TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIL6_LEIBR

TriTrypDb:

LbrM.30.2800 , LBRM2903_300034500

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.446
CLV_C14_Caspase3-7	92	96	PF00656	0.619
CLV_NRD_NRD_1	14	16	PF00675	0.749
CLV_NRD_NRD_1	174	176	PF00675	0.407
CLV_NRD_NRD_1	203	205	PF00675	0.398
CLV_NRD_NRD_1	236	238	PF00675	0.601
CLV_NRD_NRD_1	268	270	PF00675	0.468
CLV_NRD_NRD_1	278	280	PF00675	0.470
CLV_NRD_NRD_1	323	325	PF00675	0.436
CLV_NRD_NRD_1	331	333	PF00675	0.445
CLV_NRD_NRD_1	413	415	PF00675	0.503
CLV_NRD_NRD_1	448	450	PF00675	0.546
CLV_NRD_NRD_1	456	458	PF00675	0.583
CLV_NRD_NRD_1	587	589	PF00675	0.475
CLV_NRD_NRD_1	608	610	PF00675	0.542
CLV_NRD_NRD_1	619	621	PF00675	0.413
CLV_NRD_NRD_1	701	703	PF00675	0.399
CLV_NRD_NRD_1	736	738	PF00675	0.489
CLV_NRD_NRD_1	82	84	PF00675	0.615
CLV_PCSK_FUR_1	265	269	PF00082	0.590
CLV_PCSK_FUR_1	321	325	PF00082	0.469
CLV_PCSK_FUR_1	329	333	PF00082	0.446
CLV_PCSK_FUR_1	384	388	PF00082	0.446
CLV_PCSK_KEX2_1	145	147	PF00082	0.529
CLV_PCSK_KEX2_1	188	190	PF00082	0.512
CLV_PCSK_KEX2_1	203	205	PF00082	0.408
CLV_PCSK_KEX2_1	236	238	PF00082	0.601
CLV_PCSK_KEX2_1	265	267	PF00082	0.481
CLV_PCSK_KEX2_1	268	270	PF00082	0.462
CLV_PCSK_KEX2_1	278	280	PF00082	0.457
CLV_PCSK_KEX2_1	323	325	PF00082	0.453
CLV_PCSK_KEX2_1	331	333	PF00082	0.419
CLV_PCSK_KEX2_1	386	388	PF00082	0.444
CLV_PCSK_KEX2_1	413	415	PF00082	0.503
CLV_PCSK_KEX2_1	448	450	PF00082	0.547
CLV_PCSK_KEX2_1	471	473	PF00082	0.480
CLV_PCSK_KEX2_1	587	589	PF00082	0.463
CLV_PCSK_KEX2_1	608	610	PF00082	0.485
CLV_PCSK_KEX2_1	619	621	PF00082	0.467
CLV_PCSK_KEX2_1	62	64	PF00082	0.680
CLV_PCSK_KEX2_1	701	703	PF00082	0.436
CLV_PCSK_KEX2_1	736	738	PF00082	0.501
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.529
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.504
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.368
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.480
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.680
CLV_PCSK_SKI1_1	165	169	PF00082	0.490
CLV_PCSK_SKI1_1	298	302	PF00082	0.496
CLV_PCSK_SKI1_1	315	319	PF00082	0.478
CLV_PCSK_SKI1_1	343	347	PF00082	0.525
CLV_PCSK_SKI1_1	351	355	PF00082	0.427
CLV_PCSK_SKI1_1	367	371	PF00082	0.351
CLV_PCSK_SKI1_1	413	417	PF00082	0.606
CLV_PCSK_SKI1_1	541	545	PF00082	0.495
CLV_PCSK_SKI1_1	587	591	PF00082	0.413
CLV_PCSK_SKI1_1	609	613	PF00082	0.420
CLV_PCSK_SKI1_1	619	623	PF00082	0.404
CLV_PCSK_SKI1_1	711	715	PF00082	0.440
CLV_PCSK_SKI1_1	726	730	PF00082	0.417
CLV_PCSK_SKI1_1	792	796	PF00082	0.463
CLV_PCSK_SKI1_1	89	93	PF00082	0.608
DEG_APCC_DBOX_1	440	448	PF00400	0.615
DEG_APCC_DBOX_1	608	616	PF00400	0.477
DEG_APCC_DBOX_1	791	799	PF00400	0.476
DEG_SCF_FBW7_1	226	233	PF00400	0.502
DEG_SPOP_SBC_1	90	94	PF00917	0.535
DOC_CDC14_PxL_1	4	12	PF14671	0.589
DOC_CKS1_1	118	123	PF01111	0.454
DOC_MAPK_gen_1	346	355	PF00069	0.340
DOC_MAPK_gen_1	471	477	PF00069	0.401
DOC_MIT_MIM_1	520	530	PF04212	0.453
DOC_PP1_RVXF_1	748	754	PF00149	0.424
DOC_USP7_MATH_1	218	222	PF00917	0.650
DOC_USP7_MATH_1	256	260	PF00917	0.462
DOC_USP7_MATH_1	42	46	PF00917	0.639
DOC_USP7_MATH_1	55	59	PF00917	0.707
DOC_USP7_MATH_1	575	579	PF00917	0.471
DOC_USP7_MATH_1	652	656	PF00917	0.649
DOC_USP7_MATH_1	671	675	PF00917	0.327
DOC_USP7_MATH_1	742	746	PF00917	0.513
DOC_USP7_MATH_1	85	89	PF00917	0.634
DOC_USP7_UBL2_3	50	54	PF12436	0.592
DOC_WW_Pin1_4	117	122	PF00397	0.639
DOC_WW_Pin1_4	125	130	PF00397	0.690
DOC_WW_Pin1_4	226	231	PF00397	0.499
DOC_WW_Pin1_4	8	13	PF00397	0.667
LIG_14-3-3_CanoR_1	146	152	PF00244	0.578
LIG_14-3-3_CanoR_1	15	25	PF00244	0.625
LIG_14-3-3_CanoR_1	526	530	PF00244	0.593
LIG_14-3-3_CanoR_1	690	696	PF00244	0.479
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_CaM_IQ_9	527	543	PF13499	0.524
LIG_FHA_1	157	163	PF00498	0.357
LIG_FHA_1	428	434	PF00498	0.628
LIG_FHA_1	664	670	PF00498	0.543
LIG_FHA_2	148	154	PF00498	0.531
LIG_FHA_2	366	372	PF00498	0.466
LIG_FHA_2	505	511	PF00498	0.581
LIG_FHA_2	515	521	PF00498	0.617
LIG_FHA_2	90	96	PF00498	0.582
LIG_LIR_Apic_2	111	117	PF02991	0.617
LIG_LIR_Apic_2	27	32	PF02991	0.598
LIG_LIR_Gen_1	103	109	PF02991	0.477
LIG_LIR_Gen_1	299	309	PF02991	0.453
LIG_LIR_Gen_1	623	634	PF02991	0.408
LIG_LIR_Gen_1	730	739	PF02991	0.506
LIG_LIR_Nem_3	103	108	PF02991	0.555
LIG_LIR_Nem_3	299	304	PF02991	0.460
LIG_LIR_Nem_3	363	369	PF02991	0.477
LIG_LIR_Nem_3	623	629	PF02991	0.406
LIG_LIR_Nem_3	730	735	PF02991	0.498
LIG_MYND_1	8	12	PF01753	0.665
LIG_PCNA_yPIPBox_3	197	209	PF02747	0.379
LIG_SH2_CRK	148	152	PF00017	0.529
LIG_SH2_CRK	597	601	PF00017	0.536
LIG_SH2_NCK_1	148	152	PF00017	0.573
LIG_SH2_PTP2	114	117	PF00017	0.534
LIG_SH2_PTP2	29	32	PF00017	0.563
LIG_SH2_SRC	114	117	PF00017	0.620
LIG_SH2_STAP1	101	105	PF00017	0.592
LIG_SH2_STAT3	440	443	PF00017	0.500
LIG_SH2_STAT5	114	117	PF00017	0.648
LIG_SH2_STAT5	29	32	PF00017	0.578
LIG_SH3_3	115	121	PF00018	0.467
LIG_SH3_3	127	133	PF00018	0.681
LIG_SUMO_SIM_anti_2	525	531	PF11976	0.446
LIG_TRAF2_1	150	153	PF00917	0.551
LIG_TRAF2_1	280	283	PF00917	0.563
LIG_TRAF2_1	507	510	PF00917	0.619
LIG_TRAF2_1	553	556	PF00917	0.428
LIG_TRAF2_1	674	677	PF00917	0.417
LIG_TRAF2_1	69	72	PF00917	0.622
LIG_TRAF2_1	744	747	PF00917	0.518
LIG_WRC_WIRS_1	366	371	PF05994	0.472
LIG_WRC_WIRS_1	576	581	PF05994	0.473
MOD_CDK_SPxxK_3	125	132	PF00069	0.572
MOD_CDK_SPxxK_3	8	15	PF00069	0.669
MOD_CK1_1	11	17	PF00069	0.725
MOD_CK1_1	19	25	PF00069	0.651
MOD_CK1_1	221	227	PF00069	0.564
MOD_CK1_1	43	49	PF00069	0.654
MOD_CK1_1	554	560	PF00069	0.508
MOD_CK1_1	577	583	PF00069	0.424
MOD_CK1_1	685	691	PF00069	0.499
MOD_CK1_1	77	83	PF00069	0.637
MOD_CK1_1	779	785	PF00069	0.423
MOD_CK2_1	147	153	PF00069	0.576
MOD_CK2_1	256	262	PF00069	0.579
MOD_CK2_1	365	371	PF00069	0.598
MOD_CK2_1	496	502	PF00069	0.531
MOD_CK2_1	504	510	PF00069	0.554
MOD_CK2_1	514	520	PF00069	0.649
MOD_CK2_1	671	677	PF00069	0.536
MOD_CK2_1	727	733	PF00069	0.581
MOD_CK2_1	741	747	PF00069	0.387
MOD_GlcNHglycan	19	22	PF01048	0.586
MOD_GlcNHglycan	42	45	PF01048	0.520
MOD_GlcNHglycan	77	80	PF01048	0.593
MOD_GlcNHglycan	778	781	PF01048	0.446
MOD_GSK3_1	226	233	PF00069	0.736
MOD_GSK3_1	40	47	PF00069	0.688
MOD_GSK3_1	504	511	PF00069	0.610
MOD_GSK3_1	685	692	PF00069	0.499
MOD_GSK3_1	74	81	PF00069	0.648
MOD_GSK3_1	772	779	PF00069	0.506
MOD_GSK3_1	85	92	PF00069	0.615
MOD_N-GLC_1	304	309	PF02516	0.407
MOD_N-GLC_1	496	501	PF02516	0.529
MOD_N-GLC_1	85	90	PF02516	0.503
MOD_NEK2_1	147	152	PF00069	0.531
MOD_NEK2_1	304	309	PF00069	0.428
MOD_NEK2_1	427	432	PF00069	0.694
MOD_NEK2_1	504	509	PF00069	0.560
MOD_NEK2_1	512	517	PF00069	0.610
MOD_NEK2_1	574	579	PF00069	0.469
MOD_NEK2_1	776	781	PF00069	0.464
MOD_PIKK_1	211	217	PF00454	0.598
MOD_PIKK_1	55	61	PF00454	0.518
MOD_PIKK_1	551	557	PF00454	0.512
MOD_PIKK_1	742	748	PF00454	0.573
MOD_PK_1	682	688	PF00069	0.537
MOD_PKA_1	203	209	PF00069	0.379
MOD_PKA_1	61	67	PF00069	0.525
MOD_PKA_2	203	209	PF00069	0.520
MOD_PKA_2	391	397	PF00069	0.544
MOD_PKA_2	525	531	PF00069	0.599
MOD_PKA_2	55	61	PF00069	0.813
MOD_PKA_2	689	695	PF00069	0.536
MOD_Plk_1	304	310	PF00069	0.442
MOD_Plk_1	464	470	PF00069	0.466
MOD_Plk_1	496	502	PF00069	0.588
MOD_Plk_1	652	658	PF00069	0.552
MOD_Plk_4	304	310	PF00069	0.449
MOD_Plk_4	464	470	PF00069	0.407
MOD_Plk_4	525	531	PF00069	0.670
MOD_Plk_4	652	658	PF00069	0.552
MOD_Plk_4	772	778	PF00069	0.432
MOD_ProDKin_1	117	123	PF00069	0.644
MOD_ProDKin_1	125	131	PF00069	0.692
MOD_ProDKin_1	226	232	PF00069	0.500
MOD_ProDKin_1	8	14	PF00069	0.666
MOD_SUMO_for_1	167	170	PF00179	0.545
MOD_SUMO_for_1	317	320	PF00179	0.441
MOD_SUMO_for_1	415	418	PF00179	0.724
MOD_SUMO_for_1	570	573	PF00179	0.463
MOD_SUMO_for_1	681	684	PF00179	0.447
MOD_SUMO_for_1	696	699	PF00179	0.453
MOD_SUMO_rev_2	139	147	PF00179	0.521
MOD_SUMO_rev_2	347	355	PF00179	0.512
MOD_SUMO_rev_2	360	366	PF00179	0.406
MOD_SUMO_rev_2	534	543	PF00179	0.418
MOD_SUMO_rev_2	545	554	PF00179	0.466
MOD_SUMO_rev_2	674	681	PF00179	0.533
MOD_SUMO_rev_2	719	728	PF00179	0.466
MOD_SUMO_rev_2	81	91	PF00179	0.506
TRG_AP2beta_CARGO_1	363	373	PF09066	0.490
TRG_DiLeu_BaEn_1	312	317	PF01217	0.412
TRG_DiLeu_BaEn_1	724	729	PF01217	0.440
TRG_DiLeu_LyEn_5	312	317	PF01217	0.412
TRG_ENDOCYTIC_2	148	151	PF00928	0.574
TRG_ENDOCYTIC_2	569	572	PF00928	0.370
TRG_ENDOCYTIC_2	597	600	PF00928	0.418
TRG_ER_diArg_1	180	183	PF00400	0.639
TRG_ER_diArg_1	203	205	PF00400	0.390
TRG_ER_diArg_1	265	268	PF00400	0.478
TRG_ER_diArg_1	277	279	PF00400	0.467
TRG_ER_diArg_1	322	324	PF00400	0.495
TRG_ER_diArg_1	447	449	PF00400	0.555
TRG_ER_diArg_1	562	565	PF00400	0.404
TRG_ER_diArg_1	587	589	PF00400	0.357
TRG_ER_diArg_1	608	610	PF00400	0.485
TRG_ER_diArg_1	619	621	PF00400	0.467
TRG_ER_diArg_1	672	675	PF00400	0.533
TRG_ER_diArg_1	701	703	PF00400	0.420
TRG_ER_diArg_1	735	737	PF00400	0.496
TRG_ER_diArg_1	748	751	PF00400	0.657
TRG_NLS_Bipartite_1	50	64	PF00514	0.686
TRG_NLS_MonoCore_2	59	64	PF00514	0.799
TRG_NLS_MonoExtC_3	49	54	PF00514	0.570
TRG_NLS_MonoExtC_3	59	65	PF00514	0.770
TRG_NLS_MonoExtN_4	48	55	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC64	Leptomonas seymouri	71%	100%
A0A1X0P1G0	Trypanosomatidae	41%	99%
A0A3R7M5L7	Trypanosoma rangeli	43%	100%
A0A3S7X3P7	Leishmania donovani	85%	100%
A4I5W1	Leishmania infantum	85%	100%
C9ZR81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B156	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q710	Leishmania major	84%	100%