AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Stabilization of polarity axis, putative

Species:

Leishmania braziliensis

UniProt:

A4HIK5_LEIBR

TriTrypDb:

LbrM.30.2690 , LBRM2903_300033500

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIK5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051666	actin cortical patch localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.552
CLV_C14_Caspase3-7	256	260	PF00656	0.562
CLV_C14_Caspase3-7	341	345	PF00656	0.670
CLV_C14_Caspase3-7	395	399	PF00656	0.542
CLV_C14_Caspase3-7	757	761	PF00656	0.484
CLV_NRD_NRD_1	170	172	PF00675	0.534
CLV_NRD_NRD_1	402	404	PF00675	0.625
CLV_NRD_NRD_1	52	54	PF00675	0.564
CLV_NRD_NRD_1	553	555	PF00675	0.346
CLV_NRD_NRD_1	638	640	PF00675	0.673
CLV_NRD_NRD_1	814	816	PF00675	0.439
CLV_PCSK_KEX2_1	169	171	PF00082	0.549
CLV_PCSK_KEX2_1	396	398	PF00082	0.535
CLV_PCSK_KEX2_1	402	404	PF00082	0.564
CLV_PCSK_KEX2_1	453	455	PF00082	0.467
CLV_PCSK_KEX2_1	52	54	PF00082	0.564
CLV_PCSK_KEX2_1	521	523	PF00082	0.445
CLV_PCSK_KEX2_1	814	816	PF00082	0.439
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.535
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.467
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.348
CLV_PCSK_SKI1_1	13	17	PF00082	0.491
CLV_PCSK_SKI1_1	203	207	PF00082	0.585
CLV_PCSK_SKI1_1	450	454	PF00082	0.476
CLV_PCSK_SKI1_1	547	551	PF00082	0.346
CLV_PCSK_SKI1_1	577	581	PF00082	0.281
CLV_PCSK_SKI1_1	686	690	PF00082	0.450
CLV_PCSK_SKI1_1	810	814	PF00082	0.539
DEG_APCC_DBOX_1	469	477	PF00400	0.362
DEG_APCC_DBOX_1	521	529	PF00400	0.405
DEG_COP1_1	56	65	PF00400	0.545
DEG_SCF_SKP2-CKS1_1	257	264	PF00560	0.562
DOC_MAPK_gen_1	705	713	PF00069	0.442
DOC_MAPK_gen_1	814	820	PF00069	0.448
DOC_MAPK_MEF2A_6	583	590	PF00069	0.542
DOC_MAPK_MEF2A_6	705	713	PF00069	0.442
DOC_MAPK_MEF2A_6	769	777	PF00069	0.470
DOC_MAPK_RevD_3	534	548	PF00069	0.501
DOC_PP1_RVXF_1	195	202	PF00149	0.355
DOC_PP2B_LxvP_1	333	336	PF13499	0.719
DOC_PP2B_LxvP_1	60	63	PF13499	0.380
DOC_PP4_FxxP_1	677	680	PF00568	0.623
DOC_USP7_MATH_1	21	25	PF00917	0.416
DOC_USP7_MATH_1	241	245	PF00917	0.650
DOC_USP7_MATH_1	257	261	PF00917	0.547
DOC_USP7_MATH_1	267	271	PF00917	0.668
DOC_USP7_MATH_1	297	301	PF00917	0.565
DOC_USP7_MATH_1	340	344	PF00917	0.720
DOC_USP7_MATH_1	35	39	PF00917	0.535
DOC_USP7_MATH_1	360	364	PF00917	0.530
DOC_USP7_MATH_1	369	373	PF00917	0.505
DOC_USP7_MATH_1	392	396	PF00917	0.465
DOC_USP7_MATH_1	513	517	PF00917	0.421
DOC_USP7_MATH_1	586	590	PF00917	0.546
DOC_USP7_MATH_1	727	731	PF00917	0.466
DOC_USP7_MATH_1	742	746	PF00917	0.405
DOC_USP7_MATH_1	857	861	PF00917	0.575
DOC_USP7_MATH_2	91	97	PF00917	0.590
DOC_WW_Pin1_4	156	161	PF00397	0.555
DOC_WW_Pin1_4	232	237	PF00397	0.631
DOC_WW_Pin1_4	258	263	PF00397	0.609
DOC_WW_Pin1_4	381	386	PF00397	0.415
DOC_WW_Pin1_4	787	792	PF00397	0.568
DOC_WW_Pin1_4	829	834	PF00397	0.481
LIG_14-3-3_CanoR_1	169	178	PF00244	0.449
LIG_14-3-3_CanoR_1	203	209	PF00244	0.529
LIG_14-3-3_CanoR_1	454	460	PF00244	0.306
LIG_14-3-3_CanoR_1	522	526	PF00244	0.495
LIG_14-3-3_CanoR_1	577	586	PF00244	0.462
LIG_14-3-3_CanoR_1	639	645	PF00244	0.470
LIG_14-3-3_CanoR_1	744	750	PF00244	0.499
LIG_14-3-3_CanoR_1	783	788	PF00244	0.383
LIG_Actin_WH2_2	685	701	PF00022	0.484
LIG_BIR_III_2	348	352	PF00653	0.553
LIG_BRCT_BRCA1_1	126	130	PF00533	0.687
LIG_eIF4E_1	523	529	PF01652	0.619
LIG_eIF4E_1	61	67	PF01652	0.505
LIG_FAT_LD_1	796	804	PF03623	0.300
LIG_FHA_1	10	16	PF00498	0.508
LIG_FHA_1	101	107	PF00498	0.374
LIG_FHA_1	118	124	PF00498	0.433
LIG_FHA_1	207	213	PF00498	0.561
LIG_FHA_1	215	221	PF00498	0.590
LIG_FHA_1	300	306	PF00498	0.558
LIG_FHA_1	374	380	PF00498	0.649
LIG_FHA_1	405	411	PF00498	0.525
LIG_FHA_1	475	481	PF00498	0.497
LIG_FHA_1	639	645	PF00498	0.627
LIG_FHA_1	654	660	PF00498	0.498
LIG_FHA_1	669	675	PF00498	0.456
LIG_FHA_1	687	693	PF00498	0.326
LIG_FHA_1	70	76	PF00498	0.620
LIG_FHA_1	717	723	PF00498	0.444
LIG_FHA_2	208	214	PF00498	0.397
LIG_FHA_2	339	345	PF00498	0.608
LIG_FHA_2	416	422	PF00498	0.419
LIG_FHA_2	630	636	PF00498	0.560
LIG_FHA_2	68	74	PF00498	0.545
LIG_FHA_2	784	790	PF00498	0.441
LIG_FHA_2	80	86	PF00498	0.467
LIG_FHA_2	803	809	PF00498	0.463
LIG_FHA_2	844	850	PF00498	0.319
LIG_LIR_Apic_2	416	422	PF02991	0.576
LIG_LIR_Gen_1	173	183	PF02991	0.508
LIG_LIR_Gen_1	198	208	PF02991	0.459
LIG_LIR_Gen_1	24	34	PF02991	0.393
LIG_LIR_Gen_1	330	340	PF02991	0.554
LIG_LIR_Gen_1	594	604	PF02991	0.434
LIG_LIR_Gen_1	616	625	PF02991	0.503
LIG_LIR_Gen_1	715	726	PF02991	0.454
LIG_LIR_Nem_3	127	132	PF02991	0.535
LIG_LIR_Nem_3	173	179	PF02991	0.520
LIG_LIR_Nem_3	198	204	PF02991	0.453
LIG_LIR_Nem_3	24	29	PF02991	0.401
LIG_LIR_Nem_3	304	309	PF02991	0.555
LIG_LIR_Nem_3	330	335	PF02991	0.661
LIG_LIR_Nem_3	421	427	PF02991	0.547
LIG_LIR_Nem_3	481	486	PF02991	0.459
LIG_LIR_Nem_3	517	523	PF02991	0.600
LIG_LIR_Nem_3	594	599	PF02991	0.434
LIG_LIR_Nem_3	616	622	PF02991	0.503
LIG_LIR_Nem_3	715	721	PF02991	0.436
LIG_LIR_Nem_3	735	741	PF02991	0.294
LIG_LYPXL_S_1	305	309	PF13949	0.554
LIG_LYPXL_S_1	737	741	PF13949	0.342
LIG_LYPXL_yS_3	306	309	PF13949	0.552
LIG_MLH1_MIPbox_1	126	130	PF16413	0.530
LIG_NRBOX	111	117	PF00104	0.393
LIG_NRBOX	207	213	PF00104	0.449
LIG_NRBOX	535	541	PF00104	0.540
LIG_NRBOX	795	801	PF00104	0.454
LIG_NRP_CendR_1	876	878	PF00754	0.501
LIG_PCNA_PIPBox_1	710	719	PF02747	0.279
LIG_PCNA_yPIPBox_3	705	717	PF02747	0.283
LIG_Pex14_1	419	423	PF04695	0.447
LIG_PTB_Apo_2	605	612	PF02174	0.546
LIG_SH2_CRK	483	487	PF00017	0.534
LIG_SH2_CRK	685	689	PF00017	0.464
LIG_SH2_CRK	718	722	PF00017	0.437
LIG_SH2_GRB2like	869	872	PF00017	0.417
LIG_SH2_NCK_1	183	187	PF00017	0.521
LIG_SH2_NCK_1	496	500	PF00017	0.476
LIG_SH2_PTP2	176	179	PF00017	0.328
LIG_SH2_PTP2	587	590	PF00017	0.546
LIG_SH2_SRC	869	872	PF00017	0.417
LIG_SH2_STAP1	183	187	PF00017	0.527
LIG_SH2_STAP1	375	379	PF00017	0.516
LIG_SH2_STAP1	718	722	PF00017	0.437
LIG_SH2_STAP1	807	811	PF00017	0.312
LIG_SH2_STAP1	869	873	PF00017	0.383
LIG_SH2_STAT5	155	158	PF00017	0.571
LIG_SH2_STAT5	176	179	PF00017	0.456
LIG_SH2_STAT5	183	186	PF00017	0.528
LIG_SH2_STAT5	194	197	PF00017	0.335
LIG_SH2_STAT5	26	29	PF00017	0.483
LIG_SH2_STAT5	332	335	PF00017	0.562
LIG_SH2_STAT5	375	378	PF00017	0.579
LIG_SH2_STAT5	483	486	PF00017	0.518
LIG_SH2_STAT5	493	496	PF00017	0.390
LIG_SH2_STAT5	587	590	PF00017	0.546
LIG_SH2_STAT5	602	605	PF00017	0.436
LIG_SH2_STAT5	61	64	PF00017	0.520
LIG_SH2_STAT5	718	721	PF00017	0.435
LIG_SH2_STAT5	725	728	PF00017	0.443
LIG_SH3_3	409	415	PF00018	0.460
LIG_SH3_3	419	425	PF00018	0.379
LIG_SH3_3	504	510	PF00018	0.414
LIG_SH3_3	728	734	PF00018	0.526
LIG_SH3_3	96	102	PF00018	0.568
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.422
LIG_SUMO_SIM_anti_2	64	73	PF11976	0.559
LIG_SUMO_SIM_anti_2	719	724	PF11976	0.453
LIG_SUMO_SIM_par_1	548	553	PF11976	0.563
LIG_SUMO_SIM_par_1	64	73	PF11976	0.354
LIG_SUMO_SIM_par_1	797	805	PF11976	0.306
LIG_TRAF2_1	189	192	PF00917	0.547
LIG_TRAF2_1	444	447	PF00917	0.325
LIG_UBA3_1	539	548	PF00899	0.546
LIG_UBA3_1	549	555	PF00899	0.473
LIG_UBA3_1	621	628	PF00899	0.546
LIG_WRC_WIRS_1	738	743	PF05994	0.510
MOD_CDK_SPxK_1	258	264	PF00069	0.562
MOD_CK1_1	118	124	PF00069	0.506
MOD_CK1_1	128	134	PF00069	0.650
MOD_CK1_1	260	266	PF00069	0.597
MOD_CK1_1	377	383	PF00069	0.521
MOD_CK1_1	38	44	PF00069	0.653
MOD_CK1_1	524	530	PF00069	0.479
MOD_CK1_1	589	595	PF00069	0.546
MOD_CK1_1	629	635	PF00069	0.546
MOD_CK1_1	646	652	PF00069	0.494
MOD_CK1_1	653	659	PF00069	0.607
MOD_CK1_1	732	738	PF00069	0.395
MOD_CK1_1	745	751	PF00069	0.352
MOD_CK1_1	801	807	PF00069	0.317
MOD_CK1_1	97	103	PF00069	0.459
MOD_CK2_1	162	168	PF00069	0.568
MOD_CK2_1	207	213	PF00069	0.404
MOD_CK2_1	295	301	PF00069	0.582
MOD_CK2_1	415	421	PF00069	0.428
MOD_CK2_1	524	530	PF00069	0.546
MOD_CK2_1	629	635	PF00069	0.611
MOD_CK2_1	67	73	PF00069	0.531
MOD_CK2_1	783	789	PF00069	0.354
MOD_CK2_1	79	85	PF00069	0.461
MOD_CK2_1	843	849	PF00069	0.318
MOD_GlcNHglycan	164	167	PF01048	0.583
MOD_GlcNHglycan	172	175	PF01048	0.484
MOD_GlcNHglycan	223	226	PF01048	0.682
MOD_GlcNHglycan	255	258	PF01048	0.578
MOD_GlcNHglycan	269	272	PF01048	0.666
MOD_GlcNHglycan	297	300	PF01048	0.777
MOD_GlcNHglycan	362	365	PF01048	0.527
MOD_GlcNHglycan	367	370	PF01048	0.517
MOD_GlcNHglycan	37	40	PF01048	0.670
MOD_GlcNHglycan	376	379	PF01048	0.480
MOD_GlcNHglycan	441	445	PF01048	0.603
MOD_GlcNHglycan	487	490	PF01048	0.575
MOD_GlcNHglycan	591	594	PF01048	0.316
MOD_GlcNHglycan	646	649	PF01048	0.673
MOD_GlcNHglycan	652	655	PF01048	0.586
MOD_GlcNHglycan	734	737	PF01048	0.390
MOD_GlcNHglycan	823	826	PF01048	0.383
MOD_GlcNHglycan	833	836	PF01048	0.492
MOD_GSK3_1	118	125	PF00069	0.691
MOD_GSK3_1	158	165	PF00069	0.570
MOD_GSK3_1	253	260	PF00069	0.699
MOD_GSK3_1	295	302	PF00069	0.700
MOD_GSK3_1	319	326	PF00069	0.807
MOD_GSK3_1	338	345	PF00069	0.751
MOD_GSK3_1	34	41	PF00069	0.506
MOD_GSK3_1	365	372	PF00069	0.596
MOD_GSK3_1	373	380	PF00069	0.674
MOD_GSK3_1	392	399	PF00069	0.421
MOD_GSK3_1	474	481	PF00069	0.440
MOD_GSK3_1	638	645	PF00069	0.644
MOD_GSK3_1	646	653	PF00069	0.629
MOD_GSK3_1	69	76	PF00069	0.612
MOD_GSK3_1	783	790	PF00069	0.434
MOD_GSK3_1	798	805	PF00069	0.274
MOD_GSK3_1	843	850	PF00069	0.435
MOD_GSK3_1	93	100	PF00069	0.509
MOD_N-GLC_1	437	442	PF02516	0.517
MOD_N-GLC_1	577	582	PF02516	0.234
MOD_N-GLC_1	612	617	PF02516	0.268
MOD_N-GLC_1	626	631	PF02516	0.322
MOD_N-GLC_1	650	655	PF02516	0.650
MOD_N-GLC_1	668	673	PF02516	0.393
MOD_N-GLC_1	68	73	PF02516	0.599
MOD_N-GLC_1	93	98	PF02516	0.684
MOD_NEK2_1	204	209	PF00069	0.578
MOD_NEK2_1	320	325	PF00069	0.667
MOD_NEK2_1	34	39	PF00069	0.396
MOD_NEK2_1	501	506	PF00069	0.508
MOD_NEK2_1	550	555	PF00069	0.486
MOD_NEK2_1	644	649	PF00069	0.672
MOD_NEK2_1	67	72	PF00069	0.360
MOD_NEK2_1	688	693	PF00069	0.468
MOD_NEK2_1	716	721	PF00069	0.458
MOD_NEK2_1	753	758	PF00069	0.380
MOD_NEK2_1	802	807	PF00069	0.482
MOD_NEK2_1	828	833	PF00069	0.527
MOD_PIKK_1	118	124	PF00454	0.505
MOD_PIKK_1	43	49	PF00454	0.613
MOD_PK_1	847	853	PF00069	0.330
MOD_PKA_1	169	175	PF00069	0.500
MOD_PKA_1	396	402	PF00069	0.572
MOD_PKA_1	521	527	PF00069	0.247
MOD_PKA_1	639	645	PF00069	0.627
MOD_PKA_2	169	175	PF00069	0.500
MOD_PKA_2	35	41	PF00069	0.572
MOD_PKA_2	396	402	PF00069	0.572
MOD_PKA_2	521	527	PF00069	0.405
MOD_PKA_2	638	644	PF00069	0.607
MOD_Plk_1	118	124	PF00069	0.631
MOD_Plk_1	440	446	PF00069	0.446
MOD_Plk_1	55	61	PF00069	0.446
MOD_Plk_1	612	618	PF00069	0.467
MOD_Plk_1	626	632	PF00069	0.522
MOD_Plk_1	869	875	PF00069	0.359
MOD_Plk_1	93	99	PF00069	0.662
MOD_Plk_2-3	344	350	PF00069	0.586
MOD_Plk_4	125	131	PF00069	0.650
MOD_Plk_4	207	213	PF00069	0.543
MOD_Plk_4	22	28	PF00069	0.355
MOD_Plk_4	301	307	PF00069	0.555
MOD_Plk_4	328	334	PF00069	0.557
MOD_Plk_4	415	421	PF00069	0.527
MOD_Plk_4	524	530	PF00069	0.606
MOD_Plk_4	532	538	PF00069	0.513
MOD_Plk_4	626	632	PF00069	0.546
MOD_Plk_4	688	694	PF00069	0.468
MOD_Plk_4	716	722	PF00069	0.435
MOD_Plk_4	754	760	PF00069	0.459
MOD_Plk_4	798	804	PF00069	0.299
MOD_ProDKin_1	156	162	PF00069	0.555
MOD_ProDKin_1	232	238	PF00069	0.632
MOD_ProDKin_1	258	264	PF00069	0.609
MOD_ProDKin_1	381	387	PF00069	0.401
MOD_ProDKin_1	787	793	PF00069	0.561
MOD_ProDKin_1	829	835	PF00069	0.487
MOD_SUMO_rev_2	620	630	PF00179	0.546
MOD_SUMO_rev_2	804	812	PF00179	0.476
MOD_SUMO_rev_2	849	857	PF00179	0.489
TRG_DiLeu_BaEn_1	546	551	PF01217	0.546
TRG_DiLeu_BaEn_1	771	776	PF01217	0.451
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.324
TRG_ENDOCYTIC_2	176	179	PF00928	0.485
TRG_ENDOCYTIC_2	26	29	PF00928	0.483
TRG_ENDOCYTIC_2	306	309	PF00928	0.552
TRG_ENDOCYTIC_2	332	335	PF00928	0.562
TRG_ENDOCYTIC_2	456	459	PF00928	0.461
TRG_ENDOCYTIC_2	483	486	PF00928	0.518
TRG_ENDOCYTIC_2	587	590	PF00928	0.553
TRG_ENDOCYTIC_2	685	688	PF00928	0.466
TRG_ENDOCYTIC_2	718	721	PF00928	0.435
TRG_ENDOCYTIC_2	738	741	PF00928	0.306
TRG_ER_diArg_1	169	171	PF00400	0.549
TRG_ER_diArg_1	52	54	PF00400	0.564
TRG_ER_diArg_1	813	815	PF00400	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3N9	Leishmania donovani	74%	100%
A4I5V0	Leishmania infantum	74%	93%
E9B145	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q721	Leishmania major	73%	100%