Reticulon-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

reticulon domain protein, 22 kDa potentially aggravating protein (paple22)

Species:

Leishmania braziliensis

UniProt:

A4HII9_LEIBR

TriTrypDb:

LbrM.30.2530 , LBRM2903_300031800

Length:

197

Annotations

LeishMANIAdb annotations

Similar to reticulons (structural ER membrane proteins) of multicellular animals.. The toplology is difficult to assess, likely owing to the fact that these proteins are curvature-inducing. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HII9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII9

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	10
GO:0009607	response to biotic stimulus	2	10
GO:0009617	response to bacterium	3	10
GO:0043207	response to external biotic stimulus	3	10
GO:0044419	biological process involved in interspecies interaction between organisms	1	10
GO:0050896	response to stimulus	1	10
GO:0051707	response to other organism	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.403
CLV_PCSK_KEX2_1	68	70	PF00082	0.283
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.283
CLV_PCSK_SKI1_1	6	10	PF00082	0.410
DOC_MAPK_gen_1	6	16	PF00069	0.439
DOC_MAPK_MEF2A_6	52	60	PF00069	0.243
DOC_PP4_FxxP_1	143	146	PF00568	0.213
DOC_USP7_MATH_1	22	26	PF00917	0.442
DOC_WW_Pin1_4	71	76	PF00397	0.449
LIG_APCC_ABBA_1	38	43	PF00400	0.241
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_FHA_1	120	126	PF00498	0.236
LIG_FHA_1	130	136	PF00498	0.198
LIG_FHA_1	142	148	PF00498	0.285
LIG_FHA_1	174	180	PF00498	0.644
LIG_FHA_1	45	51	PF00498	0.328
LIG_FHA_1	55	61	PF00498	0.415
LIG_FHA_1	92	98	PF00498	0.470
LIG_FHA_2	103	109	PF00498	0.483
LIG_LIR_Gen_1	168	178	PF02991	0.462
LIG_LIR_Gen_1	27	37	PF02991	0.326
LIG_LIR_Gen_1	83	93	PF02991	0.494
LIG_LIR_LC3C_4	133	138	PF02991	0.153
LIG_LIR_Nem_3	105	109	PF02991	0.419
LIG_LIR_Nem_3	27	32	PF02991	0.126
LIG_LIR_Nem_3	34	39	PF02991	0.232
LIG_LIR_Nem_3	7	11	PF02991	0.568
LIG_LIR_Nem_3	83	89	PF02991	0.445
LIG_NRBOX	135	141	PF00104	0.153
LIG_Pex14_2	116	120	PF04695	0.271
LIG_Pex14_2	124	128	PF04695	0.294
LIG_Pex14_2	29	33	PF04695	0.281
LIG_SH2_STAP1	109	113	PF00017	0.553
LIG_SH2_STAT5	109	112	PF00017	0.415
LIG_SH2_STAT5	166	169	PF00017	0.519
LIG_SH2_STAT5	170	173	PF00017	0.486
LIG_SH2_STAT5	44	47	PF00017	0.190
LIG_SH3_3	69	75	PF00018	0.421
LIG_SUMO_SIM_anti_2	130	139	PF11976	0.270
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.241
LIG_SUMO_SIM_par_1	51	57	PF11976	0.181
LIG_WRC_WIRS_1	46	51	PF05994	0.181
MOD_CK1_1	130	136	PF00069	0.239
MOD_CK1_1	31	37	PF00069	0.355
MOD_GlcNHglycan	1	4	PF01048	0.325
MOD_GlcNHglycan	111	114	PF01048	0.228
MOD_GlcNHglycan	24	27	PF01048	0.281
MOD_GSK3_1	169	176	PF00069	0.610
MOD_GSK3_1	177	184	PF00069	0.608
MOD_GSK3_1	24	31	PF00069	0.430
MOD_GSK3_1	44	51	PF00069	0.245
MOD_GSK3_1	67	74	PF00069	0.522
MOD_NEK2_1	116	121	PF00069	0.274
MOD_NEK2_1	129	134	PF00069	0.218
MOD_NEK2_1	173	178	PF00069	0.546
MOD_NEK2_2	24	29	PF00069	0.396
MOD_PK_1	52	58	PF00069	0.241
MOD_PKA_1	181	187	PF00069	0.511
MOD_PKA_2	89	95	PF00069	0.513
MOD_Plk_1	130	136	PF00069	0.253
MOD_Plk_1	42	48	PF00069	0.250
MOD_Plk_4	116	122	PF00069	0.222
MOD_Plk_4	130	136	PF00069	0.181
MOD_Plk_4	169	175	PF00069	0.605
MOD_Plk_4	24	30	PF00069	0.387
MOD_Plk_4	45	51	PF00069	0.244
MOD_ProDKin_1	71	77	PF00069	0.449
MOD_SUMO_rev_2	191	196	PF00179	0.641
MOD_SUMO_rev_2	2	11	PF00179	0.609
TRG_ENDOCYTIC_2	170	173	PF00928	0.550
TRG_ENDOCYTIC_2	86	89	PF00928	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P527	Leptomonas seymouri	56%	100%
A0A0S4JFE7	Bodo saltans	31%	100%
A0A1X0P1J2	Trypanosomatidae	36%	100%
A0A3Q8IFS1	Leishmania donovani	78%	100%
A0A3R7L2P9	Trypanosoma rangeli	37%	100%
C9ZR54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B128	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q28D16	Xenopus tropicalis	24%	92%
Q4Q737	Leishmania major	74%	100%
Q5J6M8	Xenopus laevis	23%	92%
Q9NJS2	Leishmania infantum	78%	100%