CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania braziliensis

UniProt:

A4HIN7_LEIBR

TriTrypDb:

LbrM.30.3020 , LBRM2903_300036900

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HIN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIN7

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	11
GO:0042592	homeostatic process	3	11
GO:0048878	chemical homeostasis	4	11
GO:0050801	monoatomic ion homeostasis	5	11
GO:0055065	obsolete metal ion homeostasis	7	11
GO:0055080	monoatomic cation homeostasis	6	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0072507	obsolete divalent inorganic cation homeostasis	7	11
GO:0098771	inorganic ion homeostasis	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.219
CLV_NRD_NRD_1	284	286	PF00675	0.546
CLV_PCSK_KEX2_1	284	286	PF00082	0.503
CLV_PCSK_KEX2_1	400	402	PF00082	0.604
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.650
CLV_PCSK_SKI1_1	267	271	PF00082	0.471
CLV_PCSK_SKI1_1	52	56	PF00082	0.243
CLV_PCSK_SKI1_1	67	71	PF00082	0.129
DEG_APCC_DBOX_1	172	180	PF00400	0.240
DEG_APCC_DBOX_1	47	55	PF00400	0.440
DEG_Nend_UBRbox_2	1	3	PF02207	0.474
DEG_SPOP_SBC_1	53	57	PF00917	0.504
DOC_CKS1_1	444	449	PF01111	0.377
DOC_MAPK_gen_1	400	407	PF00069	0.505
DOC_PP2B_LxvP_1	435	438	PF13499	0.355
DOC_PP4_FxxP_1	301	304	PF00568	0.335
DOC_USP7_MATH_1	133	137	PF00917	0.287
DOC_USP7_MATH_1	308	312	PF00917	0.304
DOC_WW_Pin1_4	440	445	PF00397	0.511
DOC_WW_Pin1_4	56	61	PF00397	0.465
LIG_14-3-3_CanoR_1	234	240	PF00244	0.248
LIG_14-3-3_CanoR_1	245	254	PF00244	0.246
LIG_14-3-3_CanoR_1	267	276	PF00244	0.222
LIG_14-3-3_CanoR_1	401	406	PF00244	0.349
LIG_14-3-3_CanoR_1	52	60	PF00244	0.440
LIG_BRCT_BRCA1_1	297	301	PF00533	0.336
LIG_Clathr_ClatBox_1	43	47	PF01394	0.409
LIG_EH1_1	285	293	PF00400	0.349
LIG_FHA_1	104	110	PF00498	0.167
LIG_FHA_1	111	117	PF00498	0.123
LIG_FHA_1	147	153	PF00498	0.255
LIG_FHA_1	235	241	PF00498	0.316
LIG_FHA_1	397	403	PF00498	0.474
LIG_FHA_1	91	97	PF00498	0.305
LIG_FHA_2	300	306	PF00498	0.291
LIG_FHA_2	354	360	PF00498	0.209
LIG_FHA_2	57	63	PF00498	0.504
LIG_LIR_Apic_2	298	304	PF02991	0.399
LIG_LIR_Gen_1	270	279	PF02991	0.369
LIG_LIR_Gen_1	329	338	PF02991	0.303
LIG_LIR_Gen_1	47	54	PF02991	0.440
LIG_LIR_Gen_1	99	110	PF02991	0.213
LIG_LIR_Nem_3	270	276	PF02991	0.380
LIG_LIR_Nem_3	326	331	PF02991	0.254
LIG_LIR_Nem_3	47	53	PF02991	0.422
LIG_LIR_Nem_3	99	105	PF02991	0.213
LIG_MAD2	52	60	PF02301	0.465
LIG_NBox_RRM_1	138	148	PF00076	0.308
LIG_PCNA_yPIPBox_3	377	390	PF02747	0.351
LIG_PTB_Apo_2	84	91	PF02174	0.377
LIG_Rb_pABgroove_1	96	104	PF01858	0.351
LIG_SH2_CRK	273	277	PF00017	0.269
LIG_SH2_NCK_1	22	26	PF00017	0.286
LIG_SH2_NCK_1	273	277	PF00017	0.269
LIG_SH2_STAP1	22	26	PF00017	0.286
LIG_SH2_STAP1	328	332	PF00017	0.265
LIG_SH2_STAT5	137	140	PF00017	0.377
LIG_SH2_STAT5	331	334	PF00017	0.240
LIG_SH2_STAT5	379	382	PF00017	0.437
LIG_SH2_STAT5	50	53	PF00017	0.419
LIG_SH3_3	145	151	PF00018	0.266
LIG_SH3_3	301	307	PF00018	0.334
LIG_SH3_3	366	372	PF00018	0.453
LIG_SH3_3	400	406	PF00018	0.413
LIG_SH3_3	409	415	PF00018	0.424
LIG_SH3_3	441	447	PF00018	0.396
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.205
LIG_SUMO_SIM_par_1	108	113	PF11976	0.207
LIG_SUMO_SIM_par_1	353	359	PF11976	0.265
LIG_SUMO_SIM_par_1	385	391	PF11976	0.412
LIG_SUMO_SIM_par_1	93	99	PF11976	0.259
LIG_UBA3_1	69	74	PF00899	0.322
MOD_CDK_SPK_2	56	61	PF00069	0.377
MOD_CDK_SPxxK_3	56	63	PF00069	0.322
MOD_CK1_1	236	242	PF00069	0.440
MOD_CK1_1	256	262	PF00069	0.214
MOD_CK1_1	295	301	PF00069	0.477
MOD_CK1_1	3	9	PF00069	0.565
MOD_CK1_1	443	449	PF00069	0.586
MOD_CK2_1	414	420	PF00069	0.635
MOD_CK2_1	56	62	PF00069	0.287
MOD_GlcNHglycan	189	193	PF01048	0.564
MOD_GlcNHglycan	279	282	PF01048	0.411
MOD_GlcNHglycan	346	350	PF01048	0.422
MOD_GSK3_1	146	153	PF00069	0.244
MOD_GSK3_1	209	216	PF00069	0.593
MOD_GSK3_1	252	259	PF00069	0.427
MOD_GSK3_1	267	274	PF00069	0.425
MOD_GSK3_1	295	302	PF00069	0.485
MOD_GSK3_1	319	326	PF00069	0.254
MOD_GSK3_1	52	59	PF00069	0.262
MOD_LATS_1	243	249	PF00433	0.291
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	108	113	PF00069	0.144
MOD_NEK2_1	20	25	PF00069	0.138
MOD_NEK2_1	252	257	PF00069	0.447
MOD_NEK2_1	299	304	PF00069	0.384
MOD_NEK2_1	396	401	PF00069	0.515
MOD_NEK2_1	407	412	PF00069	0.632
MOD_NEK2_1	54	59	PF00069	0.262
MOD_NEK2_1	90	95	PF00069	0.285
MOD_PIKK_1	299	305	PF00454	0.433
MOD_PIKK_1	319	325	PF00454	0.243
MOD_PKA_2	221	227	PF00069	0.478
MOD_PKA_2	233	239	PF00069	0.391
MOD_PKA_2	256	262	PF00069	0.453
MOD_Plk_1	103	109	PF00069	0.341
MOD_Plk_1	188	194	PF00069	0.616
MOD_Plk_1	323	329	PF00069	0.271
MOD_Plk_4	133	139	PF00069	0.291
MOD_Plk_4	261	267	PF00069	0.387
MOD_Plk_4	323	329	PF00069	0.255
MOD_Plk_4	65	71	PF00069	0.349
MOD_ProDKin_1	440	446	PF00069	0.668
MOD_ProDKin_1	56	62	PF00069	0.322
MOD_SUMO_rev_2	223	229	PF00179	0.494
TRG_DiLeu_BaEn_1	104	109	PF01217	0.322
TRG_DiLeu_BaEn_2	390	396	PF01217	0.349
TRG_ENDOCYTIC_2	273	276	PF00928	0.338
TRG_ENDOCYTIC_2	331	334	PF00928	0.281
TRG_ENDOCYTIC_2	50	53	PF00928	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M9	Leptomonas seymouri	25%	100%
A0A0N1I470	Leptomonas seymouri	70%	88%
A0A0N1PDI6	Leptomonas seymouri	22%	75%
A0A0S4IPA6	Bodo saltans	43%	100%
A0A0S4IPI7	Bodo saltans	28%	90%
A0A0S4JSF9	Bodo saltans	23%	84%
A0A1X0NRR8	Trypanosomatidae	21%	100%
A0A1X0P1F1	Trypanosomatidae	48%	100%
A0A1X0PAL3	Trypanosomatidae	25%	80%
A0A3Q8IC75	Leishmania donovani	80%	90%
A0A3Q8IL77	Leishmania donovani	23%	74%
A0A3Q8ITK0	Leishmania donovani	25%	100%
A0A3R7LBY6	Trypanosoma rangeli	46%	100%
A0A3R7M693	Trypanosoma rangeli	23%	67%
A0A422NS01	Trypanosoma rangeli	23%	80%
A0A422NYJ0	Trypanosoma rangeli	23%	97%
A4H9B8	Leishmania braziliensis	25%	70%
A4HAY2	Leishmania braziliensis	22%	76%
A4HKU5	Leishmania braziliensis	26%	100%
A4I5Y4	Leishmania infantum	80%	90%
A4I8C4	Leishmania infantum	25%	100%
A4IA41	Leishmania infantum	23%	74%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	80%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	90%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	74%
Q4Q2T0	Leishmania major	23%	74%
Q4Q4X2	Leishmania major	24%	100%
Q4Q6Y7	Leishmania major	82%	100%
Q4V3C7	Arabidopsis thaliana	32%	91%
Q67XQ0	Arabidopsis thaliana	32%	91%
Q8RY60	Arabidopsis thaliana	30%	86%
Q8VZI2	Arabidopsis thaliana	30%	100%
Q9LTD8	Arabidopsis thaliana	29%	90%
Q9USJ3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	66%
Q9ZQR4	Arabidopsis thaliana	31%	100%
Q9ZVS8	Arabidopsis thaliana	33%	90%
V5BEH2	Trypanosoma cruzi	23%	66%
V5BKR5	Trypanosoma cruzi	24%	78%
V5DM70	Trypanosoma cruzi	24%	100%
V5DNW3	Trypanosoma cruzi	48%	100%