NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 42 (RNA-binding motif protein 42), putative

Species:

Leishmania braziliensis

UniProt:

A4HIP3_LEIBR

TriTrypDb:

LbrM.30.3080 , LBRM2903_300037500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HIP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.812
CLV_PCSK_KEX2_1	248	250	PF00082	0.815
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.815
CLV_PCSK_SKI1_1	154	158	PF00082	0.648
CLV_PCSK_SKI1_1	18	22	PF00082	0.567
CLV_PCSK_SKI1_1	264	268	PF00082	0.549
CLV_PCSK_SKI1_1	279	283	PF00082	0.556
CLV_PCSK_SKI1_1	32	36	PF00082	0.553
DEG_APCC_DBOX_1	278	286	PF00400	0.633
DEG_SCF_FBW7_1	233	238	PF00400	0.627
DOC_CKS1_1	155	160	PF01111	0.712
DOC_PP1_RVXF_1	262	268	PF00149	0.561
DOC_USP7_MATH_1	150	154	PF00917	0.745
DOC_USP7_MATH_1	197	201	PF00917	0.722
DOC_USP7_MATH_1	235	239	PF00917	0.866
DOC_WW_Pin1_4	154	159	PF00397	0.813
DOC_WW_Pin1_4	179	184	PF00397	0.731
DOC_WW_Pin1_4	231	236	PF00397	0.728
DOC_WW_Pin1_4	241	246	PF00397	0.796
LIG_14-3-3_CanoR_1	293	302	PF00244	0.533
LIG_14-3-3_CanoR_1	32	37	PF00244	0.575
LIG_APCC_ABBA_1	309	314	PF00400	0.664
LIG_APCC_ABBAyCdc20_2	298	304	PF00400	0.595
LIG_APCC_ABBAyCdc20_2	308	314	PF00400	0.622
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_2	161	165	PF00653	0.626
LIG_BIR_III_3	1	5	PF00653	0.597
LIG_FHA_1	109	115	PF00498	0.615
LIG_FHA_1	138	144	PF00498	0.655
LIG_FHA_1	21	27	PF00498	0.476
LIG_FHA_1	268	274	PF00498	0.711
LIG_FHA_1	33	39	PF00498	0.492
LIG_FHA_2	101	107	PF00498	0.546
LIG_FHA_2	180	186	PF00498	0.687
LIG_FHA_2	258	264	PF00498	0.727
LIG_FHA_2	272	278	PF00498	0.594
LIG_FHA_2	35	41	PF00498	0.471
LIG_IRF3_LxIS_1	41	46	PF10401	0.613
LIG_LIR_Gen_1	204	213	PF02991	0.635
LIG_LIR_Nem_3	204	208	PF02991	0.602
LIG_LIR_Nem_3	50	55	PF02991	0.560
LIG_Pex14_2	11	15	PF04695	0.453
LIG_PTAP_UEV_1	236	241	PF05743	0.633
LIG_SH2_CRK	80	84	PF00017	0.476
LIG_SH2_CRK	99	103	PF00017	0.270
LIG_SH2_PTP2	52	55	PF00017	0.616
LIG_SH2_SRC	52	55	PF00017	0.616
LIG_SH2_STAT5	118	121	PF00017	0.466
LIG_SH2_STAT5	52	55	PF00017	0.616
LIG_SH3_1	152	158	PF00018	0.721
LIG_SH3_3	129	135	PF00018	0.690
LIG_SH3_3	152	158	PF00018	0.794
LIG_SH3_3	234	240	PF00018	0.745
LIG_SUMO_SIM_par_1	34	40	PF11976	0.534
LIG_TRAF2_1	165	168	PF00917	0.785
LIG_TRAF2_1	274	277	PF00917	0.487
LIG_WRC_WIRS_1	105	110	PF05994	0.627
LIG_WW_3	250	254	PF00397	0.818
MOD_CDK_SPxxK_3	241	248	PF00069	0.631
MOD_CK1_1	179	185	PF00069	0.624
MOD_CK1_1	204	210	PF00069	0.654
MOD_CK2_1	100	106	PF00069	0.549
MOD_CK2_1	179	185	PF00069	0.717
MOD_CK2_1	271	277	PF00069	0.565
MOD_Cter_Amidation	229	232	PF01082	0.865
MOD_GlcNHglycan	140	143	PF01048	0.690
MOD_GlcNHglycan	178	181	PF01048	0.818
MOD_GlcNHglycan	194	197	PF01048	0.663
MOD_GlcNHglycan	236	240	PF01048	0.826
MOD_GlcNHglycan	285	288	PF01048	0.596
MOD_GlcNHglycan	295	298	PF01048	0.452
MOD_GSK3_1	100	107	PF00069	0.551
MOD_GSK3_1	150	157	PF00069	0.788
MOD_GSK3_1	192	199	PF00069	0.788
MOD_GSK3_1	231	238	PF00069	0.628
MOD_GSK3_1	240	247	PF00069	0.577
MOD_GSK3_1	267	274	PF00069	0.657
MOD_GSK3_1	60	67	PF00069	0.569
MOD_N-GLC_1	267	272	PF02516	0.659
MOD_N-GLC_1	293	298	PF02516	0.547
MOD_NEK2_1	108	113	PF00069	0.679
MOD_NEK2_1	266	271	PF00069	0.700
MOD_NEK2_1	64	69	PF00069	0.578
MOD_NEK2_1	87	92	PF00069	0.378
MOD_PK_1	70	76	PF00069	0.575
MOD_PKA_1	255	261	PF00069	0.828
MOD_PKB_1	253	261	PF00069	0.837
MOD_PKB_1	68	76	PF00069	0.627
MOD_Plk_4	204	210	PF00069	0.696
MOD_Plk_4	327	333	PF00069	0.593
MOD_ProDKin_1	154	160	PF00069	0.810
MOD_ProDKin_1	179	185	PF00069	0.730
MOD_ProDKin_1	231	237	PF00069	0.727
MOD_ProDKin_1	241	247	PF00069	0.794
MOD_SUMO_for_1	169	172	PF00179	0.869
MOD_SUMO_rev_2	185	194	PF00179	0.816
TRG_ENDOCYTIC_2	52	55	PF00928	0.616
TRG_ENDOCYTIC_2	80	83	PF00928	0.483
TRG_ENDOCYTIC_2	98	101	PF00928	0.448
TRG_ER_diArg_1	332	335	PF00400	0.616
TRG_ER_diArg_1	68	71	PF00400	0.630
TRG_NLS_MonoExtC_3	150	155	PF00514	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL25	Leptomonas seymouri	66%	97%
A0A3R7N1J6	Trypanosoma rangeli	38%	87%
A0A3S5H7N8	Leishmania donovani	85%	100%
A4I5Z0	Leishmania infantum	86%	100%
E9B183	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q6Y1	Leishmania major	87%	100%
V5BX42	Trypanosoma cruzi	39%	81%