Peptidase S1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM8_LEIBR

TriTrypDb:

LbrM.30.2920 , LBRM2903_300035900

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 0
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.555
CLV_C14_Caspase3-7	213	217	PF00656	0.398
CLV_NRD_NRD_1	297	299	PF00675	0.492
CLV_NRD_NRD_1	50	52	PF00675	0.472
CLV_NRD_NRD_1	53	55	PF00675	0.454
CLV_PCSK_FUR_1	51	55	PF00082	0.469
CLV_PCSK_KEX2_1	297	299	PF00082	0.466
CLV_PCSK_KEX2_1	52	54	PF00082	0.462
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.498
CLV_PCSK_SKI1_1	298	302	PF00082	0.460
CLV_PCSK_SKI1_1	58	62	PF00082	0.382
CLV_Separin_Metazoa	230	234	PF03568	0.337
DOC_CDC14_PxL_1	95	103	PF14671	0.305
DOC_MAPK_gen_1	5	15	PF00069	0.344
DOC_MAPK_gen_1	51	59	PF00069	0.398
DOC_MAPK_MEF2A_6	281	289	PF00069	0.397
DOC_MAPK_MEF2A_6	51	59	PF00069	0.362
DOC_MAPK_MEF2A_6	8	17	PF00069	0.454
DOC_MAPK_NFAT4_5	52	60	PF00069	0.504
DOC_PP1_RVXF_1	235	241	PF00149	0.502
DOC_PP4_MxPP_1	1	4	PF00568	0.519
DOC_USP7_MATH_1	135	139	PF00917	0.583
DOC_USP7_MATH_1	190	194	PF00917	0.677
DOC_USP7_MATH_1	197	201	PF00917	0.635
DOC_USP7_MATH_1	29	33	PF00917	0.440
DOC_WW_Pin1_4	33	38	PF00397	0.438
LIG_14-3-3_CanoR_1	126	131	PF00244	0.433
LIG_14-3-3_CanoR_1	28	38	PF00244	0.367
LIG_14-3-3_CanoR_1	298	308	PF00244	0.564
LIG_FHA_1	114	120	PF00498	0.453
LIG_FHA_1	14	20	PF00498	0.371
LIG_FHA_1	146	152	PF00498	0.459
LIG_FHA_1	158	164	PF00498	0.364
LIG_FHA_1	284	290	PF00498	0.439
LIG_FHA_2	105	111	PF00498	0.444
LIG_FHA_2	138	144	PF00498	0.316
LIG_FHA_2	194	200	PF00498	0.421
LIG_FHA_2	61	67	PF00498	0.512
LIG_LIR_Gen_1	256	265	PF02991	0.503
LIG_LIR_Gen_1	317	327	PF02991	0.388
LIG_LIR_Nem_3	256	261	PF02991	0.501
LIG_LIR_Nem_3	317	323	PF02991	0.367
LIG_LIR_Nem_3	328	333	PF02991	0.405
LIG_LIR_Nem_3	80	86	PF02991	0.522
LIG_PCNA_PIPBox_1	285	294	PF02747	0.237
LIG_PDZ_Class_2	336	341	PF00595	0.395
LIG_PTB_Apo_2	178	185	PF02174	0.467
LIG_Rb_LxCxE_1	16	36	PF01857	0.326
LIG_SH2_CRK	258	262	PF00017	0.528
LIG_SH2_NCK_1	258	262	PF00017	0.505
LIG_SH2_SRC	186	189	PF00017	0.361
LIG_SH2_STAT3	42	45	PF00017	0.381
LIG_SH2_STAT5	105	108	PF00017	0.488
LIG_SH2_STAT5	127	130	PF00017	0.334
LIG_SH2_STAT5	186	189	PF00017	0.410
LIG_SH2_STAT5	258	261	PF00017	0.466
LIG_SH3_3	1	7	PF00018	0.503
LIG_SUMO_SIM_par_1	168	174	PF11976	0.327
LIG_SUMO_SIM_par_1	285	290	PF11976	0.232
LIG_WRC_WIRS_1	311	316	PF05994	0.571
LIG_WRC_WIRS_1	327	332	PF05994	0.596
LIG_WRC_WIRS_1	90	95	PF05994	0.466
LIG_WW_3	2	6	PF00397	0.378
MOD_CDK_SPxxK_3	33	40	PF00069	0.292
MOD_CK1_1	104	110	PF00069	0.413
MOD_CK1_1	136	142	PF00069	0.421
MOD_CK1_1	147	153	PF00069	0.353
MOD_CK1_1	158	164	PF00069	0.299
MOD_CK1_1	193	199	PF00069	0.556
MOD_CK1_1	209	215	PF00069	0.462
MOD_CK1_1	256	262	PF00069	0.481
MOD_CK1_1	275	281	PF00069	0.365
MOD_CK1_1	32	38	PF00069	0.550
MOD_CK1_1	91	97	PF00069	0.491
MOD_CK2_1	104	110	PF00069	0.428
MOD_CK2_1	137	143	PF00069	0.319
MOD_CK2_1	326	332	PF00069	0.492
MOD_CK2_1	60	66	PF00069	0.509
MOD_Cter_Amidation	265	268	PF01082	0.406
MOD_GlcNHglycan	110	114	PF01048	0.456
MOD_GlcNHglycan	302	305	PF01048	0.375
MOD_GSK3_1	100	107	PF00069	0.367
MOD_GSK3_1	109	116	PF00069	0.363
MOD_GSK3_1	133	140	PF00069	0.355
MOD_GSK3_1	157	164	PF00069	0.366
MOD_GSK3_1	193	200	PF00069	0.447
MOD_GSK3_1	201	208	PF00069	0.432
MOD_GSK3_1	24	31	PF00069	0.409
MOD_GSK3_1	283	290	PF00069	0.360
MOD_GSK3_1	89	96	PF00069	0.425
MOD_N-GLC_1	108	113	PF02516	0.355
MOD_N-GLC_1	136	141	PF02516	0.441
MOD_N-GLC_1	155	160	PF02516	0.556
MOD_N-GLC_1	201	206	PF02516	0.554
MOD_N-GLC_1	209	214	PF02516	0.657
MOD_N-GLC_1	333	338	PF02516	0.618
MOD_N-GLC_1	67	72	PF02516	0.518
MOD_NEK2_1	100	105	PF00069	0.354
MOD_NEK2_1	13	18	PF00069	0.423
MOD_NEK2_1	133	138	PF00069	0.442
MOD_NEK2_1	205	210	PF00069	0.703
MOD_NEK2_1	214	219	PF00069	0.369
MOD_NEK2_1	60	65	PF00069	0.388
MOD_NEK2_1	93	98	PF00069	0.319
MOD_PK_1	126	132	PF00069	0.400
MOD_PKA_2	158	164	PF00069	0.298
MOD_Plk_1	201	207	PF00069	0.583
MOD_Plk_1	67	73	PF00069	0.508
MOD_Plk_4	101	107	PF00069	0.306
MOD_Plk_4	126	132	PF00069	0.393
MOD_Plk_4	147	153	PF00069	0.400
MOD_Plk_4	168	174	PF00069	0.337
MOD_Plk_4	201	207	PF00069	0.661
MOD_Plk_4	253	259	PF00069	0.446
MOD_Plk_4	283	289	PF00069	0.349
MOD_Plk_4	310	316	PF00069	0.515
MOD_Plk_4	326	332	PF00069	0.482
MOD_ProDKin_1	33	39	PF00069	0.426
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.358
TRG_ENDOCYTIC_2	127	130	PF00928	0.379
TRG_ENDOCYTIC_2	258	261	PF00928	0.466
TRG_ER_diArg_1	51	54	PF00400	0.404
TRG_NLS_MonoCore_2	50	55	PF00514	0.405
TRG_NLS_MonoExtC_3	50	56	PF00514	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A9	Leptomonas seymouri	41%	95%
A0A0S4IU13	Bodo saltans	26%	100%
A0A1X0P1Q5	Trypanosomatidae	26%	100%
A0A1X0P2Z8	Trypanosomatidae	41%	89%
A0A3R7LKG2	Trypanosoma rangeli	38%	100%
A0A3S7X3Q6	Leishmania donovani	66%	100%
A4I5X3	Leishmania infantum	65%	100%
B6DTB5	Bodo saltans	30%	100%
C9ZR97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZR98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B167	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q6Z8	Leishmania major	66%	100%