Putative replication factor C, subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C, subunit 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HIJ5_LEIBR

TriTrypDb:

LbrM.30.2590 , LBRM2903_300032400

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005663	DNA replication factor C complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006261	DNA-templated DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.440
CLV_C14_Caspase3-7	87	91	PF00656	0.154
CLV_NRD_NRD_1	101	103	PF00675	0.303
CLV_NRD_NRD_1	230	232	PF00675	0.450
CLV_NRD_NRD_1	274	276	PF00675	0.360
CLV_PCSK_KEX2_1	101	103	PF00082	0.303
CLV_PCSK_KEX2_1	230	232	PF00082	0.405
CLV_PCSK_KEX2_1	274	276	PF00082	0.303
CLV_PCSK_SKI1_1	130	134	PF00082	0.303
CLV_PCSK_SKI1_1	141	145	PF00082	0.378
CLV_PCSK_SKI1_1	264	268	PF00082	0.370
DOC_ANK_TNKS_1	230	237	PF00023	0.450
DOC_ANK_TNKS_1	273	280	PF00023	0.423
DOC_MAPK_gen_1	262	269	PF00069	0.388
DOC_MAPK_MEF2A_6	262	269	PF00069	0.303
DOC_MAPK_NFAT4_5	262	270	PF00069	0.360
DOC_PP4_FxxP_1	6	9	PF00568	0.303
DOC_SPAK_OSR1_1	112	116	PF12202	0.303
DOC_USP7_MATH_1	126	130	PF00917	0.303
DOC_USP7_MATH_1	256	260	PF00917	0.319
DOC_USP7_MATH_1	60	64	PF00917	0.423
DOC_USP7_UBL2_3	133	137	PF12436	0.303
DOC_USP7_UBL2_3	264	268	PF12436	0.450
DOC_WW_Pin1_4	157	162	PF00397	0.516
LIG_Actin_WH2_2	160	178	PF00022	0.384
LIG_BIR_III_4	95	99	PF00653	0.332
LIG_BRCT_BRCA1_1	214	218	PF00533	0.398
LIG_Clathr_ClatBox_1	83	87	PF01394	0.319
LIG_eIF4E_1	134	140	PF01652	0.410
LIG_EVH1_1	76	80	PF00568	0.360
LIG_FHA_1	13	19	PF00498	0.303
LIG_FHA_2	192	198	PF00498	0.346
LIG_FHA_2	67	73	PF00498	0.450
LIG_LIR_Gen_1	105	115	PF02991	0.299
LIG_LIR_Gen_1	142	152	PF02991	0.428
LIG_LIR_Gen_1	196	206	PF02991	0.398
LIG_LIR_Gen_1	281	289	PF02991	0.319
LIG_LIR_Nem_3	105	110	PF02991	0.299
LIG_LIR_Nem_3	111	116	PF02991	0.303
LIG_LIR_Nem_3	142	148	PF02991	0.408
LIG_LIR_Nem_3	196	201	PF02991	0.411
LIG_LIR_Nem_3	281	286	PF02991	0.319
LIG_SH2_STAT3	150	153	PF00017	0.495
LIG_SH2_STAT5	119	122	PF00017	0.303
LIG_SH2_STAT5	150	153	PF00017	0.495
LIG_SH2_STAT5	213	216	PF00017	0.303
LIG_SH2_STAT5	249	252	PF00017	0.337
LIG_SH2_STAT5	283	286	PF00017	0.388
LIG_SH2_STAT5	30	33	PF00017	0.303
LIG_SH3_1	74	80	PF00018	0.388
LIG_SH3_2	77	82	PF14604	0.360
LIG_SH3_3	74	80	PF00018	0.360
LIG_SH3_4	137	144	PF00018	0.408
LIG_Sin3_3	89	96	PF02671	0.303
LIG_SUMO_SIM_par_1	285	291	PF11976	0.360
LIG_SUMO_SIM_par_1	82	88	PF11976	0.316
LIG_UBA3_1	179	187	PF00899	0.425
MOD_CK1_1	108	114	PF00069	0.319
MOD_CK1_1	160	166	PF00069	0.395
MOD_CK1_1	63	69	PF00069	0.423
MOD_GlcNHglycan	141	144	PF01048	0.502
MOD_GlcNHglycan	170	173	PF01048	0.393
MOD_GlcNHglycan	183	186	PF01048	0.363
MOD_GlcNHglycan	201	204	PF01048	0.261
MOD_GlcNHglycan	214	217	PF01048	0.309
MOD_GlcNHglycan	251	254	PF01048	0.370
MOD_GlcNHglycan	258	261	PF01048	0.345
MOD_GSK3_1	197	204	PF00069	0.483
MOD_GSK3_1	212	219	PF00069	0.292
MOD_GSK3_1	245	252	PF00069	0.317
MOD_GSK3_1	59	66	PF00069	0.369
MOD_GSK3_1	9	16	PF00069	0.317
MOD_N-GLC_1	38	43	PF02516	0.303
MOD_N-GLC_1	63	68	PF02516	0.197
MOD_NEK2_1	139	144	PF00069	0.507
MOD_PIKK_1	66	72	PF00454	0.450
MOD_PK_1	14	20	PF00069	0.388
MOD_Plk_1	108	114	PF00069	0.303
MOD_Plk_4	14	20	PF00069	0.388
MOD_Plk_4	245	251	PF00069	0.372
MOD_Plk_4	288	294	PF00069	0.320
MOD_ProDKin_1	157	163	PF00069	0.509
MOD_SUMO_rev_2	66	75	PF00179	0.354
TRG_DiLeu_BaEn_1	88	93	PF01217	0.303
TRG_ENDOCYTIC_2	145	148	PF00928	0.406
TRG_ENDOCYTIC_2	283	286	PF00928	0.388
TRG_ER_diArg_1	100	102	PF00400	0.303
TRG_ER_diArg_1	230	232	PF00400	0.450
TRG_ER_diArg_1	274	276	PF00400	0.396
TRG_ER_diArg_1	31	34	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P564	Leptomonas seymouri	43%	81%
A0A0N0P777	Leptomonas seymouri	36%	82%
A0A0N1IAI3	Leptomonas seymouri	29%	84%
A0A0N1PCT2	Leptomonas seymouri	88%	84%
A0A0S4IM83	Bodo saltans	35%	91%
A0A0S4JFI8	Bodo saltans	67%	84%
A0A0S4JGB9	Bodo saltans	34%	78%
A0A1X0NN25	Trypanosomatidae	29%	85%
A0A1X0P333	Trypanosomatidae	74%	85%
A0A1X0P3R4	Trypanosomatidae	37%	87%
A0A1X0P5L7	Trypanosomatidae	38%	82%
A0A3Q8IDA5	Leishmania donovani	36%	82%
A0A3Q8IVD9	Leishmania donovani	39%	81%
A0A3R7KCC2	Trypanosoma rangeli	38%	83%
A0A3R7KEM0	Trypanosoma rangeli	71%	85%
A0A3R7KKZ5	Trypanosoma rangeli	28%	85%
A0A3R7LYZ3	Trypanosoma rangeli	37%	87%
A0A3S7X3R0	Leishmania donovani	96%	84%
A0A3S7XCG1	Leishmania donovani	29%	84%
A1RSA2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	40%	90%
A1RV38	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	41%	92%
A1RWU7	Thermofilum pendens (strain DSM 2475 / Hrk 5)	42%	91%
A2SQT3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	37%	92%
A3CUX9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	36%	92%
A3DNV9	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	38%	90%
A3MS28	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	38%	91%
A4FZ74	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	38%	94%
A4HFI1	Leishmania braziliensis	36%	100%
A4HMZ2	Leishmania braziliensis	38%	81%
A4HQJ4	Leishmania braziliensis	29%	84%
A4I5T9	Leishmania infantum	96%	84%
A4IBL6	Leishmania infantum	39%	81%
A4WGV2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	42%	90%
A4WLY0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	42%	92%
A5UMF3	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	38%	94%
A6US36	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	35%	94%
A6VJ61	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	38%	94%
A9A6K6	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	38%	94%
B0R7H7	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	36%	92%
B1YC69	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	27%	70%
C9ZR59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	85%
C9ZZ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	83%
D0A3P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
D0A8F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	87%
E9AD32	Leishmania major	36%	100%
E9AFE9	Leishmania major	42%	100%
E9AHC5	Leishmania infantum	36%	82%
E9AI03	Leishmania infantum	29%	84%
E9AUA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	84%
E9AYV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	82%
E9B134	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	84%
E9B6K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	81%
O26343	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	92%
O28219	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	39%	93%
O74111	Blastobotrys adeninivorans	38%	88%
O94449	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	87%
O94697	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	83%
P0C7N7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	39%	72%
P34429	Caenorhabditis elegans	38%	80%
P35249	Homo sapiens	47%	82%
P35250	Homo sapiens	32%	84%
P38251	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	84%
P38629	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	87%
P40339	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	92%
P40348	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	84%
P40937	Homo sapiens	36%	87%
P40938	Homo sapiens	30%	83%
P53016	Caenorhabditis elegans	38%	89%
P53033	Gallus gallus	33%	82%
P53034	Drosophila melanogaster	31%	89%
P60373	Nanoarchaeum equitans (strain Kin4-M)	28%	69%
P60374	Nanoarchaeum equitans (strain Kin4-M)	40%	92%
Q05B83	Bos taurus	32%	84%
Q09843	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	87%
Q0W037	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	36%	92%
Q2FQT9	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	36%	92%
Q2NH89	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	32%	92%
Q2TBV1	Bos taurus	30%	83%
Q3ITJ2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	37%	91%
Q46C63	Methanosarcina barkeri (strain Fusaro / DSM 804)	38%	89%
Q4JAB0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	38%	91%
Q4Q084	Leishmania major	30%	100%
Q4Q732	Leishmania major	95%	100%
Q54BN3	Dictyostelium discoideum	32%	85%
Q54E21	Dictyostelium discoideum	33%	88%
Q54MD4	Dictyostelium discoideum	44%	85%
Q54ST4	Dictyostelium discoideum	37%	85%
Q5UP47	Acanthamoeba polyphaga mimivirus	38%	86%
Q5UQ72	Acanthamoeba polyphaga mimivirus	34%	82%
Q5UZE5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	37%	91%
Q641W4	Rattus norvegicus	33%	85%
Q6L1I0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	34%	93%
Q6M044	Methanococcus maripaludis (strain S2 / LL)	38%	94%
Q6YZ54	Oryza sativa subsp. japonica	35%	82%
Q7XRX1	Oryza sativa subsp. japonica	36%	88%
Q852K3	Oryza sativa subsp. japonica	26%	84%
Q8PVY4	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	36%	88%
Q8R323	Mus musculus	29%	83%
Q8SQM0	Encephalitozoon cuniculi (strain GB-M1)	35%	96%
Q8TSX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	36%	88%
Q8VXX4	Arabidopsis thaliana	26%	84%
Q8X082	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	84%
Q8ZYK4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	40%	90%
Q93ZX1	Arabidopsis thaliana	51%	87%
Q975D3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	37%	91%
Q977Z9	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	33%	93%
Q99J62	Mus musculus	46%	81%
Q9CAQ8	Arabidopsis thaliana	37%	80%
Q9D0F6	Mus musculus	36%	87%
Q9FXM3	Oryza sativa subsp. japonica	48%	87%
Q9HI47	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	34%	93%
Q9HN27	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	36%	92%
Q9UXF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	37%	90%
Q9WUK4	Mus musculus	33%	85%
Q9YBS7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	40%	91%
V5BM57	Trypanosoma cruzi	28%	85%
V5BMW7	Trypanosoma cruzi	70%	85%
V5C2V9	Trypanosoma cruzi	39%	83%
V5DA61	Trypanosoma cruzi	33%	100%