Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIJ0_LEIBR

TriTrypDb:

LbrM.30.2540 , LBRM2903_300031900

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HIJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009057	macromolecule catabolic process	4	13
GO:0019538	protein metabolic process	3	13
GO:0030163	protein catabolic process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901565	organonitrogen compound catabolic process	4	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008914	leucyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016746	acyltransferase activity	3	13
GO:0016755	aminoacyltransferase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.501
CLV_NRD_NRD_1	103	105	PF00675	0.707
CLV_NRD_NRD_1	285	287	PF00675	0.325
CLV_NRD_NRD_1	397	399	PF00675	0.310
CLV_NRD_NRD_1	451	453	PF00675	0.428
CLV_NRD_NRD_1	57	59	PF00675	0.610
CLV_PCSK_KEX2_1	103	105	PF00082	0.684
CLV_PCSK_KEX2_1	285	287	PF00082	0.304
CLV_PCSK_KEX2_1	319	321	PF00082	0.539
CLV_PCSK_KEX2_1	397	399	PF00082	0.310
CLV_PCSK_KEX2_1	451	453	PF00082	0.428
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.539
CLV_PCSK_SKI1_1	175	179	PF00082	0.467
CLV_PCSK_SKI1_1	184	188	PF00082	0.385
CLV_PCSK_SKI1_1	269	273	PF00082	0.704
CLV_PCSK_SKI1_1	44	48	PF00082	0.593
CLV_PCSK_SKI1_1	446	450	PF00082	0.436
CLV_PCSK_SKI1_1	81	85	PF00082	0.636
CLV_PCSK_SKI1_1	86	90	PF00082	0.679
CLV_Separin_Metazoa	443	447	PF03568	0.261
DEG_ODPH_VHL_1	14	26	PF01847	0.442
DEG_SPOP_SBC_1	134	138	PF00917	0.551
DEG_SPOP_SBC_1	250	254	PF00917	0.624
DOC_CKS1_1	3	8	PF01111	0.556
DOC_MAPK_DCC_7	457	465	PF00069	0.255
DOC_MAPK_MEF2A_6	457	465	PF00069	0.255
DOC_PP4_FxxP_1	187	190	PF00568	0.542
DOC_PP4_FxxP_1	212	215	PF00568	0.315
DOC_USP7_MATH_1	250	254	PF00917	0.632
DOC_USP7_MATH_1	346	350	PF00917	0.733
DOC_USP7_MATH_1	351	355	PF00917	0.727
DOC_USP7_MATH_1	73	77	PF00917	0.578
DOC_WW_Pin1_4	2	7	PF00397	0.559
DOC_WW_Pin1_4	243	248	PF00397	0.634
DOC_WW_Pin1_4	95	100	PF00397	0.471
LIG_14-3-3_CanoR_1	237	241	PF00244	0.411
LIG_14-3-3_CanoR_1	310	315	PF00244	0.534
LIG_14-3-3_CanoR_1	320	324	PF00244	0.502
LIG_APCC_ABBA_1	475	480	PF00400	0.397
LIG_BIR_III_2	458	462	PF00653	0.417
LIG_BRCT_BRCA1_1	165	169	PF00533	0.493
LIG_BRCT_BRCA1_1	37	41	PF00533	0.622
LIG_Clathr_ClatBox_1	362	366	PF01394	0.451
LIG_CtBP_PxDLS_1	151	155	PF00389	0.658
LIG_CtBP_PxDLS_1	215	219	PF00389	0.426
LIG_deltaCOP1_diTrp_1	205	212	PF00928	0.364
LIG_FHA_1	119	125	PF00498	0.602
LIG_FHA_1	134	140	PF00498	0.635
LIG_FHA_1	17	23	PF00498	0.440
LIG_FHA_1	172	178	PF00498	0.573
LIG_FHA_1	195	201	PF00498	0.422
LIG_FHA_1	237	243	PF00498	0.402
LIG_FHA_1	246	252	PF00498	0.457
LIG_FHA_1	270	276	PF00498	0.545
LIG_FHA_1	370	376	PF00498	0.434
LIG_FHA_1	406	412	PF00498	0.302
LIG_FHA_1	45	51	PF00498	0.668
LIG_FHA_1	480	486	PF00498	0.630
LIG_FHA_2	135	141	PF00498	0.527
LIG_FHA_2	265	271	PF00498	0.590
LIG_LIR_Apic_2	145	151	PF02991	0.623
LIG_LIR_Gen_1	290	301	PF02991	0.394
LIG_LIR_Gen_1	326	332	PF02991	0.381
LIG_LIR_Nem_3	183	188	PF02991	0.451
LIG_LIR_Nem_3	205	211	PF02991	0.330
LIG_LIR_Nem_3	225	231	PF02991	0.340
LIG_LIR_Nem_3	290	296	PF02991	0.391
LIG_LIR_Nem_3	326	331	PF02991	0.391
LIG_LIR_Nem_3	390	394	PF02991	0.326
LIG_LIR_Nem_3	421	427	PF02991	0.449
LIG_LIR_Nem_3	436	442	PF02991	0.376
LIG_PCNA_TLS_4	400	409	PF02747	0.477
LIG_PCNA_yPIPBox_3	279	288	PF02747	0.419
LIG_PCNA_yPIPBox_3	71	81	PF02747	0.517
LIG_Pex14_1	423	427	PF04695	0.326
LIG_Pex14_2	169	173	PF04695	0.472
LIG_Pex14_2	449	453	PF04695	0.256
LIG_PTAP_UEV_1	246	251	PF05743	0.451
LIG_Rb_LxCxE_1	359	374	PF01857	0.439
LIG_SH2_CRK	208	212	PF00017	0.304
LIG_SH2_CRK	293	297	PF00017	0.348
LIG_SH2_SRC	188	191	PF00017	0.475
LIG_SH2_STAP1	120	124	PF00017	0.465
LIG_SH2_STAP1	238	242	PF00017	0.531
LIG_SH2_STAP1	293	297	PF00017	0.291
LIG_SH2_STAP1	420	424	PF00017	0.353
LIG_SH2_STAP1	435	439	PF00017	0.417
LIG_SH2_STAT3	431	434	PF00017	0.297
LIG_SH2_STAT5	120	123	PF00017	0.543
LIG_SH2_STAT5	188	191	PF00017	0.523
LIG_SH2_STAT5	238	241	PF00017	0.464
LIG_SH2_STAT5	391	394	PF00017	0.466
LIG_SH2_STAT5	420	423	PF00017	0.349
LIG_SH2_STAT5	468	471	PF00017	0.333
LIG_SH3_2	274	279	PF14604	0.307
LIG_SH3_3	187	193	PF00018	0.608
LIG_SH3_3	241	247	PF00018	0.492
LIG_SH3_3	271	277	PF00018	0.375
LIG_SH3_3	439	445	PF00018	0.489
LIG_TRFH_1	187	191	PF08558	0.336
LIG_UBA3_1	362	370	PF00899	0.453
LIG_WRC_WIRS_1	403	408	PF05994	0.411
MOD_CK1_1	118	124	PF00069	0.584
MOD_CK1_1	125	131	PF00069	0.612
MOD_CK1_1	133	139	PF00069	0.604
MOD_CK1_1	336	342	PF00069	0.618
MOD_CK1_1	399	405	PF00069	0.304
MOD_CK1_1	76	82	PF00069	0.662
MOD_CK2_1	134	140	PF00069	0.687
MOD_CK2_1	210	216	PF00069	0.481
MOD_CK2_1	264	270	PF00069	0.492
MOD_GlcNHglycan	289	292	PF01048	0.483
MOD_GlcNHglycan	47	50	PF01048	0.478
MOD_GSK3_1	114	121	PF00069	0.437
MOD_GSK3_1	124	131	PF00069	0.502
MOD_GSK3_1	210	217	PF00069	0.419
MOD_GSK3_1	245	252	PF00069	0.497
MOD_GSK3_1	260	267	PF00069	0.613
MOD_GSK3_1	31	38	PF00069	0.586
MOD_GSK3_1	336	343	PF00069	0.627
MOD_GSK3_1	392	399	PF00069	0.365
MOD_GSK3_1	464	471	PF00069	0.428
MOD_GSK3_1	481	488	PF00069	0.426
MOD_GSK3_1	73	80	PF00069	0.565
MOD_GSK3_1	84	91	PF00069	0.497
MOD_LATS_1	317	323	PF00433	0.331
MOD_N-GLC_1	17	22	PF02516	0.440
MOD_NEK2_1	194	199	PF00069	0.469
MOD_NEK2_1	35	40	PF00069	0.591
MOD_NEK2_1	485	490	PF00069	0.688
MOD_NEK2_1	84	89	PF00069	0.495
MOD_PIKK_1	346	352	PF00454	0.592
MOD_PK_1	356	362	PF00069	0.455
MOD_PKA_1	319	325	PF00069	0.451
MOD_PKA_1	58	64	PF00069	0.697
MOD_PKA_2	236	242	PF00069	0.419
MOD_PKA_2	319	325	PF00069	0.593
MOD_PKA_2	396	402	PF00069	0.525
MOD_Plk_1	17	23	PF00069	0.695
MOD_Plk_1	269	275	PF00069	0.431
MOD_Plk_1	389	395	PF00069	0.310
MOD_Plk_1	461	467	PF00069	0.439
MOD_Plk_1	84	90	PF00069	0.428
MOD_Plk_4	107	113	PF00069	0.435
MOD_Plk_4	115	121	PF00069	0.473
MOD_Plk_4	163	169	PF00069	0.517
MOD_Plk_4	17	23	PF00069	0.592
MOD_Plk_4	31	37	PF00069	0.595
MOD_Plk_4	319	325	PF00069	0.377
MOD_Plk_4	389	395	PF00069	0.353
MOD_Plk_4	402	408	PF00069	0.473
MOD_Plk_4	418	424	PF00069	0.310
MOD_Plk_4	464	470	PF00069	0.290
MOD_Plk_4	73	79	PF00069	0.566
MOD_Plk_4	88	94	PF00069	0.536
MOD_ProDKin_1	2	8	PF00069	0.559
MOD_ProDKin_1	243	249	PF00069	0.645
MOD_ProDKin_1	95	101	PF00069	0.470
MOD_SUMO_rev_2	135	143	PF00179	0.687
MOD_SUMO_rev_2	38	46	PF00179	0.709
TRG_DiLeu_BaEn_1	63	68	PF01217	0.616
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.413
TRG_ENDOCYTIC_2	208	211	PF00928	0.301
TRG_ENDOCYTIC_2	293	296	PF00928	0.453
TRG_ENDOCYTIC_2	424	427	PF00928	0.317
TRG_ER_diArg_1	102	104	PF00400	0.541
TRG_ER_diArg_1	284	286	PF00400	0.339
TRG_ER_diArg_1	396	398	PF00400	0.310
TRG_ER_diArg_1	450	452	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	361	366	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI6	Leptomonas seymouri	47%	98%
A0A0S4JJJ8	Bodo saltans	30%	100%
A0A1X0P1I4	Trypanosomatidae	32%	100%
A0A1X0P1L0	Trypanosomatidae	32%	100%
A0A3R7NR23	Trypanosoma rangeli	32%	100%
A0A3S5H7N5	Leishmania donovani	73%	99%
A4I5T4	Leishmania infantum	73%	99%
C9ZR56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B129	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q736	Leishmania major	73%	100%
V5DNZ0	Trypanosoma cruzi	31%	100%