DUF2817 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2817), putative

Species:

Leishmania braziliensis

UniProt:

A4HIN1_LEIBR

TriTrypDb:

LbrM.30.2960 , LBRM2903_300036300

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HIN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.560
CLV_NRD_NRD_1	247	249	PF00675	0.445
CLV_NRD_NRD_1	93	95	PF00675	0.608
CLV_PCSK_KEX2_1	149	151	PF00082	0.560
CLV_PCSK_KEX2_1	219	221	PF00082	0.510
CLV_PCSK_KEX2_1	390	392	PF00082	0.608
CLV_PCSK_KEX2_1	77	79	PF00082	0.573
CLV_PCSK_KEX2_1	93	95	PF00082	0.480
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.560
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.608
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.570
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.504
CLV_PCSK_SKI1_1	185	189	PF00082	0.573
CLV_PCSK_SKI1_1	199	203	PF00082	0.457
CLV_PCSK_SKI1_1	214	218	PF00082	0.456
CLV_PCSK_SKI1_1	219	223	PF00082	0.511
CLV_PCSK_SKI1_1	248	252	PF00082	0.515
CLV_PCSK_SKI1_1	292	296	PF00082	0.525
CLV_PCSK_SKI1_1	374	378	PF00082	0.525
CLV_PCSK_SKI1_1	385	389	PF00082	0.525
CLV_PCSK_SKI1_1	94	98	PF00082	0.486
DEG_COP1_1	182	192	PF00400	0.217
DEG_MDM2_SWIB_1	396	403	PF02201	0.390
DOC_MAPK_gen_1	93	100	PF00069	0.305
DOC_MAPK_MEF2A_6	292	300	PF00069	0.245
DOC_PP2B_LxvP_1	187	190	PF13499	0.327
DOC_USP7_UBL2_3	249	253	PF12436	0.217
DOC_USP7_UBL2_3	93	97	PF12436	0.360
LIG_14-3-3_CanoR_1	160	168	PF00244	0.325
LIG_14-3-3_CanoR_1	361	369	PF00244	0.217
LIG_14-3-3_CanoR_1	391	400	PF00244	0.391
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BIR_III_1	1	5	PF00653	0.533
LIG_BIR_III_3	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	132	136	PF00533	0.297
LIG_BRCT_BRCA1_1	392	396	PF00533	0.419
LIG_Clathr_ClatBox_1	19	23	PF01394	0.357
LIG_eIF4E_1	7	13	PF01652	0.240
LIG_FHA_1	103	109	PF00498	0.352
LIG_FHA_1	184	190	PF00498	0.217
LIG_FHA_1	259	265	PF00498	0.342
LIG_FHA_1	277	283	PF00498	0.201
LIG_FHA_1	329	335	PF00498	0.312
LIG_FHA_1	363	369	PF00498	0.217
LIG_FHA_1	9	15	PF00498	0.331
LIG_FHA_2	177	183	PF00498	0.276
LIG_FHA_2	273	279	PF00498	0.302
LIG_KLC1_Yacidic_2	262	267	PF13176	0.398
LIG_LIR_Apic_2	224	230	PF02991	0.325
LIG_LIR_Gen_1	165	176	PF02991	0.396
LIG_LIR_Gen_1	179	189	PF02991	0.277
LIG_LIR_Gen_1	198	207	PF02991	0.309
LIG_LIR_Gen_1	262	272	PF02991	0.327
LIG_LIR_Gen_1	398	404	PF02991	0.249
LIG_LIR_Gen_1	6	16	PF02991	0.376
LIG_LIR_Nem_3	165	171	PF02991	0.304
LIG_LIR_Nem_3	179	184	PF02991	0.290
LIG_LIR_Nem_3	198	203	PF02991	0.309
LIG_LIR_Nem_3	262	268	PF02991	0.327
LIG_LIR_Nem_3	293	298	PF02991	0.220
LIG_LIR_Nem_3	336	341	PF02991	0.325
LIG_LIR_Nem_3	398	403	PF02991	0.314
LIG_LIR_Nem_3	6	12	PF02991	0.376
LIG_NRBOX	15	21	PF00104	0.240
LIG_Pex14_2	184	188	PF04695	0.387
LIG_Pex14_2	396	400	PF04695	0.354
LIG_PTAP_UEV_1	189	194	PF05743	0.217
LIG_PTB_Apo_2	339	346	PF02174	0.388
LIG_PTB_Apo_2	351	358	PF02174	0.312
LIG_PTB_Phospho_1	339	345	PF10480	0.371
LIG_PTB_Phospho_1	351	357	PF10480	0.353
LIG_SH2_GRB2like	37	40	PF00017	0.378
LIG_SH2_NCK_1	314	318	PF00017	0.398
LIG_SH2_NCK_1	37	41	PF00017	0.316
LIG_SH2_PTP2	200	203	PF00017	0.370
LIG_SH2_PTP2	265	268	PF00017	0.315
LIG_SH2_SRC	265	268	PF00017	0.385
LIG_SH2_SRC	37	40	PF00017	0.373
LIG_SH2_STAP1	314	318	PF00017	0.279
LIG_SH2_STAP1	364	368	PF00017	0.217
LIG_SH2_STAP1	48	52	PF00017	0.338
LIG_SH2_STAT5	111	114	PF00017	0.300
LIG_SH2_STAT5	162	165	PF00017	0.360
LIG_SH2_STAT5	200	203	PF00017	0.324
LIG_SH2_STAT5	204	207	PF00017	0.327
LIG_SH2_STAT5	265	268	PF00017	0.398
LIG_SH2_STAT5	345	348	PF00017	0.252
LIG_SH2_STAT5	364	367	PF00017	0.301
LIG_SH2_STAT5	402	405	PF00017	0.365
LIG_SH2_STAT5	7	10	PF00017	0.240
LIG_SH3_2	190	195	PF14604	0.360
LIG_SH3_3	187	193	PF00018	0.334
LIG_SH3_CIN85_PxpxPR_1	190	195	PF14604	0.287
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.364
LIG_SUMO_SIM_anti_2	243	248	PF11976	0.325
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.217
LIG_SUMO_SIM_par_1	10	17	PF11976	0.391
LIG_SUMO_SIM_par_1	330	337	PF11976	0.354
LIG_TRAF2_1	164	167	PF00917	0.398
LIG_TRAF2_1	26	29	PF00917	0.416
LIG_WW_3	192	196	PF00397	0.360
MOD_CK1_1	130	136	PF00069	0.354
MOD_CK1_1	308	314	PF00069	0.350
MOD_CK1_1	398	404	PF00069	0.249
MOD_CK2_1	161	167	PF00069	0.371
MOD_CK2_1	176	182	PF00069	0.221
MOD_CMANNOS	397	400	PF00535	0.631
MOD_Cter_Amidation	91	94	PF01082	0.560
MOD_GlcNHglycan	102	105	PF01048	0.531
MOD_GlcNHglycan	113	116	PF01048	0.522
MOD_GlcNHglycan	129	132	PF01048	0.501
MOD_GlcNHglycan	190	193	PF01048	0.418
MOD_GlcNHglycan	307	310	PF01048	0.530
MOD_GlcNHglycan	311	314	PF01048	0.520
MOD_GlcNHglycan	33	36	PF01048	0.557
MOD_GlcNHglycan	393	396	PF01048	0.518
MOD_GlcNHglycan	397	400	PF01048	0.499
MOD_GSK3_1	202	209	PF00069	0.357
MOD_GSK3_1	27	34	PF00069	0.431
MOD_GSK3_1	272	279	PF00069	0.312
MOD_GSK3_1	300	307	PF00069	0.356
MOD_GSK3_1	360	367	PF00069	0.217
MOD_GSK3_1	391	398	PF00069	0.307
MOD_N-GLC_1	124	129	PF02516	0.501
MOD_N-GLC_1	176	181	PF02516	0.483
MOD_N-GLC_1	38	43	PF02516	0.563
MOD_NEK2_1	202	207	PF00069	0.351
MOD_NEK2_1	27	32	PF00069	0.370
MOD_NEK2_1	99	104	PF00069	0.388
MOD_PIKK_1	300	306	PF00454	0.236
MOD_PIKK_1	38	44	PF00454	0.294
MOD_PK_1	242	248	PF00069	0.398
MOD_PKA_1	390	396	PF00069	0.396
MOD_PKA_2	31	37	PF00069	0.377
MOD_PKA_2	360	366	PF00069	0.360
MOD_PKA_2	390	396	PF00069	0.396
MOD_Plk_1	124	130	PF00069	0.360
MOD_Plk_1	380	386	PF00069	0.354
MOD_Plk_4	130	136	PF00069	0.301
MOD_Plk_4	206	212	PF00069	0.251
MOD_Plk_4	276	282	PF00069	0.344
MOD_Plk_4	364	370	PF00069	0.305
MOD_Plk_4	8	14	PF00069	0.365
MOD_SUMO_rev_2	238	244	PF00179	0.371
TRG_DiLeu_BaEn_4	153	159	PF01217	0.346
TRG_ENDOCYTIC_2	181	184	PF00928	0.301
TRG_ENDOCYTIC_2	200	203	PF00928	0.301
TRG_ENDOCYTIC_2	265	268	PF00928	0.398
TRG_ER_diArg_1	148	150	PF00400	0.360
TRG_ER_diArg_1	211	214	PF00400	0.255
TRG_NLS_Bipartite_1	77	98	PF00514	0.217
TRG_NLS_MonoExtC_3	92	97	PF00514	0.217
TRG_NLS_MonoExtN_4	91	98	PF00514	0.217
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP4	Leptomonas seymouri	66%	100%
A0A1X0P1D9	Trypanosomatidae	50%	100%
A0A3Q8II59	Leishmania donovani	82%	100%
A4I5X8	Leishmania infantum	82%	100%
C9ZRA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B171	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q6Z3	Leishmania major	82%	100%