Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIK0_LEIBR

TriTrypDb:

LbrM.30.2640 , LBRM2903_300032900

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HIK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.529
CLV_NRD_NRD_1	290	292	PF00675	0.534
CLV_PCSK_KEX2_1	290	292	PF00082	0.482
CLV_PCSK_SKI1_1	12	16	PF00082	0.561
CLV_PCSK_SKI1_1	183	187	PF00082	0.569
CLV_PCSK_SKI1_1	290	294	PF00082	0.534
CLV_PCSK_SKI1_1	338	342	PF00082	0.333
DEG_Nend_UBRbox_2	1	3	PF02207	0.424
DOC_AGCK_PIF_1	140	145	PF00069	0.281
DOC_MAPK_gen_1	131	140	PF00069	0.262
DOC_PP1_RVXF_1	288	295	PF00149	0.249
DOC_PP4_FxxP_1	162	165	PF00568	0.289
DOC_USP7_MATH_1	158	162	PF00917	0.354
DOC_USP7_MATH_1	16	20	PF00917	0.417
DOC_USP7_MATH_1	221	225	PF00917	0.375
DOC_USP7_MATH_1	235	239	PF00917	0.292
DOC_USP7_MATH_1	305	309	PF00917	0.348
DOC_WW_Pin1_4	230	235	PF00397	0.251
LIG_14-3-3_CanoR_1	131	140	PF00244	0.365
LIG_14-3-3_CanoR_1	141	146	PF00244	0.231
LIG_14-3-3_CanoR_1	338	343	PF00244	0.630
LIG_14-3-3_CanoR_1	97	104	PF00244	0.437
LIG_eIF4E_1	214	220	PF01652	0.357
LIG_FHA_1	245	251	PF00498	0.269
LIG_FHA_1	334	340	PF00498	0.583
LIG_FHA_1	56	62	PF00498	0.421
LIG_FHA_1	93	99	PF00498	0.290
LIG_FHA_2	121	127	PF00498	0.311
LIG_FHA_2	213	219	PF00498	0.312
LIG_LIR_Apic_2	159	165	PF02991	0.308
LIG_LIR_Gen_1	353	361	PF02991	0.682
LIG_LIR_Nem_3	179	185	PF02991	0.399
LIG_LIR_Nem_3	353	358	PF02991	0.653
LIG_NRBOX	21	27	PF00104	0.550
LIG_NRBOX	288	294	PF00104	0.344
LIG_Pex14_2	296	300	PF04695	0.252
LIG_Pex14_2	49	53	PF04695	0.413
LIG_Pex14_2	78	82	PF04695	0.295
LIG_Pex3_1	289	300	PF04882	0.291
LIG_PTB_Apo_2	90	97	PF02174	0.368
LIG_PTB_Phospho_1	90	96	PF10480	0.363
LIG_Rb_LxCxE_1	319	336	PF01857	0.503
LIG_SH2_CRK	232	236	PF00017	0.342
LIG_SH2_CRK	312	316	PF00017	0.531
LIG_SH2_CRK	355	359	PF00017	0.714
LIG_SH2_GRB2like	146	149	PF00017	0.273
LIG_SH2_GRB2like	91	94	PF00017	0.364
LIG_SH2_SRC	91	94	PF00017	0.364
LIG_SH2_STAP1	57	61	PF00017	0.228
LIG_SH2_STAT5	181	184	PF00017	0.312
LIG_SH2_STAT5	214	217	PF00017	0.385
LIG_SH2_STAT5	243	246	PF00017	0.318
LIG_SH2_STAT5	312	315	PF00017	0.678
LIG_SH2_STAT5	57	60	PF00017	0.298
LIG_SH2_STAT5	91	94	PF00017	0.364
LIG_SH3_3	171	177	PF00018	0.354
LIG_SH3_3	182	188	PF00018	0.283
LIG_SH3_3	358	364	PF00018	0.639
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.539
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.270
LIG_SUMO_SIM_par_1	2	8	PF11976	0.411
LIG_SUMO_SIM_par_1	246	251	PF11976	0.224
LIG_SUMO_SIM_par_1	57	62	PF11976	0.244
LIG_Vh1_VBS_1	15	33	PF01044	0.345
LIG_WRC_WIRS_1	142	147	PF05994	0.291
MOD_CK1_1	269	275	PF00069	0.581
MOD_CK1_1	329	335	PF00069	0.676
MOD_CK2_1	120	126	PF00069	0.365
MOD_GlcNHglycan	170	173	PF01048	0.570
MOD_GlcNHglycan	197	200	PF01048	0.619
MOD_GlcNHglycan	215	218	PF01048	0.547
MOD_GlcNHglycan	223	226	PF01048	0.588
MOD_GlcNHglycan	271	274	PF01048	0.774
MOD_GlcNHglycan	275	278	PF01048	0.608
MOD_GlcNHglycan	307	310	PF01048	0.531
MOD_GSK3_1	244	251	PF00069	0.268
MOD_GSK3_1	257	264	PF00069	0.481
MOD_GSK3_1	265	272	PF00069	0.516
MOD_GSK3_1	275	282	PF00069	0.504
MOD_GSK3_1	329	336	PF00069	0.616
MOD_GSK3_1	92	99	PF00069	0.409
MOD_N-GLC_1	269	274	PF02516	0.669
MOD_N-GLC_1	92	97	PF02516	0.470
MOD_N-GLC_2	311	313	PF02516	0.284
MOD_NEK2_1	92	97	PF00069	0.225
MOD_NEK2_2	333	338	PF00069	0.535
MOD_PK_1	284	290	PF00069	0.397
MOD_PKA_2	261	267	PF00069	0.416
MOD_PKA_2	96	102	PF00069	0.425
MOD_Plk_1	158	164	PF00069	0.407
MOD_Plk_1	92	98	PF00069	0.270
MOD_Plk_4	158	164	PF00069	0.328
MOD_Plk_4	16	22	PF00069	0.501
MOD_Plk_4	176	182	PF00069	0.409
MOD_Plk_4	284	290	PF00069	0.354
MOD_ProDKin_1	230	236	PF00069	0.259
TRG_DiLeu_BaEn_1	69	74	PF01217	0.284
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.451
TRG_ENDOCYTIC_2	312	315	PF00928	0.613
TRG_ENDOCYTIC_2	355	358	PF00928	0.615
TRG_ENDOCYTIC_2	91	94	PF00928	0.212
TRG_ER_diArg_1	130	133	PF00400	0.382
TRG_ER_diArg_1	289	291	PF00400	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT9	Leptomonas seymouri	45%	97%
A0A1X0P1M4	Trypanosomatidae	32%	94%
A0A3S7X3V1	Leishmania donovani	70%	99%
A0A422NM26	Trypanosoma rangeli	34%	95%
A4I5U4	Leishmania infantum	70%	99%
C9ZR64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B139	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q727	Leishmania major	68%	100%
V5DNY7	Trypanosoma cruzi	35%	88%