Protein ORF2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein ORF2

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIM0_LEIBR

TriTrypDb:

LbrM.30.2840 , LBRM2903_300035100

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.458
CLV_C14_Caspase3-7	56	60	PF00656	0.658
CLV_NRD_NRD_1	144	146	PF00675	0.401
CLV_NRD_NRD_1	276	278	PF00675	0.610
CLV_PCSK_KEX2_1	143	145	PF00082	0.415
CLV_PCSK_KEX2_1	182	184	PF00082	0.476
CLV_PCSK_KEX2_1	276	278	PF00082	0.610
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.476
CLV_PCSK_SKI1_1	132	136	PF00082	0.400
CLV_PCSK_SKI1_1	6	10	PF00082	0.556
CLV_Separin_Metazoa	81	85	PF03568	0.519
DEG_APCC_DBOX_1	5	13	PF00400	0.563
DEG_ODPH_VHL_1	241	253	PF01847	0.475
DOC_CKS1_1	224	229	PF01111	0.424
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.543
DOC_MAPK_HePTP_8	205	217	PF00069	0.564
DOC_MAPK_MEF2A_6	208	217	PF00069	0.431
DOC_PP2B_LxvP_1	41	44	PF13499	0.416
DOC_PP2B_LxvP_1	89	92	PF13499	0.501
DOC_PP2B_LxvP_1	93	96	PF13499	0.561
DOC_WW_Pin1_4	123	128	PF00397	0.687
DOC_WW_Pin1_4	223	228	PF00397	0.486
DOC_WW_Pin1_4	264	269	PF00397	0.514
DOC_WW_Pin1_4	97	102	PF00397	0.609
LIG_14-3-3_CanoR_1	144	150	PF00244	0.426
LIG_14-3-3_CanoR_1	220	225	PF00244	0.551
LIG_14-3-3_CanoR_1	6	16	PF00244	0.340
LIG_Actin_WH2_2	184	202	PF00022	0.366
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_BIR_III_4	59	63	PF00653	0.405
LIG_CSL_BTD_1	230	233	PF09270	0.534
LIG_CtBP_PxDLS_1	101	105	PF00389	0.386
LIG_FHA_1	112	118	PF00498	0.459
LIG_FHA_1	186	192	PF00498	0.513
LIG_FHA_1	201	207	PF00498	0.509
LIG_FHA_1	224	230	PF00498	0.616
LIG_FHA_1	292	298	PF00498	0.487
LIG_FHA_1	344	350	PF00498	0.412
LIG_FHA_1	40	46	PF00498	0.563
LIG_FHA_1	66	72	PF00498	0.568
LIG_FHA_2	268	274	PF00498	0.579
LIG_FHA_2	310	316	PF00498	0.497
LIG_FHA_2	319	325	PF00498	0.391
LIG_LIR_Apic_2	257	263	PF02991	0.535
LIG_LIR_Gen_1	181	191	PF02991	0.546
LIG_LIR_Gen_1	321	330	PF02991	0.550
LIG_LIR_Gen_1	50	55	PF02991	0.367
LIG_LIR_Nem_3	136	141	PF02991	0.442
LIG_LIR_Nem_3	181	187	PF02991	0.522
LIG_LIR_Nem_3	321	326	PF02991	0.561
LIG_LIR_Nem_3	50	54	PF02991	0.545
LIG_MYND_1	91	95	PF01753	0.552
LIG_PCNA_yPIPBox_3	6	20	PF02747	0.331
LIG_SH2_CRK	260	264	PF00017	0.533
LIG_SH2_CRK	278	282	PF00017	0.462
LIG_SH2_GRB2like	278	281	PF00017	0.472
LIG_SH2_NCK_1	330	334	PF00017	0.438
LIG_SH2_NCK_1	51	55	PF00017	0.607
LIG_SH2_SRC	184	187	PF00017	0.525
LIG_SH2_SRC	330	333	PF00017	0.485
LIG_SH2_SRC	51	54	PF00017	0.376
LIG_SH2_STAP1	330	334	PF00017	0.509
LIG_SH2_STAP1	51	55	PF00017	0.385
LIG_SH2_STAT5	184	187	PF00017	0.446
LIG_SH3_3	246	252	PF00018	0.563
LIG_SH3_3	262	268	PF00018	0.491
LIG_SH3_3	299	305	PF00018	0.461
LIG_SH3_3	89	95	PF00018	0.625
LIG_SUMO_SIM_par_1	254	259	PF11976	0.661
LIG_TRAF2_1	333	336	PF00917	0.521
LIG_TRAF2_1	78	81	PF00917	0.473
MOD_CDK_SPK_2	127	132	PF00069	0.588
MOD_CK1_1	11	17	PF00069	0.307
MOD_CK1_1	121	127	PF00069	0.740
MOD_CK1_1	2	8	PF00069	0.469
MOD_CK1_1	223	229	PF00069	0.550
MOD_CK1_1	267	273	PF00069	0.584
MOD_CK2_1	267	273	PF00069	0.659
MOD_CK2_1	318	324	PF00069	0.587
MOD_CK2_1	75	81	PF00069	0.370
MOD_GlcNHglycan	149	152	PF01048	0.375
MOD_GlcNHglycan	164	167	PF01048	0.425
MOD_GlcNHglycan	233	236	PF01048	0.525
MOD_GlcNHglycan	68	71	PF01048	0.443
MOD_GSK3_1	118	125	PF00069	0.616
MOD_GSK3_1	185	192	PF00069	0.493
MOD_GSK3_1	200	207	PF00069	0.591
MOD_GSK3_1	219	226	PF00069	0.480
MOD_GSK3_1	287	294	PF00069	0.469
MOD_GSK3_1	311	318	PF00069	0.601
MOD_GSK3_1	39	46	PF00069	0.400
MOD_GSK3_1	4	11	PF00069	0.453
MOD_LATS_1	198	204	PF00433	0.404
MOD_N-GLC_1	121	126	PF02516	0.609
MOD_NEK2_1	147	152	PF00069	0.442
MOD_NEK2_1	8	13	PF00069	0.326
MOD_PKA_2	219	225	PF00069	0.547
MOD_PKA_2	341	347	PF00069	0.332
MOD_PKB_1	143	151	PF00069	0.429
MOD_Plk_1	287	293	PF00069	0.434
MOD_Plk_1	39	45	PF00069	0.435
MOD_Plk_2-3	53	59	PF00069	0.492
MOD_Plk_4	287	293	PF00069	0.418
MOD_Plk_4	318	324	PF00069	0.491
MOD_Plk_4	43	49	PF00069	0.343
MOD_ProDKin_1	123	129	PF00069	0.688
MOD_ProDKin_1	223	229	PF00069	0.485
MOD_ProDKin_1	264	270	PF00069	0.515
MOD_ProDKin_1	97	103	PF00069	0.597
TRG_AP2beta_CARGO_1	136	145	PF09066	0.454
TRG_DiLeu_BaEn_1	335	340	PF01217	0.483
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.383
TRG_ENDOCYTIC_2	184	187	PF00928	0.473
TRG_ENDOCYTIC_2	278	281	PF00928	0.581
TRG_ENDOCYTIC_2	323	326	PF00928	0.418
TRG_ENDOCYTIC_2	51	54	PF00928	0.586
TRG_ER_diArg_1	143	145	PF00400	0.432
TRG_ER_diArg_1	275	277	PF00400	0.611
TRG_ER_diArg_1	83	86	PF00400	0.498
TRG_ER_diArg_1	88	91	PF00400	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X8	Leptomonas seymouri	58%	93%
A0A0S4ITH9	Bodo saltans	29%	84%
A0A1X0P300	Trypanosomatidae	42%	100%
A0A3S5IQF3	Trypanosoma rangeli	40%	100%
A0A3S7X3T3	Leishmania donovani	80%	100%
A4I5W5	Leishmania infantum	80%	100%
C9ZR87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	81%
Q4Q706	Leishmania major	79%	100%
V5BSH3	Trypanosoma cruzi	40%	100%