Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIJ9_LEIBR

TriTrypDb:

LbrM.30.2630 , LBRM2903_300032800

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ9

PDB structure(s): 7aih_Aj , 7am2_Aj , 7ane_Aj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.494
CLV_NRD_NRD_1	113	115	PF00675	0.623
CLV_NRD_NRD_1	175	177	PF00675	0.435
CLV_NRD_NRD_1	178	180	PF00675	0.467
CLV_NRD_NRD_1	256	258	PF00675	0.349
CLV_NRD_NRD_1	307	309	PF00675	0.350
CLV_NRD_NRD_1	335	337	PF00675	0.410
CLV_NRD_NRD_1	58	60	PF00675	0.501
CLV_PCSK_FUR_1	176	180	PF00082	0.299
CLV_PCSK_KEX2_1	113	115	PF00082	0.576
CLV_PCSK_KEX2_1	175	177	PF00082	0.421
CLV_PCSK_KEX2_1	178	180	PF00082	0.458
CLV_PCSK_KEX2_1	256	258	PF00082	0.349
CLV_PCSK_KEX2_1	334	336	PF00082	0.410
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.501
CLV_PCSK_PC7_1	330	336	PF00082	0.494
CLV_PCSK_SKI1_1	178	182	PF00082	0.296
CLV_PCSK_SKI1_1	23	27	PF00082	0.422
CLV_PCSK_SKI1_1	314	318	PF00082	0.343
CLV_PCSK_SKI1_1	361	365	PF00082	0.394
CLV_Separin_Metazoa	348	352	PF03568	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.618
DEG_SPOP_SBC_1	66	70	PF00917	0.702
DOC_AGCK_PIF_2	269	274	PF00069	0.316
DOC_CDC14_PxL_1	248	256	PF14671	0.332
DOC_MAPK_gen_1	113	119	PF00069	0.487
DOC_MAPK_gen_1	253	262	PF00069	0.384
DOC_MAPK_gen_1	295	304	PF00069	0.511
DOC_MAPK_RevD_3	299	315	PF00069	0.442
DOC_PP1_RVXF_1	263	270	PF00149	0.332
DOC_PP2B_LxvP_1	367	370	PF13499	0.406
DOC_USP7_MATH_1	106	110	PF00917	0.603
DOC_USP7_MATH_1	65	69	PF00917	0.726
DOC_USP7_UBL2_3	408	412	PF12436	0.552
DOC_WW_Pin1_4	267	272	PF00397	0.319
DOC_WW_Pin1_4	342	347	PF00397	0.361
DOC_WW_Pin1_4	350	355	PF00397	0.396
DOC_WW_Pin1_4	77	82	PF00397	0.651
LIG_14-3-3_CanoR_1	27	33	PF00244	0.408
LIG_14-3-3_CanoR_1	325	330	PF00244	0.375
LIG_14-3-3_CanoR_1	395	403	PF00244	0.340
LIG_BIR_III_4	417	421	PF00653	0.404
LIG_EH1_1	244	252	PF00400	0.332
LIG_eIF4E_1	32	38	PF01652	0.517
LIG_FHA_1	175	181	PF00498	0.422
LIG_FHA_1	90	96	PF00498	0.598
LIG_FHA_2	224	230	PF00498	0.395
LIG_FHA_2	231	237	PF00498	0.380
LIG_FHA_2	343	349	PF00498	0.360
LIG_FHA_2	83	89	PF00498	0.733
LIG_IBAR_NPY_1	390	392	PF08397	0.417
LIG_Integrin_RGD_1	415	417	PF01839	0.349
LIG_LIR_Gen_1	263	274	PF02991	0.328
LIG_LIR_Gen_1	85	94	PF02991	0.678
LIG_LIR_Nem_3	143	148	PF02991	0.352
LIG_LIR_Nem_3	26	32	PF02991	0.378
LIG_LIR_Nem_3	263	269	PF02991	0.335
LIG_LIR_Nem_3	273	277	PF02991	0.318
LIG_LIR_Nem_3	407	413	PF02991	0.423
LIG_LIR_Nem_3	85	89	PF02991	0.689
LIG_MAD2	383	391	PF02301	0.451
LIG_PCNA_yPIPBox_3	373	385	PF02747	0.564
LIG_PDZ_Class_2	416	421	PF00595	0.574
LIG_Pex14_2	258	262	PF04695	0.388
LIG_REV1ctd_RIR_1	314	324	PF16727	0.367
LIG_SH2_CRK	145	149	PF00017	0.335
LIG_SH2_CRK	274	278	PF00017	0.515
LIG_SH2_NCK_1	152	156	PF00017	0.353
LIG_SH2_NCK_1	274	278	PF00017	0.375
LIG_SH2_PTP2	116	119	PF00017	0.384
LIG_SH2_STAP1	152	156	PF00017	0.372
LIG_SH2_STAP1	274	278	PF00017	0.311
LIG_SH2_STAP1	29	33	PF00017	0.407
LIG_SH2_STAP1	365	369	PF00017	0.421
LIG_SH2_STAT5	116	119	PF00017	0.399
LIG_SH2_STAT5	131	134	PF00017	0.373
LIG_SH2_STAT5	268	271	PF00017	0.312
LIG_SH2_STAT5	29	32	PF00017	0.417
LIG_SH2_STAT5	413	416	PF00017	0.423
LIG_SH3_3	109	115	PF00018	0.507
LIG_SUMO_SIM_anti_2	229	237	PF11976	0.335
LIG_TYR_ITIM	142	147	PF00017	0.484
LIG_WRC_WIRS_1	235	240	PF05994	0.329
MOD_CK1_1	223	229	PF00069	0.375
MOD_CK1_1	241	247	PF00069	0.372
MOD_CK1_1	69	75	PF00069	0.660
MOD_CK2_1	223	229	PF00069	0.393
MOD_CK2_1	342	348	PF00069	0.361
MOD_Cter_Amidation	254	257	PF01082	0.337
MOD_GlcNHglycan	221	225	PF01048	0.271
MOD_GlcNHglycan	240	243	PF01048	0.374
MOD_GlcNHglycan	69	72	PF01048	0.700
MOD_GSK3_1	174	181	PF00069	0.456
MOD_GSK3_1	23	30	PF00069	0.411
MOD_GSK3_1	230	237	PF00069	0.346
MOD_GSK3_1	338	345	PF00069	0.379
MOD_GSK3_1	61	68	PF00069	0.712
MOD_GSK3_1	94	101	PF00069	0.603
MOD_NEK2_1	154	159	PF00069	0.502
MOD_NEK2_1	174	179	PF00069	0.362
MOD_NEK2_1	180	185	PF00069	0.357
MOD_NEK2_1	234	239	PF00069	0.479
MOD_NEK2_1	28	33	PF00069	0.386
MOD_PIKK_1	396	402	PF00454	0.495
MOD_PK_1	51	57	PF00069	0.330
MOD_PKA_1	178	184	PF00069	0.284
MOD_PKA_2	174	180	PF00069	0.401
MOD_PKB_1	176	184	PF00069	0.282
MOD_Plk_1	106	112	PF00069	0.420
MOD_Plk_1	98	104	PF00069	0.467
MOD_Plk_2-3	230	236	PF00069	0.416
MOD_Plk_2-3	82	88	PF00069	0.660
MOD_Plk_4	223	229	PF00069	0.425
MOD_Plk_4	230	236	PF00069	0.418
MOD_Plk_4	28	34	PF00069	0.375
MOD_ProDKin_1	267	273	PF00069	0.326
MOD_ProDKin_1	342	348	PF00069	0.361
MOD_ProDKin_1	350	356	PF00069	0.397
MOD_ProDKin_1	77	83	PF00069	0.648
MOD_SUMO_for_1	123	126	PF00179	0.391
MOD_SUMO_for_1	363	366	PF00179	0.405
MOD_SUMO_rev_2	310	317	PF00179	0.354
TRG_DiLeu_BaEn_1	230	235	PF01217	0.393
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.440
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.333
TRG_ENDOCYTIC_2	116	119	PF00928	0.384
TRG_ENDOCYTIC_2	144	147	PF00928	0.358
TRG_ENDOCYTIC_2	274	277	PF00928	0.519
TRG_ER_diArg_1	112	114	PF00400	0.531
TRG_ER_diArg_1	174	176	PF00400	0.430
TRG_ER_diArg_1	178	180	PF00400	0.467
TRG_ER_diArg_1	256	258	PF00400	0.349
TRG_ER_diArg_1	392	395	PF00400	0.421
TRG_NES_CRM1_1	203	217	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P524	Leptomonas seymouri	79%	99%
A0A0S4JJI8	Bodo saltans	55%	100%
A0A1X0P1I0	Trypanosomatidae	62%	97%
A0A3Q8IC59	Leishmania donovani	87%	100%
A0A3S5IRF5	Trypanosoma rangeli	65%	100%
A4I5U3	Leishmania infantum	87%	100%
C9ZR63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
E9B138	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	81%
Q4Q728	Leishmania major	87%	100%
V5BSI7	Trypanosoma cruzi	64%	100%