Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIP4_LEIBR

TriTrypDb:

LbrM.30.3090 , LBRM2903_300037600

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.473
CLV_C14_Caspase3-7	73	77	PF00656	0.553
CLV_NRD_NRD_1	2	4	PF00675	0.467
CLV_NRD_NRD_1	358	360	PF00675	0.452
CLV_NRD_NRD_1	414	416	PF00675	0.511
CLV_NRD_NRD_1	595	597	PF00675	0.400
CLV_PCSK_KEX2_1	2	4	PF00082	0.455
CLV_PCSK_KEX2_1	358	360	PF00082	0.341
CLV_PCSK_KEX2_1	414	416	PF00082	0.539
CLV_PCSK_KEX2_1	595	597	PF00082	0.400
CLV_PCSK_SKI1_1	121	125	PF00082	0.367
CLV_PCSK_SKI1_1	33	37	PF00082	0.370
CLV_PCSK_SKI1_1	337	341	PF00082	0.350
CLV_PCSK_SKI1_1	386	390	PF00082	0.370
CLV_PCSK_SKI1_1	408	412	PF00082	0.492
CLV_PCSK_SKI1_1	88	92	PF00082	0.443
DEG_APCC_DBOX_1	214	222	PF00400	0.494
DEG_APCC_DBOX_1	385	393	PF00400	0.486
DEG_APCC_KENBOX_2	364	368	PF00400	0.461
DEG_Nend_UBRbox_1	1	4	PF02207	0.655
DEG_SCF_FBW7_1	271	277	PF00400	0.291
DEG_SPOP_SBC_1	305	309	PF00917	0.619
DEG_SPOP_SBC_1	499	503	PF00917	0.568
DOC_CKS1_1	271	276	PF01111	0.439
DOC_CYCLIN_RxL_1	408	422	PF00134	0.581
DOC_MAPK_DCC_7	215	223	PF00069	0.480
DOC_MAPK_gen_1	2	8	PF00069	0.547
DOC_MAPK_gen_1	381	391	PF00069	0.490
DOC_MAPK_MEF2A_6	215	223	PF00069	0.293
DOC_MAPK_MEF2A_6	254	261	PF00069	0.444
DOC_MAPK_MEF2A_6	402	411	PF00069	0.517
DOC_PIKK_1	155	162	PF02985	0.288
DOC_PP2B_LxvP_1	522	525	PF13499	0.556
DOC_USP7_MATH_1	298	302	PF00917	0.617
DOC_USP7_MATH_1	304	308	PF00917	0.644
DOC_USP7_MATH_1	464	468	PF00917	0.371
DOC_USP7_MATH_1	568	572	PF00917	0.461
DOC_USP7_MATH_1	67	71	PF00917	0.596
DOC_USP7_MATH_1	83	87	PF00917	0.330
DOC_WW_Pin1_4	132	137	PF00397	0.385
DOC_WW_Pin1_4	16	21	PF00397	0.519
DOC_WW_Pin1_4	253	258	PF00397	0.479
DOC_WW_Pin1_4	270	275	PF00397	0.415
DOC_WW_Pin1_4	292	297	PF00397	0.660
DOC_WW_Pin1_4	309	314	PF00397	0.603
DOC_WW_Pin1_4	429	434	PF00397	0.503
LIG_14-3-3_CanoR_1	121	129	PF00244	0.476
LIG_14-3-3_CanoR_1	2	7	PF00244	0.549
LIG_14-3-3_CanoR_1	290	296	PF00244	0.715
LIG_14-3-3_CanoR_1	384	392	PF00244	0.418
LIG_14-3-3_CanoR_1	414	419	PF00244	0.447
LIG_14-3-3_CanoR_1	47	53	PF00244	0.478
LIG_Actin_WH2_2	172	189	PF00022	0.401
LIG_APCC_ABBA_1	231	236	PF00400	0.375
LIG_BRCT_BRCA1_1	307	311	PF00533	0.470
LIG_Clathr_ClatBox_1	373	377	PF01394	0.327
LIG_CSL_BTD_1	195	198	PF09270	0.376
LIG_EH1_1	156	164	PF00400	0.498
LIG_eIF4E_1	157	163	PF01652	0.495
LIG_eIF4E_1	357	363	PF01652	0.333
LIG_FHA_1	102	108	PF00498	0.458
LIG_FHA_1	123	129	PF00498	0.479
LIG_FHA_1	133	139	PF00498	0.540
LIG_FHA_1	208	214	PF00498	0.536
LIG_FHA_1	235	241	PF00498	0.484
LIG_FHA_1	254	260	PF00498	0.429
LIG_FHA_1	419	425	PF00498	0.522
LIG_FHA_1	430	436	PF00498	0.531
LIG_FHA_1	467	473	PF00498	0.399
LIG_FHA_1	502	508	PF00498	0.327
LIG_FHA_1	513	519	PF00498	0.354
LIG_FHA_1	615	621	PF00498	0.483
LIG_FHA_1	625	631	PF00498	0.483
LIG_FHA_2	151	157	PF00498	0.433
LIG_FHA_2	436	442	PF00498	0.504
LIG_FHA_2	450	456	PF00498	0.633
LIG_FHA_2	482	488	PF00498	0.265
LIG_FHA_2	71	77	PF00498	0.569
LIG_GBD_Chelix_1	175	183	PF00786	0.437
LIG_IRF3_LxIS_1	143	149	PF10401	0.329
LIG_LIR_Gen_1	139	148	PF02991	0.386
LIG_LIR_Gen_1	19	28	PF02991	0.447
LIG_LIR_Gen_1	242	252	PF02991	0.370
LIG_LIR_Gen_1	502	513	PF02991	0.362
LIG_LIR_Nem_3	139	144	PF02991	0.321
LIG_LIR_Nem_3	151	157	PF02991	0.390
LIG_LIR_Nem_3	180	185	PF02991	0.324
LIG_LIR_Nem_3	19	24	PF02991	0.411
LIG_LIR_Nem_3	242	247	PF02991	0.353
LIG_LIR_Nem_3	330	335	PF02991	0.482
LIG_LIR_Nem_3	356	360	PF02991	0.433
LIG_LIR_Nem_3	40	45	PF02991	0.361
LIG_LIR_Nem_3	502	508	PF02991	0.355
LIG_LYPXL_yS_3	216	219	PF13949	0.400
LIG_NRBOX	469	475	PF00104	0.444
LIG_PCNA_yPIPBox_3	365	374	PF02747	0.498
LIG_SH2_CRK	21	25	PF00017	0.420
LIG_SH2_CRK	400	404	PF00017	0.550
LIG_SH2_CRK	505	509	PF00017	0.452
LIG_SH2_GRB2like	353	356	PF00017	0.333
LIG_SH2_NCK_1	400	404	PF00017	0.550
LIG_SH2_NCK_1	496	500	PF00017	0.442
LIG_SH2_SRC	21	24	PF00017	0.322
LIG_SH2_SRC	375	378	PF00017	0.403
LIG_SH2_STAP1	235	239	PF00017	0.477
LIG_SH2_STAP1	505	509	PF00017	0.452
LIG_SH2_STAP1	512	516	PF00017	0.468
LIG_SH2_STAT5	185	188	PF00017	0.360
LIG_SH2_STAT5	263	266	PF00017	0.482
LIG_SH2_STAT5	353	356	PF00017	0.366
LIG_SH2_STAT5	375	378	PF00017	0.393
LIG_SH3_2	217	222	PF14604	0.473
LIG_SH3_3	214	220	PF00018	0.503
LIG_SH3_3	317	323	PF00018	0.462
LIG_SH3_3	393	399	PF00018	0.552
LIG_SH3_3	437	443	PF00018	0.528
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.397
LIG_SUMO_SIM_anti_2	202	210	PF11976	0.424
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.379
LIG_SUMO_SIM_par_1	144	149	PF11976	0.409
LIG_SUMO_SIM_par_1	444	450	PF11976	0.419
LIG_TRFH_1	216	220	PF08558	0.482
LIG_TYR_ITIM	183	188	PF00017	0.316
LIG_TYR_ITIM	261	266	PF00017	0.360
LIG_TYR_ITSM	17	24	PF00017	0.545
LIG_UBA3_1	107	116	PF00899	0.358
MOD_CK1_1	307	313	PF00069	0.592
MOD_CK1_1	327	333	PF00069	0.427
MOD_CK1_1	417	423	PF00069	0.529
MOD_CK1_1	603	609	PF00069	0.540
MOD_CK1_1	70	76	PF00069	0.691
MOD_CK1_1	9	15	PF00069	0.454
MOD_CK2_1	150	156	PF00069	0.296
MOD_CK2_1	291	297	PF00069	0.502
MOD_CK2_1	435	441	PF00069	0.408
MOD_CK2_1	449	455	PF00069	0.557
MOD_CK2_1	481	487	PF00069	0.266
MOD_GlcNHglycan	266	269	PF01048	0.391
MOD_GlcNHglycan	313	316	PF01048	0.626
MOD_GlcNHglycan	386	389	PF01048	0.416
MOD_GlcNHglycan	587	590	PF01048	0.317
MOD_GlcNHglycan	85	88	PF01048	0.346
MOD_GSK3_1	146	153	PF00069	0.352
MOD_GSK3_1	2	9	PF00069	0.624
MOD_GSK3_1	269	276	PF00069	0.515
MOD_GSK3_1	305	312	PF00069	0.652
MOD_GSK3_1	323	330	PF00069	0.342
MOD_GSK3_1	345	352	PF00069	0.573
MOD_GSK3_1	410	417	PF00069	0.500
MOD_GSK3_1	495	502	PF00069	0.468
MOD_GSK3_1	600	607	PF00069	0.487
MOD_N-GLC_1	132	137	PF02516	0.316
MOD_N-GLC_1	269	274	PF02516	0.454
MOD_N-GLC_1	604	609	PF02516	0.473
MOD_NEK2_1	122	127	PF00069	0.432
MOD_NEK2_1	146	151	PF00069	0.348
MOD_NEK2_1	264	269	PF00069	0.363
MOD_NEK2_1	410	415	PF00069	0.512
MOD_NEK2_1	48	53	PF00069	0.451
MOD_NEK2_1	6	11	PF00069	0.609
MOD_NEK2_1	600	605	PF00069	0.440
MOD_NEK2_1	623	628	PF00069	0.339
MOD_PIKK_1	122	128	PF00454	0.469
MOD_PIKK_1	54	60	PF00454	0.438
MOD_PK_1	134	140	PF00069	0.494
MOD_PKA_1	2	8	PF00069	0.561
MOD_PKA_1	414	420	PF00069	0.475
MOD_PKA_2	2	8	PF00069	0.527
MOD_PKA_2	414	420	PF00069	0.492
MOD_PKA_2	601	607	PF00069	0.442
MOD_PKA_2	70	76	PF00069	0.480
MOD_PKB_1	288	296	PF00069	0.580
MOD_Plk_1	327	333	PF00069	0.366
MOD_Plk_1	604	610	PF00069	0.476
MOD_Plk_4	101	107	PF00069	0.461
MOD_Plk_4	177	183	PF00069	0.337
MOD_Plk_4	2	8	PF00069	0.455
MOD_Plk_4	226	232	PF00069	0.336
MOD_Plk_4	255	261	PF00069	0.374
MOD_Plk_4	274	280	PF00069	0.472
MOD_Plk_4	345	351	PF00069	0.468
MOD_Plk_4	414	420	PF00069	0.454
MOD_ProDKin_1	132	138	PF00069	0.378
MOD_ProDKin_1	16	22	PF00069	0.516
MOD_ProDKin_1	253	259	PF00069	0.473
MOD_ProDKin_1	270	276	PF00069	0.415
MOD_ProDKin_1	292	298	PF00069	0.662
MOD_ProDKin_1	309	315	PF00069	0.603
MOD_ProDKin_1	429	435	PF00069	0.498
TRG_DiLeu_BaEn_1	158	163	PF01217	0.488
TRG_DiLeu_BaEn_1	242	247	PF01217	0.335
TRG_DiLeu_BaEn_2	117	123	PF01217	0.344
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.378
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.401
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.381
TRG_ENDOCYTIC_2	185	188	PF00928	0.341
TRG_ENDOCYTIC_2	21	24	PF00928	0.401
TRG_ENDOCYTIC_2	216	219	PF00928	0.446
TRG_ENDOCYTIC_2	263	266	PF00928	0.350
TRG_ENDOCYTIC_2	357	360	PF00928	0.402
TRG_ENDOCYTIC_2	505	508	PF00928	0.443
TRG_ER_diArg_1	1	3	PF00400	0.481
TRG_ER_diArg_1	357	359	PF00400	0.316
TRG_ER_diArg_1	414	416	PF00400	0.525
TRG_ER_diArg_1	594	596	PF00400	0.396
TRG_NES_CRM1_1	139	152	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D3	Leptomonas seymouri	66%	100%
A0A1X0P1N4	Trypanosomatidae	42%	100%
A0A3S7X3S8	Leishmania donovani	85%	92%
A0A422P0R1	Trypanosoma rangeli	39%	100%
A4I5Z1	Leishmania infantum	85%	100%
C9ZRB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B184	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6Y0	Leishmania major	84%	100%
V5BSF5	Trypanosoma cruzi	38%	100%