TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HIN3_LEIBR

TriTrypDb:

LbrM.30.2980 , LBRM2903_300036500

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.452
CLV_NRD_NRD_1	172	174	PF00675	0.599
CLV_NRD_NRD_1	253	255	PF00675	0.617
CLV_NRD_NRD_1	291	293	PF00675	0.678
CLV_NRD_NRD_1	333	335	PF00675	0.474
CLV_NRD_NRD_1	523	525	PF00675	0.352
CLV_NRD_NRD_1	693	695	PF00675	0.323
CLV_NRD_NRD_1	780	782	PF00675	0.199
CLV_PCSK_KEX2_1	126	128	PF00082	0.406
CLV_PCSK_KEX2_1	172	174	PF00082	0.599
CLV_PCSK_KEX2_1	253	255	PF00082	0.620
CLV_PCSK_KEX2_1	291	293	PF00082	0.727
CLV_PCSK_KEX2_1	609	611	PF00082	0.527
CLV_PCSK_KEX2_1	646	648	PF00082	0.244
CLV_PCSK_KEX2_1	780	782	PF00082	0.199
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.298
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.247
CLV_PCSK_SKI1_1	325	329	PF00082	0.454
CLV_PCSK_SKI1_1	446	450	PF00082	0.289
CLV_PCSK_SKI1_1	606	610	PF00082	0.291
CLV_PCSK_SKI1_1	613	617	PF00082	0.273
CLV_PCSK_SKI1_1	813	817	PF00082	0.406
DEG_APCC_DBOX_1	101	109	PF00400	0.524
DEG_APCC_DBOX_1	188	196	PF00400	0.621
DEG_APCC_DBOX_1	798	806	PF00400	0.484
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DOC_CKS1_1	235	240	PF01111	0.568
DOC_CKS1_1	273	278	PF01111	0.547
DOC_MAPK_DCC_7	189	197	PF00069	0.639
DOC_MAPK_gen_1	189	197	PF00069	0.652
DOC_MAPK_gen_1	48	58	PF00069	0.400
DOC_MAPK_gen_1	606	616	PF00069	0.339
DOC_MAPK_MEF2A_6	189	197	PF00069	0.489
DOC_MAPK_MEF2A_6	609	616	PF00069	0.448
DOC_MAPK_MEF2A_6	660	669	PF00069	0.349
DOC_MAPK_MEF2A_6	813	820	PF00069	0.468
DOC_MAPK_NFAT4_5	813	821	PF00069	0.474
DOC_PP1_RVXF_1	611	617	PF00149	0.491
DOC_PP1_RVXF_1	756	763	PF00149	0.362
DOC_PP4_FxxP_1	541	544	PF00568	0.278
DOC_USP7_MATH_1	11	15	PF00917	0.672
DOC_USP7_MATH_1	196	200	PF00917	0.673
DOC_USP7_MATH_1	241	245	PF00917	0.728
DOC_USP7_MATH_1	260	264	PF00917	0.654
DOC_USP7_MATH_1	266	270	PF00917	0.702
DOC_USP7_MATH_1	279	283	PF00917	0.478
DOC_USP7_MATH_1	316	320	PF00917	0.727
DOC_USP7_MATH_1	80	84	PF00917	0.586
DOC_USP7_MATH_1	829	833	PF00917	0.443
DOC_USP7_MATH_1	87	91	PF00917	0.480
DOC_USP7_UBL2_3	609	613	PF12436	0.303
DOC_WW_Pin1_4	201	206	PF00397	0.578
DOC_WW_Pin1_4	207	212	PF00397	0.573
DOC_WW_Pin1_4	23	28	PF00397	0.377
DOC_WW_Pin1_4	234	239	PF00397	0.654
DOC_WW_Pin1_4	272	277	PF00397	0.597
DOC_WW_Pin1_4	312	317	PF00397	0.553
DOC_WW_Pin1_4	438	443	PF00397	0.383
DOC_WW_Pin1_4	75	80	PF00397	0.539
LIG_14-3-3_CanoR_1	102	112	PF00244	0.404
LIG_14-3-3_CanoR_1	172	180	PF00244	0.650
LIG_14-3-3_CanoR_1	2	7	PF00244	0.487
LIG_14-3-3_CanoR_1	253	258	PF00244	0.752
LIG_14-3-3_CanoR_1	477	483	PF00244	0.362
LIG_14-3-3_CanoR_1	655	660	PF00244	0.323
LIG_14-3-3_CanoR_1	758	763	PF00244	0.323
LIG_Actin_WH2_2	798	815	PF00022	0.466
LIG_BIR_III_4	110	114	PF00653	0.199
LIG_Clathr_ClatBox_1	230	234	PF01394	0.506
LIG_EH_1	477	481	PF12763	0.422
LIG_FHA_1	11	17	PF00498	0.655
LIG_FHA_1	114	120	PF00498	0.383
LIG_FHA_1	265	271	PF00498	0.640
LIG_FHA_1	3	9	PF00498	0.656
LIG_FHA_1	33	39	PF00498	0.548
LIG_FHA_1	360	366	PF00498	0.580
LIG_FHA_1	433	439	PF00498	0.383
LIG_FHA_1	45	51	PF00498	0.440
LIG_FHA_1	467	473	PF00498	0.395
LIG_FHA_1	501	507	PF00498	0.383
LIG_FHA_1	528	534	PF00498	0.390
LIG_FHA_1	535	541	PF00498	0.357
LIG_FHA_1	569	575	PF00498	0.219
LIG_FHA_1	637	643	PF00498	0.289
LIG_FHA_1	705	711	PF00498	0.293
LIG_FHA_1	716	722	PF00498	0.376
LIG_FHA_1	745	751	PF00498	0.352
LIG_FHA_1	774	780	PF00498	0.323
LIG_FHA_1	795	801	PF00498	0.453
LIG_FHA_1	90	96	PF00498	0.449
LIG_FHA_2	181	187	PF00498	0.527
LIG_FHA_2	355	361	PF00498	0.650
LIG_FHA_2	368	374	PF00498	0.477
LIG_FHA_2	76	82	PF00498	0.450
LIG_LIR_Apic_2	75	80	PF02991	0.432
LIG_LIR_Gen_1	114	123	PF02991	0.466
LIG_LIR_Gen_1	740	749	PF02991	0.289
LIG_LIR_Nem_3	114	118	PF02991	0.399
LIG_LIR_Nem_3	443	448	PF02991	0.396
LIG_LIR_Nem_3	481	485	PF02991	0.198
LIG_LIR_Nem_3	740	744	PF02991	0.289
LIG_LYPXL_SIV_4	725	733	PF13949	0.428
LIG_MYND_1	190	194	PF01753	0.612
LIG_MYND_1	23	27	PF01753	0.534
LIG_NRBOX	45	51	PF00104	0.454
LIG_Pex14_2	445	449	PF04695	0.289
LIG_PTB_Apo_2	447	454	PF02174	0.289
LIG_PTB_Apo_2	515	522	PF02174	0.350
LIG_REV1ctd_RIR_1	513	523	PF16727	0.406
LIG_RPA_C_Fungi	582	594	PF08784	0.292
LIG_SH2_CRK	273	277	PF00017	0.671
LIG_SH2_CRK	625	629	PF00017	0.383
LIG_SH2_CRK	97	101	PF00017	0.429
LIG_SH2_GRB2like	142	145	PF00017	0.429
LIG_SH2_GRB2like	482	485	PF00017	0.205
LIG_SH2_GRB2like	584	587	PF00017	0.289
LIG_SH2_NCK_1	130	134	PF00017	0.289
LIG_SH2_NCK_1	273	277	PF00017	0.671
LIG_SH2_NCK_1	551	555	PF00017	0.319
LIG_SH2_NCK_1	77	81	PF00017	0.460
LIG_SH2_PTP2	55	58	PF00017	0.465
LIG_SH2_SRC	142	145	PF00017	0.199
LIG_SH2_SRC	563	566	PF00017	0.383
LIG_SH2_STAP1	130	134	PF00017	0.289
LIG_SH2_STAP1	149	153	PF00017	0.289
LIG_SH2_STAP1	34	38	PF00017	0.438
LIG_SH2_STAP1	372	376	PF00017	0.554
LIG_SH2_STAP1	434	438	PF00017	0.289
LIG_SH2_STAP1	461	465	PF00017	0.368
LIG_SH2_STAP1	468	472	PF00017	0.188
LIG_SH2_STAP1	529	533	PF00017	0.378
LIG_SH2_STAP1	536	540	PF00017	0.288
LIG_SH2_STAP1	563	567	PF00017	0.311
LIG_SH2_STAP1	570	574	PF00017	0.266
LIG_SH2_STAP1	631	635	PF00017	0.383
LIG_SH2_STAP1	672	676	PF00017	0.323
LIG_SH2_STAP1	686	690	PF00017	0.323
LIG_SH2_STAP1	699	703	PF00017	0.243
LIG_SH2_STAP1	706	710	PF00017	0.162
LIG_SH2_STAP1	741	745	PF00017	0.311
LIG_SH2_STAP1	768	772	PF00017	0.272
LIG_SH2_STAT3	34	37	PF00017	0.314
LIG_SH2_STAT3	413	416	PF00017	0.292
LIG_SH2_STAT5	142	145	PF00017	0.241
LIG_SH2_STAT5	273	276	PF00017	0.669
LIG_SH2_STAT5	304	307	PF00017	0.539
LIG_SH2_STAT5	34	37	PF00017	0.476
LIG_SH2_STAT5	413	416	PF00017	0.441
LIG_SH2_STAT5	434	437	PF00017	0.340
LIG_SH2_STAT5	468	471	PF00017	0.248
LIG_SH2_STAT5	529	532	PF00017	0.390
LIG_SH2_STAT5	536	539	PF00017	0.350
LIG_SH2_STAT5	55	58	PF00017	0.406
LIG_SH2_STAT5	555	558	PF00017	0.233
LIG_SH2_STAT5	570	573	PF00017	0.226
LIG_SH2_STAT5	706	709	PF00017	0.206
LIG_SH2_STAT5	726	729	PF00017	0.191
LIG_SH2_STAT5	77	80	PF00017	0.455
LIG_SH3_1	780	786	PF00018	0.362
LIG_SH3_3	190	196	PF00018	0.573
LIG_SH3_3	205	211	PF00018	0.664
LIG_SH3_3	235	241	PF00018	0.668
LIG_SH3_3	473	479	PF00018	0.362
LIG_SH3_3	780	786	PF00018	0.362
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.493
LIG_SUMO_SIM_par_1	229	234	PF11976	0.504
LIG_TRAF2_1	256	259	PF00917	0.506
LIG_TYR_ITIM	623	628	PF00017	0.383
LIG_TYR_ITIM	95	100	PF00017	0.427
LIG_WRC_WIRS_1	197	202	PF05994	0.539
LIG_WRC_WIRS_1	830	835	PF05994	0.332
MOD_CDK_SPK_2	234	239	PF00069	0.551
MOD_CK1_1	14	20	PF00069	0.708
MOD_CK1_1	244	250	PF00069	0.658
MOD_CK1_1	309	315	PF00069	0.590
MOD_CK1_1	319	325	PF00069	0.565
MOD_CK1_1	366	372	PF00069	0.645
MOD_CK1_1	4	10	PF00069	0.662
MOD_CK1_1	400	406	PF00069	0.564
MOD_CK1_1	578	584	PF00069	0.299
MOD_CK1_1	794	800	PF00069	0.370
MOD_CK1_1	832	838	PF00069	0.387
MOD_CK2_1	180	186	PF00069	0.522
MOD_CK2_1	253	259	PF00069	0.713
MOD_CK2_1	281	287	PF00069	0.542
MOD_CK2_1	307	313	PF00069	0.662
MOD_CK2_1	87	93	PF00069	0.611
MOD_Cter_Amidation	159	162	PF01082	0.428
MOD_Cter_Amidation	251	254	PF01082	0.556
MOD_Cter_Amidation	289	292	PF01082	0.773
MOD_DYRK1A_RPxSP_1	203	207	PF00069	0.478
MOD_GlcNHglycan	222	225	PF01048	0.607
MOD_GlcNHglycan	250	253	PF01048	0.670
MOD_GlcNHglycan	262	265	PF01048	0.777
MOD_GlcNHglycan	350	353	PF01048	0.597
MOD_GlcNHglycan	423	426	PF01048	0.291
MOD_GlcNHglycan	62	65	PF01048	0.451
MOD_GlcNHglycan	671	675	PF01048	0.433
MOD_GlcNHglycan	768	771	PF01048	0.199
MOD_GlcNHglycan	81	85	PF01048	0.742
MOD_GSK3_1	10	17	PF00069	0.680
MOD_GSK3_1	180	187	PF00069	0.682
MOD_GSK3_1	203	210	PF00069	0.667
MOD_GSK3_1	214	221	PF00069	0.769
MOD_GSK3_1	233	240	PF00069	0.722
MOD_GSK3_1	244	251	PF00069	0.805
MOD_GSK3_1	260	267	PF00069	0.612
MOD_GSK3_1	277	284	PF00069	0.533
MOD_GSK3_1	291	298	PF00069	0.593
MOD_GSK3_1	307	314	PF00069	0.672
MOD_GSK3_1	348	355	PF00069	0.522
MOD_GSK3_1	359	366	PF00069	0.625
MOD_GSK3_1	394	401	PF00069	0.685
MOD_GSK3_1	485	492	PF00069	0.231
MOD_GSK3_1	681	688	PF00069	0.399
MOD_GSK3_1	75	82	PF00069	0.539
MOD_GSK3_1	791	798	PF00069	0.339
MOD_LATS_1	653	659	PF00433	0.323
MOD_N-GLC_1	367	372	PF02516	0.524
MOD_NEK2_1	1	6	PF00069	0.683
MOD_NEK2_1	16	21	PF00069	0.580
MOD_NEK2_1	233	238	PF00069	0.641
MOD_NEK2_1	271	276	PF00069	0.496
MOD_NEK2_1	614	619	PF00069	0.215
MOD_PIKK_1	103	109	PF00454	0.362
MOD_PIKK_1	291	297	PF00454	0.721
MOD_PK_1	253	259	PF00069	0.518
MOD_PKA_1	172	178	PF00069	0.554
MOD_PKA_1	253	259	PF00069	0.605
MOD_PKA_1	291	297	PF00069	0.672
MOD_PKA_2	1	7	PF00069	0.487
MOD_PKA_2	103	109	PF00069	0.411
MOD_PKA_2	172	178	PF00069	0.554
MOD_PKA_2	244	250	PF00069	0.640
MOD_PKA_2	253	259	PF00069	0.705
MOD_PKA_2	291	297	PF00069	0.743
MOD_PKA_2	32	38	PF00069	0.438
MOD_PKA_2	39	45	PF00069	0.562
MOD_PKA_2	421	427	PF00069	0.199
MOD_PKA_2	794	800	PF00069	0.352
MOD_Plk_1	316	322	PF00069	0.630
MOD_Plk_4	266	272	PF00069	0.491
MOD_Plk_4	316	322	PF00069	0.634
MOD_Plk_4	647	653	PF00069	0.247
MOD_Plk_4	67	73	PF00069	0.318
MOD_ProDKin_1	201	207	PF00069	0.574
MOD_ProDKin_1	23	29	PF00069	0.369
MOD_ProDKin_1	234	240	PF00069	0.656
MOD_ProDKin_1	272	278	PF00069	0.597
MOD_ProDKin_1	312	318	PF00069	0.554
MOD_ProDKin_1	438	444	PF00069	0.383
MOD_ProDKin_1	75	81	PF00069	0.546
TRG_DiLeu_BaEn_1	222	227	PF01217	0.489
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.493
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.520
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.457
TRG_DiLeu_BaLyEn_6	838	843	PF01217	0.445
TRG_ENDOCYTIC_2	482	485	PF00928	0.196
TRG_ENDOCYTIC_2	55	58	PF00928	0.440
TRG_ENDOCYTIC_2	625	628	PF00928	0.383
TRG_ENDOCYTIC_2	659	662	PF00928	0.383
TRG_ENDOCYTIC_2	741	744	PF00928	0.323
TRG_ENDOCYTIC_2	97	100	PF00928	0.467
TRG_ER_diArg_1	102	105	PF00400	0.434
TRG_ER_diArg_1	188	191	PF00400	0.673
TRG_ER_diArg_1	291	293	PF00400	0.653
TRG_ER_diArg_1	779	781	PF00400	0.199
TRG_NLS_MonoCore_2	160	165	PF00514	0.445
TRG_NLS_MonoExtN_4	161	166	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	606	611	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	841	845	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB6	Leptomonas seymouri	55%	98%
A0A0S4ITS9	Bodo saltans	30%	100%
A0A3S7X3S0	Leishmania donovani	73%	100%
A4I5Y0	Leishmania infantum	73%	100%
E9B173	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q6Z1	Leishmania major	73%	100%
V5BSG3	Trypanosoma cruzi	28%	100%