	176	PF00069	0.586
MOD_SUMO_rev_2	111	120	PF00179	0.665
TRG_DiLeu_BaEn_4	72	78	PF01217	0.441
TRG_ENDOCYTIC_2	177	180	PF00928	0.483
TRG_ER_diArg_1	152	154	PF00400	0.517
TRG_ER_diArg_1	208	210	PF00400	0.543
TRG_ER_diArg_1	84	87	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB3	Leptomonas seymouri	67%	97%
A0A3S7X3W4	Leishmania donovani	77%	100%
A4I663	Leishmania infantum	77%	100%
E9B188	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	97%
Q4Q6X6	Leishmania major	77%	100%