Zf-CHCC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM9_LEIBR

TriTrypDb:

LbrM.30.2940 , LBRM2903_300036100

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.654
CLV_NRD_NRD_1	68	70	PF00675	0.560
CLV_PCSK_SKI1_1	188	192	PF00082	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.568
DEG_SCF_FBW7_2	150	157	PF00400	0.655
DOC_MAPK_MEF2A_6	15	24	PF00069	0.632
DOC_PP1_RVXF_1	125	131	PF00149	0.413
DOC_PP1_RVXF_1	34	41	PF00149	0.518
DOC_PP2B_PxIxI_1	108	114	PF00149	0.402
DOC_PP4_FxxP_1	40	43	PF00568	0.507
DOC_USP7_MATH_2	25	31	PF00917	0.498
DOC_USP7_UBL2_3	199	203	PF12436	0.595
DOC_WW_Pin1_4	150	155	PF00397	0.519
DOC_WW_Pin1_4	16	21	PF00397	0.446
DOC_WW_Pin1_4	171	176	PF00397	0.630
DOC_WW_Pin1_4	68	73	PF00397	0.560
LIG_14-3-3_CanoR_1	8	18	PF00244	0.481
LIG_BRCT_BRCA1_1	172	176	PF00533	0.497
LIG_FHA_1	2	8	PF00498	0.602
LIG_FHA_1	69	75	PF00498	0.556
LIG_FHA_2	133	139	PF00498	0.449
LIG_FHA_2	150	156	PF00498	0.519
LIG_FHA_2	8	14	PF00498	0.673
LIG_Pex14_2	5	9	PF04695	0.630
LIG_SH2_CRK	18	22	PF00017	0.535
LIG_SH2_CRK	187	191	PF00017	0.526
LIG_SH2_STAP1	28	32	PF00017	0.462
LIG_SH2_STAT3	212	215	PF00017	0.456
LIG_SH2_STAT5	185	188	PF00017	0.643
LIG_SH2_STAT5	48	51	PF00017	0.647
LIG_SH2_STAT5	76	79	PF00017	0.627
LIG_SH3_3	187	193	PF00018	0.515
LIG_SH3_3	19	25	PF00018	0.524
LIG_SH3_3	40	46	PF00018	0.523
LIG_SH3_3	84	90	PF00018	0.437
LIG_TRAF2_1	144	147	PF00917	0.459
LIG_WW_1	20	23	PF00397	0.510
MOD_CK1_1	226	232	PF00069	0.572
MOD_CK1_1	30	36	PF00069	0.521
MOD_CK2_1	131	137	PF00069	0.469
MOD_CK2_1	149	155	PF00069	0.414
MOD_Cter_Amidation	67	70	PF01082	0.561
MOD_GlcNHglycan	221	224	PF01048	0.618
MOD_GSK3_1	149	156	PF00069	0.568
MOD_GSK3_1	219	226	PF00069	0.562
MOD_N-GLC_1	131	136	PF02516	0.413
MOD_N-GLC_1	74	79	PF02516	0.665
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	38	43	PF00069	0.542
MOD_NEK2_1	7	12	PF00069	0.561
MOD_NEK2_1	74	79	PF00069	0.650
MOD_PKA_2	30	36	PF00069	0.511
MOD_PKA_2	7	13	PF00069	0.479
MOD_Plk_1	55	61	PF00069	0.596
MOD_ProDKin_1	150	156	PF00069	0.519
MOD_ProDKin_1	16	22	PF00069	0.442
MOD_ProDKin_1	171	177	PF00069	0.628
MOD_ProDKin_1	68	74	PF00069	0.550
MOD_SUMO_rev_2	141	151	PF00179	0.530
MOD_SUMO_rev_2	173	182	PF00179	0.665
TRG_ENDOCYTIC_2	187	190	PF00928	0.571
TRG_ENDOCYTIC_2	23	26	PF00928	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q1	Leptomonas seymouri	82%	100%
A0A0S4ITD8	Bodo saltans	67%	100%
A0A1X0P1R4	Trypanosomatidae	78%	100%
A0A3S7X3U1	Leishmania donovani	90%	100%
A4I5X5	Leishmania infantum	90%	100%
C9ZR99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
E9B169	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6Z6	Leishmania major	89%	100%
V5BSK1	Trypanosoma cruzi	75%	100%