Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIK3_LEIBR

TriTrypDb:

LbrM.30.2670 , LBRM2903_300033200

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.605
CLV_C14_Caspase3-7	237	241	PF00656	0.590
CLV_C14_Caspase3-7	384	388	PF00656	0.559
CLV_C14_Caspase3-7	780	784	PF00656	0.588
CLV_MEL_PAP_1	867	873	PF00089	0.577
CLV_NRD_NRD_1	133	135	PF00675	0.626
CLV_NRD_NRD_1	169	171	PF00675	0.863
CLV_NRD_NRD_1	233	235	PF00675	0.610
CLV_NRD_NRD_1	270	272	PF00675	0.864
CLV_NRD_NRD_1	431	433	PF00675	0.658
CLV_NRD_NRD_1	480	482	PF00675	0.728
CLV_NRD_NRD_1	506	508	PF00675	0.846
CLV_NRD_NRD_1	807	809	PF00675	0.767
CLV_PCSK_FUR_1	167	171	PF00082	0.862
CLV_PCSK_KEX2_1	133	135	PF00082	0.695
CLV_PCSK_KEX2_1	169	171	PF00082	0.863
CLV_PCSK_KEX2_1	270	272	PF00082	0.864
CLV_PCSK_KEX2_1	431	433	PF00082	0.873
CLV_PCSK_KEX2_1	506	508	PF00082	0.846
CLV_PCSK_KEX2_1	807	809	PF00082	0.767
CLV_PCSK_SKI1_1	20	24	PF00082	0.685
CLV_PCSK_SKI1_1	25	29	PF00082	0.595
CLV_PCSK_SKI1_1	270	274	PF00082	0.858
CLV_PCSK_SKI1_1	30	34	PF00082	0.518
CLV_PCSK_SKI1_1	333	337	PF00082	0.560
CLV_PCSK_SKI1_1	474	478	PF00082	0.698
CLV_PCSK_SKI1_1	574	578	PF00082	0.775
CLV_PCSK_SKI1_1	661	665	PF00082	0.694
CLV_Separin_Metazoa	709	713	PF03568	0.522
DEG_Nend_UBRbox_2	1	3	PF02207	0.789
DEG_SCF_FBW7_1	272	278	PF00400	0.583
DOC_ANK_TNKS_1	483	490	PF00023	0.790
DOC_CKS1_1	272	277	PF01111	0.852
DOC_CYCLIN_yCln2_LP_2	898	904	PF00134	0.543
DOC_MAPK_gen_1	56	66	PF00069	0.542
DOC_MAPK_MEF2A_6	59	68	PF00069	0.780
DOC_MAPK_MEF2A_6	752	760	PF00069	0.587
DOC_PP1_RVXF_1	63	69	PF00149	0.563
DOC_PP2B_LxvP_1	589	592	PF13499	0.797
DOC_PP2B_LxvP_1	665	668	PF13499	0.740
DOC_PP2B_LxvP_1	898	901	PF13499	0.775
DOC_PP4_FxxP_1	313	316	PF00568	0.814
DOC_USP7_MATH_1	172	176	PF00917	0.652
DOC_USP7_MATH_1	275	279	PF00917	0.666
DOC_USP7_MATH_1	425	429	PF00917	0.709
DOC_USP7_MATH_1	442	446	PF00917	0.540
DOC_USP7_MATH_1	69	73	PF00917	0.832
DOC_USP7_MATH_1	705	709	PF00917	0.466
DOC_USP7_MATH_1	723	727	PF00917	0.694
DOC_USP7_MATH_1	828	832	PF00917	0.746
DOC_USP7_MATH_1	838	842	PF00917	0.742
DOC_USP7_MATH_1	98	102	PF00917	0.719
DOC_USP7_UBL2_3	482	486	PF12436	0.757
DOC_USP7_UBL2_3	490	494	PF12436	0.711
DOC_WW_Pin1_4	102	107	PF00397	0.588
DOC_WW_Pin1_4	150	155	PF00397	0.653
DOC_WW_Pin1_4	218	223	PF00397	0.587
DOC_WW_Pin1_4	271	276	PF00397	0.850
DOC_WW_Pin1_4	289	294	PF00397	0.565
DOC_WW_Pin1_4	312	317	PF00397	0.776
DOC_WW_Pin1_4	320	325	PF00397	0.632
DOC_WW_Pin1_4	352	357	PF00397	0.844
DOC_WW_Pin1_4	364	369	PF00397	0.632
DOC_WW_Pin1_4	398	403	PF00397	0.817
DOC_WW_Pin1_4	433	438	PF00397	0.643
DOC_WW_Pin1_4	446	451	PF00397	0.601
DOC_WW_Pin1_4	501	506	PF00397	0.572
DOC_WW_Pin1_4	587	592	PF00397	0.796
DOC_WW_Pin1_4	630	635	PF00397	0.839
DOC_WW_Pin1_4	783	788	PF00397	0.784
DOC_WW_Pin1_4	789	794	PF00397	0.833
DOC_WW_Pin1_4	82	87	PF00397	0.787
DOC_WW_Pin1_4	834	839	PF00397	0.638
DOC_WW_Pin1_4	857	862	PF00397	0.710
DOC_WW_Pin1_4	93	98	PF00397	0.733
LIG_14-3-3_CanoR_1	113	117	PF00244	0.830
LIG_14-3-3_CanoR_1	133	141	PF00244	0.529
LIG_14-3-3_CanoR_1	270	275	PF00244	0.825
LIG_14-3-3_CanoR_1	277	284	PF00244	0.749
LIG_14-3-3_CanoR_1	431	437	PF00244	0.795
LIG_14-3-3_CanoR_1	574	579	PF00244	0.777
LIG_14-3-3_CanoR_1	661	666	PF00244	0.706
LIG_14-3-3_CanoR_1	724	728	PF00244	0.783
LIG_CtBP_PxDLS_1	248	252	PF00389	0.556
LIG_deltaCOP1_diTrp_1	698	704	PF00928	0.653
LIG_FHA_1	122	128	PF00498	0.821
LIG_FHA_1	172	178	PF00498	0.593
LIG_FHA_1	200	206	PF00498	0.838
LIG_FHA_1	242	248	PF00498	0.831
LIG_FHA_1	271	277	PF00498	0.812
LIG_FHA_1	296	302	PF00498	0.847
LIG_FHA_1	641	647	PF00498	0.577
LIG_FHA_1	658	664	PF00498	0.637
LIG_FHA_1	730	736	PF00498	0.564
LIG_FHA_1	753	759	PF00498	0.816
LIG_FHA_1	796	802	PF00498	0.818
LIG_FHA_1	87	93	PF00498	0.819
LIG_FHA_2	155	161	PF00498	0.643
LIG_FHA_2	235	241	PF00498	0.621
LIG_FHA_2	353	359	PF00498	0.572
LIG_FHA_2	382	388	PF00498	0.601
LIG_FHA_2	434	440	PF00498	0.851
LIG_FHA_2	508	514	PF00498	0.842
LIG_FHA_2	575	581	PF00498	0.780
LIG_FHA_2	615	621	PF00498	0.716
LIG_FHA_2	645	651	PF00498	0.764
LIG_FHA_2	771	777	PF00498	0.757
LIG_FHA_2	871	877	PF00498	0.847
LIG_Integrin_isoDGR_2	3	5	PF01839	0.514
LIG_Integrin_RGD_1	61	63	PF01839	0.544
LIG_LIR_Apic_2	311	316	PF02991	0.814
LIG_LIR_Gen_1	403	412	PF02991	0.845
LIG_LIR_Gen_1	607	616	PF02991	0.558
LIG_LIR_Gen_1	698	705	PF02991	0.654
LIG_LIR_Gen_1	860	871	PF02991	0.572
LIG_LIR_Gen_1	891	900	PF02991	0.796
LIG_LIR_Nem_3	561	565	PF02991	0.645
LIG_LIR_Nem_3	571	576	PF02991	0.747
LIG_LIR_Nem_3	584	589	PF02991	0.586
LIG_LIR_Nem_3	607	613	PF02991	0.552
LIG_LIR_Nem_3	698	704	PF02991	0.653
LIG_LIR_Nem_3	860	866	PF02991	0.569
LIG_LIR_Nem_3	891	895	PF02991	0.799
LIG_MYND_1	834	838	PF01753	0.598
LIG_SH2_CRK	8	12	PF00017	0.766
LIG_SH2_CRK	863	867	PF00017	0.571
LIG_SH2_PTP2	365	368	PF00017	0.825
LIG_SH2_STAP1	642	646	PF00017	0.548
LIG_SH2_STAP1	863	867	PF00017	0.571
LIG_SH2_STAT3	242	245	PF00017	0.840
LIG_SH2_STAT5	114	117	PF00017	0.561
LIG_SH2_STAT5	365	368	PF00017	0.825
LIG_SH2_STAT5	585	588	PF00017	0.802
LIG_SH2_STAT5	642	645	PF00017	0.550
LIG_SH3_2	516	521	PF14604	0.857
LIG_SH3_3	261	267	PF00018	0.846
LIG_SH3_3	281	287	PF00018	0.530
LIG_SH3_3	290	296	PF00018	0.544
LIG_SH3_3	299	305	PF00018	0.520
LIG_SH3_3	413	419	PF00018	0.591
LIG_SH3_3	441	447	PF00018	0.723
LIG_SH3_3	513	519	PF00018	0.850
LIG_SH3_3	589	595	PF00018	0.785
LIG_SH3_3	63	69	PF00018	0.680
LIG_SH3_3	798	804	PF00018	0.656
LIG_SH3_3	822	828	PF00018	0.810
LIG_SH3_3	851	857	PF00018	0.587
LIG_SH3_3	89	95	PF00018	0.854
LIG_SUMO_SIM_anti_2	757	762	PF11976	0.602
LIG_SUMO_SIM_par_1	753	759	PF11976	0.763
LIG_SUMO_SIM_par_1	9	17	PF11976	0.734
LIG_TRAF2_1	355	358	PF00917	0.566
LIG_TRAF2_1	648	651	PF00917	0.743
LIG_WRC_WIRS_1	892	897	PF05994	0.823
MOD_CDK_SPK_2	364	369	PF00069	0.830
MOD_CDK_SPK_2	501	506	PF00069	0.572
MOD_CDK_SPxK_1	271	277	PF00069	0.853
MOD_CDK_SPxK_1	398	404	PF00069	0.820
MOD_CDK_SPxK_1	501	507	PF00069	0.573
MOD_CDK_SPxxK_3	218	225	PF00069	0.590
MOD_CDK_SPxxK_3	352	359	PF00069	0.842
MOD_CDK_SPxxK_3	433	440	PF00069	0.863
MOD_CDK_SPxxK_3	783	790	PF00069	0.597
MOD_CK1_1	142	148	PF00069	0.599
MOD_CK1_1	221	227	PF00069	0.778
MOD_CK1_1	259	265	PF00069	0.771
MOD_CK1_1	278	284	PF00069	0.727
MOD_CK1_1	590	596	PF00069	0.532
MOD_CK1_1	632	638	PF00069	0.601
MOD_CK1_1	644	650	PF00069	0.602
MOD_CK1_1	657	663	PF00069	0.483
MOD_CK1_1	716	722	PF00069	0.723
MOD_CK1_1	725	731	PF00069	0.811
MOD_CK1_1	750	756	PF00069	0.542
MOD_CK1_1	96	102	PF00069	0.852
MOD_CK2_1	114	120	PF00069	0.555
MOD_CK2_1	154	160	PF00069	0.637
MOD_CK2_1	352	358	PF00069	0.576
MOD_CK2_1	433	439	PF00069	0.848
MOD_CK2_1	574	580	PF00069	0.778
MOD_CK2_1	608	614	PF00069	0.814
MOD_CK2_1	644	650	PF00069	0.775
MOD_CK2_1	692	698	PF00069	0.583
MOD_CK2_1	703	709	PF00069	0.503
MOD_CK2_1	71	77	PF00069	0.581
MOD_CK2_1	715	721	PF00069	0.535
MOD_CK2_1	751	757	PF00069	0.770
MOD_CK2_1	812	818	PF00069	0.756
MOD_CK2_1	870	876	PF00069	0.849
MOD_GlcNHglycan	130	133	PF01048	0.639
MOD_GlcNHglycan	178	181	PF01048	0.871
MOD_GlcNHglycan	280	283	PF01048	0.863
MOD_GlcNHglycan	284	287	PF01048	0.790
MOD_GlcNHglycan	350	353	PF01048	0.784
MOD_GlcNHglycan	392	396	PF01048	0.841
MOD_GlcNHglycan	416	419	PF01048	0.824
MOD_GlcNHglycan	423	426	PF01048	0.765
MOD_GlcNHglycan	494	497	PF01048	0.642
MOD_GlcNHglycan	501	504	PF01048	0.582
MOD_GlcNHglycan	532	535	PF01048	0.831
MOD_GlcNHglycan	647	650	PF01048	0.749
MOD_GlcNHglycan	71	74	PF01048	0.817
MOD_GlcNHglycan	715	718	PF01048	0.700
MOD_GlcNHglycan	798	801	PF01048	0.779
MOD_GlcNHglycan	838	841	PF01048	0.859
MOD_GlcNHglycan	849	852	PF01048	0.680
MOD_GSK3_1	105	112	PF00069	0.682
MOD_GSK3_1	135	142	PF00069	0.846
MOD_GSK3_1	150	157	PF00069	0.597
MOD_GSK3_1	172	179	PF00069	0.848
MOD_GSK3_1	207	214	PF00069	0.580
MOD_GSK3_1	221	228	PF00069	0.767
MOD_GSK3_1	271	278	PF00069	0.769
MOD_GSK3_1	348	355	PF00069	0.725
MOD_GSK3_1	381	388	PF00069	0.598
MOD_GSK3_1	400	407	PF00069	0.826
MOD_GSK3_1	410	417	PF00069	0.685
MOD_GSK3_1	421	428	PF00069	0.686
MOD_GSK3_1	442	449	PF00069	0.728
MOD_GSK3_1	608	615	PF00069	0.822
MOD_GSK3_1	625	632	PF00069	0.580
MOD_GSK3_1	638	645	PF00069	0.608
MOD_GSK3_1	657	664	PF00069	0.386
MOD_GSK3_1	692	699	PF00069	0.361
MOD_GSK3_1	722	729	PF00069	0.793
MOD_GSK3_1	747	754	PF00069	0.542
MOD_GSK3_1	76	83	PF00069	0.797
MOD_GSK3_1	791	798	PF00069	0.839
MOD_GSK3_1	808	815	PF00069	0.470
MOD_GSK3_1	834	841	PF00069	0.621
MOD_GSK3_1	870	877	PF00069	0.607
MOD_GSK3_1	96	103	PF00069	0.551
MOD_LATS_1	430	436	PF00433	0.599
MOD_N-GLC_1	207	212	PF02516	0.844
MOD_N-GLC_1	259	264	PF02516	0.569
MOD_N-GLC_1	311	316	PF02516	0.587
MOD_N-GLC_1	385	390	PF02516	0.790
MOD_N-GLC_1	846	851	PF02516	0.592
MOD_NEK2_1	135	140	PF00069	0.707
MOD_NEK2_1	276	281	PF00069	0.593
MOD_NEK2_1	335	340	PF00069	0.565
MOD_NEK2_1	420	425	PF00069	0.602
MOD_NEK2_1	480	485	PF00069	0.747
MOD_NEK2_1	6	11	PF00069	0.507
MOD_NEK2_1	703	708	PF00069	0.424
MOD_NEK2_1	747	752	PF00069	0.543
MOD_NEK2_1	829	834	PF00069	0.608
MOD_NEK2_2	114	119	PF00069	0.825
MOD_NEK2_2	121	126	PF00069	0.695
MOD_NEK2_2	649	654	PF00069	0.736
MOD_PIKK_1	241	247	PF00454	0.836
MOD_PIKK_1	442	448	PF00454	0.583
MOD_PIKK_1	692	698	PF00454	0.583
MOD_PIKK_1	791	797	PF00454	0.841
MOD_PIKK_1	808	814	PF00454	0.470
MOD_PK_1	404	410	PF00069	0.844
MOD_PKA_1	234	240	PF00069	0.594
MOD_PKA_1	270	276	PF00069	0.812
MOD_PKA_1	431	437	PF00069	0.594
MOD_PKA_1	808	814	PF00069	0.750
MOD_PKA_2	112	118	PF00069	0.558
MOD_PKA_2	270	276	PF00069	0.828
MOD_PKA_2	430	436	PF00069	0.667
MOD_PKA_2	442	448	PF00069	0.546
MOD_PKA_2	480	486	PF00069	0.754
MOD_PKA_2	723	729	PF00069	0.578
MOD_Plk_1	109	115	PF00069	0.802
MOD_Plk_1	259	265	PF00069	0.572
MOD_Plk_1	391	397	PF00069	0.840
MOD_Plk_1	404	410	PF00069	0.564
MOD_Plk_1	622	628	PF00069	0.586
MOD_Plk_1	649	655	PF00069	0.739
MOD_Plk_2-3	614	620	PF00069	0.677
MOD_Plk_4	404	410	PF00069	0.844
MOD_Plk_4	581	587	PF00069	0.796
MOD_Plk_4	696	702	PF00069	0.369
MOD_ProDKin_1	102	108	PF00069	0.586
MOD_ProDKin_1	150	156	PF00069	0.653
MOD_ProDKin_1	218	224	PF00069	0.587
MOD_ProDKin_1	271	277	PF00069	0.853
MOD_ProDKin_1	289	295	PF00069	0.565
MOD_ProDKin_1	312	318	PF00069	0.778
MOD_ProDKin_1	320	326	PF00069	0.633
MOD_ProDKin_1	352	358	PF00069	0.844
MOD_ProDKin_1	364	370	PF00069	0.625
MOD_ProDKin_1	398	404	PF00069	0.820
MOD_ProDKin_1	433	439	PF00069	0.647
MOD_ProDKin_1	446	452	PF00069	0.600
MOD_ProDKin_1	501	507	PF00069	0.573
MOD_ProDKin_1	587	593	PF00069	0.797
MOD_ProDKin_1	630	636	PF00069	0.836
MOD_ProDKin_1	783	789	PF00069	0.783
MOD_ProDKin_1	82	88	PF00069	0.789
MOD_ProDKin_1	834	840	PF00069	0.637
MOD_ProDKin_1	857	863	PF00069	0.713
MOD_ProDKin_1	93	99	PF00069	0.736
MOD_SUMO_for_1	125	128	PF00179	0.561
MOD_SUMO_for_1	476	479	PF00179	0.699
MOD_SUMO_rev_2	351	361	PF00179	0.579
MOD_SUMO_rev_2	757	766	PF00179	0.567
TRG_DiLeu_BaEn_4	650	656	PF01217	0.733
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.562
TRG_ENDOCYTIC_2	406	409	PF00928	0.847
TRG_ENDOCYTIC_2	585	588	PF00928	0.802
TRG_ENDOCYTIC_2	863	866	PF00928	0.573
TRG_ER_diArg_1	133	135	PF00400	0.700
TRG_ER_diArg_1	167	170	PF00400	0.851
TRG_ER_diArg_1	269	271	PF00400	0.860
TRG_ER_diArg_1	505	507	PF00400	0.851
TRG_ER_diArg_1	806	808	PF00400	0.772
TRG_ER_diArg_1	833	836	PF00400	0.602
TRG_ER_FFAT_2	311	319	PF00635	0.584
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7N6	Leishmania donovani	68%	97%
A4I5U8	Leishmania infantum	68%	97%
E9B143	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	98%
Q4Q723	Leishmania major	68%	100%