Eukaryotic translation initiation factor 3 subunit 7-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit d

Species:

Leishmania braziliensis

UniProt:

A4HIN8_LEIBR

TriTrypDb:

LbrM.30.3030 , LBRM2903_300037000

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIN8

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.532
CLV_C14_Caspase3-7	377	381	PF00656	0.520
CLV_C14_Caspase3-7	53	57	PF00656	0.481
CLV_NRD_NRD_1	121	123	PF00675	0.330
CLV_NRD_NRD_1	124	126	PF00675	0.338
CLV_NRD_NRD_1	210	212	PF00675	0.368
CLV_NRD_NRD_1	324	326	PF00675	0.308
CLV_NRD_NRD_1	334	336	PF00675	0.234
CLV_NRD_NRD_1	384	386	PF00675	0.279
CLV_NRD_NRD_1	68	70	PF00675	0.368
CLV_PCSK_FUR_1	122	126	PF00082	0.320
CLV_PCSK_KEX2_1	121	123	PF00082	0.319
CLV_PCSK_KEX2_1	124	126	PF00082	0.323
CLV_PCSK_KEX2_1	334	336	PF00082	0.265
CLV_PCSK_KEX2_1	384	386	PF00082	0.345
CLV_PCSK_KEX2_1	49	51	PF00082	0.330
CLV_PCSK_KEX2_1	68	70	PF00082	0.350
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.330
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.350
CLV_PCSK_SKI1_1	125	129	PF00082	0.285
CLV_PCSK_SKI1_1	201	205	PF00082	0.364
CLV_PCSK_SKI1_1	335	339	PF00082	0.368
CLV_PCSK_SKI1_1	420	424	PF00082	0.337
CLV_PCSK_SKI1_1	69	73	PF00082	0.292
DEG_APCC_DBOX_1	218	226	PF00400	0.568
DOC_CKS1_1	168	173	PF01111	0.568
DOC_CYCLIN_RxL_1	182	192	PF00134	0.568
DOC_MAPK_gen_1	406	415	PF00069	0.568
DOC_MAPK_gen_1	85	94	PF00069	0.610
DOC_PP1_RVXF_1	421	427	PF00149	0.465
DOC_PP1_RVXF_1	88	95	PF00149	0.520
DOC_PP4_FxxP_1	3	6	PF00568	0.465
DOC_USP7_MATH_1	52	56	PF00917	0.520
DOC_USP7_MATH_2	30	36	PF00917	0.520
DOC_USP7_UBL2_3	493	497	PF12436	0.568
DOC_WW_Pin1_4	167	172	PF00397	0.568
DOC_WW_Pin1_4	26	31	PF00397	0.585
DOC_WW_Pin1_4	318	323	PF00397	0.545
DOC_WW_Pin1_4	339	344	PF00397	0.575
DOC_WW_Pin1_4	451	456	PF00397	0.535
LIG_14-3-3_CanoR_1	124	134	PF00244	0.479
LIG_14-3-3_CanoR_1	155	163	PF00244	0.559
LIG_14-3-3_CanoR_1	201	210	PF00244	0.514
LIG_14-3-3_CanoR_1	238	242	PF00244	0.508
LIG_14-3-3_CanoR_1	289	294	PF00244	0.491
LIG_14-3-3_CanoR_1	329	334	PF00244	0.568
LIG_14-3-3_CanoR_1	409	416	PF00244	0.505
LIG_Actin_WH2_2	139	157	PF00022	0.565
LIG_Actin_WH2_2	196	213	PF00022	0.534
LIG_APCC_ABBA_1	477	482	PF00400	0.568
LIG_CaM_IQ_9	139	155	PF13499	0.568
LIG_Clathr_ClatBox_1	500	504	PF01394	0.644
LIG_FHA_1	168	174	PF00498	0.568
LIG_FHA_1	224	230	PF00498	0.486
LIG_FHA_2	174	180	PF00498	0.540
LIG_FHA_2	202	208	PF00498	0.483
LIG_FHA_2	84	90	PF00498	0.557
LIG_LIR_Apic_2	15	19	PF02991	0.442
LIG_LIR_Apic_2	7	12	PF02991	0.488
LIG_LIR_Gen_1	298	308	PF02991	0.532
LIG_LIR_Gen_1	344	354	PF02991	0.467
LIG_LIR_Gen_1	467	477	PF02991	0.568
LIG_LIR_Nem_3	29	34	PF02991	0.466
LIG_LIR_Nem_3	298	304	PF02991	0.532
LIG_LIR_Nem_3	312	316	PF02991	0.536
LIG_LIR_Nem_3	332	336	PF02991	0.538
LIG_LIR_Nem_3	344	349	PF02991	0.416
LIG_LIR_Nem_3	394	398	PF02991	0.548
LIG_LIR_Nem_3	44	48	PF02991	0.483
LIG_LIR_Nem_3	467	473	PF02991	0.550
LIG_PTB_Apo_2	8	15	PF02174	0.490
LIG_SH2_CRK	168	172	PF00017	0.585
LIG_SH2_CRK	346	350	PF00017	0.476
LIG_SH2_GRB2like	9	12	PF00017	0.532
LIG_SH2_NCK_1	34	38	PF00017	0.520
LIG_SH2_NCK_1	453	457	PF00017	0.568
LIG_SH2_PTP2	9	12	PF00017	0.568
LIG_SH2_SRC	346	349	PF00017	0.532
LIG_SH2_SRC	9	12	PF00017	0.532
LIG_SH2_STAP1	194	198	PF00017	0.573
LIG_SH2_STAP1	346	350	PF00017	0.476
LIG_SH2_STAT5	198	201	PF00017	0.574
LIG_SH2_STAT5	336	339	PF00017	0.523
LIG_SH2_STAT5	475	478	PF00017	0.489
LIG_SH2_STAT5	9	12	PF00017	0.542
LIG_SH3_4	493	500	PF00018	0.568
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.492
LIG_SUMO_SIM_anti_2	411	418	PF11976	0.568
LIG_SUMO_SIM_anti_2	498	509	PF11976	0.595
LIG_SUMO_SIM_par_1	220	228	PF11976	0.494
LIG_SUMO_SIM_par_1	231	237	PF11976	0.505
LIG_SUMO_SIM_par_1	446	452	PF11976	0.520
LIG_SUMO_SIM_par_1	498	514	PF11976	0.641
LIG_TRAF2_1	18	21	PF00917	0.562
LIG_TRAF2_1	428	431	PF00917	0.568
LIG_TYR_ITIM	248	253	PF00017	0.568
LIG_WW_1	171	174	PF00397	0.508
MOD_CDK_SPxK_1	339	345	PF00069	0.572
MOD_CDK_SPxxK_3	318	325	PF00069	0.577
MOD_CK1_1	321	327	PF00069	0.568
MOD_CK1_1	414	420	PF00069	0.566
MOD_CK1_1	449	455	PF00069	0.550
MOD_CK1_1	457	463	PF00069	0.551
MOD_CK2_1	173	179	PF00069	0.532
MOD_CK2_1	189	195	PF00069	0.565
MOD_CK2_1	26	32	PF00069	0.518
MOD_CK2_1	289	295	PF00069	0.552
MOD_CK2_1	425	431	PF00069	0.568
MOD_CK2_1	56	62	PF00069	0.568
MOD_CK2_1	83	89	PF00069	0.594
MOD_Cter_Amidation	108	111	PF01082	0.392
MOD_GlcNHglycan	136	139	PF01048	0.343
MOD_GSK3_1	130	137	PF00069	0.589
MOD_GSK3_1	374	381	PF00069	0.545
MOD_GSK3_1	482	489	PF00069	0.545
MOD_GSK3_1	52	59	PF00069	0.588
MOD_N-GLC_1	134	139	PF02516	0.327
MOD_N-GLC_2	403	405	PF02516	0.368
MOD_NEK2_1	130	135	PF00069	0.486
MOD_NEK2_1	154	159	PF00069	0.580
MOD_NEK2_1	189	194	PF00069	0.528
MOD_NEK2_1	234	239	PF00069	0.470
MOD_PIKK_1	457	463	PF00454	0.519
MOD_PKA_1	125	131	PF00069	0.570
MOD_PKA_2	115	121	PF00069	0.504
MOD_PKA_2	154	160	PF00069	0.574
MOD_PKA_2	237	243	PF00069	0.552
MOD_PKA_2	277	283	PF00069	0.493
MOD_PKA_2	288	294	PF00069	0.434
MOD_PKA_2	408	414	PF00069	0.561
MOD_Plk_1	134	140	PF00069	0.499
MOD_Plk_1	379	385	PF00069	0.568
MOD_Plk_1	88	94	PF00069	0.618
MOD_Plk_2-3	509	515	PF00069	0.749
MOD_Plk_2-3	56	62	PF00069	0.567
MOD_Plk_4	228	234	PF00069	0.547
MOD_Plk_4	391	397	PF00069	0.532
MOD_Plk_4	411	417	PF00069	0.373
MOD_Plk_4	486	492	PF00069	0.524
MOD_Plk_4	88	94	PF00069	0.597
MOD_ProDKin_1	167	173	PF00069	0.568
MOD_ProDKin_1	26	32	PF00069	0.585
MOD_ProDKin_1	318	324	PF00069	0.545
MOD_ProDKin_1	339	345	PF00069	0.575
MOD_ProDKin_1	451	457	PF00069	0.535
MOD_SUMO_for_1	257	260	PF00179	0.568
MOD_SUMO_rev_2	414	422	PF00179	0.568
MOD_SUMO_rev_2	428	433	PF00179	0.537
TRG_DiLeu_BaEn_1	228	233	PF01217	0.476
TRG_DiLeu_BaEn_1	353	358	PF01217	0.585
TRG_DiLeu_BaEn_2	194	200	PF01217	0.476
TRG_DiLeu_BaEn_4	20	26	PF01217	0.562
TRG_ENDOCYTIC_2	250	253	PF00928	0.490
TRG_ENDOCYTIC_2	301	304	PF00928	0.568
TRG_ENDOCYTIC_2	346	349	PF00928	0.497
TRG_ER_diArg_1	121	124	PF00400	0.538
TRG_ER_diArg_1	333	335	PF00400	0.465
TRG_ER_diArg_1	383	385	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.173

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH4	Leptomonas seymouri	79%	99%
A0A0S4IWX5	Bodo saltans	31%	88%
A0A1X0P1D0	Trypanosomatidae	38%	100%
A0A3R7P1P7	Trypanosoma rangeli	38%	100%
A0A3S7X3V2	Leishmania donovani	94%	100%
A1DI25	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	91%
A4I5Y5	Leishmania infantum	94%	100%
A4RFH6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	92%
A7SMR1	Nematostella vectensis	26%	94%
B0X6P7	Culex quinquefasciatus	24%	87%
B0XU47	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	24%	91%
B3LY71	Drosophila ananassae	23%	94%
B3LZN3	Drosophila ananassae	24%	97%
B3P1F9	Drosophila erecta	25%	96%
B3P8G6	Drosophila erecta	23%	95%
B4GFS1	Drosophila persimilis	25%	97%
B4GP93	Drosophila persimilis	22%	98%
B4HFV9	Drosophila sechellia	23%	95%
B4HHG8	Drosophila sechellia	24%	96%
B4JTN0	Drosophila grimshawi	23%	94%
B4JUM0	Drosophila grimshawi	22%	95%
B4K892	Drosophila mojavensis	23%	94%
B4KDI2	Drosophila mojavensis	23%	96%
B4LYI3	Drosophila virilis	23%	94%
B4M5A7	Drosophila virilis	23%	96%
B4N8Z4	Drosophila willistoni	24%	96%
B4NLG2	Drosophila willistoni	23%	94%
B4PNN4	Drosophila yakuba	25%	96%
B4PNV2	Drosophila yakuba	23%	95%
B4QT07	Drosophila simulans	24%	96%
B4R222	Drosophila simulans	23%	95%
B5DY99	Drosophila pseudoobscura pseudoobscura	22%	94%
C9ZRB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	95%
E9B178	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
K7IM66	Nasonia vitripennis	25%	95%
O15371	Homo sapiens	24%	97%
O70194	Mus musculus	24%	97%
P0CN48	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	97%
P0CN49	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	97%
P30642	Caenorhabditis elegans	23%	93%
Q0ZB77	Bombyx mori	24%	97%
Q16UF8	Aedes aegypti	24%	86%
Q295S1	Drosophila pseudoobscura pseudoobscura	25%	97%
Q3T122	Bos taurus	24%	97%
Q4Q6Y6	Leishmania major	94%	100%
Q4R8R4	Macaca fascicularis	24%	97%
Q4X054	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	91%
Q554U9	Dictyostelium discoideum	24%	100%
Q5AVZ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	90%
Q5R925	Pongo abelii	24%	97%
Q6AYK8	Rattus norvegicus	24%	97%
Q6P8G0	Xenopus tropicalis	25%	96%
Q7QBW3	Anopheles gambiae	24%	91%
Q9VCK0	Drosophila melanogaster	23%	95%
Q9VGC7	Drosophila melanogaster	24%	96%
V5B793	Trypanosoma cruzi	37%	100%