ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HIJ4_LEIBR

TriTrypDb:

LbrM.30.2580 , LBRM2903_300032300

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 0
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HIJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	126	132	PF00089	0.460
CLV_NRD_NRD_1	145	147	PF00675	0.519
CLV_NRD_NRD_1	208	210	PF00675	0.413
CLV_PCSK_KEX2_1	145	147	PF00082	0.519
CLV_PCSK_KEX2_1	208	210	PF00082	0.413
CLV_PCSK_SKI1_1	156	160	PF00082	0.628
CLV_PCSK_SKI1_1	48	52	PF00082	0.499
DOC_MAPK_MEF2A_6	156	165	PF00069	0.274
DOC_PP1_RVXF_1	3	10	PF00149	0.462
DOC_PP2B_LxvP_1	73	76	PF13499	0.294
DOC_PP4_FxxP_1	22	25	PF00568	0.450
DOC_SPAK_OSR1_1	129	133	PF12202	0.287
DOC_USP7_UBL2_3	134	138	PF12436	0.297
DOC_WW_Pin1_4	120	125	PF00397	0.331
LIG_14-3-3_CanoR_1	102	111	PF00244	0.259
LIG_14-3-3_CanoR_1	129	133	PF00244	0.269
LIG_14-3-3_CanoR_1	156	165	PF00244	0.327
LIG_14-3-3_CanoR_1	208	213	PF00244	0.646
LIG_14-3-3_CanoR_1	85	91	PF00244	0.367
LIG_APCC_ABBA_1	147	152	PF00400	0.278
LIG_CtBP_PxDLS_1	215	219	PF00389	0.599
LIG_FHA_1	103	109	PF00498	0.307
LIG_FHA_2	157	163	PF00498	0.295
LIG_FHA_2	93	99	PF00498	0.292
LIG_LIR_Gen_1	109	119	PF02991	0.343
LIG_LIR_Gen_1	162	171	PF02991	0.326
LIG_LIR_Gen_1	67	76	PF02991	0.274
LIG_LIR_Gen_1	95	103	PF02991	0.305
LIG_LIR_Nem_3	109	114	PF02991	0.358
LIG_LIR_Nem_3	162	167	PF02991	0.317
LIG_LIR_Nem_3	184	189	PF02991	0.260
LIG_LIR_Nem_3	67	73	PF02991	0.323
LIG_LIR_Nem_3	95	100	PF02991	0.306
LIG_NRBOX	188	194	PF00104	0.297
LIG_Pex14_1	70	74	PF04695	0.254
LIG_Pex14_2	164	168	PF04695	0.259
LIG_SH2_CRK	111	115	PF00017	0.279
LIG_SH2_STAP1	86	90	PF00017	0.389
LIG_SH2_STAT3	150	153	PF00017	0.313
LIG_SH2_STAT3	86	89	PF00017	0.393
LIG_SH2_STAT5	117	120	PF00017	0.257
LIG_SH3_3	173	179	PF00018	0.354
LIG_SH3_3	210	216	PF00018	0.613
LIG_SH3_3	40	46	PF00018	0.342
LIG_SUMO_SIM_par_1	138	143	PF11976	0.259
LIG_WRC_WIRS_1	202	207	PF05994	0.467
LIG_WRC_WIRS_1	94	99	PF05994	0.323
LIG_WW_2	178	181	PF00397	0.360
MOD_CK1_1	217	223	PF00069	0.619
MOD_CK1_1	96	102	PF00069	0.295
MOD_CK2_1	156	162	PF00069	0.282
MOD_GlcNHglycan	135	138	PF01048	0.510
MOD_GlcNHglycan	142	145	PF01048	0.480
MOD_GlcNHglycan	210	213	PF01048	0.408
MOD_GlcNHglycan	61	64	PF01048	0.660
MOD_GlcNHglycan	66	69	PF01048	0.497
MOD_GSK3_1	102	109	PF00069	0.279
MOD_GSK3_1	128	135	PF00069	0.295
MOD_GSK3_1	214	221	PF00069	0.615
MOD_GSK3_1	59	66	PF00069	0.377
MOD_GSK3_1	75	82	PF00069	0.348
MOD_GSK3_1	92	99	PF00069	0.257
MOD_LATS_1	154	160	PF00433	0.297
MOD_NEK2_1	1	6	PF00069	0.502
MOD_NEK2_1	163	168	PF00069	0.269
MOD_NEK2_1	201	206	PF00069	0.396
MOD_NEK2_1	218	223	PF00069	0.597
MOD_PIKK_1	56	62	PF00454	0.346
MOD_PIKK_1	84	90	PF00454	0.357
MOD_PKA_1	208	214	PF00069	0.579
MOD_PKA_2	101	107	PF00069	0.259
MOD_PKA_2	128	134	PF00069	0.281
MOD_PKA_2	208	214	PF00069	0.649
MOD_PKA_2	84	90	PF00069	0.374
MOD_Plk_1	92	98	PF00069	0.303
MOD_Plk_2-3	93	99	PF00069	0.330
MOD_Plk_4	106	112	PF00069	0.224
MOD_Plk_4	163	169	PF00069	0.271
MOD_Plk_4	181	187	PF00069	0.383
MOD_Plk_4	96	102	PF00069	0.276
MOD_ProDKin_1	120	126	PF00069	0.328
TRG_ENDOCYTIC_2	111	114	PF00928	0.282
TRG_ER_diArg_1	145	147	PF00400	0.396
TRG_ER_diArg_1	207	209	PF00400	0.609
TRG_NES_CRM1_1	160	172	PF08389	0.256
TRG_NES_CRM1_1	93	106	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK85	Leptomonas seymouri	48%	100%
E9B133	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%