Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIN2_LEIBR

TriTrypDb:

LbrM.30.2970 , LBRM2903_300036400

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	103	107	PF00082	0.331
CLV_PCSK_SKI1_1	31	35	PF00082	0.419
CLV_PCSK_SKI1_1	94	98	PF00082	0.421
CLV_Separin_Metazoa	181	185	PF03568	0.502
DEG_APCC_DBOX_1	102	110	PF00400	0.404
DEG_APCC_DBOX_1	30	38	PF00400	0.429
DOC_MAPK_gen_1	161	169	PF00069	0.555
DOC_MAPK_MEF2A_6	163	171	PF00069	0.510
DOC_MAPK_MEF2A_6	192	200	PF00069	0.488
DOC_MAPK_MEF2A_6	27	36	PF00069	0.543
DOC_PP2B_LxvP_1	133	136	PF13499	0.565
DOC_PP2B_LxvP_1	4	7	PF13499	0.727
DOC_PP2B_LxvP_1	58	61	PF13499	0.539
DOC_USP7_MATH_1	14	18	PF00917	0.664
DOC_USP7_MATH_1	41	45	PF00917	0.449
DOC_WW_Pin1_4	2	7	PF00397	0.738
LIG_14-3-3_CanoR_1	117	121	PF00244	0.496
LIG_14-3-3_CanoR_1	31	37	PF00244	0.422
LIG_14-3-3_CanoR_1	85	93	PF00244	0.395
LIG_Actin_WH2_2	168	186	PF00022	0.447
LIG_FHA_1	184	190	PF00498	0.421
LIG_FHA_2	176	182	PF00498	0.491
LIG_GBD_Chelix_1	143	151	PF00786	0.495
LIG_LIR_Gen_1	119	128	PF02991	0.458
LIG_LIR_Gen_1	137	147	PF02991	0.281
LIG_LIR_Gen_1	35	42	PF02991	0.455
LIG_LIR_Nem_3	119	124	PF02991	0.431
LIG_LIR_Nem_3	137	143	PF02991	0.339
LIG_LIR_Nem_3	35	39	PF02991	0.457
LIG_LIR_Nem_3	87	93	PF02991	0.429
LIG_LYPXL_S_1	89	93	PF13949	0.305
LIG_LYPXL_yS_3	90	93	PF13949	0.383
LIG_SH2_STAT5	101	104	PF00017	0.520
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.417
LIG_SUMO_SIM_par_1	173	178	PF11976	0.291
LIG_SUMO_SIM_par_1	55	63	PF11976	0.474
LIG_WRC_WIRS_1	33	38	PF05994	0.490
MOD_CK1_1	65	71	PF00069	0.683
MOD_CK2_1	175	181	PF00069	0.453
MOD_CK2_1	65	71	PF00069	0.712
MOD_GlcNHglycan	39	42	PF01048	0.441
MOD_GlcNHglycan	48	51	PF01048	0.397
MOD_GSK3_1	138	145	PF00069	0.296
MOD_GSK3_1	183	190	PF00069	0.516
MOD_GSK3_1	37	44	PF00069	0.494
MOD_GSK3_1	59	66	PF00069	0.598
MOD_GSK3_1	69	76	PF00069	0.672
MOD_NEK2_1	15	20	PF00069	0.773
MOD_NEK2_1	183	188	PF00069	0.420
MOD_NEK2_1	32	37	PF00069	0.376
MOD_NEK2_1	64	69	PF00069	0.468
MOD_NEK2_2	116	121	PF00069	0.476
MOD_NEK2_2	194	199	PF00069	0.579
MOD_PIKK_1	175	181	PF00454	0.513
MOD_PK_1	187	193	PF00069	0.352
MOD_PKA_2	116	122	PF00069	0.455
MOD_PKA_2	183	189	PF00069	0.469
MOD_PKA_2	84	90	PF00069	0.419
MOD_Plk_4	116	122	PF00069	0.404
MOD_Plk_4	142	148	PF00069	0.390
MOD_Plk_4	32	38	PF00069	0.432
MOD_ProDKin_1	2	8	PF00069	0.737
TRG_DiLeu_BaEn_1	92	97	PF01217	0.469
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.566
TRG_ENDOCYTIC_2	90	93	PF00928	0.383
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z8	Leptomonas seymouri	66%	92%
A0A1X0P230	Trypanosomatidae	29%	100%
A0A3Q8IF51	Leishmania donovani	77%	100%
A0A3R7N1I2	Trypanosoma rangeli	29%	100%
A4I5X9	Leishmania infantum	78%	100%
C9ZRA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q6Z2	Leishmania major	80%	99%