BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM1_LEIBR

TriTrypDb:

LbrM.30.2850 , LBRM2903_300035200

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.340
CLV_C14_Caspase3-7	360	364	PF00656	0.576
CLV_NRD_NRD_1	259	261	PF00675	0.656
CLV_NRD_NRD_1	319	321	PF00675	0.587
CLV_PCSK_KEX2_1	399	401	PF00082	0.720
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.720
CLV_PCSK_SKI1_1	381	385	PF00082	0.533
CLV_Separin_Metazoa	25	29	PF03568	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DEG_SCF_FBW7_1	127	134	PF00400	0.554
DEG_SCF_FBW7_1	62	68	PF00400	0.466
DEG_SPOP_SBC_1	401	405	PF00917	0.698
DOC_CKS1_1	62	67	PF01111	0.537
DOC_PP1_RVXF_1	287	293	PF00149	0.331
DOC_PP2B_LxvP_1	114	117	PF13499	0.624
DOC_PP2B_LxvP_1	57	60	PF13499	0.542
DOC_PP4_MxPP_1	63	66	PF00568	0.556
DOC_USP7_MATH_1	131	135	PF00917	0.547
DOC_USP7_MATH_1	136	140	PF00917	0.454
DOC_USP7_MATH_1	35	39	PF00917	0.497
DOC_USP7_MATH_1	354	358	PF00917	0.610
DOC_USP7_MATH_1	455	459	PF00917	0.771
DOC_USP7_MATH_1	49	53	PF00917	0.528
DOC_WW_Pin1_4	123	128	PF00397	0.764
DOC_WW_Pin1_4	152	157	PF00397	0.546
DOC_WW_Pin1_4	230	235	PF00397	0.503
DOC_WW_Pin1_4	394	399	PF00397	0.780
DOC_WW_Pin1_4	405	410	PF00397	0.717
DOC_WW_Pin1_4	415	420	PF00397	0.734
DOC_WW_Pin1_4	434	439	PF00397	0.669
DOC_WW_Pin1_4	61	66	PF00397	0.442
DOC_WW_Pin1_4	90	95	PF00397	0.491
LIG_14-3-3_CanoR_1	180	189	PF00244	0.453
LIG_Actin_WH2_2	207	224	PF00022	0.446
LIG_CaM_NSCaTE_8	76	83	PF13499	0.419
LIG_CtBP_PxDLS_1	450	454	PF00389	0.783
LIG_deltaCOP1_diTrp_1	184	193	PF00928	0.401
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.483
LIG_FHA_1	28	34	PF00498	0.581
LIG_FHA_1	434	440	PF00498	0.658
LIG_FHA_1	87	93	PF00498	0.464
LIG_FHA_2	128	134	PF00498	0.622
LIG_FHA_2	180	186	PF00498	0.543
LIG_FHA_2	2	8	PF00498	0.606
LIG_FHA_2	358	364	PF00498	0.588
LIG_LIR_Apic_2	175	179	PF02991	0.546
LIG_LIR_Gen_1	185	195	PF02991	0.413
LIG_LIR_Gen_1	273	283	PF02991	0.440
LIG_LIR_Gen_1	334	345	PF02991	0.513
LIG_LIR_Gen_1	368	374	PF02991	0.426
LIG_LIR_Nem_3	166	171	PF02991	0.543
LIG_LIR_Nem_3	185	191	PF02991	0.231
LIG_LIR_Nem_3	273	279	PF02991	0.409
LIG_LIR_Nem_3	334	340	PF02991	0.497
LIG_LIR_Nem_3	368	373	PF02991	0.425
LIG_LIR_Nem_3	385	390	PF02991	0.504
LIG_NRBOX	313	319	PF00104	0.445
LIG_PCNA_yPIPBox_3	375	384	PF02747	0.380
LIG_SH2_CRK	29	33	PF00017	0.458
LIG_SH2_CRK	337	341	PF00017	0.519
LIG_SH2_NCK_1	154	158	PF00017	0.586
LIG_SH2_NCK_1	283	287	PF00017	0.542
LIG_SH2_PTP2	176	179	PF00017	0.546
LIG_SH2_STAT5	154	157	PF00017	0.546
LIG_SH2_STAT5	163	166	PF00017	0.521
LIG_SH2_STAT5	176	179	PF00017	0.434
LIG_SH2_STAT5	29	32	PF00017	0.453
LIG_SH3_2	118	123	PF14604	0.764
LIG_SH3_2	395	400	PF14604	0.769
LIG_SH3_3	115	121	PF00018	0.647
LIG_SH3_3	389	395	PF00018	0.574
LIG_SUMO_SIM_par_1	54	61	PF11976	0.632
LIG_TRAF2_1	285	288	PF00917	0.338
LIG_TRAF2_1	421	424	PF00917	0.552
LIG_TRAF2_1	72	75	PF00917	0.464
LIG_TYR_ITIM	27	32	PF00017	0.615
LIG_UBA3_1	313	321	PF00899	0.450
LIG_UBA3_1	369	375	PF00899	0.462
LIG_WRC_WIRS_1	2	7	PF05994	0.571
MOD_CDC14_SPxK_1	397	400	PF00782	0.555
MOD_CDK_SPK_2	394	399	PF00069	0.776
MOD_CDK_SPxK_1	394	400	PF00069	0.771
MOD_CDK_SPxxK_3	434	441	PF00069	0.548
MOD_CK1_1	3	9	PF00069	0.556
MOD_CK1_1	357	363	PF00069	0.565
MOD_CK1_1	38	44	PF00069	0.702
MOD_CK1_1	403	409	PF00069	0.761
MOD_CK1_1	434	440	PF00069	0.684
MOD_CK2_1	129	135	PF00069	0.641
MOD_CK2_1	179	185	PF00069	0.496
MOD_CK2_1	390	396	PF00069	0.665
MOD_CK2_1	42	48	PF00069	0.567
MOD_CK2_1	422	428	PF00069	0.662
MOD_CK2_1	69	75	PF00069	0.459
MOD_Cter_Amidation	121	124	PF01082	0.545
MOD_GlcNHglycan	10	13	PF01048	0.608
MOD_GlcNHglycan	138	141	PF01048	0.708
MOD_GlcNHglycan	240	243	PF01048	0.788
MOD_GlcNHglycan	307	310	PF01048	0.493
MOD_GlcNHglycan	365	368	PF01048	0.559
MOD_GlcNHglycan	392	395	PF01048	0.643
MOD_GlcNHglycan	405	408	PF01048	0.700
MOD_GlcNHglycan	445	448	PF01048	0.718
MOD_GlcNHglycan	457	460	PF01048	0.740
MOD_GSK3_1	123	130	PF00069	0.771
MOD_GSK3_1	327	334	PF00069	0.426
MOD_GSK3_1	357	364	PF00069	0.591
MOD_GSK3_1	38	45	PF00069	0.570
MOD_GSK3_1	390	397	PF00069	0.624
MOD_GSK3_1	401	408	PF00069	0.672
MOD_GSK3_1	411	418	PF00069	0.728
MOD_GSK3_1	424	431	PF00069	0.726
MOD_GSK3_1	433	440	PF00069	0.669
MOD_GSK3_1	61	68	PF00069	0.532
MOD_GSK3_1	8	15	PF00069	0.495
MOD_GSK3_1	86	93	PF00069	0.469
MOD_LATS_1	268	274	PF00433	0.477
MOD_N-GLC_1	43	48	PF02516	0.662
MOD_N-GLC_2	88	90	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	107	112	PF00069	0.482
MOD_NEK2_1	147	152	PF00069	0.414
MOD_NEK2_1	210	215	PF00069	0.531
MOD_NEK2_1	313	318	PF00069	0.450
MOD_NEK2_1	327	332	PF00069	0.296
MOD_NEK2_1	361	366	PF00069	0.538
MOD_OFUCOSY	444	449	PF10250	0.535
MOD_PK_1	55	61	PF00069	0.621
MOD_PKA_2	179	185	PF00069	0.486
MOD_PKA_2	27	33	PF00069	0.650
MOD_PKA_2	298	304	PF00069	0.508
MOD_Plk_1	472	478	PF00069	0.668
MOD_Plk_2-3	428	434	PF00069	0.551
MOD_Plk_2-3	472	478	PF00069	0.598
MOD_Plk_4	313	319	PF00069	0.525
MOD_Plk_4	327	333	PF00069	0.368
MOD_Plk_4	357	363	PF00069	0.454
MOD_Plk_4	365	371	PF00069	0.406
MOD_ProDKin_1	123	129	PF00069	0.764
MOD_ProDKin_1	152	158	PF00069	0.549
MOD_ProDKin_1	230	236	PF00069	0.507
MOD_ProDKin_1	394	400	PF00069	0.785
MOD_ProDKin_1	405	411	PF00069	0.714
MOD_ProDKin_1	415	421	PF00069	0.729
MOD_ProDKin_1	434	440	PF00069	0.668
MOD_ProDKin_1	61	67	PF00069	0.453
MOD_ProDKin_1	90	96	PF00069	0.494
MOD_SUMO_rev_2	100	110	PF00179	0.556
MOD_SUMO_rev_2	378	383	PF00179	0.433
MOD_SUMO_rev_2	472	481	PF00179	0.747
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.468
TRG_ENDOCYTIC_2	283	286	PF00928	0.565
TRG_ENDOCYTIC_2	29	32	PF00928	0.511
TRG_ENDOCYTIC_2	337	340	PF00928	0.499
TRG_ER_diArg_1	278	281	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q4	Leptomonas seymouri	45%	100%
A0A1X0P2L0	Trypanosomatidae	27%	100%
A0A3Q8IC68	Leishmania donovani	69%	100%
A0A422N306	Trypanosoma rangeli	27%	100%
A4I5W6	Leishmania infantum	69%	100%
C9ZR88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q705	Leishmania major	70%	99%
V5DNX2	Trypanosoma cruzi	26%	100%