DYW_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM2_LEIBR

TriTrypDb:

LbrM.30.2860 , LBRM2903_300035300

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.502
CLV_C14_Caspase3-7	493	497	PF00656	0.466
CLV_C14_Caspase3-7	603	607	PF00656	0.508
CLV_NRD_NRD_1	28	30	PF00675	0.439
CLV_NRD_NRD_1	308	310	PF00675	0.402
CLV_NRD_NRD_1	54	56	PF00675	0.681
CLV_PCSK_KEX2_1	28	30	PF00082	0.439
CLV_PCSK_KEX2_1	308	310	PF00082	0.480
CLV_PCSK_KEX2_1	53	55	PF00082	0.690
CLV_PCSK_PC7_1	50	56	PF00082	0.723
CLV_PCSK_SKI1_1	180	184	PF00082	0.476
CLV_PCSK_SKI1_1	28	32	PF00082	0.451
CLV_PCSK_SKI1_1	308	312	PF00082	0.485
CLV_PCSK_SKI1_1	521	525	PF00082	0.380
CLV_PCSK_SKI1_1	652	656	PF00082	0.433
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DEG_SPOP_SBC_1	193	197	PF00917	0.488
DEG_SPOP_SBC_1	69	73	PF00917	0.591
DEG_SPOP_SBC_1	82	86	PF00917	0.570
DOC_CYCLIN_RxL_1	304	313	PF00134	0.532
DOC_PP4_FxxP_1	131	134	PF00568	0.621
DOC_PP4_FxxP_1	320	323	PF00568	0.326
DOC_USP7_MATH_1	139	143	PF00917	0.497
DOC_USP7_MATH_1	156	160	PF00917	0.518
DOC_USP7_MATH_1	182	186	PF00917	0.434
DOC_USP7_MATH_1	3	7	PF00917	0.389
DOC_USP7_MATH_1	386	390	PF00917	0.460
DOC_USP7_MATH_1	431	435	PF00917	0.444
DOC_USP7_MATH_1	48	52	PF00917	0.748
DOC_USP7_MATH_1	566	570	PF00917	0.545
DOC_USP7_MATH_1	639	643	PF00917	0.536
DOC_USP7_MATH_1	661	665	PF00917	0.284
DOC_USP7_MATH_1	93	97	PF00917	0.608
DOC_USP7_UBL2_3	183	187	PF12436	0.320
DOC_WW_Pin1_4	370	375	PF00397	0.393
DOC_WW_Pin1_4	641	646	PF00397	0.464
DOC_WW_Pin1_4	656	661	PF00397	0.454
LIG_14-3-3_CanoR_1	387	393	PF00244	0.514
LIG_14-3-3_CanoR_1	441	449	PF00244	0.497
LIG_14-3-3_CanoR_1	55	63	PF00244	0.658
LIG_14-3-3_CterR_2	668	673	PF00244	0.512
LIG_Actin_WH2_2	13	30	PF00022	0.448
LIG_BRCT_BRCA1_1	162	166	PF00533	0.627
LIG_BRCT_BRCA1_1	630	634	PF00533	0.480
LIG_CaM_IQ_9	343	359	PF13499	0.523
LIG_eIF4E_1	289	295	PF01652	0.374
LIG_EVH1_1	221	225	PF00568	0.371
LIG_FHA_1	127	133	PF00498	0.723
LIG_FHA_1	193	199	PF00498	0.570
LIG_FHA_1	254	260	PF00498	0.408
LIG_FHA_1	331	337	PF00498	0.388
LIG_FHA_1	353	359	PF00498	0.527
LIG_FHA_1	395	401	PF00498	0.511
LIG_FHA_1	470	476	PF00498	0.507
LIG_FHA_1	653	659	PF00498	0.476
LIG_FHA_2	32	38	PF00498	0.505
LIG_FHA_2	401	407	PF00498	0.498
LIG_FHA_2	474	480	PF00498	0.452
LIG_FHA_2	491	497	PF00498	0.379
LIG_FHA_2	601	607	PF00498	0.451
LIG_FHA_2	642	648	PF00498	0.395
LIG_LIR_Apic_2	129	134	PF02991	0.613
LIG_LIR_Gen_1	364	374	PF02991	0.436
LIG_LIR_Gen_1	434	443	PF02991	0.376
LIG_LIR_Nem_3	364	369	PF02991	0.416
LIG_LIR_Nem_3	434	439	PF02991	0.367
LIG_LIR_Nem_3	442	446	PF02991	0.377
LIG_NRBOX	229	235	PF00104	0.433
LIG_NRBOX	6	12	PF00104	0.446
LIG_Rb_LxCxE_1	278	290	PF01857	0.502
LIG_REV1ctd_RIR_1	363	372	PF16727	0.370
LIG_SH2_CRK	436	440	PF00017	0.334
LIG_SH2_STAP1	418	422	PF00017	0.407
LIG_SH2_STAP1	613	617	PF00017	0.409
LIG_SH2_STAT3	220	223	PF00017	0.432
LIG_SH2_STAT3	350	353	PF00017	0.541
LIG_SH2_STAT5	220	223	PF00017	0.512
LIG_SH2_STAT5	297	300	PF00017	0.473
LIG_SH3_3	219	225	PF00018	0.428
LIG_SH3_3	290	296	PF00018	0.366
LIG_SH3_3	571	577	PF00018	0.449
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.446
LIG_SxIP_EBH_1	165	177	PF03271	0.500
LIG_TRAF2_1	34	37	PF00917	0.572
LIG_WRC_WIRS_1	440	445	PF05994	0.347
LIG_WRC_WIRS_1	63	68	PF05994	0.499
MOD_CDK_SPxxK_3	641	648	PF00069	0.461
MOD_CK1_1	159	165	PF00069	0.644
MOD_CK1_1	457	463	PF00069	0.475
MOD_CK1_1	503	509	PF00069	0.490
MOD_CK1_1	59	65	PF00069	0.721
MOD_CK1_1	6	12	PF00069	0.515
MOD_CK1_1	75	81	PF00069	0.718
MOD_CK1_1	83	89	PF00069	0.709
MOD_CK2_1	31	37	PF00069	0.521
MOD_CK2_1	473	479	PF00069	0.460
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.565
MOD_GlcNHglycan	141	144	PF01048	0.621
MOD_GlcNHglycan	300	303	PF01048	0.409
MOD_GlcNHglycan	312	315	PF01048	0.385
MOD_GlcNHglycan	443	446	PF01048	0.470
MOD_GlcNHglycan	479	483	PF01048	0.388
MOD_GlcNHglycan	496	499	PF01048	0.431
MOD_GlcNHglycan	95	98	PF01048	0.680
MOD_GSK3_1	156	163	PF00069	0.773
MOD_GSK3_1	188	195	PF00069	0.532
MOD_GSK3_1	2	9	PF00069	0.381
MOD_GSK3_1	201	208	PF00069	0.489
MOD_GSK3_1	39	46	PF00069	0.651
MOD_GSK3_1	431	438	PF00069	0.428
MOD_GSK3_1	469	476	PF00069	0.423
MOD_GSK3_1	486	493	PF00069	0.493
MOD_GSK3_1	500	507	PF00069	0.572
MOD_GSK3_1	535	542	PF00069	0.328
MOD_GSK3_1	562	569	PF00069	0.552
MOD_GSK3_1	652	659	PF00069	0.468
MOD_GSK3_1	68	75	PF00069	0.716
MOD_GSK3_1	76	83	PF00069	0.684
MOD_GSK3_1	87	94	PF00069	0.533
MOD_N-GLC_1	102	107	PF02516	0.664
MOD_N-GLC_1	253	258	PF02516	0.334
MOD_N-GLC_2	21	23	PF02516	0.405
MOD_NEK2_1	11	16	PF00069	0.569
MOD_NEK2_1	181	186	PF00069	0.465
MOD_NEK2_1	192	197	PF00069	0.536
MOD_NEK2_1	201	206	PF00069	0.484
MOD_NEK2_1	229	234	PF00069	0.383
MOD_NEK2_1	253	258	PF00069	0.450
MOD_NEK2_1	298	303	PF00069	0.432
MOD_NEK2_1	31	36	PF00069	0.538
MOD_NEK2_1	310	315	PF00069	0.343
MOD_NEK2_1	426	431	PF00069	0.464
MOD_NEK2_1	439	444	PF00069	0.294
MOD_NEK2_1	494	499	PF00069	0.457
MOD_NEK2_1	501	506	PF00069	0.492
MOD_NEK2_1	600	605	PF00069	0.487
MOD_NEK2_1	77	82	PF00069	0.787
MOD_NEK2_2	182	187	PF00069	0.425
MOD_NEK2_2	48	53	PF00069	0.642
MOD_PIKK_1	349	355	PF00454	0.514
MOD_PIKK_1	400	406	PF00454	0.455
MOD_PIKK_1	501	507	PF00454	0.349
MOD_PIKK_1	566	572	PF00454	0.550
MOD_PKA_2	386	392	PF00069	0.514
MOD_PKA_2	39	45	PF00069	0.624
MOD_PKA_2	639	645	PF00069	0.483
MOD_Plk_1	102	108	PF00069	0.437
MOD_Plk_1	188	194	PF00069	0.388
MOD_Plk_1	394	400	PF00069	0.412
MOD_Plk_1	463	469	PF00069	0.511
MOD_Plk_1	628	634	PF00069	0.492
MOD_Plk_2-3	473	479	PF00069	0.481
MOD_Plk_4	188	194	PF00069	0.386
MOD_Plk_4	224	230	PF00069	0.387
MOD_Plk_4	265	271	PF00069	0.377
MOD_Plk_4	435	441	PF00069	0.389
MOD_Plk_4	454	460	PF00069	0.286
MOD_Plk_4	490	496	PF00069	0.427
MOD_Plk_4	6	12	PF00069	0.578
MOD_ProDKin_1	370	376	PF00069	0.391
MOD_ProDKin_1	641	647	PF00069	0.458
MOD_ProDKin_1	656	662	PF00069	0.445
MOD_SUMO_rev_2	389	393	PF00179	0.538
TRG_DiLeu_BaEn_1	354	359	PF01217	0.575
TRG_ENDOCYTIC_2	436	439	PF00928	0.353
TRG_ER_diArg_1	27	29	PF00400	0.428
TRG_ER_diArg_1	308	310	PF00400	0.316
TRG_ER_diArg_1	52	55	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I481	Leptomonas seymouri	68%	98%
A0A0S4IPG5	Bodo saltans	36%	100%
A0A1X0P1H7	Trypanosomatidae	47%	100%
A0A3Q8IG13	Leishmania donovani	85%	100%
A0A3R7JPV2	Trypanosoma rangeli	48%	100%
A4I5W7	Leishmania infantum	85%	100%
C9ZR90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B161	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q704	Leishmania major	85%	100%
V5B7A2	Trypanosoma cruzi	48%	100%