Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIJ2_LEIBR

TriTrypDb:

LbrM.30.2560 , LBRM2903_300032100

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.581
CLV_PCSK_KEX2_1	150	152	PF00082	0.507
CLV_PCSK_KEX2_1	33	35	PF00082	0.627
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.474
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.583
CLV_PCSK_PC7_1	146	152	PF00082	0.367
CLV_PCSK_SKI1_1	93	97	PF00082	0.268
DOC_PP1_RVXF_1	91	97	PF00149	0.468
DOC_USP7_MATH_1	65	69	PF00917	0.652
LIG_14-3-3_CanoR_1	104	108	PF00244	0.567
LIG_14-3-3_CanoR_1	73	80	PF00244	0.483
LIG_14-3-3_CanoR_1	86	94	PF00244	0.498
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_FHA_1	116	122	PF00498	0.560
LIG_FHA_2	86	92	PF00498	0.468
LIG_IBAR_NPY_1	197	199	PF08397	0.667
LIG_LIR_Gen_1	118	127	PF02991	0.551
LIG_LIR_Nem_3	118	123	PF02991	0.571
LIG_LIR_Nem_3	193	199	PF02991	0.669
LIG_SH2_STAT5	120	123	PF00017	0.494
LIG_SH2_STAT5	167	170	PF00017	0.583
LIG_SUMO_SIM_anti_2	103	110	PF11976	0.551
LIG_TRAF2_1	38	41	PF00917	0.546
LIG_TRAF2_1	47	50	PF00917	0.516
MOD_CK2_1	35	41	PF00069	0.542
MOD_GlcNHglycan	13	16	PF01048	0.703
MOD_GlcNHglycan	50	53	PF01048	0.668
MOD_GlcNHglycan	68	71	PF01048	0.717
MOD_N-GLC_1	74	79	PF02516	0.420
MOD_NEK2_1	48	53	PF00069	0.596
MOD_NEK2_1	95	100	PF00069	0.511
MOD_PIKK_1	190	196	PF00454	0.660
MOD_PKA_2	103	109	PF00069	0.518
MOD_PKA_2	58	64	PF00069	0.604
MOD_PKA_2	85	91	PF00069	0.487
MOD_Plk_1	74	80	PF00069	0.413
MOD_Plk_4	103	109	PF00069	0.496
MOD_Plk_4	74	80	PF00069	0.416
MOD_SUMO_for_1	53	56	PF00179	0.674
TRG_ENDOCYTIC_2	120	123	PF00928	0.468
TRG_ER_diArg_1	169	172	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I450	Leptomonas seymouri	73%	99%
A0A0S4JLX4	Bodo saltans	47%	93%
A0A1X0P1L3	Trypanosomatidae	61%	100%
A0A3Q8IJK6	Leishmania donovani	91%	99%
A4I5T6	Leishmania infantum	91%	99%
A6NDY0	Homo sapiens	31%	77%
E9B131	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q09295	Caenorhabditis elegans	27%	100%
Q09301	Caenorhabditis elegans	30%	100%
Q28ZX3	Drosophila pseudoobscura pseudoobscura	31%	95%
Q4Q734	Leishmania major	90%	100%
Q7KNF2	Drosophila melanogaster	29%	96%
Q93VI4	Arabidopsis thaliana	36%	94%
Q9LX90	Arabidopsis thaliana	38%	99%
V5B7C6	Trypanosoma cruzi	60%	93%