LeishMANIAdb
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TIR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TIR domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HIL9_LEIBR
TriTrypDb:
LbrM.30.2830 , LBRM2903_300034800 *
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 14
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 30
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4HIL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 109 113 PF00082 0.441
CLV_PCSK_SKI1_1 50 54 PF00082 0.468
DOC_MAPK_MEF2A_6 74 81 PF00069 0.409
DOC_PP1_RVXF_1 107 113 PF00149 0.420
DOC_PP4_FxxP_1 10 13 PF00568 0.397
DOC_USP7_MATH_1 94 98 PF00917 0.553
DOC_USP7_UBL2_3 46 50 PF12436 0.489
LIG_14-3-3_CanoR_1 93 99 PF00244 0.564
LIG_Actin_WH2_2 78 95 PF00022 0.454
LIG_BRCT_BRCA1_1 6 10 PF00533 0.373
LIG_BRCT_BRCA1_1 74 78 PF00533 0.413
LIG_FHA_1 105 111 PF00498 0.412
LIG_FHA_1 12 18 PF00498 0.426
LIG_FHA_2 19 25 PF00498 0.539
LIG_FHA_2 99 105 PF00498 0.384
LIG_LIR_Apic_2 7 13 PF02991 0.392
LIG_LIR_Gen_1 75 85 PF02991 0.410
LIG_LIR_Nem_3 75 81 PF02991 0.409
LIG_PDZ_Class_2 110 115 PF00595 0.358
LIG_REV1ctd_RIR_1 109 115 PF16727 0.444
LIG_SUMO_SIM_anti_2 14 21 PF11976 0.483
LIG_SUMO_SIM_par_1 78 84 PF11976 0.464
MOD_CK2_1 18 24 PF00069 0.551
MOD_GSK3_1 13 20 PF00069 0.409
MOD_GSK3_1 94 101 PF00069 0.490
MOD_N-GLC_1 102 107 PF02516 0.602
MOD_N-GLC_2 3 5 PF02516 0.420
MOD_NEK2_1 17 22 PF00069 0.427
MOD_NEK2_1 36 41 PF00069 0.478
MOD_NEK2_1 4 9 PF00069 0.362
MOD_NEK2_1 72 77 PF00069 0.431
MOD_NEK2_1 92 97 PF00069 0.515
MOD_PIKK_1 29 35 PF00454 0.541
MOD_PKA_2 92 98 PF00069 0.542
MOD_Plk_1 23 29 PF00069 0.466
MOD_Plk_4 73 79 PF00069 0.475
TRG_ER_diArg_1 90 93 PF00400 0.564

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2D0 Leptomonas seymouri 34% 77%
A0A0N0P3C7 Leptomonas seymouri 36% 91%
A0A0N1HW96 Leptomonas seymouri 86% 100%
A0A0N1IHI7 Leptomonas seymouri 39% 97%
A0A0S4IPF2 Bodo saltans 54% 100%
A0A0S4IRP9 Bodo saltans 37% 97%
A0A0S4JBB4 Bodo saltans 35% 97%
A0A0S4JFI1 Bodo saltans 46% 100%
A0A1X0NKC2 Trypanosomatidae 38% 97%
A0A1X0P0Q8 Trypanosomatidae 37% 91%
A0A1X0P259 Trypanosomatidae 64% 99%
A0A1X0P760 Trypanosomatidae 36% 100%
A0A3Q8IB96 Leishmania donovani 39% 97%
A0A3R7K0R9 Trypanosoma rangeli 62% 99%
A0A3S5H506 Leishmania donovani 29% 71%
A0A3S7X3W3 Leishmania donovani 89% 100%
A0A3S7X6I1 Leishmania donovani 36% 68%
A0A422N867 Trypanosoma rangeli 34% 92%
A0A422NFX4 Trypanosoma rangeli 39% 96%
A0A422NPM1 Trypanosoma rangeli 37% 100%
A4H3E5 Leishmania braziliensis 32% 98%
A4H9R6 Leishmania braziliensis 38% 100%
A4HLA1 Leishmania braziliensis 34% 91%
A4HRQ0 Leishmania infantum 29% 71%
A4HY35 Leishmania infantum 39% 97%
A4I5W4 Leishmania infantum 89% 100%
A4I8S7 Leishmania infantum 36% 91%
C9ZJ38 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 92%
C9ZR85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A4S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 91%
E9ACC9 Leishmania major 29% 99%
E9AJL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 71%
E9ARU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 97%
E9B159 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9B3P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 92%
Q4Q707 Leishmania major 85% 100%
Q4QDM4 Leishmania major 38% 100%
V5BMX8 Trypanosoma cruzi 68% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS