Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIJ6_LEIBR

TriTrypDb:

LbrM.30.2600 , LBRM2903_300032500

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.414
CLV_C14_Caspase3-7	434	438	PF00656	0.407
CLV_NRD_NRD_1	396	398	PF00675	0.450
CLV_NRD_NRD_1	440	442	PF00675	0.461
CLV_NRD_NRD_1	625	627	PF00675	0.725
CLV_NRD_NRD_1	742	744	PF00675	0.802
CLV_NRD_NRD_1	816	818	PF00675	0.661
CLV_PCSK_KEX2_1	253	255	PF00082	0.503
CLV_PCSK_KEX2_1	295	297	PF00082	0.521
CLV_PCSK_KEX2_1	396	398	PF00082	0.450
CLV_PCSK_KEX2_1	625	627	PF00082	0.725
CLV_PCSK_KEX2_1	676	678	PF00082	0.770
CLV_PCSK_KEX2_1	742	744	PF00082	0.795
CLV_PCSK_KEX2_1	816	818	PF00082	0.661
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.604
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.521
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.770
CLV_PCSK_SKI1_1	253	257	PF00082	0.499
CLV_PCSK_SKI1_1	296	300	PF00082	0.469
CLV_PCSK_SKI1_1	381	385	PF00082	0.471
CLV_PCSK_SKI1_1	539	543	PF00082	0.707
CLV_PCSK_SKI1_1	625	629	PF00082	0.570
CLV_PCSK_SKI1_1	690	694	PF00082	0.707
CLV_PCSK_SKI1_1	823	827	PF00082	0.733
CLV_PCSK_SKI1_1	88	92	PF00082	0.460
DEG_APCC_DBOX_1	295	303	PF00400	0.475
DEG_APCC_DBOX_1	380	388	PF00400	0.539
DEG_APCC_DBOX_1	396	404	PF00400	0.401
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DEG_SPOP_SBC_1	793	797	PF00917	0.549
DOC_CYCLIN_RxL_1	376	388	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.464
DOC_MAPK_gen_1	119	129	PF00069	0.522
DOC_MAPK_gen_1	253	262	PF00069	0.577
DOC_MAPK_gen_1	396	405	PF00069	0.430
DOC_MAPK_gen_1	414	424	PF00069	0.492
DOC_MAPK_MEF2A_6	122	129	PF00069	0.436
DOC_MAPK_MEF2A_6	301	310	PF00069	0.539
DOC_PP2B_LxvP_1	204	207	PF13499	0.513
DOC_PP2B_LxvP_1	758	761	PF13499	0.817
DOC_SPAK_OSR1_1	50	54	PF12202	0.575
DOC_USP7_MATH_1	138	142	PF00917	0.486
DOC_USP7_MATH_1	226	230	PF00917	0.526
DOC_USP7_MATH_1	239	243	PF00917	0.506
DOC_USP7_MATH_1	283	287	PF00917	0.461
DOC_USP7_MATH_1	357	361	PF00917	0.490
DOC_USP7_MATH_1	370	374	PF00917	0.354
DOC_USP7_MATH_1	446	450	PF00917	0.416
DOC_USP7_MATH_1	537	541	PF00917	0.807
DOC_USP7_MATH_1	569	573	PF00917	0.782
DOC_USP7_MATH_1	619	623	PF00917	0.810
DOC_USP7_MATH_1	627	631	PF00917	0.665
DOC_USP7_MATH_1	684	688	PF00917	0.688
DOC_USP7_MATH_1	724	728	PF00917	0.676
DOC_USP7_MATH_1	794	798	PF00917	0.705
DOC_USP7_UBL2_3	136	140	PF12436	0.618
DOC_WW_Pin1_4	20	25	PF00397	0.392
DOC_WW_Pin1_4	222	227	PF00397	0.570
DOC_WW_Pin1_4	312	317	PF00397	0.461
DOC_WW_Pin1_4	435	440	PF00397	0.509
DOC_WW_Pin1_4	547	552	PF00397	0.633
DOC_WW_Pin1_4	631	636	PF00397	0.774
DOC_WW_Pin1_4	667	672	PF00397	0.738
DOC_WW_Pin1_4	741	746	PF00397	0.793
LIG_14-3-3_CanoR_1	122	126	PF00244	0.522
LIG_14-3-3_CanoR_1	254	264	PF00244	0.563
LIG_14-3-3_CanoR_1	326	336	PF00244	0.513
LIG_14-3-3_CanoR_1	445	451	PF00244	0.405
LIG_14-3-3_CanoR_1	511	515	PF00244	0.683
LIG_14-3-3_CanoR_1	620	624	PF00244	0.748
LIG_14-3-3_CanoR_1	659	663	PF00244	0.580
LIG_14-3-3_CanoR_1	695	704	PF00244	0.833
LIG_14-3-3_CanoR_1	736	742	PF00244	0.629
LIG_14-3-3_CanoR_1	792	801	PF00244	0.781
LIG_14-3-3_CanoR_1	810	816	PF00244	0.656
LIG_Actin_WH2_2	108	124	PF00022	0.505
LIG_Actin_WH2_2	240	258	PF00022	0.533
LIG_Actin_WH2_2	351	369	PF00022	0.459
LIG_Actin_WH2_2	415	433	PF00022	0.338
LIG_AP2alpha_1	193	197	PF02296	0.749
LIG_BRCT_BRCA1_1	189	193	PF00533	0.498
LIG_BRCT_BRCA1_1	197	201	PF00533	0.471
LIG_BRCT_BRCA1_1	60	64	PF00533	0.325
LIG_BRCT_BRCA1_1	794	798	PF00533	0.553
LIG_CtBP_PxDLS_1	774	778	PF00389	0.686
LIG_EVH1_2	269	273	PF00568	0.341
LIG_FHA_1	122	128	PF00498	0.534
LIG_FHA_1	201	207	PF00498	0.506
LIG_FHA_1	250	256	PF00498	0.518
LIG_FHA_1	275	281	PF00498	0.503
LIG_FHA_1	285	291	PF00498	0.446
LIG_FHA_1	366	372	PF00498	0.315
LIG_FHA_1	531	537	PF00498	0.579
LIG_FHA_1	736	742	PF00498	0.558
LIG_FHA_2	190	196	PF00498	0.752
LIG_FHA_2	206	212	PF00498	0.504
LIG_GBD_Chelix_1	379	387	PF00786	0.469
LIG_GBD_Chelix_1	98	106	PF00786	0.396
LIG_LIR_Gen_1	198	209	PF02991	0.611
LIG_LIR_Gen_1	56	67	PF02991	0.479
LIG_LIR_Nem_3	147	151	PF02991	0.467
LIG_LIR_Nem_3	161	167	PF02991	0.500
LIG_LIR_Nem_3	198	204	PF02991	0.609
LIG_LIR_Nem_3	56	62	PF02991	0.460
LIG_LIR_Nem_3	795	801	PF02991	0.620
LIG_NRBOX	174	180	PF00104	0.542
LIG_NRBOX	420	426	PF00104	0.470
LIG_NRBOX	495	501	PF00104	0.489
LIG_Pex14_2	193	197	PF04695	0.749
LIG_SH2_PTP2	114	117	PF00017	0.482
LIG_SH2_PTP2	352	355	PF00017	0.514
LIG_SH2_SRC	151	154	PF00017	0.340
LIG_SH2_STAP1	164	168	PF00017	0.598
LIG_SH2_STAP1	662	666	PF00017	0.799
LIG_SH2_STAT5	114	117	PF00017	0.482
LIG_SH2_STAT5	148	151	PF00017	0.411
LIG_SH2_STAT5	272	275	PF00017	0.489
LIG_SH2_STAT5	352	355	PF00017	0.514
LIG_SH2_STAT5	40	43	PF00017	0.405
LIG_SH2_STAT5	402	405	PF00017	0.368
LIG_SH2_STAT5	432	435	PF00017	0.450
LIG_SH3_1	18	24	PF00018	0.650
LIG_SH3_3	14	20	PF00018	0.537
LIG_SH3_3	450	456	PF00018	0.472
LIG_SH3_3	612	618	PF00018	0.826
LIG_SH3_3	754	760	PF00018	0.819
LIG_SH3_3	761	767	PF00018	0.668
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.457
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.214
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.616
LIG_SUMO_SIM_par_1	202	208	PF11976	0.509
LIG_SUMO_SIM_par_1	367	373	PF11976	0.316
LIG_SUMO_SIM_par_1	611	617	PF11976	0.585
LIG_SUMO_SIM_par_1	773	779	PF11976	0.570
LIG_TRAF2_1	683	686	PF00917	0.620
LIG_TRAF2_1	752	755	PF00917	0.774
LIG_TYR_ITIM	400	405	PF00017	0.421
LIG_UBA3_1	424	431	PF00899	0.324
LIG_WRC_WIRS_1	227	232	PF05994	0.510
LIG_WRC_WIRS_1	503	508	PF05994	0.464
LIG_WRC_WIRS_1	59	64	PF05994	0.321
LIG_WW_1	269	272	PF00397	0.352
MOD_CDC14_SPxK_1	438	441	PF00782	0.505
MOD_CDC14_SPxK_1	674	677	PF00782	0.651
MOD_CDK_SPK_2	671	676	PF00069	0.560
MOD_CDK_SPxK_1	435	441	PF00069	0.510
MOD_CDK_SPxK_1	671	677	PF00069	0.649
MOD_CDK_SPxxK_3	435	442	PF00069	0.508
MOD_CK1_1	174	180	PF00069	0.643
MOD_CK1_1	184	190	PF00069	0.587
MOD_CK1_1	225	231	PF00069	0.628
MOD_CK1_1	242	248	PF00069	0.409
MOD_CK1_1	331	337	PF00069	0.465
MOD_CK1_1	359	365	PF00069	0.485
MOD_CK1_1	43	49	PF00069	0.592
MOD_CK1_1	509	515	PF00069	0.674
MOD_CK1_1	518	524	PF00069	0.713
MOD_CK1_1	561	567	PF00069	0.755
MOD_CK1_1	572	578	PF00069	0.719
MOD_CK1_1	634	640	PF00069	0.744
MOD_CK1_1	694	700	PF00069	0.774
MOD_CK1_1	765	771	PF00069	0.572
MOD_CK1_1	776	782	PF00069	0.505
MOD_CK2_1	138	144	PF00069	0.485
MOD_CK2_1	480	486	PF00069	0.380
MOD_CK2_1	723	729	PF00069	0.573
MOD_GlcNHglycan	189	192	PF01048	0.641
MOD_GlcNHglycan	197	200	PF01048	0.544
MOD_GlcNHglycan	247	250	PF01048	0.566
MOD_GlcNHglycan	296	299	PF01048	0.493
MOD_GlcNHglycan	331	334	PF01048	0.569
MOD_GlcNHglycan	336	339	PF01048	0.501
MOD_GlcNHglycan	359	362	PF01048	0.569
MOD_GlcNHglycan	387	390	PF01048	0.507
MOD_GlcNHglycan	514	517	PF01048	0.726
MOD_GlcNHglycan	539	542	PF01048	0.775
MOD_GlcNHglycan	560	563	PF01048	0.726
MOD_GlcNHglycan	571	574	PF01048	0.810
MOD_GlcNHglycan	629	632	PF01048	0.683
MOD_GlcNHglycan	639	642	PF01048	0.573
MOD_GlcNHglycan	697	700	PF01048	0.712
MOD_GSK3_1	134	141	PF00069	0.510
MOD_GSK3_1	170	177	PF00069	0.540
MOD_GSK3_1	189	196	PF00069	0.648
MOD_GSK3_1	218	225	PF00069	0.690
MOD_GSK3_1	239	246	PF00069	0.611
MOD_GSK3_1	274	281	PF00069	0.448
MOD_GSK3_1	325	332	PF00069	0.536
MOD_GSK3_1	334	341	PF00069	0.443
MOD_GSK3_1	375	382	PF00069	0.307
MOD_GSK3_1	431	438	PF00069	0.382
MOD_GSK3_1	501	508	PF00069	0.576
MOD_GSK3_1	518	525	PF00069	0.709
MOD_GSK3_1	54	61	PF00069	0.485
MOD_GSK3_1	557	564	PF00069	0.686
MOD_GSK3_1	565	572	PF00069	0.746
MOD_GSK3_1	627	634	PF00069	0.729
MOD_GSK3_1	63	70	PF00069	0.523
MOD_GSK3_1	667	674	PF00069	0.729
MOD_GSK3_1	690	697	PF00069	0.741
MOD_GSK3_1	713	720	PF00069	0.738
MOD_GSK3_1	737	744	PF00069	0.701
MOD_GSK3_1	762	769	PF00069	0.677
MOD_NEK2_1	121	126	PF00069	0.512
MOD_NEK2_1	13	18	PF00069	0.504
MOD_NEK2_1	189	194	PF00069	0.656
MOD_NEK2_1	197	202	PF00069	0.668
MOD_NEK2_1	255	260	PF00069	0.577
MOD_NEK2_1	284	289	PF00069	0.307
MOD_NEK2_1	342	347	PF00069	0.426
MOD_NEK2_1	501	506	PF00069	0.572
MOD_NEK2_1	63	68	PF00069	0.467
MOD_NEK2_1	636	641	PF00069	0.583
MOD_NEK2_1	737	742	PF00069	0.607
MOD_NEK2_1	90	95	PF00069	0.450
MOD_NEK2_2	40	45	PF00069	0.460
MOD_NEK2_2	684	689	PF00069	0.573
MOD_PIKK_1	255	261	PF00454	0.571
MOD_PIKK_1	515	521	PF00454	0.805
MOD_PIKK_1	809	815	PF00454	0.782
MOD_PKA_2	121	127	PF00069	0.516
MOD_PKA_2	325	331	PF00069	0.635
MOD_PKA_2	510	516	PF00069	0.683
MOD_PKA_2	558	564	PF00069	0.719
MOD_PKA_2	576	582	PF00069	0.710
MOD_PKA_2	619	625	PF00069	0.809
MOD_PKA_2	658	664	PF00069	0.565
MOD_PKA_2	694	700	PF00069	0.830
MOD_PKA_2	704	710	PF00069	0.670
MOD_PKA_2	735	741	PF00069	0.676
MOD_PKA_2	809	815	PF00069	0.681
MOD_PKB_1	555	563	PF00069	0.587
MOD_PKB_1	790	798	PF00069	0.559
MOD_Plk_1	138	144	PF00069	0.438
MOD_Plk_1	182	188	PF00069	0.713
MOD_Plk_1	242	248	PF00069	0.586
MOD_Plk_1	480	486	PF00069	0.380
MOD_Plk_1	501	507	PF00069	0.422
MOD_Plk_1	684	690	PF00069	0.618
MOD_Plk_2-3	147	153	PF00069	0.327
MOD_Plk_4	147	153	PF00069	0.388
MOD_Plk_4	174	180	PF00069	0.643
MOD_Plk_4	2	8	PF00069	0.523
MOD_Plk_4	200	206	PF00069	0.505
MOD_Plk_4	226	232	PF00069	0.518
MOD_Plk_4	338	344	PF00069	0.318
MOD_Plk_4	375	381	PF00069	0.304
MOD_Plk_4	446	452	PF00069	0.419
MOD_Plk_4	502	508	PF00069	0.587
MOD_Plk_4	54	60	PF00069	0.474
MOD_ProDKin_1	20	26	PF00069	0.392
MOD_ProDKin_1	222	228	PF00069	0.571
MOD_ProDKin_1	312	318	PF00069	0.470
MOD_ProDKin_1	435	441	PF00069	0.510
MOD_ProDKin_1	547	553	PF00069	0.636
MOD_ProDKin_1	631	637	PF00069	0.773
MOD_ProDKin_1	667	673	PF00069	0.740
MOD_ProDKin_1	741	747	PF00069	0.796
MOD_SUMO_for_1	127	130	PF00179	0.558
MOD_SUMO_rev_2	130	138	PF00179	0.533
MOD_SUMO_rev_2	820	825	PF00179	0.657
TRG_DiLeu_BaEn_1	420	425	PF01217	0.475
TRG_DiLeu_BaEn_1	472	477	PF01217	0.440
TRG_DiLeu_BaEn_1	495	500	PF01217	0.528
TRG_DiLeu_BaEn_2	501	507	PF01217	0.568
TRG_ENDOCYTIC_2	114	117	PF00928	0.482
TRG_ENDOCYTIC_2	352	355	PF00928	0.454
TRG_ENDOCYTIC_2	402	405	PF00928	0.420
TRG_ER_diArg_1	395	397	PF00400	0.453
TRG_ER_diArg_1	526	529	PF00400	0.724
TRG_ER_diArg_1	741	743	PF00400	0.698
TRG_ER_diArg_1	815	817	PF00400	0.665
TRG_NES_CRM1_1	278	294	PF08389	0.462
TRG_NES_CRM1_1	42	56	PF08389	0.380
TRG_NLS_Bipartite_1	235	257	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	817	821	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P525	Leptomonas seymouri	52%	95%
A0A3Q8II38	Leishmania donovani	74%	100%
A4I5U0	Leishmania infantum	74%	100%
E9B135	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q731	Leishmania major	73%	100%