UCR_hinge domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase subunit 3

Species:

Leishmania braziliensis

UniProt:

A4HIL8_LEIBR

TriTrypDb:

LbrM.30.2820 , LBRM2903_300034700

Length:

104

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	4	1
GO:0016020	membrane	2	8
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045257	succinate dehydrogenase complex (ubiquinone)	5	1

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Expansion

Sequence features

A4HIL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.418
CLV_NRD_NRD_1	65	67	PF00675	0.607
CLV_PCSK_KEX2_1	6	8	PF00082	0.364
CLV_PCSK_KEX2_1	65	67	PF00082	0.607
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.374
CLV_PCSK_SKI1_1	75	79	PF00082	0.569
DOC_MAPK_gen_1	6	14	PF00069	0.630
DOC_MAPK_gen_1	62	71	PF00069	0.405
DOC_PP2B_LxvP_1	12	15	PF13499	0.664
DOC_PP4_FxxP_1	27	30	PF00568	0.482

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD88	Leptomonas seymouri	83%	100%
A0A0S4ITZ5	Bodo saltans	62%	100%
A0A1X0P1F7	Trypanosomatidae	73%	98%
A0A3S7X3P6	Leishmania donovani	92%	100%
A0A422N2Z8	Trypanosoma rangeli	65%	94%
A4I5W3	Leishmania infantum	92%	100%
C9ZR84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B158	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q708	Leishmania major	91%	100%
V5BSK5	Trypanosoma cruzi	67%	98%

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