EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIJ3_LEIBR

TriTrypDb:

LbrM.30.2570 , LBRM2903_300032200

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	677	681	PF00656	0.538
CLV_NRD_NRD_1	393	395	PF00675	0.403
CLV_NRD_NRD_1	406	408	PF00675	0.621
CLV_NRD_NRD_1	719	721	PF00675	0.517
CLV_PCSK_KEX2_1	393	395	PF00082	0.515
CLV_PCSK_KEX2_1	406	408	PF00082	0.481
CLV_PCSK_KEX2_1	719	721	PF00082	0.517
CLV_PCSK_SKI1_1	162	166	PF00082	0.541
CLV_PCSK_SKI1_1	220	224	PF00082	0.545
CLV_PCSK_SKI1_1	377	381	PF00082	0.457
CLV_PCSK_SKI1_1	406	410	PF00082	0.474
CLV_PCSK_SKI1_1	458	462	PF00082	0.442
CLV_PCSK_SKI1_1	485	489	PF00082	0.350
CLV_PCSK_SKI1_1	619	623	PF00082	0.547
DEG_APCC_DBOX_1	219	227	PF00400	0.531
DEG_APCC_DBOX_1	505	513	PF00400	0.482
DEG_Nend_UBRbox_4	1	3	PF02207	0.483
DEG_SPOP_SBC_1	167	171	PF00917	0.620
DEG_SPOP_SBC_1	240	244	PF00917	0.682
DOC_CDC14_PxL_1	576	584	PF14671	0.671
DOC_CKS1_1	430	435	PF01111	0.443
DOC_CYCLIN_RxL_1	214	227	PF00134	0.528
DOC_CYCLIN_RxL_1	523	533	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	582	588	PF00134	0.515
DOC_MAPK_DCC_7	574	584	PF00069	0.648
DOC_MAPK_gen_1	414	421	PF00069	0.467
DOC_MAPK_gen_1	526	536	PF00069	0.443
DOC_PP2B_LxvP_1	582	585	PF13499	0.664
DOC_USP7_MATH_1	167	171	PF00917	0.678
DOC_USP7_MATH_1	188	192	PF00917	0.575
DOC_USP7_MATH_1	198	202	PF00917	0.545
DOC_USP7_MATH_1	240	244	PF00917	0.685
DOC_USP7_MATH_1	259	263	PF00917	0.508
DOC_USP7_MATH_1	287	291	PF00917	0.516
DOC_USP7_MATH_1	329	333	PF00917	0.616
DOC_USP7_MATH_1	668	672	PF00917	0.669
DOC_USP7_MATH_1	68	72	PF00917	0.566
DOC_USP7_MATH_1	80	84	PF00917	0.522
DOC_USP7_UBL2_3	644	648	PF12436	0.708
DOC_WW_Pin1_4	178	183	PF00397	0.541
DOC_WW_Pin1_4	2	7	PF00397	0.485
DOC_WW_Pin1_4	241	246	PF00397	0.668
DOC_WW_Pin1_4	255	260	PF00397	0.595
DOC_WW_Pin1_4	267	272	PF00397	0.600
DOC_WW_Pin1_4	301	306	PF00397	0.557
DOC_WW_Pin1_4	429	434	PF00397	0.473
DOC_WW_Pin1_4	495	500	PF00397	0.402
DOC_WW_Pin1_4	599	604	PF00397	0.525
LIG_14-3-3_CanoR_1	101	111	PF00244	0.551
LIG_14-3-3_CanoR_1	232	237	PF00244	0.521
LIG_14-3-3_CanoR_1	306	315	PF00244	0.634
LIG_14-3-3_CanoR_1	369	373	PF00244	0.490
LIG_14-3-3_CanoR_1	558	567	PF00244	0.494
LIG_Actin_WH2_2	423	441	PF00022	0.422
LIG_APCC_ABBA_1	528	533	PF00400	0.436
LIG_BRCT_BRCA1_1	370	374	PF00533	0.533
LIG_BRCT_BRCA1_1	453	457	PF00533	0.448
LIG_eIF4E_1	531	537	PF01652	0.449
LIG_EVH1_1	576	580	PF00568	0.530
LIG_FHA_1	104	110	PF00498	0.634
LIG_FHA_1	267	273	PF00498	0.573
LIG_FHA_1	307	313	PF00498	0.546
LIG_FHA_1	337	343	PF00498	0.531
LIG_FHA_1	41	47	PF00498	0.534
LIG_FHA_1	523	529	PF00498	0.479
LIG_FHA_1	571	577	PF00498	0.527
LIG_FHA_1	595	601	PF00498	0.583
LIG_FHA_1	683	689	PF00498	0.534
LIG_FHA_2	167	173	PF00498	0.543
LIG_FHA_2	210	216	PF00498	0.572
LIG_FHA_2	357	363	PF00498	0.493
LIG_FHA_2	454	460	PF00498	0.440
LIG_FHA_2	675	681	PF00498	0.678
LIG_Integrin_isoDGR_2	659	661	PF01839	0.551
LIG_LIR_Apic_2	732	737	PF02991	0.490
LIG_LIR_Gen_1	47	56	PF02991	0.533
LIG_LIR_Gen_1	473	482	PF02991	0.481
LIG_LIR_Nem_3	404	408	PF02991	0.338
LIG_LIR_Nem_3	454	460	PF02991	0.573
LIG_LIR_Nem_3	47	51	PF02991	0.535
LIG_LIR_Nem_3	473	477	PF02991	0.291
LIG_NRBOX	423	429	PF00104	0.440
LIG_PCNA_PIPBox_1	360	369	PF02747	0.476
LIG_PCNA_yPIPBox_3	701	712	PF02747	0.623
LIG_RPA_C_Fungi	129	141	PF08784	0.559
LIG_SH2_CRK	405	409	PF00017	0.324
LIG_SH2_CRK	572	576	PF00017	0.528
LIG_SH2_NCK_1	127	131	PF00017	0.704
LIG_SH2_NCK_1	531	535	PF00017	0.306
LIG_SH2_SRC	127	130	PF00017	0.704
LIG_SH2_SRC	531	534	PF00017	0.309
LIG_SH2_STAP1	531	535	PF00017	0.446
LIG_SH2_STAP1	563	567	PF00017	0.624
LIG_SH2_STAT3	567	570	PF00017	0.521
LIG_SH2_STAT5	11	14	PF00017	0.540
LIG_SH2_STAT5	230	233	PF00017	0.632
LIG_SH2_STAT5	234	237	PF00017	0.610
LIG_SH2_STAT5	48	51	PF00017	0.538
LIG_SH2_STAT5	572	575	PF00017	0.528
LIG_SH3_1	572	578	PF00018	0.633
LIG_SH3_3	108	114	PF00018	0.580
LIG_SH3_3	179	185	PF00018	0.639
LIG_SH3_3	24	30	PF00018	0.660
LIG_SH3_3	242	248	PF00018	0.571
LIG_SH3_3	268	274	PF00018	0.574
LIG_SH3_3	281	287	PF00018	0.573
LIG_SH3_3	339	345	PF00018	0.532
LIG_SH3_3	572	578	PF00018	0.633
LIG_SH3_3	597	603	PF00018	0.525
LIG_SH3_3	614	620	PF00018	0.506
LIG_SH3_3	691	697	PF00018	0.655
LIG_SH3_4	18	25	PF00018	0.556
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.482
LIG_SUMO_SIM_par_1	337	347	PF11976	0.533
LIG_SUMO_SIM_par_1	426	432	PF11976	0.379
LIG_TRAF2_1	118	121	PF00917	0.551
LIG_TRAF2_1	145	148	PF00917	0.568
LIG_TRAF2_1	30	33	PF00917	0.636
LIG_TRAF2_1	401	404	PF00917	0.373
LIG_TYR_ITIM	46	51	PF00017	0.535
LIG_UBA3_1	408	416	PF00899	0.467
LIG_WW_1	124	127	PF00397	0.572
LIG_WW_2	577	580	PF00397	0.531
MOD_CDC14_SPxK_1	498	501	PF00782	0.397
MOD_CDK_SPK_2	241	246	PF00069	0.556
MOD_CDK_SPK_2	301	306	PF00069	0.557
MOD_CDK_SPxK_1	255	261	PF00069	0.640
MOD_CDK_SPxK_1	495	501	PF00069	0.401
MOD_CK1_1	192	198	PF00069	0.661
MOD_CK1_1	209	215	PF00069	0.531
MOD_CK1_1	241	247	PF00069	0.668
MOD_CK1_1	298	304	PF00069	0.667
MOD_CK1_1	332	338	PF00069	0.618
MOD_CK1_1	356	362	PF00069	0.579
MOD_CK1_1	453	459	PF00069	0.310
MOD_CK1_1	47	53	PF00069	0.673
MOD_CK1_1	602	608	PF00069	0.671
MOD_CK1_1	682	688	PF00069	0.649
MOD_CK1_1	73	79	PF00069	0.557
MOD_CK2_1	142	148	PF00069	0.569
MOD_CK2_1	166	172	PF00069	0.638
MOD_CK2_1	200	206	PF00069	0.562
MOD_CK2_1	209	215	PF00069	0.532
MOD_CK2_1	38	44	PF00069	0.664
MOD_CK2_1	434	440	PF00069	0.442
MOD_CK2_1	60	66	PF00069	0.699
MOD_CK2_1	72	78	PF00069	0.587
MOD_GlcNHglycan	144	147	PF01048	0.568
MOD_GlcNHglycan	174	177	PF01048	0.657
MOD_GlcNHglycan	297	300	PF01048	0.629
MOD_GlcNHglycan	62	65	PF01048	0.649
MOD_GlcNHglycan	690	694	PF01048	0.556
MOD_GlcNHglycan	70	73	PF01048	0.674
MOD_GlcNHglycan	97	100	PF01048	0.583
MOD_GSK3_1	162	169	PF00069	0.663
MOD_GSK3_1	188	195	PF00069	0.597
MOD_GSK3_1	232	239	PF00069	0.605
MOD_GSK3_1	240	247	PF00069	0.632
MOD_GSK3_1	255	262	PF00069	0.626
MOD_GSK3_1	266	273	PF00069	0.623
MOD_GSK3_1	297	304	PF00069	0.651
MOD_GSK3_1	318	325	PF00069	0.609
MOD_GSK3_1	330	337	PF00069	0.559
MOD_GSK3_1	346	353	PF00069	0.511
MOD_GSK3_1	40	47	PF00069	0.600
MOD_GSK3_1	648	655	PF00069	0.599
MOD_GSK3_1	66	73	PF00069	0.693
MOD_GSK3_1	674	681	PF00069	0.587
MOD_GSK3_1	725	732	PF00069	0.558
MOD_GSK3_1	80	87	PF00069	0.568
MOD_GSK3_1	95	102	PF00069	0.558
MOD_N-GLC_1	38	43	PF02516	0.541
MOD_N-GLC_1	66	71	PF02516	0.587
MOD_NEK2_1	236	241	PF00069	0.606
MOD_NEK2_1	266	271	PF00069	0.560
MOD_NEK2_1	297	302	PF00069	0.643
MOD_NEK2_1	315	320	PF00069	0.505
MOD_NEK2_1	334	339	PF00069	0.512
MOD_NEK2_1	350	355	PF00069	0.563
MOD_NEK2_1	38	43	PF00069	0.625
MOD_NEK2_1	486	491	PF00069	0.339
MOD_NEK2_1	49	54	PF00069	0.628
MOD_NEK2_1	60	65	PF00069	0.547
MOD_NEK2_1	689	694	PF00069	0.554
MOD_NEK2_2	434	439	PF00069	0.445
MOD_PIKK_1	192	198	PF00454	0.650
MOD_PIKK_1	234	240	PF00454	0.519
MOD_PIKK_1	725	731	PF00454	0.554
MOD_PKA_2	100	106	PF00069	0.546
MOD_PKA_2	139	145	PF00069	0.643
MOD_PKA_2	172	178	PF00069	0.625
MOD_PKA_2	209	215	PF00069	0.553
MOD_PKA_2	260	266	PF00069	0.622
MOD_PKA_2	305	311	PF00069	0.627
MOD_PKA_2	368	374	PF00069	0.541
MOD_PKA_2	396	402	PF00069	0.441
MOD_PKA_2	522	528	PF00069	0.411
MOD_PKA_2	682	688	PF00069	0.611
MOD_Plk_1	216	222	PF00069	0.554
MOD_Plk_1	346	352	PF00069	0.624
MOD_Plk_1	356	362	PF00069	0.506
MOD_Plk_1	397	403	PF00069	0.363
MOD_Plk_1	689	695	PF00069	0.554
MOD_Plk_2-3	417	423	PF00069	0.451
MOD_Plk_4	44	50	PF00069	0.548
MOD_Plk_4	619	625	PF00069	0.550
MOD_Plk_4	7	13	PF00069	0.508
MOD_Plk_4	729	735	PF00069	0.597
MOD_Plk_4	80	86	PF00069	0.548
MOD_ProDKin_1	178	184	PF00069	0.542
MOD_ProDKin_1	2	8	PF00069	0.487
MOD_ProDKin_1	241	247	PF00069	0.668
MOD_ProDKin_1	255	261	PF00069	0.596
MOD_ProDKin_1	267	273	PF00069	0.596
MOD_ProDKin_1	301	307	PF00069	0.555
MOD_ProDKin_1	429	435	PF00069	0.469
MOD_ProDKin_1	495	501	PF00069	0.401
MOD_ProDKin_1	599	605	PF00069	0.527
MOD_SUMO_rev_2	53	63	PF00179	0.681
TRG_DiLeu_BaEn_1	532	537	PF01217	0.450
TRG_DiLeu_BaEn_2	439	445	PF01217	0.424
TRG_ENDOCYTIC_2	294	297	PF00928	0.556
TRG_ENDOCYTIC_2	405	408	PF00928	0.332
TRG_ENDOCYTIC_2	474	477	PF00928	0.474
TRG_ENDOCYTIC_2	48	51	PF00928	0.538
TRG_ENDOCYTIC_2	531	534	PF00928	0.449
TRG_ER_diArg_1	218	221	PF00400	0.554
TRG_ER_diArg_1	392	394	PF00400	0.382
TRG_ER_diArg_1	405	407	PF00400	0.473
TRG_ER_diArg_1	467	470	PF00400	0.433
TRG_ER_diArg_1	719	721	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEY6	Leishmania donovani	58%	100%
A4I5T8	Leishmania infantum	58%	100%
E9B132	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4Q733	Leishmania major	58%	98%