C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania braziliensis

UniProt:

A4HIL1_LEIBR

TriTrypDb:

LbrM.30.2750 , LBRM2903_300034000

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HIL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIL1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.566
CLV_MEL_PAP_1	227	233	PF00089	0.551
CLV_NRD_NRD_1	250	252	PF00675	0.657
CLV_PCSK_KEX2_1	250	252	PF00082	0.657
CLV_PCSK_SKI1_1	126	130	PF00082	0.592
CLV_PCSK_SKI1_1	360	364	PF00082	0.601
CLV_PCSK_SKI1_1	372	376	PF00082	0.490
CLV_PCSK_SKI1_1	79	83	PF00082	0.374
DEG_APCC_DBOX_1	78	86	PF00400	0.368
DEG_SPOP_SBC_1	141	145	PF00917	0.748
DOC_CKS1_1	388	393	PF01111	0.513
DOC_CKS1_1	460	465	PF01111	0.532
DOC_MAPK_MEF2A_6	75	82	PF00069	0.371
DOC_MAPK_NFAT4_5	75	83	PF00069	0.373
DOC_PP2B_LxvP_1	362	365	PF13499	0.524
DOC_PP4_FxxP_1	105	108	PF00568	0.544
DOC_PP4_FxxP_1	384	387	PF00568	0.483
DOC_USP7_MATH_1	116	120	PF00917	0.743
DOC_USP7_MATH_1	184	188	PF00917	0.549
DOC_USP7_MATH_1	343	347	PF00917	0.553
DOC_USP7_MATH_1	61	65	PF00917	0.422
DOC_USP7_MATH_1	71	75	PF00917	0.531
DOC_WW_Pin1_4	136	141	PF00397	0.588
DOC_WW_Pin1_4	255	260	PF00397	0.719
DOC_WW_Pin1_4	322	327	PF00397	0.530
DOC_WW_Pin1_4	387	392	PF00397	0.502
DOC_WW_Pin1_4	414	419	PF00397	0.555
DOC_WW_Pin1_4	459	464	PF00397	0.527
DOC_WW_Pin1_4	95	100	PF00397	0.729
LIG_14-3-3_CanoR_1	176	184	PF00244	0.645
LIG_14-3-3_CanoR_1	190	198	PF00244	0.653
LIG_14-3-3_CanoR_1	226	230	PF00244	0.719
LIG_14-3-3_CanoR_1	307	311	PF00244	0.499
LIG_14-3-3_CanoR_1	354	359	PF00244	0.531
LIG_14-3-3_CanoR_1	360	365	PF00244	0.503
LIG_APCC_ABBA_1	209	214	PF00400	0.747
LIG_BRCT_BRCA1_1	218	222	PF00533	0.773
LIG_BRCT_BRCA1_1	227	231	PF00533	0.655
LIG_BRCT_BRCA1_1	53	57	PF00533	0.372
LIG_Clathr_ClatBox_1	85	89	PF01394	0.413
LIG_CtBP_PxDLS_1	418	422	PF00389	0.529
LIG_DLG_GKlike_1	354	362	PF00625	0.531
LIG_EVH1_1	384	388	PF00568	0.485
LIG_FHA_1	104	110	PF00498	0.775
LIG_FHA_1	11	17	PF00498	0.697
LIG_FHA_1	178	184	PF00498	0.630
LIG_FHA_1	278	284	PF00498	0.726
LIG_FHA_1	293	299	PF00498	0.412
LIG_FHA_1	41	47	PF00498	0.438
LIG_FHA_1	460	466	PF00498	0.533
LIG_FHA_1	57	63	PF00498	0.615
LIG_FHA_1	68	74	PF00498	0.501
LIG_FHA_2	142	148	PF00498	0.851
LIG_FHA_2	280	286	PF00498	0.614
LIG_FHA_2	323	329	PF00498	0.541
LIG_FHA_2	401	407	PF00498	0.578
LIG_LIR_Apic_2	102	108	PF02991	0.673
LIG_LIR_Apic_2	29	35	PF02991	0.403
LIG_LIR_Apic_2	93	99	PF02991	0.623
LIG_LIR_Gen_1	378	388	PF02991	0.491
LIG_LIR_Nem_3	22	27	PF02991	0.589
LIG_LIR_Nem_3	240	245	PF02991	0.608
LIG_LIR_Nem_3	378	383	PF02991	0.496
LIG_LIR_Nem_3	48	53	PF02991	0.466
LIG_MYND_1	161	165	PF01753	0.719
LIG_MYND_1	463	467	PF01753	0.515
LIG_PDZ_Class_2	463	468	PF00595	0.522
LIG_Pex14_1	380	384	PF04695	0.499
LIG_SH2_PTP2	382	385	PF00017	0.496
LIG_SH2_STAT5	27	30	PF00017	0.615
LIG_SH2_STAT5	382	385	PF00017	0.496
LIG_SH2_STAT5	393	396	PF00017	0.502
LIG_SH3_1	382	388	PF00018	0.490
LIG_SH3_3	135	141	PF00018	0.783
LIG_SH3_3	183	189	PF00018	0.700
LIG_SH3_3	258	264	PF00018	0.681
LIG_SH3_3	269	275	PF00018	0.754
LIG_SH3_3	382	388	PF00018	0.490
LIG_SH3_3	413	419	PF00018	0.558
LIG_SH3_3	436	442	PF00018	0.527
LIG_SH3_3	461	467	PF00018	0.526
LIG_SUMO_SIM_par_1	279	285	PF11976	0.468
MOD_CK1_1	127	133	PF00069	0.755
MOD_CK1_1	169	175	PF00069	0.638
MOD_CK1_1	412	418	PF00069	0.568
MOD_CK1_1	48	54	PF00069	0.505
MOD_CK2_1	141	147	PF00069	0.847
MOD_CK2_1	279	285	PF00069	0.605
MOD_CK2_1	322	328	PF00069	0.530
MOD_CK2_1	400	406	PF00069	0.577
MOD_CK2_1	71	77	PF00069	0.548
MOD_Cter_Amidation	248	251	PF01082	0.550
MOD_DYRK1A_RPxSP_1	255	259	PF00069	0.719
MOD_GlcNHglycan	129	132	PF01048	0.626
MOD_GlcNHglycan	349	352	PF01048	0.532
MOD_GlcNHglycan	377	380	PF01048	0.524
MOD_GlcNHglycan	436	439	PF01048	0.527
MOD_GlcNHglycan	453	456	PF01048	0.496
MOD_GlcNHglycan	47	50	PF01048	0.380
MOD_GlcNHglycan	64	67	PF01048	0.615
MOD_GSK3_1	10	17	PF00069	0.705
MOD_GSK3_1	132	139	PF00069	0.666
MOD_GSK3_1	155	162	PF00069	0.796
MOD_GSK3_1	175	182	PF00069	0.690
MOD_GSK3_1	225	232	PF00069	0.625
MOD_GSK3_1	253	260	PF00069	0.820
MOD_GSK3_1	302	309	PF00069	0.411
MOD_GSK3_1	318	325	PF00069	0.396
MOD_GSK3_1	343	350	PF00069	0.539
MOD_GSK3_1	354	361	PF00069	0.488
MOD_GSK3_1	36	43	PF00069	0.534
MOD_GSK3_1	430	437	PF00069	0.533
MOD_GSK3_1	57	64	PF00069	0.467
MOD_GSK3_1	67	74	PF00069	0.471
MOD_GSK3_1	95	102	PF00069	0.669
MOD_N-GLC_1	141	146	PF02516	0.593
MOD_N-GLC_1	40	45	PF02516	0.364
MOD_N-GLC_1	430	435	PF02516	0.536
MOD_NEK2_1	103	108	PF00069	0.537
MOD_NEK2_1	177	182	PF00069	0.655
MOD_NEK2_1	302	307	PF00069	0.411
MOD_NEK2_1	358	363	PF00069	0.603
MOD_NEK2_1	375	380	PF00069	0.435
MOD_NEK2_1	430	435	PF00069	0.536
MOD_NEK2_1	443	448	PF00069	0.499
MOD_NEK2_1	57	62	PF00069	0.455
MOD_NEK2_2	225	230	PF00069	0.542
MOD_PKA_2	163	169	PF00069	0.686
MOD_PKA_2	172	178	PF00069	0.721
MOD_PKA_2	225	231	PF00069	0.677
MOD_PKA_2	270	276	PF00069	0.541
MOD_PKA_2	306	312	PF00069	0.513
MOD_PKA_2	434	440	PF00069	0.531
MOD_PKB_1	407	415	PF00069	0.577
MOD_Plk_1	430	436	PF00069	0.534
MOD_Plk_1	99	105	PF00069	0.499
MOD_Plk_2-3	400	406	PF00069	0.577
MOD_Plk_4	2	8	PF00069	0.558
MOD_Plk_4	366	372	PF00069	0.521
MOD_Plk_4	389	395	PF00069	0.523
MOD_Plk_4	443	449	PF00069	0.545
MOD_ProDKin_1	136	142	PF00069	0.591
MOD_ProDKin_1	255	261	PF00069	0.716
MOD_ProDKin_1	322	328	PF00069	0.530
MOD_ProDKin_1	387	393	PF00069	0.508
MOD_ProDKin_1	414	420	PF00069	0.552
MOD_ProDKin_1	459	465	PF00069	0.529
MOD_ProDKin_1	95	101	PF00069	0.725
TRG_DiLeu_BaEn_2	207	213	PF01217	0.483
TRG_DiLeu_BaEn_2	284	290	PF01217	0.712
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.559
TRG_ER_diArg_1	250	252	PF00400	0.662
TRG_NES_CRM1_1	77	91	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD74	Leptomonas seymouri	30%	100%
A0A3S7X3N7	Leishmania donovani	67%	100%
A4I5V6	Leishmania infantum	67%	100%
E9B151	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q715	Leishmania major	67%	100%