S-adenosylmethionine decarboxylase proenzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylmethionine decarboxylase

Species:

Leishmania braziliensis

UniProt:

A4HIP5_LEIBR

TriTrypDb:

LbrM.30.3100 , LBRM2903_300037800

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP5

Function

Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	12
GO:0006595	polyamine metabolic process	6	12
GO:0006596	polyamine biosynthetic process	7	12
GO:0006597	spermine biosynthetic process	8	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008215	spermine metabolic process	7	12
GO:0008216	spermidine metabolic process	7	12
GO:0008295	spermidine biosynthetic process	8	12
GO:0009058	biosynthetic process	2	12
GO:0009308	amine metabolic process	4	12
GO:0009309	amine biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042401	biogenic amine biosynthetic process	6	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004014	adenosylmethionine decarboxylase activity	5	12
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	12
GO:0016831	carboxy-lyase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.254
CLV_PCSK_KEX2_1	22	24	PF00082	0.511
CLV_PCSK_KEX2_1	37	39	PF00082	0.205
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.511
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.205
CLV_PCSK_SKI1_1	228	232	PF00082	0.246
CLV_PCSK_SKI1_1	293	297	PF00082	0.352
CLV_PCSK_SKI1_1	98	102	PF00082	0.222
DEG_APCC_DBOX_1	123	131	PF00400	0.369
DEG_Nend_UBRbox_3	1	3	PF02207	0.554
DOC_MAPK_gen_1	291	298	PF00069	0.293
DOC_MAPK_gen_1	300	310	PF00069	0.258
DOC_MAPK_gen_1	37	43	PF00069	0.236
DOC_MAPK_MEF2A_6	303	310	PF00069	0.236
DOC_PP4_FxxP_1	309	312	PF00568	0.254
DOC_PP4_FxxP_1	32	35	PF00568	0.222
DOC_SPAK_OSR1_1	303	307	PF12202	0.222
DOC_USP7_MATH_1	146	150	PF00917	0.314
DOC_USP7_MATH_1	171	175	PF00917	0.236
DOC_USP7_MATH_1	188	192	PF00917	0.236
DOC_USP7_MATH_1	226	230	PF00917	0.318
DOC_USP7_UBL2_3	206	210	PF12436	0.360
DOC_WW_Pin1_4	266	271	PF00397	0.222
DOC_WW_Pin1_4	311	316	PF00397	0.349
LIG_14-3-3_CanoR_1	187	197	PF00244	0.278
LIG_14-3-3_CanoR_1	228	237	PF00244	0.334
LIG_14-3-3_CanoR_1	303	307	PF00244	0.296
LIG_14-3-3_CanoR_1	44	48	PF00244	0.431
LIG_APCC_ABBA_1	306	311	PF00400	0.254
LIG_BRCT_BRCA1_1	89	93	PF00533	0.241
LIG_deltaCOP1_diTrp_1	126	132	PF00928	0.222
LIG_deltaCOP1_diTrp_1	238	248	PF00928	0.236
LIG_FHA_1	104	110	PF00498	0.256
LIG_FHA_1	222	228	PF00498	0.222
LIG_FHA_1	263	269	PF00498	0.222
LIG_FHA_1	303	309	PF00498	0.292
LIG_FHA_1	358	364	PF00498	0.378
LIG_FHA_1	61	67	PF00498	0.249
LIG_FHA_2	218	224	PF00498	0.236
LIG_FHA_2	229	235	PF00498	0.236
LIG_FHA_2	267	273	PF00498	0.222
LIG_FHA_2	340	346	PF00498	0.235
LIG_FHA_2	47	53	PF00498	0.236
LIG_FHA_2	5	11	PF00498	0.565
LIG_LIR_Apic_2	31	35	PF02991	0.237
LIG_LIR_Gen_1	126	137	PF02991	0.222
LIG_LIR_Gen_1	260	270	PF02991	0.227
LIG_LIR_Gen_1	59	69	PF02991	0.175
LIG_LIR_Nem_3	126	132	PF02991	0.251
LIG_LIR_Nem_3	174	180	PF02991	0.222
LIG_LIR_Nem_3	260	266	PF02991	0.189
LIG_LIR_Nem_3	275	279	PF02991	0.254
LIG_LIR_Nem_3	331	336	PF02991	0.287
LIG_LIR_Nem_3	59	65	PF02991	0.236
LIG_SH2_CRK	263	267	PF00017	0.162
LIG_SH2_CRK	336	340	PF00017	0.314
LIG_SH2_GRB2like	81	84	PF00017	0.250
LIG_SH2_SRC	182	185	PF00017	0.254
LIG_SH2_SRC	81	84	PF00017	0.250
LIG_SH2_STAP1	182	186	PF00017	0.254
LIG_SH2_STAP1	253	257	PF00017	0.254
LIG_SH2_STAP1	288	292	PF00017	0.236
LIG_SH2_STAT5	167	170	PF00017	0.314
LIG_SH2_STAT5	177	180	PF00017	0.183
LIG_SH2_STAT5	350	353	PF00017	0.243
LIG_SH2_STAT5	357	360	PF00017	0.260
LIG_SH2_STAT5	81	84	PF00017	0.258
LIG_SH2_STAT5	85	88	PF00017	0.269
LIG_SH3_3	295	301	PF00018	0.222
LIG_SH3_3	309	315	PF00018	0.222
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.387
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.162
LIG_SUMO_SIM_par_1	97	103	PF11976	0.220
LIG_TRAF2_1	362	365	PF00917	0.508
LIG_UBA3_1	14	22	PF00899	0.426
LIG_UBA3_1	92	96	PF00899	0.314
MOD_CDK_SPxxK_3	311	318	PF00069	0.369
MOD_CK1_1	214	220	PF00069	0.319
MOD_CK1_1	275	281	PF00069	0.222
MOD_CK1_1	4	10	PF00069	0.557
MOD_CK1_1	60	66	PF00069	0.400
MOD_CK2_1	217	223	PF00069	0.236
MOD_CK2_1	339	345	PF00069	0.222
MOD_GlcNHglycan	120	123	PF01048	0.314
MOD_GlcNHglycan	228	231	PF01048	0.211
MOD_GSK3_1	1	8	PF00069	0.459
MOD_GSK3_1	100	107	PF00069	0.244
MOD_GSK3_1	188	195	PF00069	0.254
MOD_GSK3_1	217	224	PF00069	0.251
MOD_GSK3_1	262	269	PF00069	0.224
MOD_GSK3_1	53	60	PF00069	0.298
MOD_GSK3_1	81	88	PF00069	0.222
MOD_N-GLC_1	1	6	PF02516	0.496
MOD_N-GLC_1	135	140	PF02516	0.222
MOD_N-GLC_1	286	291	PF02516	0.273
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	109	114	PF00069	0.278
MOD_NEK2_1	17	22	PF00069	0.384
MOD_NEK2_1	197	202	PF00069	0.254
MOD_NEK2_1	339	344	PF00069	0.316
MOD_NEK2_1	57	62	PF00069	0.296
MOD_NEK2_1	87	92	PF00069	0.226
MOD_PIKK_1	192	198	PF00454	0.254
MOD_PKA_2	302	308	PF00069	0.248
MOD_PKA_2	340	346	PF00069	0.306
MOD_PKA_2	43	49	PF00069	0.431
MOD_Plk_1	1	7	PF00069	0.410
MOD_Plk_1	135	141	PF00069	0.222
MOD_Plk_1	192	198	PF00069	0.274
MOD_Plk_1	214	220	PF00069	0.331
MOD_Plk_1	237	243	PF00069	0.150
MOD_Plk_1	57	63	PF00069	0.282
MOD_Plk_1	88	94	PF00069	0.222
MOD_Plk_4	10	16	PF00069	0.402
MOD_Plk_4	105	111	PF00069	0.116
MOD_Plk_4	128	134	PF00069	0.222
MOD_Plk_4	197	203	PF00069	0.222
MOD_Plk_4	57	63	PF00069	0.314
MOD_Plk_4	81	87	PF00069	0.242
MOD_Plk_4	88	94	PF00069	0.200
MOD_ProDKin_1	266	272	PF00069	0.222
MOD_ProDKin_1	311	317	PF00069	0.349
MOD_SUMO_rev_2	138	146	PF00179	0.148
TRG_DiLeu_BaEn_2	127	133	PF01217	0.222
TRG_DiLeu_BaEn_2	88	94	PF01217	0.230
TRG_ENDOCYTIC_2	177	180	PF00928	0.240
TRG_ENDOCYTIC_2	182	185	PF00928	0.231
TRG_ENDOCYTIC_2	263	266	PF00928	0.222
TRG_ENDOCYTIC_2	336	339	PF00928	0.310
TRG_ENDOCYTIC_2	350	353	PF00928	0.245
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z0	Leptomonas seymouri	89%	95%
A0A0N1PCH0	Leptomonas seymouri	26%	100%
A0A0S4JHX8	Bodo saltans	67%	97%
A0A0S4JRG8	Bodo saltans	28%	100%
A0A1X0P1C0	Trypanosomatidae	27%	100%
A0A1X0P1E2	Trypanosomatidae	70%	100%
A0A3Q8IEH8	Leishmania donovani	91%	97%
A0A3S7X3S7	Leishmania donovani	23%	100%
A0A422P0Q5	Trypanosoma rangeli	26%	100%
A0A422P0V0	Trypanosoma rangeli	70%	100%
A2XV58	Oryza sativa subsp. indica	35%	93%
A4HIP6	Leishmania braziliensis	26%	100%
A4I5Z2	Leishmania infantum	92%	97%
A4I5Z3	Leishmania infantum	24%	100%
A5HNV6	Trypanosoma brucei brucei	27%	100%
C9ZRB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
C9ZRB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D3Z6H8	Mus musculus	33%	100%
E9B185	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	97%
E9B186	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O02655	Caenorhabditis elegans	32%	100%
O04009	Nicotiana tabacum	33%	100%
O24575	Zea mays	35%	92%
O49972	Brassica juncea	33%	100%
O65354	Helianthus annuus	34%	100%
O76240	Trypanosoma cruzi	72%	100%
O80402	Nicotiana sylvestris	33%	100%
P0DMN7	Mus musculus	33%	100%
P17707	Homo sapiens	33%	100%
P17708	Rattus norvegicus	33%	100%
P21182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	93%
P28918	Mesocricetus auratus	33%	100%
P46255	Spinacia oleracea	33%	100%
P50243	Bos taurus	33%	100%
P50244	Trypanosoma brucei brucei	65%	100%
P79888	Xenopus laevis	33%	100%
P82185	Mus spretus	33%	100%
P91931	Drosophila melanogaster	34%	100%
Q04694	Solanum tuberosum	33%	100%
Q0JC10	Oryza sativa subsp. japonica	35%	93%
Q25264	Leishmania donovani	92%	97%
Q27883	Onchocerca volvulus	33%	100%
Q38IY3	Solanum chilense	33%	100%
Q39676	Dianthus caryophyllus	35%	97%
Q39677	Dianthus caryophyllus	34%	98%
Q3E9D5	Arabidopsis thaliana	29%	100%
Q42613	Brassica juncea	33%	100%
Q42679	Catharanthus roseus	35%	100%
Q42829	Hordeum chilense	35%	94%
Q43820	Pisum sativum	36%	100%
Q4Q6X8	Leishmania major	23%	85%
Q4Q6X9	Leishmania major	91%	100%
Q8T1E3	Dictyostelium discoideum	35%	98%
Q96286	Arabidopsis thaliana	33%	100%
Q96471	Ipomoea nil	34%	100%
Q96555	Datura stramonium	34%	100%
Q9AXE3	Daucus carota	30%	100%
Q9LSU6	Arabidopsis thaliana	35%	100%
Q9M4D8	Vicia faba	36%	100%
Q9M6K1	Ipomoea batatas	34%	100%
Q9NGA0	Leishmania infantum	92%	94%
Q9P7E3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	98%
Q9S7T9	Arabidopsis thaliana	33%	100%
Q9SDM8	Brassica juncea	33%	100%
V5B784	Trypanosoma cruzi	27%	100%
V5DNV4	Trypanosoma cruzi	72%	100%