Putative S-adenosylmethionine decarboxylase proenzyme-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylmethionine decarboxylase proenzyme- like, putative

Species:

Leishmania braziliensis

UniProt:

A4HIP6_LEIBR

TriTrypDb:

LbrM.30.3110 , LBRM2903_300037900

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HIP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP6

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	23
GO:0006595	polyamine metabolic process	6	23
GO:0006596	polyamine biosynthetic process	7	23
GO:0006597	spermine biosynthetic process	8	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0008215	spermine metabolic process	7	23
GO:0008216	spermidine metabolic process	7	23
GO:0008295	spermidine biosynthetic process	8	23
GO:0009058	biosynthetic process	2	23
GO:0009308	amine metabolic process	4	23
GO:0009309	amine biosynthetic process	5	23
GO:0009987	cellular process	1	23
GO:0034641	cellular nitrogen compound metabolic process	3	23
GO:0042401	biogenic amine biosynthetic process	6	23
GO:0044237	cellular metabolic process	2	23
GO:0044249	cellular biosynthetic process	3	23
GO:0044271	cellular nitrogen compound biosynthetic process	4	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:1901566	organonitrogen compound biosynthetic process	4	23
GO:1901576	organic substance biosynthetic process	3	23

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0004014	adenosylmethionine decarboxylase activity	5	22
GO:0016829	lyase activity	2	23
GO:0016830	carbon-carbon lyase activity	3	22
GO:0016831	carboxy-lyase activity	4	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.380
CLV_NRD_NRD_1	169	171	PF00675	0.349
CLV_NRD_NRD_1	262	264	PF00675	0.517
CLV_PCSK_KEX2_1	20	22	PF00082	0.286
CLV_PCSK_KEX2_1	232	234	PF00082	0.354
CLV_PCSK_KEX2_1	262	264	PF00082	0.517
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.286
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.354
CLV_PCSK_SKI1_1	137	141	PF00082	0.266
CLV_PCSK_SKI1_1	144	148	PF00082	0.268
CLV_PCSK_SKI1_1	58	62	PF00082	0.370
DOC_CKS1_1	228	233	PF01111	0.285
DOC_CKS1_1	90	95	PF01111	0.264
DOC_CYCLIN_RxL_1	17	28	PF00134	0.320
DOC_CYCLIN_RxL_1	193	205	PF00134	0.317
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.173
DOC_MAPK_DCC_7	210	220	PF00069	0.335
DOC_MAPK_gen_1	170	177	PF00069	0.418
DOC_MAPK_gen_1	20	26	PF00069	0.262
DOC_MAPK_HePTP_8	167	179	PF00069	0.208
DOC_MAPK_MEF2A_6	170	179	PF00069	0.389
DOC_MAPK_MEF2A_6	58	65	PF00069	0.316
DOC_MAPK_NFAT4_5	58	66	PF00069	0.316
DOC_PP1_RVXF_1	102	108	PF00149	0.264
DOC_PP1_RVXF_1	274	281	PF00149	0.249
DOC_PP2B_LxvP_1	199	202	PF13499	0.278
DOC_PP4_FxxP_1	7	10	PF00568	0.481
DOC_USP7_MATH_1	216	220	PF00917	0.269
DOC_WW_Pin1_4	114	119	PF00397	0.286
DOC_WW_Pin1_4	227	232	PF00397	0.472
DOC_WW_Pin1_4	52	57	PF00397	0.383
DOC_WW_Pin1_4	89	94	PF00397	0.264
LIG_14-3-3_CanoR_1	112	118	PF00244	0.347
LIG_14-3-3_CterR_2	294	297	PF00244	0.308
LIG_BIR_II_1	1	5	PF00653	0.421
LIG_BIR_III_4	255	259	PF00653	0.515
LIG_Clathr_ClatBox_1	60	64	PF01394	0.302
LIG_eIF4E_1	285	291	PF01652	0.467
LIG_FHA_1	123	129	PF00498	0.335
LIG_FHA_1	146	152	PF00498	0.327
LIG_FHA_1	32	38	PF00498	0.371
LIG_FHA_1	64	70	PF00498	0.430
LIG_FHA_1	90	96	PF00498	0.370
LIG_FHA_2	119	125	PF00498	0.173
LIG_FHA_2	26	32	PF00498	0.329
LIG_LIR_Gen_1	132	141	PF02991	0.318
LIG_LIR_Gen_1	195	206	PF02991	0.503
LIG_LIR_Nem_3	106	110	PF02991	0.314
LIG_LIR_Nem_3	132	136	PF02991	0.289
LIG_LIR_Nem_3	195	201	PF02991	0.518
LIG_LIR_Nem_3	2	7	PF02991	0.542
LIG_LIR_Nem_3	209	215	PF02991	0.387
LIG_PTB_Apo_2	155	162	PF02174	0.316
LIG_PTB_Apo_2	200	207	PF02174	0.397
LIG_PTB_Phospho_1	155	161	PF10480	0.316
LIG_PTB_Phospho_1	200	206	PF10480	0.403
LIG_SH2_CRK	161	165	PF00017	0.173
LIG_SH2_GRB2like	156	159	PF00017	0.374
LIG_SH2_NCK_1	182	186	PF00017	0.490
LIG_SH2_STAT3	271	274	PF00017	0.392
LIG_SH2_STAT5	110	113	PF00017	0.449
LIG_SH2_STAT5	156	159	PF00017	0.250
LIG_SH2_STAT5	245	248	PF00017	0.210
LIG_SH2_STAT5	271	274	PF00017	0.383
LIG_SH3_3	225	231	PF00018	0.501
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.225
LIG_SUMO_SIM_par_1	59	64	PF11976	0.390
LIG_TRAF2_1	47	50	PF00917	0.391
LIG_UBA3_1	69	76	PF00899	0.375
LIG_UBA3_1	90	99	PF00899	0.336
LIG_WRC_WIRS_1	238	243	PF05994	0.492
LIG_WRC_WIRS_1	32	37	PF05994	0.426
MOD_CDC14_SPxK_1	55	58	PF00782	0.173
MOD_CDK_SPK_2	227	232	PF00069	0.279
MOD_CDK_SPxK_1	227	233	PF00069	0.513
MOD_CDK_SPxK_1	52	58	PF00069	0.469
MOD_CK1_1	123	129	PF00069	0.311
MOD_CK1_1	145	151	PF00069	0.401
MOD_CK1_1	219	225	PF00069	0.365
MOD_CK2_1	118	124	PF00069	0.196
MOD_CK2_1	13	19	PF00069	0.450
MOD_CK2_1	78	84	PF00069	0.433
MOD_GlcNHglycan	15	18	PF01048	0.435
MOD_GlcNHglycan	80	83	PF01048	0.372
MOD_GSK3_1	114	121	PF00069	0.238
MOD_GSK3_1	59	66	PF00069	0.313
MOD_N-GLC_1	113	118	PF02516	0.311
MOD_N-GLC_1	13	18	PF02516	0.474
MOD_N-GLC_1	274	279	PF02516	0.399
MOD_NEK2_1	237	242	PF00069	0.431
MOD_NEK2_1	63	68	PF00069	0.327
MOD_NEK2_1	77	82	PF00069	0.420
MOD_NEK2_1	97	102	PF00069	0.259
MOD_PIKK_1	192	198	PF00454	0.393
MOD_PIKK_1	63	69	PF00454	0.448
MOD_PKA_1	112	118	PF00069	0.399
MOD_Plk_1	26	32	PF00069	0.290
MOD_Plk_1	274	280	PF00069	0.440
MOD_Plk_2-3	59	65	PF00069	0.173
MOD_Plk_4	106	112	PF00069	0.306
MOD_Plk_4	142	148	PF00069	0.341
MOD_Plk_4	65	71	PF00069	0.245
MOD_ProDKin_1	114	120	PF00069	0.286
MOD_ProDKin_1	227	233	PF00069	0.470
MOD_ProDKin_1	52	58	PF00069	0.383
MOD_ProDKin_1	89	95	PF00069	0.264
MOD_SUMO_rev_2	132	139	PF00179	0.288
TRG_ENDOCYTIC_2	133	136	PF00928	0.293
TRG_ENDOCYTIC_2	156	159	PF00928	0.312
TRG_ENDOCYTIC_2	161	164	PF00928	0.301
TRG_ENDOCYTIC_2	245	248	PF00928	0.224
TRG_ER_diArg_1	261	263	PF00400	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z0	Leptomonas seymouri	24%	76%
A0A0N1PCH0	Leptomonas seymouri	73%	94%
A0A0S4JHX8	Bodo saltans	25%	78%
A0A0S4JRG8	Bodo saltans	38%	90%
A0A1X0P1C0	Trypanosomatidae	41%	91%
A0A1X0P1E2	Trypanosomatidae	26%	81%
A0A3Q8IEH8	Leishmania donovani	26%	78%
A0A3S7X3S7	Leishmania donovani	80%	100%
A0A422P0Q5	Trypanosoma rangeli	41%	91%
A0A422P0V0	Trypanosoma rangeli	26%	80%
A4HIP5	Leishmania braziliensis	26%	100%
A4I5Z2	Leishmania infantum	26%	78%
A4I5Z3	Leishmania infantum	80%	100%
A5HNV6	Trypanosoma brucei brucei	42%	91%
C9ZRB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	80%
C9ZRB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
E9B185	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	78%
E9B186	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O76240	Trypanosoma cruzi	27%	80%
P50244	Trypanosoma brucei brucei	24%	80%
Q25264	Leishmania donovani	26%	78%
Q4Q6X8	Leishmania major	79%	100%
Q4Q6X9	Leishmania major	26%	100%
Q9NGA0	Leishmania infantum	26%	76%
V5B784	Trypanosoma cruzi	42%	91%
V5DNV4	Trypanosoma cruzi	27%	80%