Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF872), putative

Species:

Leishmania braziliensis

UniProt:

A4HIL2_LEIBR

TriTrypDb:

LbrM.30.2760 , LBRM2903_300034100

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HIL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.456
CLV_NRD_NRD_1	54	56	PF00675	0.394
CLV_PCSK_FUR_1	60	64	PF00082	0.433
CLV_PCSK_KEX2_1	5	7	PF00082	0.422
CLV_PCSK_KEX2_1	54	56	PF00082	0.400
CLV_PCSK_KEX2_1	62	64	PF00082	0.505
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.422
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.444
CLV_PCSK_PC7_1	50	56	PF00082	0.332
CLV_PCSK_SKI1_1	115	119	PF00082	0.275
CLV_PCSK_SKI1_1	88	92	PF00082	0.377
DEG_APCC_DBOX_1	49	57	PF00400	0.535
DEG_Nend_UBRbox_1	1	4	PF02207	0.691
DOC_MAPK_gen_1	145	153	PF00069	0.275
DOC_MAPK_gen_1	81	89	PF00069	0.539
DOC_MAPK_MEF2A_6	145	153	PF00069	0.260
DOC_PP1_RVXF_1	106	112	PF00149	0.575
DOC_PP2B_LxvP_1	158	161	PF13499	0.312
DOC_PP2B_LxvP_1	182	185	PF13499	0.608
DOC_USP7_UBL2_3	58	62	PF12436	0.631
DOC_WW_Pin1_4	10	15	PF00397	0.661
LIG_14-3-3_CanoR_1	176	182	PF00244	0.606
LIG_14-3-3_CanoR_1	4	14	PF00244	0.651
LIG_14-3-3_CanoR_1	44	53	PF00244	0.665
LIG_14-3-3_CanoR_1	60	66	PF00244	0.666
LIG_FHA_2	43	49	PF00498	0.609
LIG_LIR_Gen_1	180	187	PF02991	0.610
LIG_LIR_Nem_3	165	170	PF02991	0.482
LIG_LIR_Nem_3	180	184	PF02991	0.517
LIG_LIR_Nem_3	72	78	PF02991	0.687
LIG_NRBOX	152	158	PF00104	0.231
LIG_Pex14_2	117	121	PF04695	0.312
LIG_Pex14_2	89	93	PF04695	0.523
LIG_SH2_CRK	170	174	PF00017	0.603
LIG_SH2_CRK	179	183	PF00017	0.554
LIG_SH2_STAP1	164	168	PF00017	0.388
LIG_SH2_STAP1	85	89	PF00017	0.640
LIG_SH2_STAT5	141	144	PF00017	0.389
LIG_SH2_STAT5	172	175	PF00017	0.574
LIG_SH2_STAT5	179	182	PF00017	0.691
LIG_SH3_3	8	14	PF00018	0.679
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.312
LIG_TRAF2_1	67	70	PF00917	0.603
LIG_TYR_ITIM	168	173	PF00017	0.485
LIG_TYR_ITSM	71	78	PF00017	0.573
MOD_CK1_1	61	67	PF00069	0.654
MOD_CK2_1	42	48	PF00069	0.618
MOD_CK2_1	64	70	PF00069	0.630
MOD_GlcNHglycan	123	126	PF01048	0.388
MOD_GSK3_1	121	128	PF00069	0.388
MOD_GSK3_1	70	77	PF00069	0.572
MOD_GSK3_1	93	100	PF00069	0.591
MOD_NEK2_1	121	126	PF00069	0.414
MOD_NEK2_1	171	176	PF00069	0.555
MOD_NEK2_2	162	167	PF00069	0.388
MOD_PKA_1	5	11	PF00069	0.614
MOD_PKA_2	5	11	PF00069	0.614
MOD_Plk_1	70	76	PF00069	0.571
MOD_Plk_4	125	131	PF00069	0.388
MOD_Plk_4	162	168	PF00069	0.428
MOD_Plk_4	177	183	PF00069	0.542
MOD_Plk_4	70	76	PF00069	0.571
MOD_ProDKin_1	10	16	PF00069	0.661
TRG_ENDOCYTIC_2	119	122	PF00928	0.312
TRG_ENDOCYTIC_2	163	166	PF00928	0.312
TRG_ENDOCYTIC_2	170	173	PF00928	0.548
TRG_ENDOCYTIC_2	179	182	PF00928	0.597
TRG_ENDOCYTIC_2	75	78	PF00928	0.687
TRG_ER_diArg_1	1	4	PF00400	0.707
TRG_ER_diArg_1	103	106	PF00400	0.565
TRG_ER_diArg_1	53	55	PF00400	0.539
TRG_NLS_MonoExtC_3	3	9	PF00514	0.621
TRG_NLS_MonoExtN_4	2	8	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q7	Leptomonas seymouri	66%	100%
A0A3Q8IF42	Leishmania donovani	80%	100%
A4I5V7	Leishmania infantum	80%	100%
E9B152	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q714	Leishmania major	81%	100%