Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM3_LEIBR

TriTrypDb:

LbrM.30.2870 , LBRM2903_300035400

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HIM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM3

PDB structure(s): 7aih_BM , 7am2_BM , 7ane_BM

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.407
CLV_NRD_NRD_1	141	143	PF00675	0.420
CLV_NRD_NRD_1	181	183	PF00675	0.294
CLV_NRD_NRD_1	270	272	PF00675	0.358
CLV_NRD_NRD_1	45	47	PF00675	0.409
CLV_NRD_NRD_1	79	81	PF00675	0.386
CLV_PCSK_KEX2_1	141	143	PF00082	0.423
CLV_PCSK_KEX2_1	411	413	PF00082	0.436
CLV_PCSK_KEX2_1	79	81	PF00082	0.386
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.418
CLV_PCSK_PC7_1	137	143	PF00082	0.571
CLV_PCSK_SKI1_1	17	21	PF00082	0.369
CLV_PCSK_SKI1_1	182	186	PF00082	0.433
CLV_PCSK_SKI1_1	47	51	PF00082	0.406
CLV_PCSK_SKI1_1	89	93	PF00082	0.487
CLV_PCSK_SKI1_1	98	102	PF00082	0.460
DEG_APCC_DBOX_1	16	24	PF00400	0.402
DEG_COP1_1	163	172	PF00400	0.471
DOC_CDC14_PxL_1	20	28	PF14671	0.403
DOC_CKS1_1	117	122	PF01111	0.281
DOC_CYCLIN_RxL_1	83	96	PF00134	0.346
DOC_MAPK_DCC_7	339	349	PF00069	0.466
DOC_MAPK_gen_1	188	197	PF00069	0.504
DOC_MAPK_gen_1	337	346	PF00069	0.372
DOC_PP2B_LxvP_1	353	356	PF13499	0.476
DOC_USP7_MATH_1	288	292	PF00917	0.430
DOC_USP7_MATH_1	443	447	PF00917	0.622
DOC_USP7_UBL2_3	213	217	PF12436	0.338
DOC_WW_Pin1_4	116	121	PF00397	0.517
DOC_WW_Pin1_4	327	332	PF00397	0.391
LIG_14-3-3_CanoR_1	282	286	PF00244	0.458
LIG_14-3-3_CanoR_1	71	77	PF00244	0.376
LIG_14-3-3_CanoR_1	89	94	PF00244	0.488
LIG_APCC_ABBAyCdc20_2	79	85	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BIR_III_4	165	169	PF00653	0.398
LIG_BRCT_BRCA1_1	104	108	PF00533	0.291
LIG_FHA_1	117	123	PF00498	0.496
LIG_FHA_1	378	384	PF00498	0.572
LIG_FHA_1	448	454	PF00498	0.488
LIG_FHA_2	327	333	PF00498	0.437
LIG_FHA_2	90	96	PF00498	0.430
LIG_LIR_Gen_1	105	114	PF02991	0.276
LIG_LIR_Gen_1	151	161	PF02991	0.348
LIG_LIR_Gen_1	226	233	PF02991	0.432
LIG_LIR_Gen_1	368	378	PF02991	0.400
LIG_LIR_Gen_1	54	62	PF02991	0.363
LIG_LIR_Nem_3	105	111	PF02991	0.517
LIG_LIR_Nem_3	14	19	PF02991	0.437
LIG_LIR_Nem_3	151	156	PF02991	0.356
LIG_LIR_Nem_3	2	7	PF02991	0.490
LIG_LIR_Nem_3	226	230	PF02991	0.440
LIG_LIR_Nem_3	315	320	PF02991	0.395
LIG_LIR_Nem_3	368	374	PF02991	0.403
LIG_LIR_Nem_3	54	59	PF02991	0.358
LIG_PCNA_yPIPBox_3	213	223	PF02747	0.539
LIG_Pex14_1	266	270	PF04695	0.341
LIG_SH2_CRK	153	157	PF00017	0.383
LIG_SH2_CRK	227	231	PF00017	0.487
LIG_SH2_NCK_1	227	231	PF00017	0.488
LIG_SH2_NCK_1	328	332	PF00017	0.380
LIG_SH2_NCK_1	72	76	PF00017	0.357
LIG_SH2_STAP1	124	128	PF00017	0.525
LIG_SH2_STAP1	72	76	PF00017	0.373
LIG_SH2_STAT3	322	325	PF00017	0.496
LIG_SH2_STAT5	155	158	PF00017	0.412
LIG_SH2_STAT5	179	182	PF00017	0.412
LIG_SH2_STAT5	279	282	PF00017	0.451
LIG_SH2_STAT5	328	331	PF00017	0.424
LIG_SH2_STAT5	72	75	PF00017	0.382
LIG_SH3_3	114	120	PF00018	0.535
LIG_SH3_3	35	41	PF00018	0.491
LIG_SH3_3	416	422	PF00018	0.515
LIG_SUMO_SIM_par_1	237	242	PF11976	0.472
LIG_TRAF2_1	27	30	PF00917	0.394
LIG_TYR_ITIM	70	75	PF00017	0.346
LIG_UBA3_1	316	321	PF00899	0.438
MOD_CDK_SPK_2	116	121	PF00069	0.517
MOD_CK1_1	297	303	PF00069	0.488
MOD_CK2_1	420	426	PF00069	0.498
MOD_CK2_1	89	95	PF00069	0.496
MOD_GlcNHglycan	104	107	PF01048	0.539
MOD_GlcNHglycan	206	209	PF01048	0.658
MOD_GlcNHglycan	290	293	PF01048	0.442
MOD_GlcNHglycan	298	302	PF01048	0.457
MOD_GlcNHglycan	398	401	PF01048	0.560
MOD_GlcNHglycan	445	448	PF01048	0.736
MOD_GSK3_1	102	109	PF00069	0.401
MOD_GSK3_1	422	429	PF00069	0.524
MOD_GSK3_1	443	450	PF00069	0.700
MOD_GSK3_1	85	92	PF00069	0.412
MOD_NEK2_1	19	24	PF00069	0.397
MOD_NEK2_1	197	202	PF00069	0.590
MOD_NEK2_1	326	331	PF00069	0.389
MOD_NEK2_1	383	388	PF00069	0.448
MOD_NEK2_1	401	406	PF00069	0.321
MOD_NEK2_1	70	75	PF00069	0.347
MOD_NEK2_1	93	98	PF00069	0.454
MOD_PKA_1	204	210	PF00069	0.430
MOD_PKA_2	245	251	PF00069	0.422
MOD_PKA_2	281	287	PF00069	0.432
MOD_PKA_2	288	294	PF00069	0.402
MOD_PKA_2	426	432	PF00069	0.613
MOD_PKA_2	70	76	PF00069	0.369
MOD_Plk_1	225	231	PF00069	0.457
MOD_Plk_1	239	245	PF00069	0.365
MOD_Plk_1	297	303	PF00069	0.420
MOD_Plk_4	113	119	PF00069	0.483
MOD_Plk_4	281	287	PF00069	0.397
MOD_Plk_4	312	318	PF00069	0.473
MOD_Plk_4	383	389	PF00069	0.443
MOD_Plk_4	89	95	PF00069	0.427
MOD_ProDKin_1	116	122	PF00069	0.512
MOD_ProDKin_1	327	333	PF00069	0.395
MOD_SUMO_rev_2	212	219	PF00179	0.450
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.446
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.455
TRG_ENDOCYTIC_2	153	156	PF00928	0.357
TRG_ENDOCYTIC_2	16	19	PF00928	0.527
TRG_ENDOCYTIC_2	227	230	PF00928	0.454
TRG_ENDOCYTIC_2	72	75	PF00928	0.342
TRG_ER_diArg_1	432	435	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE9	Leptomonas seymouri	76%	100%
A0A0S4IPF0	Bodo saltans	43%	100%
A0A1X0P1F2	Trypanosomatidae	57%	100%
A0A3Q8IFT4	Leishmania donovani	85%	100%
A0A422N0P2	Trypanosoma rangeli	57%	100%
A4I5W8	Leishmania infantum	85%	100%
C9ZR91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	83%
E9B162	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q703	Leishmania major	86%	100%
V5BMU7	Trypanosoma cruzi	56%	100%