Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIL4_LEIBR

TriTrypDb:

LbrM.30.2780 , LBRM2903_300034300

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL4

PDB structure(s): 7aih_Ar , 7am2_Ar , 7ane_Ar

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.555
CLV_NRD_NRD_1	155	157	PF00675	0.511
CLV_NRD_NRD_1	195	197	PF00675	0.512
CLV_NRD_NRD_1	92	94	PF00675	0.526
CLV_PCSK_KEX2_1	155	157	PF00082	0.511
CLV_PCSK_KEX2_1	187	189	PF00082	0.480
CLV_PCSK_KEX2_1	43	45	PF00082	0.574
CLV_PCSK_KEX2_1	94	96	PF00082	0.517
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.468
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.574
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.510
CLV_PCSK_PC7_1	151	157	PF00082	0.499
CLV_PCSK_SKI1_1	187	191	PF00082	0.477
CLV_PCSK_SKI1_1	26	30	PF00082	0.506
CLV_PCSK_SKI1_1	40	44	PF00082	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_SCF_FBW7_2	57	62	PF00400	0.580
DOC_MAPK_gen_1	187	195	PF00069	0.484
DOC_MAPK_gen_1	93	100	PF00069	0.505
DOC_MAPK_MEF2A_6	9	17	PF00069	0.492
DOC_PP1_RVXF_1	144	151	PF00149	0.531
DOC_PP2B_LxvP_1	169	172	PF13499	0.491
DOC_WW_Pin1_4	55	60	PF00397	0.592
LIG_14-3-3_CanoR_1	113	117	PF00244	0.494
LIG_14-3-3_CanoR_1	196	202	PF00244	0.540
LIG_14-3-3_CanoR_1	83	90	PF00244	0.422
LIG_BRCT_BRCA1_1	83	87	PF00533	0.417
LIG_FHA_1	104	110	PF00498	0.504
LIG_FHA_1	23	29	PF00498	0.511
LIG_FHA_1	83	89	PF00498	0.420
LIG_LIR_Gen_1	74	81	PF02991	0.517
LIG_LIR_Gen_1	84	92	PF02991	0.472
LIG_LIR_Nem_3	106	111	PF02991	0.509
LIG_LIR_Nem_3	18	22	PF02991	0.506
LIG_LIR_Nem_3	199	204	PF02991	0.535
LIG_LIR_Nem_3	74	80	PF02991	0.519
LIG_LIR_Nem_3	84	90	PF02991	0.472
LIG_LIR_Nem_3	99	104	PF02991	0.420
LIG_Pex14_1	166	170	PF04695	0.463
LIG_Pex14_1	97	101	PF04695	0.501
LIG_SH2_CRK	201	205	PF00017	0.650
LIG_SH2_GRB2like	184	187	PF00017	0.478
LIG_SH2_PTP2	19	22	PF00017	0.538
LIG_SH2_SRC	170	173	PF00017	0.479
LIG_SH2_SRC	19	22	PF00017	0.572
LIG_SH2_STAP1	77	81	PF00017	0.526
LIG_SH2_STAT5	108	111	PF00017	0.506
LIG_SH2_STAT5	170	173	PF00017	0.505
LIG_SH2_STAT5	19	22	PF00017	0.538
LIG_SH2_STAT5	50	53	PF00017	0.491
LIG_TRAF2_1	36	39	PF00917	0.538
LIG_TYR_ITIM	17	22	PF00017	0.504
MOD_LATS_1	194	200	PF00433	0.530
MOD_N-GLC_2	165	167	PF02516	0.452
MOD_NEK2_1	2	7	PF00069	0.520
MOD_NEK2_1	24	29	PF00069	0.523
MOD_PKA_1	196	202	PF00069	0.533
MOD_PKA_2	112	118	PF00069	0.491
MOD_PKA_2	154	160	PF00069	0.475
MOD_PKA_2	2	8	PF00069	0.506
MOD_PKA_2	82	88	PF00069	0.414
MOD_ProDKin_1	55	61	PF00069	0.587
MOD_SUMO_for_1	42	45	PF00179	0.537
MOD_SUMO_rev_2	180	189	PF00179	0.492
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.514
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.650
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.568
TRG_ENDOCYTIC_2	101	104	PF00928	0.495
TRG_ENDOCYTIC_2	108	111	PF00928	0.506
TRG_ENDOCYTIC_2	19	22	PF00928	0.504
TRG_ENDOCYTIC_2	201	204	PF00928	0.671
TRG_ENDOCYTIC_2	77	80	PF00928	0.533
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV5	Leptomonas seymouri	96%	100%
A0A0S4ITY2	Bodo saltans	80%	100%
A0A1X0P1S8	Trypanosomatidae	82%	100%
A0A3Q8IS65	Leishmania donovani	98%	100%
A0A3R7NR49	Trypanosoma rangeli	84%	100%
A4I5V9	Leishmania infantum	98%	100%
C9ZR78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9B154	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q712	Leishmania major	96%	100%
V5BSJ7	Trypanosoma cruzi	84%	100%