Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIJ8_LEIBR

TriTrypDb:

LbrM.30.2620 , LBRM2903_300032700

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HIJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.599
CLV_NRD_NRD_1	28	30	PF00675	0.405
CLV_PCSK_FUR_1	23	27	PF00082	0.331
CLV_PCSK_KEX2_1	25	27	PF00082	0.335
CLV_PCSK_KEX2_1	28	30	PF00082	0.396
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.428
CLV_PCSK_SKI1_1	144	148	PF00082	0.449
CLV_PCSK_SKI1_1	29	33	PF00082	0.457
DOC_MAPK_gen_1	23	33	PF00069	0.354
DOC_USP7_MATH_1	115	119	PF00917	0.497
DOC_USP7_MATH_1	133	137	PF00917	0.450
LIG_14-3-3_CanoR_1	55	61	PF00244	0.354
LIG_14-3-3_CanoR_1	68	76	PF00244	0.371
LIG_APCC_ABBA_1	31	36	PF00400	0.352
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_BRCT_BRCA1_1	53	57	PF00533	0.468
LIG_FHA_1	11	17	PF00498	0.629
LIG_FHA_1	28	34	PF00498	0.276
LIG_FHA_1	57	63	PF00498	0.345
LIG_FHA_1	68	74	PF00498	0.391
LIG_FHA_2	145	151	PF00498	0.588
LIG_FHA_2	99	105	PF00498	0.475
LIG_LIR_Gen_1	100	111	PF02991	0.392
LIG_LIR_Nem_3	100	106	PF02991	0.405
LIG_LIR_Nem_3	85	91	PF02991	0.409
LIG_SH2_STAP1	58	62	PF00017	0.337
LIG_SH2_STAT3	64	67	PF00017	0.458
LIG_SH2_STAT5	21	24	PF00017	0.328
LIG_SH2_STAT5	34	37	PF00017	0.347
LIG_SH2_STAT5	58	61	PF00017	0.349
LIG_SUMO_SIM_anti_2	70	78	PF11976	0.429
LIG_TYR_ITIM	19	24	PF00017	0.267
MOD_CK2_1	98	104	PF00069	0.477
MOD_GSK3_1	142	149	PF00069	0.698
MOD_GSK3_1	67	74	PF00069	0.421
MOD_GSK3_1	78	85	PF00069	0.474
MOD_GSK3_1	89	96	PF00069	0.386
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	75	80	PF00069	0.394
MOD_PIKK_1	139	145	PF00454	0.466
MOD_PKA_2	27	33	PF00069	0.465
MOD_PKA_2	67	73	PF00069	0.473
MOD_Plk_1	71	77	PF00069	0.384
MOD_Plk_2-3	98	104	PF00069	0.477
MOD_Plk_4	71	77	PF00069	0.382
MOD_Plk_4	98	104	PF00069	0.604
MOD_SUMO_rev_2	104	112	PF00179	0.392
TRG_ENDOCYTIC_2	21	24	PF00928	0.328
TRG_ENDOCYTIC_2	34	37	PF00928	0.347
TRG_ER_diArg_1	26	29	PF00400	0.388
TRG_NLS_MonoExtC_3	24	29	PF00514	0.450
TRG_NLS_MonoExtN_4	23	29	PF00514	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G5	Leptomonas seymouri	69%	100%
A0A3Q8IS54	Leishmania donovani	77%	100%
A0A3R7LZP3	Trypanosoma rangeli	52%	99%
A4I5U2	Leishmania infantum	77%	100%
E9B137	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q729	Leishmania major	74%	100%
V5DP06	Trypanosoma cruzi	47%	99%