ADF-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HII8_LEIBR

TriTrypDb:

LbrM.30.2520 , LBRM2903_300031700

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0030864	cortical actin cytoskeleton	7	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HII8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII8

Function

Biological processes
Term	Name	Level	Count
GO:0008064	regulation of actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030832	regulation of actin filament length	5	1
GO:0030833	regulation of actin filament polymerization	7	1
GO:0032271	regulation of protein polymerization	6	1
GO:0032535	regulation of cellular component size	4	1
GO:0032956	regulation of actin cytoskeleton organization	5	1
GO:0032970	regulation of actin filament-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0043254	regulation of protein-containing complex assembly	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090066	regulation of anatomical structure size	3	1
GO:0110053	regulation of actin filament organization	6	1
GO:1902903	regulation of supramolecular fiber organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.400
CLV_NRD_NRD_1	144	146	PF00675	0.596
CLV_NRD_NRD_1	147	149	PF00675	0.629
CLV_NRD_NRD_1	248	250	PF00675	0.301
CLV_NRD_NRD_1	313	315	PF00675	0.610
CLV_NRD_NRD_1	8	10	PF00675	0.298
CLV_PCSK_FUR_1	145	149	PF00082	0.618
CLV_PCSK_FUR_1	246	250	PF00082	0.248
CLV_PCSK_FUR_1	350	354	PF00082	0.498
CLV_PCSK_KEX2_1	144	146	PF00082	0.601
CLV_PCSK_KEX2_1	147	149	PF00082	0.631
CLV_PCSK_KEX2_1	248	250	PF00082	0.301
CLV_PCSK_KEX2_1	313	315	PF00082	0.680
CLV_PCSK_KEX2_1	352	354	PF00082	0.510
CLV_PCSK_KEX2_1	41	43	PF00082	0.433
CLV_PCSK_KEX2_1	59	61	PF00082	0.352
CLV_PCSK_KEX2_1	8	10	PF00082	0.298
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.510
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.461
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.327
CLV_PCSK_SKI1_1	237	241	PF00082	0.264
CLV_PCSK_SKI1_1	249	253	PF00082	0.317
CLV_PCSK_SKI1_1	304	308	PF00082	0.415
DOC_CKS1_1	307	312	PF01111	0.519
DOC_MAPK_gen_1	244	253	PF00069	0.399
DOC_MAPK_gen_1	352	361	PF00069	0.671
DOC_MAPK_gen_1	41	48	PF00069	0.362
DOC_MAPK_MEF2A_6	147	156	PF00069	0.660
DOC_MAPK_RevD_3	233	249	PF00069	0.503
DOC_PP1_RVXF_1	235	241	PF00149	0.497
DOC_PP1_RVXF_1	246	253	PF00149	0.433
DOC_PP4_FxxP_1	307	310	PF00568	0.496
DOC_USP7_MATH_1	34	38	PF00917	0.551
DOC_USP7_MATH_1	351	355	PF00917	0.625
DOC_USP7_MATH_1	383	387	PF00917	0.638
DOC_WW_Pin1_4	172	177	PF00397	0.623
DOC_WW_Pin1_4	277	282	PF00397	0.555
DOC_WW_Pin1_4	306	311	PF00397	0.496
DOC_WW_Pin1_4	378	383	PF00397	0.687
LIG_14-3-3_CanoR_1	147	152	PF00244	0.649
LIG_14-3-3_CanoR_1	185	191	PF00244	0.362
LIG_14-3-3_CanoR_1	237	245	PF00244	0.448
LIG_14-3-3_CanoR_1	265	273	PF00244	0.438
LIG_14-3-3_CanoR_1	334	338	PF00244	0.495
LIG_14-3-3_CanoR_1	350	360	PF00244	0.561
LIG_BRCT_BRCA1_1	324	328	PF00533	0.499
LIG_BRCT_BRCA1_1	36	40	PF00533	0.545
LIG_BRCT_BRCA1_1	87	91	PF00533	0.456
LIG_CtBP_PxDLS_1	176	180	PF00389	0.397
LIG_deltaCOP1_diTrp_1	228	236	PF00928	0.491
LIG_FHA_1	181	187	PF00498	0.463
LIG_FHA_1	206	212	PF00498	0.392
LIG_FHA_1	356	362	PF00498	0.657
LIG_FHA_1	390	396	PF00498	0.391
LIG_FHA_1	70	76	PF00498	0.488
LIG_FHA_2	307	313	PF00498	0.599
LIG_LIR_Apic_2	305	310	PF02991	0.460
LIG_LIR_Gen_1	196	206	PF02991	0.482
LIG_LIR_Gen_1	88	98	PF02991	0.503
LIG_LIR_Nem_3	196	202	PF02991	0.482
LIG_LIR_Nem_3	88	94	PF02991	0.496
LIG_LYPXL_S_1	271	275	PF13949	0.331
LIG_LYPXL_yS_3	272	275	PF13949	0.531
LIG_Pex14_2	236	240	PF04695	0.531
LIG_SH2_PTP2	50	53	PF00017	0.457
LIG_SH2_STAP1	284	288	PF00017	0.474
LIG_SH2_STAT3	214	217	PF00017	0.392
LIG_SH2_STAT5	287	290	PF00017	0.448
LIG_SH2_STAT5	47	50	PF00017	0.378
LIG_SH3_3	157	163	PF00018	0.701
LIG_SH3_3	170	176	PF00018	0.735
LIG_SH3_3	357	363	PF00018	0.708
LIG_SUMO_SIM_anti_2	391	397	PF11976	0.434
LIG_SUMO_SIM_par_1	175	181	PF11976	0.553
LIG_TRAF2_1	346	349	PF00917	0.512
LIG_TRAF2_1	388	391	PF00917	0.493
LIG_UBA3_1	219	224	PF00899	0.476
MOD_CDK_SPxxK_3	306	313	PF00069	0.515
MOD_CK1_1	150	156	PF00069	0.660
MOD_CK1_1	180	186	PF00069	0.596
MOD_CK1_1	369	375	PF00069	0.665
MOD_CK2_1	161	167	PF00069	0.665
MOD_CK2_1	172	178	PF00069	0.670
MOD_CK2_1	201	207	PF00069	0.595
MOD_CK2_1	369	375	PF00069	0.704
MOD_CK2_1	385	391	PF00069	0.475
MOD_CK2_1	79	85	PF00069	0.362
MOD_DYRK1A_RPxSP_1	172	176	PF00069	0.643
MOD_GlcNHglycan	149	152	PF01048	0.469
MOD_GlcNHglycan	304	307	PF01048	0.532
MOD_GlcNHglycan	324	327	PF01048	0.484
MOD_GlcNHglycan	36	39	PF01048	0.606
MOD_GSK3_1	201	208	PF00069	0.535
MOD_GSK3_1	302	309	PF00069	0.464
MOD_GSK3_1	322	329	PF00069	0.505
MOD_GSK3_1	351	358	PF00069	0.758
MOD_GSK3_1	369	376	PF00069	0.526
MOD_GSK3_1	385	392	PF00069	0.453
MOD_GSK3_1	81	88	PF00069	0.443
MOD_N-GLC_1	107	112	PF02516	0.508
MOD_N-GLC_1	193	198	PF02516	0.285
MOD_N-GLC_1	68	73	PF02516	0.505
MOD_NEK2_1	28	33	PF00069	0.387
MOD_NEK2_1	322	327	PF00069	0.519
MOD_NEK2_1	366	371	PF00069	0.598
MOD_NEK2_1	373	378	PF00069	0.631
MOD_NEK2_1	98	103	PF00069	0.579
MOD_NEK2_2	36	41	PF00069	0.479
MOD_PKA_1	147	153	PF00069	0.652
MOD_PKA_1	8	14	PF00069	0.296
MOD_PKA_2	147	153	PF00069	0.643
MOD_PKA_2	264	270	PF00069	0.443
MOD_PKA_2	333	339	PF00069	0.485
MOD_PKA_2	355	361	PF00069	0.685
MOD_PKA_2	8	14	PF00069	0.438
MOD_PKA_2	98	104	PF00069	0.627
MOD_PKB_1	145	153	PF00069	0.640
MOD_Plk_1	107	113	PF00069	0.506
MOD_Plk_1	366	372	PF00069	0.630
MOD_Plk_4	333	339	PF00069	0.484
MOD_Plk_4	98	104	PF00069	0.525
MOD_ProDKin_1	172	178	PF00069	0.616
MOD_ProDKin_1	277	283	PF00069	0.555
MOD_ProDKin_1	306	312	PF00069	0.504
MOD_ProDKin_1	378	384	PF00069	0.684
MOD_SUMO_for_1	165	168	PF00179	0.681
MOD_SUMO_rev_2	120	129	PF00179	0.413
MOD_SUMO_rev_2	19	26	PF00179	0.427
MOD_SUMO_rev_2	241	245	PF00179	0.418
TRG_DiLeu_BaEn_1	391	396	PF01217	0.377
TRG_ENDOCYTIC_2	272	275	PF00928	0.509
TRG_ENDOCYTIC_2	30	33	PF00928	0.390
TRG_ER_diArg_1	144	147	PF00400	0.608
TRG_ER_diArg_1	245	248	PF00400	0.512
TRG_ER_diArg_1	313	315	PF00400	0.585
TRG_ER_diArg_1	7	9	PF00400	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G8	Leptomonas seymouri	66%	100%
A0A1X0P342	Trypanosomatidae	40%	100%
A0A3Q8IFZ1	Leishmania donovani	84%	100%
A4I5T2	Leishmania infantum	84%	100%
C9ZR53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9B127	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q738	Leishmania major	82%	100%
V5BMX2	Trypanosoma cruzi	43%	100%