GTPase activator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activator-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIL7_LEIBR

TriTrypDb:

LbrM.30.2810 , LBRM2903_300034600

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0098772	molecular function regulator activity	1	5
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.455
CLV_NRD_NRD_1	90	92	PF00675	0.276
CLV_PCSK_KEX2_1	301	303	PF00082	0.455
CLV_PCSK_KEX2_1	90	92	PF00082	0.302
CLV_PCSK_SKI1_1	272	276	PF00082	0.416
CLV_PCSK_SKI1_1	90	94	PF00082	0.265
DEG_APCC_DBOX_1	271	279	PF00400	0.441
DOC_CYCLIN_yClb1_LxF_4	171	177	PF00134	0.398
DOC_MAPK_MEF2A_6	198	205	PF00069	0.173
DOC_MAPK_MEF2A_6	243	251	PF00069	0.356
DOC_MAPK_MEF2A_6	53	60	PF00069	0.376
DOC_MAPK_NFAT4_5	198	206	PF00069	0.173
DOC_PP4_FxxP_1	176	179	PF00568	0.295
DOC_USP7_UBL2_3	276	280	PF12436	0.434
DOC_WW_Pin1_4	290	295	PF00397	0.422
DOC_WW_Pin1_4	80	85	PF00397	0.315
LIG_14-3-3_CanoR_1	91	99	PF00244	0.210
LIG_Actin_WH2_2	285	303	PF00022	0.250
LIG_BIR_III_2	254	258	PF00653	0.202
LIG_BRCT_BRCA1_1	133	137	PF00533	0.232
LIG_BRCT_BRCA1_1	56	60	PF00533	0.320
LIG_FHA_1	127	133	PF00498	0.338
LIG_FHA_1	164	170	PF00498	0.415
LIG_FHA_1	94	100	PF00498	0.435
LIG_LIR_Gen_1	180	190	PF02991	0.308
LIG_LIR_Gen_1	268	278	PF02991	0.279
LIG_LIR_Gen_1	282	289	PF02991	0.460
LIG_LIR_Gen_1	311	320	PF02991	0.425
LIG_LIR_Gen_1	44	52	PF02991	0.342
LIG_LIR_Gen_1	8	19	PF02991	0.431
LIG_LIR_Nem_3	111	115	PF02991	0.424
LIG_LIR_Nem_3	134	140	PF02991	0.243
LIG_LIR_Nem_3	180	185	PF02991	0.288
LIG_LIR_Nem_3	21	25	PF02991	0.325
LIG_LIR_Nem_3	268	273	PF02991	0.286
LIG_LIR_Nem_3	282	286	PF02991	0.456
LIG_LIR_Nem_3	44	49	PF02991	0.328
LIG_LIR_Nem_3	8	14	PF02991	0.471
LIG_PDZ_Class_1	319	324	PF00595	0.571
LIG_Pex14_1	277	281	PF04695	0.333
LIG_Pex14_2	151	155	PF04695	0.367
LIG_Pex14_2	204	208	PF04695	0.280
LIG_Pex14_2	219	223	PF04695	0.295
LIG_PTB_Apo_2	226	233	PF02174	0.261
LIG_SH2_PTP2	22	25	PF00017	0.206
LIG_SH2_SRC	72	75	PF00017	0.154
LIG_SH2_STAP1	195	199	PF00017	0.253
LIG_SH2_STAT5	105	108	PF00017	0.244
LIG_SH2_STAT5	112	115	PF00017	0.244
LIG_SH2_STAT5	146	149	PF00017	0.305
LIG_SH2_STAT5	22	25	PF00017	0.284
LIG_SH3_3	46	52	PF00018	0.326
LIG_UBA3_1	269	276	PF00899	0.432
LIG_WRC_WIRS_1	220	225	PF05994	0.276
MOD_CK1_1	126	132	PF00069	0.371
MOD_CK1_1	293	299	PF00069	0.415
MOD_CK1_1	41	47	PF00069	0.378
MOD_CK1_1	5	11	PF00069	0.266
MOD_CK1_1	68	74	PF00069	0.154
MOD_CK2_1	177	183	PF00069	0.370
MOD_CK2_1	33	39	PF00069	0.471
MOD_GlcNHglycan	133	136	PF01048	0.267
MOD_GSK3_1	315	322	PF00069	0.448
MOD_GSK3_1	33	40	PF00069	0.552
MOD_GSK3_1	68	75	PF00069	0.324
MOD_N-GLC_1	126	131	PF02516	0.353
MOD_N-GLC_1	65	70	PF02516	0.154
MOD_N-GLC_1	99	104	PF02516	0.375
MOD_NEK2_1	163	168	PF00069	0.433
MOD_NEK2_1	219	224	PF00069	0.295
MOD_NEK2_1	3	8	PF00069	0.367
MOD_NEK2_1	300	305	PF00069	0.540
MOD_NEK2_1	315	320	PF00069	0.333
MOD_NEK2_1	33	38	PF00069	0.419
MOD_NEK2_1	93	98	PF00069	0.376
MOD_PIKK_1	82	88	PF00454	0.320
MOD_PKA_2	242	248	PF00069	0.364
MOD_PKA_2	300	306	PF00069	0.369
MOD_Plk_1	41	47	PF00069	0.232
MOD_Plk_1	68	74	PF00069	0.362
MOD_Plk_1	99	105	PF00069	0.375
MOD_Plk_4	133	139	PF00069	0.334
MOD_Plk_4	177	183	PF00069	0.369
MOD_Plk_4	242	248	PF00069	0.375
MOD_Plk_4	315	321	PF00069	0.491
MOD_ProDKin_1	290	296	PF00069	0.421
MOD_ProDKin_1	80	86	PF00069	0.315
TRG_DiLeu_BaEn_2	41	47	PF01217	0.154
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.441
TRG_ENDOCYTIC_2	22	25	PF00928	0.306
TRG_ER_diArg_1	300	302	PF00400	0.437
TRG_ER_diArg_1	89	91	PF00400	0.276
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N7	Leptomonas seymouri	62%	100%
A0A0S4ITU5	Bodo saltans	40%	79%
A0A1X0NLM2	Trypanosomatidae	26%	92%
A0A1X0P1K5	Trypanosomatidae	47%	81%
A0A3S7X3S6	Leishmania donovani	83%	100%
A0A422NJ84	Trypanosoma rangeli	28%	77%
A0A422NJE8	Trypanosoma rangeli	26%	93%
A4HQC7	Leishmania braziliensis	25%	76%
A4I5W2	Leishmania infantum	82%	100%
C9ZR83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	82%
E9B157	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q0F2	Leishmania major	23%	78%
Q4Q709	Leishmania major	81%	100%
Q6PBU5	Danio rerio	24%	91%
V5B7A5	Trypanosoma cruzi	50%	100%
V5BT66	Trypanosoma cruzi	29%	79%