Mitochondrial inner membrane protein OXA1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIL3_LEIBR

TriTrypDb:

LbrM.30.2770 , LBRM2903_300034200

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HIL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.602
CLV_C14_Caspase3-7	43	47	PF00656	0.590
CLV_NRD_NRD_1	124	126	PF00675	0.394
CLV_NRD_NRD_1	181	183	PF00675	0.303
CLV_NRD_NRD_1	66	68	PF00675	0.448
CLV_PCSK_FUR_1	64	68	PF00082	0.392
CLV_PCSK_KEX2_1	181	183	PF00082	0.303
CLV_PCSK_KEX2_1	66	68	PF00082	0.397
CLV_PCSK_SKI1_1	125	129	PF00082	0.360
CLV_PCSK_SKI1_1	37	41	PF00082	0.563
DEG_APCC_DBOX_1	124	132	PF00400	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.699
DEG_SPOP_SBC_1	255	259	PF00917	0.526
DOC_MAPK_MEF2A_6	196	203	PF00069	0.549
DOC_PP1_RVXF_1	124	131	PF00149	0.566
DOC_PP1_RVXF_1	235	242	PF00149	0.578
DOC_PP1_RVXF_1	35	41	PF00149	0.690
DOC_PP2B_LxvP_1	142	145	PF13499	0.342
DOC_USP7_MATH_1	165	169	PF00917	0.317
DOC_USP7_MATH_1	227	231	PF00917	0.548
DOC_USP7_MATH_1	255	259	PF00917	0.576
DOC_USP7_MATH_1	39	43	PF00917	0.693
DOC_WW_Pin1_4	148	153	PF00397	0.409
DOC_WW_Pin1_4	6	11	PF00397	0.637
LIG_14-3-3_CanoR_1	219	223	PF00244	0.619
LIG_14-3-3_CanoR_1	240	246	PF00244	0.661
LIG_14-3-3_CanoR_1	256	263	PF00244	0.432
LIG_14-3-3_CanoR_1	31	40	PF00244	0.686
LIG_Actin_WH2_2	226	242	PF00022	0.546
LIG_eIF4E_1	133	139	PF01652	0.406
LIG_FHA_1	133	139	PF00498	0.319
LIG_FHA_1	2	8	PF00498	0.645
LIG_FHA_1	257	263	PF00498	0.511
LIG_FHA_1	33	39	PF00498	0.706
LIG_FHA_2	187	193	PF00498	0.629
LIG_LIR_Gen_1	200	211	PF02991	0.605
LIG_LIR_Nem_3	168	174	PF02991	0.374
LIG_LIR_Nem_3	200	206	PF02991	0.538
LIG_LIR_Nem_3	213	218	PF02991	0.517
LIG_LIR_Nem_3	269	273	PF02991	0.528
LIG_LYPXL_yS_3	211	214	PF13949	0.518
LIG_NRBOX	133	139	PF00104	0.406
LIG_Pex14_2	270	274	PF04695	0.573
LIG_PTB_Apo_2	126	133	PF02174	0.533
LIG_SH2_NCK_1	26	30	PF00017	0.567
LIG_SH2_STAT5	133	136	PF00017	0.363
LIG_SH2_STAT5	171	174	PF00017	0.283
LIG_SH2_STAT5	26	29	PF00017	0.568
LIG_SH3_3	115	121	PF00018	0.714
LIG_TRFH_1	98	102	PF08558	0.573
MOD_CK1_1	24	30	PF00069	0.539
MOD_CK1_1	42	48	PF00069	0.634
MOD_CK1_1	9	15	PF00069	0.569
MOD_CK2_1	177	183	PF00069	0.436
MOD_CK2_1	186	192	PF00069	0.588
MOD_CK2_1	218	224	PF00069	0.576
MOD_GlcNHglycan	108	111	PF01048	0.385
MOD_GlcNHglycan	14	17	PF01048	0.510
MOD_GlcNHglycan	167	170	PF01048	0.352
MOD_GlcNHglycan	21	24	PF01048	0.477
MOD_GlcNHglycan	229	232	PF01048	0.314
MOD_GlcNHglycan	234	237	PF01048	0.351
MOD_GlcNHglycan	52	55	PF01048	0.538
MOD_GSK3_1	1	8	PF00069	0.612
MOD_GSK3_1	148	155	PF00069	0.446
MOD_GSK3_1	227	234	PF00069	0.568
MOD_GSK3_1	40	47	PF00069	0.695
MOD_N-GLC_1	40	45	PF02516	0.516
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	132	137	PF00069	0.319
MOD_NEK2_1	146	151	PF00069	0.495
MOD_NEK2_1	241	246	PF00069	0.511
MOD_NEK2_1	33	38	PF00069	0.654
MOD_NEK2_1	40	45	PF00069	0.666
MOD_PIKK_1	205	211	PF00454	0.564
MOD_PIKK_1	218	224	PF00454	0.494
MOD_PIKK_1	46	52	PF00454	0.695
MOD_PKA_2	218	224	PF00069	0.603
MOD_PKA_2	255	261	PF00069	0.545
MOD_Plk_4	210	216	PF00069	0.583
MOD_Plk_4	241	247	PF00069	0.559
MOD_ProDKin_1	148	154	PF00069	0.408
MOD_ProDKin_1	6	12	PF00069	0.636
MOD_SUMO_for_1	187	190	PF00179	0.530
TRG_ENDOCYTIC_2	171	174	PF00928	0.364
TRG_ENDOCYTIC_2	211	214	PF00928	0.548
TRG_ER_diArg_1	66	69	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B3	Leptomonas seymouri	68%	100%
A0A0S4IU47	Bodo saltans	36%	75%
A0A1X0P2M0	Trypanosomatidae	47%	100%
A0A3R7L2S3	Trypanosoma rangeli	46%	100%
A0A3S7X3P3	Leishmania donovani	83%	100%
A4I5V8	Leishmania infantum	84%	100%
D0A1H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	86%
E9B153	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q713	Leishmania major	82%	100%